Setl1 (SET-like protein 1) - Rat Genome Database

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Gene: Setl1 (SET-like protein 1) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Setl1
Name: SET-like protein 1
RGD ID: 727855
Description: protein phosphatase regulator protein; human homolog appears to be involved in histone acetylation
Type: protein-coding (Ensembl: pseudogene)
RefSeq Status: VALIDATED
Previously known as: LRRGR00002; RGD727855; Set; SET translocation; SET translocation-like 1; SET-like protein; Setsip; similar to SET
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
NCBI Annotation Information: Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81580,920,840 - 80,921,698 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1580,920,840 - 80,921,698 (-)EnsemblGRCr8
mRatBN7.21574,512,909 - 74,513,767 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1574,512,909 - 74,513,767 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1578,512,405 - 78,513,263 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01579,589,040 - 79,589,898 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01576,536,562 - 76,537,420 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01582,080,667 - 82,081,525 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1582,080,667 - 82,081,525 (-)Ensemblrn6Rnor6.0
Rnor_5.01585,614,540 - 85,615,398 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41581,175,616 - 81,176,474 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1573,769,049 - 73,769,907 (-)NCBICelera
RGSC_v3.11581,191,395 - 81,192,254 (-)NCBI
Cytogenetic Map15q21NCBI
JBrowse:




References

References - curated
# Reference Title Reference Citation
1. The SET protein regulates G2/M transition by modulating cyclin B-cyclin-dependent kinase 1 activity. Canela N, etal., J Biol Chem 2003 Jan 10;278(2):1158-64. Epub 2002 Oct 28.
2. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:17065150   PMID:22869753  


Genomics

Variants

.
Variants in Setl1
22 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:39
Count of miRNA genes:38
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000011656
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300144Rf23Renal function QTL 233.61renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1544806773104695021Rat
1576315Schws6Schwannoma susceptibility QTL 60.0069nervous system integrity trait (VT:0010566)post-insult time of death (CMO:0002005)1560213984105213984Rat
61477Aia4Adjuvant induced arthritis QTL 43joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)156244089297773284Rat
2300326Plaw1Placental weight QTL 1150.005placenta mass (VT:0004257)placenta wet weight (CMO:0002088)1574735564106469153Rat
70182BpQTLcluster12Blood pressure QTL cluster 123.53arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)1572716871101425383Rat
152025253Hrtrt24Heart rate QTL 243.82heart pumping trait (VT:2000009)153185580392671517Rat
1582227Gluco30Glucose level QTL 303.60.0003blood glucose amount (VT:0000188)absolute change in blood glucose level area under curve (CMO:0002034)154367724488677244Rat
1582228Epfw3Epididymal fat weight QTL 34.10.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
1578646Bmd18Bone mineral density QTL 185.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1525285835104695021Rat
631655Bp126Blood pressure QTL 1264arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1564571127108192169Rat
1578647Bmd17Bone mineral density QTL 174femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)1525285835104695021Rat
61424Scl1Serum cholesterol level QTL 17.70.001blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)151915576287086765Rat
1598828Glom14Glomerulus QTL 142.5kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)154046315285463152Rat
631516Gluco31Glucose level QTL 317blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1572716871101425383Rat
2298549Neuinf12Neuroinflammation QTL 123.5nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)1561710951106710951Rat
1331724Bp223Blood pressure QTL 2233.53715arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1575928947101425383Rat
2317050Aia24Adjuvant induced arthritis QTL 242.06joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)1559257087104257087Rat
1582242Gluco28Glucose level QTL 283.30.0008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)154367724488677244Rat
2313080Bss65Bone structure and strength QTL 653.90.0001long bone metaphysis morphology trait (VT:0000133)tibia midshaft total cross-sectional area (CMO:0001715)1567399137108192169Rat
1578660Bss19Bone structure and strength QTL 194.3femur morphology trait (VT:0000559)bone trabecular cross-sectional area (CMO:0002311)1525285835104695021Rat
1582244Bw79Body weight QTL 7940.0002epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)154367724488677244Rat
1582214Stl21Serum triglyceride level QTL 213.10.022blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)154367724488677244Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
12 5 24 93 67 66 37 22 37 6 174 67 1 72 53 61 29 3 3

Sequence


Ensembl Acc Id: ENSRNOT00000011656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1580,920,840 - 80,921,698 (-)Ensembl
mRatBN7.2 Ensembl1574,512,909 - 74,513,767 (-)Ensembl
Rnor_6.0 Ensembl1582,080,667 - 82,081,525 (-)Ensembl
RefSeq Acc Id: NR_171897
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81580,920,840 - 80,921,698 (-)NCBI
mRatBN7.21574,512,909 - 74,513,767 (-)NCBI
Protein Sequences
Protein RefSeqs NP_919334 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAQ75019 (Get FASTA)   NCBI Sequence Viewer  

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727855 AgrOrtholog
BioCyc Gene G2FUF-12803 BioCyc
Ensembl Genes ENSRNOG00000008814 Ensembl
Gene3D-CATH 1.20.5.1500 UniProtKB/TrEMBL
  Nucleosome assembly protein UniProtKB/TrEMBL
InterPro NAP-like_sf UniProtKB/TrEMBL
  NAP_family UniProtKB/TrEMBL
NCBI Gene 290432 ENTREZGENE
PANTHER NAP_family UniProtKB/TrEMBL
Pfam NAP UniProtKB/TrEMBL
PhenoGen Setl1 PhenoGen
RatGTEx ENSRNOG00000008814 RatGTEx
Superfamily-SCOP SSF143113 UniProtKB/TrEMBL
UniProt Q6UN82 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-03-17 Setl1  SET-like protein 1  Setsip  SET-like protein  Name and Symbol changed 629549 APPROVED
2015-08-13 Setsip  SET-like protein  Setl1  SET translocation-like 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Setl1  SET translocation-like 1  RGD727855  similar to SET  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2007-02-06 RGD727855  similar to SET  Set  SET translocation  Symbol and Name updated 1299863 PROVISIONAL
2006-02-09 Set  SET translocation      Symbol and Name status set to provisional 70820 PROVISIONAL