Krt5 (keratin 5) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Krt5 (keratin 5) Rattus norvegicus
Analyze
Symbol: Krt5
Name: keratin 5
RGD ID: 727894
Description: Predicted to enable scaffold protein binding activity. Predicted to be a structural constituent of skin epidermis. Predicted to be involved in several processes, including intermediate filament cytoskeleton organization; keratinization; and response to mechanical stimulus. Located in keratin filament. Biomarker of urinary bladder cancer. Human ortholog(s) of this gene implicated in Dowling-Degos disease; epidermolysis bullosa simplex; and epidermolysis bullosa simplex with mottled pigmentation. Orthologous to human KRT5 (keratin 5); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CK-5; cytokeratin-5; K5; keratin 5 (epidermolysis bullosa simplex Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types); keratin 5, type II; keratin 8; keratin complex 2, basic, gene 5; keratin, type II cytoskeletal 5; keratin-5; Krt2-5; Sak57; type-II keratin Kb5
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,724,840 - 134,730,569 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7134,724,840 - 134,730,569 (-)EnsemblGRCr8
mRatBN7.27132,846,132 - 132,851,861 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,846,136 - 132,851,850 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7134,609,855 - 134,615,592 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,839,382 - 136,845,119 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,808,400 - 136,814,179 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,320,142 - 143,324,536 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,316,920 - 143,453,546 (-)Ensemblrn6Rnor6.0
Rnor_5.07141,118,058 - 141,122,452 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera7129,286,649 - 129,292,077 (-)NCBICelera
Cytogenetic Map7q36NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-chloro-2,4-dinitrobenzene  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,6-dimethoxyphenol  (ISO)
3,3',4,4'-tetrachlorobiphenyl  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
9-cis-retinoic acid  (ISO)
acrolein  (ISO)
acrylamide  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-4-oxoretinoic acid  (ISO)
all-trans-retinoic acid  (ISO)
alpha-pinene  (ISO)
ammonium chloride  (EXP)
andrographolide  (ISO)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
beauvericin  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
butane-2,3-dione  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
cantharidin  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chlorogenic acid  (ISO)
chloropicrin  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
chromium(6+)  (ISO)
copper(II) chloride  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
dimethylarsinic acid  (ISO)
diuron  (EXP)
doxycycline  (ISO)
enniatin  (ISO)
enzyme inhibitor  (ISO)
erastin  (ISO)
ethanol  (ISO)
folic acid  (ISO)
fructose  (ISO)
furfural  (ISO)
genistein  (EXP,ISO)
glucose  (ISO)
glycidyl methacrylate  (ISO)
imidacloprid  (EXP)
irinotecan  (ISO)
isobutanol  (ISO)
isoflavones  (EXP)
isotretinoin  (ISO)
ivermectin  (ISO)
L-methionine  (ISO)
lasalocid  (ISO)
lead(0)  (ISO)
methapyrilene  (ISO)
morphine  (EXP)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-nitrosodiethylamine  (EXP)
N-nitrosomorpholine  (EXP)
nickel atom  (ISO)
O-methyleugenol  (ISO)
okadaic acid  (ISO)
Osajin  (ISO)
ozone  (ISO)
paracetamol  (ISO)
perfluorodecanoic acid  (ISO)
perfluorononanoic acid  (ISO)
phenanthrene  (ISO)
phenobarbital  (EXP)
phenyl isocyanate  (ISO)
PhIP  (EXP)
Pomiferin  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium chloride  (ISO)
sulindac sulfide  (ISO)
tamoxifen  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triptonide  (ISO)
troglitazone  (ISO)
valproic acid  (ISO)
zearalenone  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
cornified envelope  (IEA,ISO)
cytoplasm  (IEA,ISO,ISS)
intermediate filament  (IEA,ISO)
keratin filament  (IBA,IDA,IEA,ISO)
plasma membrane  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Acroplaxome, an F-actin-keratin-containing plate, anchors the acrosome to the nucleus during shaping of the spermatid head. Kierszenbaum AL, etal., Mol Biol Cell 2003 Nov;14(11):4628-40. Epub 2003 Aug 07.
4. A mutation in the conserved helix termination peptide of keratin 5 in hereditary skin blistering. Lane EB, etal., Nature. 1992 Mar 19;356(6366):244-6.
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Differential expression of keratin 5 gene in non-tumorigenic and tumorigenic rat bladder cell lines. Nan L, etal., Cancer Lett. 1993 Dec 10;75(2):87-93.
7. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. Loss of keratin expression in anaplastic carcinoma cells due to posttranscriptional down-regulation acting in trans. Paine ML, etal., Cancer Res 1992 Dec 1;52(23):6603-11.
10. GOA pipeline RGD automated data pipeline
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Comprehensive gene review and curation RGD comprehensive gene curation
Additional References at PubMed
PMID:7679677   PMID:10852826   PMID:12477932   PMID:15489334   PMID:19199708   PMID:19946888   PMID:21630459   PMID:22082260   PMID:22170488   PMID:26316108  


Genomics

Comparative Map Data
Krt5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr87134,724,840 - 134,730,569 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl7134,724,840 - 134,730,569 (-)EnsemblGRCr8
mRatBN7.27132,846,132 - 132,851,861 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl7132,846,136 - 132,851,850 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx7134,609,855 - 134,615,592 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.07136,839,382 - 136,845,119 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.07136,808,400 - 136,814,179 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.07143,320,142 - 143,324,536 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl7143,316,920 - 143,453,546 (-)Ensemblrn6Rnor6.0
Rnor_5.07141,118,058 - 141,122,452 (-)NCBIRnor_5.0Rnor_5.0rn5
Celera7129,286,649 - 129,292,077 (-)NCBICelera
Cytogenetic Map7q36NCBI
KRT5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381252,514,575 - 52,520,394 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1252,514,575 - 52,520,530 (-)Ensemblhg38GRCh38
GRCh371252,908,359 - 52,914,178 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361251,194,626 - 51,200,510 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341251,194,627 - 51,200,510NCBI
Celera1252,554,605 - 52,560,489 (-)NCBICelera
Cytogenetic Map12q13.13NCBI
HuRef1249,952,275 - 49,958,159 (-)NCBIHuRef
CHM1_11252,875,216 - 52,881,100 (-)NCBICHM1_1
T2T-CHM13v2.01252,479,176 - 52,484,995 (-)NCBIT2T-CHM13v2.0
Krt5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3915101,615,504 - 101,621,340 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl15101,615,505 - 101,621,333 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm3815101,707,069 - 101,712,905 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl15101,707,070 - 101,712,898 (-)Ensemblmm10GRCm38
MGSCv3715101,537,501 - 101,543,322 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3615101,535,104 - 101,540,925 (-)NCBIMGSCv36mm8
Celera15103,860,955 - 103,866,779 (-)NCBICelera
Cytogenetic Map15F2NCBI
cM Map1556.98NCBI
Krt5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555472,773,523 - 2,932,609 (-)Ensembl
ChiLan1.0NW_0049555472,926,154 - 2,931,954 (-)NCBIChiLan1.0ChiLan1.0
KRT5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21041,674,131 - 41,682,010 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11241,670,947 - 41,678,773 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01236,243,221 - 36,249,573 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11237,021,041 - 37,027,162 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1237,021,432 - 37,025,105 (+)EnsemblpanPan2panpan1.1
KRT81
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1272,776,693 - 2,782,016 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2743,472,174 - 43,477,436 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0272,775,686 - 2,780,954 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl272,775,686 - 2,780,617 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1272,792,435 - 2,797,701 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0272,778,556 - 2,783,808 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02743,870,381 - 43,875,650 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Krt5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494563,235,313 - 63,241,237 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365129,922,523 - 9,929,517 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365129,923,593 - 9,929,517 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KRT5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl517,862,051 - 17,868,402 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1517,862,047 - 17,868,397 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2518,365,764 - 18,372,131 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KRT5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11148,660,946 - 48,673,593 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1148,660,961 - 48,666,830 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666037197,404,963 - 197,411,146 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Krt5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624904655,080 - 681,112 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_004624904655,192 - 681,046 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Krt5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11261,350,950 - 261,362,547 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Krt5
27 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:116
Count of miRNA genes:91
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000011644
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331748Bp215Blood pressure QTL 2154.043arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7110725024135371468Rat
1354582Stl11Serum triglyceride level QTL 113.42blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)7121393075137014596Rat
634331Pia17Pristane induced arthritis QTL 174.7joint integrity trait (VT:0010548)arthritic paw count (CMO:0001460)7132099939137014596Rat
731176Glom5Glomerulus QTL 52.50.0035kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)798549867137014596Rat
1300112Bp183Blood pressure QTL 1833.51arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)7119280025135560836Rat
61428Scl3Serum cholesterol level QTL 33.2blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)7100548246137014596Rat
61397Bw17Body weight QTL 176.3body mass (VT:0001259)body weight (CMO:0000012)795485047137014596Rat
1331746Kidm9Kidney mass QTL 93.934kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)782111245134948181Rat
1358914Bp266Blood pressure QTL 266arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7115313999136544683Rat
1331731Bp216Blood pressure QTL 2162.851arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)7104186212135371468Rat
1549899Stresp8Stress response QTL 84.370.0008stress-related behavior trait (VT:0010451)defensive burying duration (CMO:0001961)792362341137014596Rat
1358891Bp265Blood pressure QTL 2652.21arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)771827901136544683Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
7 6 21 40 45 50 20 15 20 6 145 49 1 27 63 70 30 1 1

Sequence


Ensembl Acc Id: ENSRNOT00000011644   ⟹   ENSRNOP00000011644
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl7134,724,840 - 134,730,569 (-)Ensembl
mRatBN7.2 Ensembl7132,846,136 - 132,851,850 (-)Ensembl
Rnor_6.0 Ensembl7143,319,919 - 143,324,536 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000080010   ⟹   ENSRNOP00000071883
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7143,316,920 - 143,317,674 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000083956   ⟹   ENSRNOP00000073248
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl7143,319,915 - 143,453,546 (-)Ensembl
RefSeq Acc Id: NM_183333   ⟹   NP_899162
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr87134,724,840 - 134,730,569 (-)NCBI
mRatBN7.27132,846,132 - 132,851,861 (-)NCBI
Rnor_6.07143,320,142 - 143,324,536 (-)NCBI
Rnor_5.07141,118,058 - 141,122,452 (-)NCBI
Celera7129,286,649 - 129,292,077 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_899162 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAA41474 (Get FASTA)   NCBI Sequence Viewer  
  AAA99993 (Get FASTA)   NCBI Sequence Viewer  
  AAB18254 (Get FASTA)   NCBI Sequence Viewer  
  AAH62086 (Get FASTA)   NCBI Sequence Viewer  
  AAQ20893 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000011644
  ENSRNOP00000011644.6
GenBank Protein Q6P6Q2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_899162   ⟸   NM_183333
- UniProtKB: Q6P6Q2 (UniProtKB/Swiss-Prot),   Q7TN97 (UniProtKB/Swiss-Prot),   A6KCR1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071883   ⟸   ENSRNOT00000080010
Ensembl Acc Id: ENSRNOP00000011644   ⟸   ENSRNOT00000011644
Ensembl Acc Id: ENSRNOP00000073248   ⟸   ENSRNOT00000083956
Protein Domains
IF rod

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6P6Q2-F1-model_v2 AlphaFold Q6P6Q2 1-576 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695678
Promoter ID:EPDNEW_R6203
Type:single initiation site
Name:Krt5_1
Description:keratin 5
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R6206  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.07143,317,549 - 143,317,609EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727894 AgrOrtholog
BioCyc Gene G2FUF-31967 BioCyc
Ensembl Genes ENSRNOG00000050420 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000011644 ENTREZGENE
  ENSRNOT00000011644.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.170 UniProtKB/Swiss-Prot
  Single helix bin UniProtKB/Swiss-Prot
  Vasodilator-stimulated phosphoprotein UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5599969 IMAGE-MGC_LOAD
InterPro IF_conserved UniProtKB/Swiss-Prot
  IF_rod_dom UniProtKB/Swiss-Prot
  Keratin_2_head UniProtKB/Swiss-Prot
  Keratin_II UniProtKB/Swiss-Prot
KEGG Report rno:369017 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72626 IMAGE-MGC_LOAD
NCBI Gene 369017 ENTREZGENE
PANTHER GATA-TYPE DOMAIN-CONTAINING PROTEIN UniProtKB/Swiss-Prot
  KERATIN, TYPE II CYTOSKELETAL 5 UniProtKB/Swiss-Prot
Pfam Filament UniProtKB/Swiss-Prot
  Keratin_2_head UniProtKB/Swiss-Prot
PhenoGen Krt5 PhenoGen
PRINTS TYPE2KERATIN UniProtKB/Swiss-Prot
PROSITE IF_ROD_1 UniProtKB/Swiss-Prot
  IF_ROD_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000050420 RatGTEx
SMART Filament UniProtKB/Swiss-Prot
Superfamily-SCOP Intermediate filament protein, coiled coil region UniProtKB/Swiss-Prot
UniProt A6KCR1 ENTREZGENE, UniProtKB/TrEMBL
  F7FFV2_RAT UniProtKB/TrEMBL
  K2C5_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q7TN97 ENTREZGENE
UniProt Secondary Q7TN97 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-15 Krt5  keratin 5  Krt5  keratin 5, type II  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-01-28 Krt5  keratin 5, type II  Krt5  keratin 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-04 Krt5  keratin 5  Krt2-5  keratin complex 2, basic, gene 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-02-13 Krt2-5  keratin complex 2, basic, gene 5  Krt5  keratin 5 (epidermolysis bullosa simplex, Dowling-Meara/Kobner/Weber-Cockayne types)  Data merged from RGD:727902 737654 APPROVED
2004-02-11 Krt2-5  keratin complex 2, basic, gene 5      Symbol and Name status set to approved 625702 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation posttranscriptionally downregulated in anaplastic malignant cells 1302413