Rtkn (rhotekin) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Rtkn (rhotekin) Rattus norvegicus
Analyze
Symbol: Rtkn
Name: rhotekin
RGD ID: 727874
Description: Predicted to enable GTPase inhibitor activity and small GTPase binding activity. Predicted to be involved in several processes, including Rho protein signal transduction; cytoskeleton-dependent cytokinesis; and septin ring organization. Predicted to be active in actomyosin contractile ring. Orthologous to human RTKN (rhotekin); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; 8-(4-chlorophenylthio)-cAMP.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: LOC103692165
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84117,198,496 - 117,215,660 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4117,198,647 - 117,215,660 (+)EnsemblGRCr8
mRatBN7.24115,640,813 - 115,657,952 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4115,640,774 - 115,657,952 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4121,118,990 - 121,134,644 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04116,894,175 - 116,909,827 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04115,508,440 - 115,524,100 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04114,833,453 - 114,850,705 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4114,835,064 - 114,850,701 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl4113,968,995 - 113,984,632 (+)Ensemblrn6Rnor6.0
Rnor_5.04179,422,348 - 179,439,775 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44117,348,330 - 117,363,967 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4104,636,452 - 104,652,089 (+)NCBICelera
RGSC_v3.14117,592,810 - 117,608,448 (+)NCBI
Cytogenetic Map4q34NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
14-Deoxy-11,12-didehydroandrographolide  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
1H-pyrazole  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-diaminodiphenylmethane  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
8-(4-chlorophenylthio)-cAMP  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (EXP,ISO)
alpha-Zearalanol  (EXP)
antirheumatic drug  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bisphenol A  (EXP)
bisphenol F  (ISO)
cadmium dichloride  (ISO)
caffeine  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
choline  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cocaine  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
diquat  (ISO)
endosulfan  (EXP)
etoposide  (ISO)
folic acid  (ISO)
FR900359  (ISO)
furan  (EXP)
gentamycin  (EXP)
GSK-J4  (ISO)
ivermectin  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
methyl methanesulfonate  (ISO)
mitomycin C  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
nickel sulfate  (ISO)
paclitaxel  (ISO)
paracetamol  (EXP,ISO)
parthenolide  (ISO)
perfluorooctanoic acid  (EXP)
phenobarbital  (ISO)
pinostrobin  (ISO)
rotenone  (ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
3. Rhotekin, a new putative target for Rho bearing homology to a serine/threonine kinase, PKN, and rhophilin in the rho-binding domain. Reid T, etal., J Biol Chem 1996 Jun 7;271(23):13556-60.
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. MicroRNA-152 inhibits tumor cell growth by directly targeting RTKN in hepatocellular carcinoma. Zhou J, etal., Oncol Rep. 2017 Feb;37(2):1227-1234. doi: 10.3892/or.2016.5290. Epub 2016 Dec 5.
Additional References at PubMed
PMID:10940294   PMID:15480428   PMID:15996550   PMID:17546647   PMID:22411704   PMID:25268128  


Genomics

Comparative Map Data
Rtkn
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr84117,198,496 - 117,215,660 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl4117,198,647 - 117,215,660 (+)EnsemblGRCr8
mRatBN7.24115,640,813 - 115,657,952 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl4115,640,774 - 115,657,952 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx4121,118,990 - 121,134,644 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.04116,894,175 - 116,909,827 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.04115,508,440 - 115,524,100 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.04114,833,453 - 114,850,705 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl4114,835,064 - 114,850,701 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl4113,968,995 - 113,984,632 (+)Ensemblrn6Rnor6.0
Rnor_5.04179,422,348 - 179,439,775 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.44117,348,330 - 117,363,967 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera4104,636,452 - 104,652,089 (+)NCBICelera
RGSC_v3.14117,592,810 - 117,608,448 (+)NCBI
Cytogenetic Map4q34NCBI
RTKN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38274,425,835 - 74,441,937 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl274,425,835 - 74,442,422 (-)Ensemblhg38GRCh38
GRCh37274,652,962 - 74,669,064 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36274,506,496 - 74,522,568 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34274,564,665 - 74,578,602NCBI
Celera274,484,177 - 74,500,249 (-)NCBICelera
Cytogenetic Map2p13.1NCBI
HuRef274,389,300 - 74,405,372 (-)NCBIHuRef
CHM1_1274,582,406 - 74,598,477 (-)NCBICHM1_1
T2T-CHM13v2.0274,434,392 - 74,450,497 (-)NCBIT2T-CHM13v2.0
Rtkn
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39683,112,485 - 83,129,560 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl683,112,444 - 83,129,560 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38683,135,505 - 83,152,579 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl683,135,463 - 83,152,579 (+)Ensemblmm10GRCm38
MGSCv37683,085,802 - 83,102,573 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36683,102,747 - 83,118,234 (+)NCBIMGSCv36mm8
Celera685,118,785 - 85,135,485 (+)NCBICelera
Cytogenetic Map6C3NCBI
cM Map635.94NCBI
Rtkn
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542411,344,220 - 11,360,832 (+)Ensembl
ChiLan1.0NW_00495542411,344,504 - 11,358,344 (+)NCBIChiLan1.0ChiLan1.0
RTKN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21251,946,823 - 51,963,372 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12A51,949,795 - 51,966,125 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02A74,492,520 - 74,509,037 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12A75,998,513 - 76,015,046 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A75,998,494 - 76,015,046 (-)EnsemblpanPan2panpan1.1
RTKN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11748,684,794 - 48,700,309 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1748,685,089 - 48,699,966 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1748,326,399 - 48,341,970 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01749,544,030 - 49,559,627 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1749,544,267 - 49,559,627 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11748,561,122 - 48,576,674 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01748,627,658 - 48,643,209 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01749,185,611 - 49,201,210 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Rtkn
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629210,072,595 - 10,087,596 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936556650,303 - 665,324 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936556650,303 - 665,324 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RTKN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl368,598,249 - 68,613,631 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1368,598,560 - 68,613,633 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2371,811,931 - 71,823,550 (-)NCBISscrofa10.2Sscrofa10.2susScr3
RTKN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11432,835,660 - 32,851,799 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1432,837,546 - 32,855,912 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604579,318,571 - 79,334,693 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rtkn
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474929,060,934 - 29,076,451 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474929,061,202 - 29,077,928 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Rtkn
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1663,074,099 - 63,090,918 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Rtkn
26 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:307
Count of miRNA genes:140
Interacting mature miRNAs:167
Transcripts:ENSRNOT00000031964, ENSRNOT00000042909
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1582232Gluco25Glucose level QTL 253.60.0023blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)486583980149763391Rat
631689Scl4Serum cholesterol level QTL 41.90.008blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)496731383141731383Rat
2302049Pia32Pristane induced arthritis QTL 325.10.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)4107346299152346299Rat
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1578655Bmd11Bone mineral density QTL 1111femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)492406430137406430Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
6478763Anxrr46Anxiety related response QTL 460.07428locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
6478760Anxrr45Anxiety related response QTL 450.06717locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)4112427331157427331Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)480212111119233320Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478687630123687630Rat
7207480Bss105Bone structure and strength QTL 1058.1femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)4111383604156383604Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
634335Anxrr16Anxiety related response QTL 167.22locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)494638356168870820Rat
737821Hcar9Hepatocarcinoma resistance QTL 93.7liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)4106848959168870974Rat
731165Uae21Urinary albumin excretion QTL 212.40.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)4108206096153206096Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
634334Xhs3X-ray hypersensitivity QTL 310intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)486058928131411333Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1549832Bss3Bone structure and strength QTL 311femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)4111383604156383604Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482944895154403548Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)4100752691179366077Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)484349032129349032Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1358202Gluco11Glucose level QTL 112.40.02adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)486709649168870974Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)482336765127336765Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
2293840Kiddil9Kidney dilation QTL 92.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)4113634167149763391Rat
12798519Anxrr54Anxiety related response QTL 542.540.05locomotor behavior trait (VT:0001392)distance moved per unit of time into, out of or within a discrete space in an experimental apparatus (CMO:0001493)4116184844161184844Rat
1578670Bss14Bone structure and strength QTL 1416.4femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)488883695133883695Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
12798523Anxrr56Anxiety related response QTL 562.830.05locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)486583980131583980Rat
70201Gcr1Gastric cancer resistance QTL 12.7stomach morphology trait (VT:0000470)stomach tumor susceptibility score (CMO:0002043)4103834277148834277Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
1578662Bss15Bone structure and strength QTL 1519.6femur width (VT:1000666)femoral neck width (CMO:0001695)488883695133883695Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
19 1 30 112 68 60 36 51 36 12 226 115 11 87 56 70 24 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001415851 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415852 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415853 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001415854 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_184046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236729 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236731 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006236732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763034 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763054 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008763055 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039107325 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285792 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285793 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285794 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285795 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285796 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063285797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC117925 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY348867 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AY348868 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473957 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000031964   ⟹   ENSRNOP00000032233
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4117,199,973 - 117,215,660 (+)Ensembl
mRatBN7.2 Ensembl4115,642,308 - 115,657,948 (+)Ensembl
Rnor_6.0 Ensembl4114,835,064 - 114,850,701 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079511   ⟹   ENSRNOP00000075723
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4117,199,973 - 117,215,660 (+)Ensembl
mRatBN7.2 Ensembl4115,642,308 - 115,657,948 (+)Ensembl
Rnor_6.0 Ensembl4113,968,995 - 113,984,632 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000079547   ⟹   ENSRNOP00000069449
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4117,205,099 - 117,215,658 (+)Ensembl
mRatBN7.2 Ensembl4115,647,842 - 115,657,952 (+)Ensembl
Rnor_6.0 Ensembl4113,970,079 - 113,984,292 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000101909   ⟹   ENSRNOP00000092765
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4117,198,647 - 117,215,658 (+)Ensembl
mRatBN7.2 Ensembl4115,640,774 - 115,657,948 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000118500   ⟹   ENSRNOP00000081167
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4117,199,973 - 117,215,660 (+)Ensembl
mRatBN7.2 Ensembl4115,642,308 - 115,657,948 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000124729   ⟹   ENSRNOP00000099265
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl4117,198,762 - 117,215,657 (+)Ensembl
RefSeq Acc Id: NM_001415851   ⟹   NP_001402780
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,199,973 - 117,215,660 (+)NCBI
mRatBN7.24115,642,262 - 115,657,952 (+)NCBI
RefSeq Acc Id: NM_001415852   ⟹   NP_001402781
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,198,775 - 117,215,660 (+)NCBI
mRatBN7.24115,641,065 - 115,657,952 (+)NCBI
RefSeq Acc Id: NM_001415853   ⟹   NP_001402782
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,198,775 - 117,215,660 (+)NCBI
mRatBN7.24115,641,065 - 115,657,952 (+)NCBI
RefSeq Acc Id: NM_001415854   ⟹   NP_001402783
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,199,973 - 117,215,660 (+)NCBI
mRatBN7.24115,642,262 - 115,657,952 (+)NCBI
RefSeq Acc Id: NM_184046   ⟹   NP_908935
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,199,973 - 117,215,660 (+)NCBI
mRatBN7.24115,642,262 - 115,657,952 (+)NCBI
Rnor_6.04114,835,064 - 114,850,701 (+)NCBI
Rnor_5.04179,422,348 - 179,439,775 (+)NCBI
RGSC_v3.44117,348,330 - 117,363,967 (+)RGD
Celera4104,636,452 - 104,652,089 (+)RGD
Sequence:
RefSeq Acc Id: XM_008763034   ⟹   XP_008761256
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,202,666 - 117,215,660 (+)NCBI
mRatBN7.24115,643,523 - 115,657,952 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008763037   ⟹   XP_008761259
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,202,659 - 117,215,660 (+)NCBI
mRatBN7.24115,643,519 - 115,657,952 (+)NCBI
Sequence:
RefSeq Acc Id: XM_008763038   ⟹   XP_008761260
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,202,646 - 117,215,660 (+)NCBI
mRatBN7.24115,643,516 - 115,657,275 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039107325   ⟹   XP_038963253
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,199,558 - 117,215,660 (+)NCBI
mRatBN7.24115,641,963 - 115,657,952 (+)NCBI
RefSeq Acc Id: XM_063285792   ⟹   XP_063141862
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,198,496 - 117,215,660 (+)NCBI
RefSeq Acc Id: XM_063285793   ⟹   XP_063141863
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,200,681 - 117,215,660 (+)NCBI
RefSeq Acc Id: XM_063285794   ⟹   XP_063141864
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,200,681 - 117,215,660 (+)NCBI
RefSeq Acc Id: XM_063285795   ⟹   XP_063141865
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,199,558 - 117,215,660 (+)NCBI
RefSeq Acc Id: XM_063285796   ⟹   XP_063141866
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,201,227 - 117,215,660 (+)NCBI
RefSeq Acc Id: XM_063285797   ⟹   XP_063141867
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr84117,200,674 - 117,215,660 (+)NCBI
RefSeq Acc Id: NP_908935   ⟸   NM_184046
- Peptide Label: isoform 1
- UniProtKB: Q6V7V1 (UniProtKB/Swiss-Prot),   Q6V7V2 (UniProtKB/Swiss-Prot),   A6IAK9 (UniProtKB/TrEMBL),   A0A8I6G5K4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000032233   ⟸   ENSRNOT00000031964
RefSeq Acc Id: XP_038963253   ⟸   XM_039107325
- Peptide Label: isoform X4
- UniProtKB: A0A8I6G5K4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_008761260   ⟸   XM_008763038
- Peptide Label: isoform X3
- UniProtKB: A0A8L2UPK3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761259   ⟸   XM_008763037
- Peptide Label: isoform X2
- UniProtKB: A0A8L2UPK3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008761256   ⟸   XM_008763034
- Peptide Label: isoform X1
- UniProtKB: A0A8L2UPK3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075723   ⟸   ENSRNOT00000079511
Ensembl Acc Id: ENSRNOP00000069449   ⟸   ENSRNOT00000079547
Ensembl Acc Id: ENSRNOP00000092765   ⟸   ENSRNOT00000101909
Ensembl Acc Id: ENSRNOP00000081167   ⟸   ENSRNOT00000118500
RefSeq Acc Id: NP_001402781   ⟸   NM_001415852
- Peptide Label: isoform 2
- UniProtKB: A0A8I6AIK7 (UniProtKB/TrEMBL),   A0A8I6G5K4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001402782   ⟸   NM_001415853
- Peptide Label: isoform 3
- UniProtKB: A0A8I6G5K4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001402780   ⟸   NM_001415851
- Peptide Label: isoform 1
- UniProtKB: Q6V7V2 (UniProtKB/Swiss-Prot),   Q6V7V1 (UniProtKB/Swiss-Prot),   A6IAK9 (UniProtKB/TrEMBL),   A0A8I6G5K4 (UniProtKB/TrEMBL)
RefSeq Acc Id: NP_001402783   ⟸   NM_001415854
- Peptide Label: isoform 4
RefSeq Acc Id: XP_063141862   ⟸   XM_063285792
- Peptide Label: isoform X5
- UniProtKB: A0A8I6G5K4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141865   ⟸   XM_063285795
- Peptide Label: isoform X7
- UniProtKB: A0A8I6G5K4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141867   ⟸   XM_063285797
- Peptide Label: isoform X9
RefSeq Acc Id: XP_063141864   ⟸   XM_063285794
- Peptide Label: isoform X7
- UniProtKB: A0A8I6G5K4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141863   ⟸   XM_063285793
- Peptide Label: isoform X6
- UniProtKB: A0A8I6G5K4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063141866   ⟸   XM_063285796
- Peptide Label: isoform X8
Ensembl Acc Id: ENSRNOP00000099265   ⟸   ENSRNOT00000124729
Protein Domains
PH   REM-1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q6V7V2-F1-model_v2 AlphaFold Q6V7V2 1-548 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727874 AgrOrtholog
BioCyc Gene G2FUF-44019 BioCyc
Ensembl Genes ENSRNOG00000009022 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000059679 Ensembl
Ensembl Transcript ENSRNOT00000031964 ENTREZGENE
  ENSRNOT00000031964.5 UniProtKB/Swiss-Prot
  ENSRNOT00000079547 ENTREZGENE
  ENSRNOT00000101909 ENTREZGENE
  ENSRNOT00000124729 ENTREZGENE
InterPro AHD UniProtKB/Swiss-Prot
  Cytokinesis/Rho-signaling UniProtKB/Swiss-Prot
  HR1_rho-bd UniProtKB/Swiss-Prot
  PH_domain UniProtKB/Swiss-Prot
KEGG Report rno:297383 UniProtKB/Swiss-Prot
NCBI Gene 297383 ENTREZGENE
PANTHER ANILLIN/RHOTEKIN RTKN UniProtKB/Swiss-Prot
  PTHR21538:SF19 UniProtKB/Swiss-Prot
Pfam Anillin UniProtKB/Swiss-Prot
PhenoGen Rtkn PhenoGen
PROSITE REM_1 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000009022 RatGTEx
  ENSRNOG00000059679 RatGTEx
SMART Hr1 UniProtKB/Swiss-Prot
  SM00233 UniProtKB/Swiss-Prot
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot
UniProt A0A0G2KBB1_RAT UniProtKB/TrEMBL
  A0A8I6AIK7 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6G5K4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2UPK3 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L8T4_RAT UniProtKB/TrEMBL
  A6IAK9 ENTREZGENE, UniProtKB/TrEMBL
  Q6V7V1 ENTREZGENE
  Q6V7V2 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q6V7V1 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Rtkn  rhotekin  LOC103692165  rhotekin  Data merged from RGD:9129186 737654 PROVISIONAL
2014-08-25 LOC103692165  rhotekin      Symbol and Name status set to provisional 70820 PROVISIONAL
2005-07-08 Rtkn  rhotekin      Symbol and Name status set to approved 1299863 APPROVED