Bst2 (bone marrow stromal cell antigen 2) - Rat Genome Database

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Gene: Bst2 (bone marrow stromal cell antigen 2) Rattus norvegicus
Analyze
Symbol: Bst2
Name: bone marrow stromal cell antigen 2
RGD ID: 727849
Description: Predicted to enable metalloendopeptidase inhibitor activity and protein homodimerization activity. Involved in regulation of actin cytoskeleton organization. Located in apical plasma membrane and cell surface. Human ortholog(s) of this gene implicated in acquired immunodeficiency syndrome and endometrial cancer. Orthologous to human BST2 (bone marrow stromal cell antigen 2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3-chloropropane-1,2-diol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: bone marrow stromal antigen 2; BST-2; DAMP-1; Damp1
RGD Orthologs
Human
Mouse
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,250,593 - 18,254,967 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1618,251,847 - 18,254,967 (-)EnsemblGRCr8
mRatBN7.21618,216,605 - 18,220,979 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,217,407 - 18,220,979 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1618,267,534 - 18,271,910 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,400,169 - 19,404,588 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,320,470 - 18,324,846 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01619,938,781 - 19,942,353 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,938,784 - 19,942,353 (-)Ensemblrn6Rnor6.0
Rnor_5.01619,800,345 - 19,803,919 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41618,698,545 - 18,701,768 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1618,422,354 - 18,425,936 (-)NCBICelera
RGSC_v3.11618,698,545 - 18,701,766 (-)NCBI
Cytogenetic Map16p14NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
(S)-nicotine  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
6alpha-methylprednisolone  (ISO)
acetamide  (EXP)
aconitine  (EXP)
aflatoxin B1  (ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
alpha-Zearalanol  (EXP)
ammonium chloride  (EXP)
antirheumatic drug  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
azathioprine  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (EXP,ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
chlordecone  (ISO)
chloroprene  (EXP)
chlorpyrifos  (ISO)
cobalt dichloride  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cytarabine  (ISO)
D-glucose  (ISO)
diarsenic trioxide  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
dicrotophos  (ISO)
dioxygen  (EXP)
diquat  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
epoxiconazole  (ISO)
fentanyl  (EXP)
fenthion  (ISO)
flusilazole  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
fructose  (ISO)
Genipin  (ISO)
glucose  (ISO)
glutathione  (EXP)
glyphosate  (ISO)
GSK-J4  (ISO)
hydroquinone  (ISO)
hydroquinone O-beta-D-glucopyranoside  (ISO)
imiquimod  (ISO)
inulin  (ISO)
kojic acid  (ISO)
levofloxacin  (EXP)
lipopolysaccharide  (ISO)
lithium chloride  (ISO)
mercury dibromide  (ISO)
methamphetamine  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
mitoxantrone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (ISO)
nickel atom  (ISO)
nickel dichloride  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
nitrofen  (EXP)
oxaliplatin  (EXP)
ozone  (ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
piroxicam  (ISO)
prednisolone  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
serpentine asbestos  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenite  (ISO)
sodium aurothiomalate  (ISO)
sunitinib  (ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
thalidomide  (ISO)
titanium dioxide  (ISO)
tofacitinib  (ISO)
toluene 2,4-diisocyanate  (ISO)
topotecan  (EXP)
Triptolide  (EXP)
trovafloxacin  (EXP,ISO)
tungsten  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)
vitamin E  (ISO)
zidovudine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
apical plasma membrane  (IDA,IEA)
cell surface  (IBA,IDA,IEA,ISO)
cytoplasm  (IEA,ISO,ISS)
Golgi apparatus  (IBA,IEA,ISO)
late endosome  (IEA)
membrane raft  (IEA)
multivesicular body  (ISO)
plasma membrane  (IEA,ISO,ISS)
side of membrane  (IEA)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Aberrant expression of the innate restriction factor bone marrow stromal antigen-2 in primary Sjögren's syndrome. Chen C, etal., J Craniomaxillofac Surg. 2018 Nov;46(11):1899-1904. doi: 10.1016/j.jcms.2018.08.008. Epub 2018 Aug 29.
2. Overexpression of BST2 is associated with nodal metastasis and poorer prognosis in oral cavity cancer. Fang KH, etal., Laryngoscope. 2014 Sep;124(9):E354-60. doi: 10.1002/lary.24700. Epub 2014 May 27.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. CpG oligodeoxynucleotides potentiate the antitumor activity of anti-BST2 antibody. Hiramatsu K, etal., Cancer Sci. 2015 Oct;106(10):1474-8. doi: 10.1111/cas.12738.
5. Bone marrow stromal cell antigen 2 (BST-2) restricts mouse mammary tumor virus (MMTV) replication in vivo. Jones PH, etal., Retrovirology. 2012 Jan 27;9:10. doi: 10.1186/1742-4690-9-10.
6. BST-2/tetherin is overexpressed in mammary gland and tumor tissues in MMTV-induced mammary cancer. Jones PH, etal., Virology. 2013 Sep;444(1-2):124-39. doi: 10.1016/j.virol.2013.05.042. Epub 2013 Jun 25.
7. Protective Role of BST2 Polymorphisms in Mother-to-Child Transmission of HIV-1 and Adult AIDS Progression. Kamada AJ, etal., J Acquir Immune Defic Syndr. 2016 Jul 1;72(3):237-41. doi: 10.1097/QAI.0000000000000949.
8. Bst-2/HM1.24 is a raft-associated apical membrane protein with an unusual topology. Kupzig S, etal., Traffic 2003 Oct;4(10):694-709.
9. Tetherin promotes the innate and adaptive cell-mediated immune response against retrovirus infection in vivo. Li SX, etal., J Immunol. 2014 Jul 1;193(1):306-16. doi: 10.4049/jimmunol.1400490. Epub 2014 May 28.
10. Tetherin Inhibits Cell-Free Virus Dissemination and Retards Murine Leukemia Virus Pathogenesis. Liberatore RA, etal., J Virol. 2017 May 26;91(12). pii: JVI.02286-16. doi: 10.1128/JVI.02286-16. Print 2017 Jun 15.
11. Critical role for bone marrow stromal antigen 2 in acute Chikungunya virus infection. Mahauad-Fernandez WD, etal., J Gen Virol. 2014 Nov;95(Pt 11):2450-61. doi: 10.1099/vir.0.068643-0. Epub 2014 Jul 22.
12. Overexpression of Transmembrane Protein BST2 is Associated with Poor Survival of Patients with Esophageal, Gastric, or Colorectal Cancer. Mukai S, etal., Ann Surg Oncol. 2017 Feb;24(2):594-602. doi: 10.1245/s10434-016-5100-z. Epub 2016 Feb 1.
13. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Information Derived from GenBank Report RGD, Sept. 2003
18. A CD317/tetherin-RICH2 complex plays a critical role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. Rollason R, etal., J Cell Biol. 2009 Mar 9;184(5):721-36. doi: 10.1083/jcb.200804154.
19. The expression of BST2 in human and experimental mouse brain tumors. Wainwright DA, etal., Exp Mol Pathol. 2011 Aug;91(1):440-6. doi: 10.1016/j.yexmp.2011.04.012. Epub 2011 May 1.
20. Plasma membrane proteomics identifies bone marrow stromal antigen 2 as a potential therapeutic target in endometrial cancer. Yokoyama T, etal., Int J Cancer. 2013 Jan 15;132(2):472-84. doi: 10.1002/ijc.27679. Epub 2012 Jul 9.
Additional References at PubMed
PMID:12761501   PMID:19036818   PMID:19056867   PMID:19564354   PMID:19879838   PMID:19946888   PMID:20399176   PMID:20458337   PMID:20686043   PMID:20880831   PMID:20940320   PMID:20943977  
PMID:21919738   PMID:22065321   PMID:22072966   PMID:22658674   PMID:23376485   PMID:25002582  


Genomics

Comparative Map Data
Bst2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,250,593 - 18,254,967 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1618,251,847 - 18,254,967 (-)EnsemblGRCr8
mRatBN7.21618,216,605 - 18,220,979 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,217,407 - 18,220,979 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1618,267,534 - 18,271,910 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,400,169 - 19,404,588 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,320,470 - 18,324,846 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01619,938,781 - 19,942,353 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1619,938,784 - 19,942,353 (-)Ensemblrn6Rnor6.0
Rnor_5.01619,800,345 - 19,803,919 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41618,698,545 - 18,701,768 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1618,422,354 - 18,425,936 (-)NCBICelera
RGSC_v3.11618,698,545 - 18,701,766 (-)NCBI
Cytogenetic Map16p14NCBI
BST2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381917,402,939 - 17,405,630 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1917,402,933 - 17,405,665 (-)Ensemblhg38GRCh38
GRCh371917,513,748 - 17,516,439 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361917,374,755 - 17,377,384 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341917,374,755 - 17,377,384NCBI
Celera1917,415,480 - 17,418,112 (-)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1917,079,843 - 17,082,475 (-)NCBIHuRef
CHM1_11917,513,253 - 17,515,885 (-)NCBICHM1_1
T2T-CHM13v2.01917,537,665 - 17,540,365 (-)NCBIT2T-CHM13v2.0
Bst2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,986,899 - 71,990,116 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl871,986,899 - 71,990,100 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38871,534,255 - 71,537,472 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl871,534,255 - 71,537,456 (-)Ensemblmm10GRCm38
MGSCv37874,058,158 - 74,061,336 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36874,463,248 - 74,466,427 (-)NCBIMGSCv36mm8
Celera874,044,534 - 74,047,712 (-)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.43NCBI
BST2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22022,273,394 - 22,276,182 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11921,279,954 - 21,282,681 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01916,890,257 - 16,892,989 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11917,863,991 - 17,866,728 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1917,863,991 - 17,866,728 (-)EnsemblpanPan2panpan1.1
BST2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12045,383,757 - 45,387,420 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2045,383,915 - 45,387,178 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2045,297,396 - 45,301,618 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02045,870,847 - 45,875,081 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,870,936 - 45,876,143 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12045,107,273 - 45,111,493 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02045,517,170 - 45,521,565 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,793,007 - 45,797,236 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ccdc194
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,948,837 - 203,952,227 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365963,492,733 - 3,501,347 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BST2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl260,305,283 - 60,309,697 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1260,305,306 - 60,308,295 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213111,049,463 - 111,049,577 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BST2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1615,900,396 - 15,903,072 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl615,900,011 - 15,903,060 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660743,533,612 - 3,536,289 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bst2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624908588,925 - 591,033 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Bst2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11313,453,700 - 13,457,226 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Bst2
31 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:225
Count of miRNA genes:156
Interacting mature miRNAs:172
Transcripts:ENSRNOT00000036276
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549842Bp248Blood pressure QTL 2480.01arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1638712345387123Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133425095Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139568015Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16423421253708481Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161574800625801629Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16474422249744222Rat
61405Niddm6Non-insulin dependent diabetes mellitus QTL 63.660.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)16126734272Rat
631830Alc7Alcohol consumption QTL 72.9consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16126734272Rat
7411664Foco30Food consumption QTL 30110.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)16435482249354822Rat
1600378Arunc4Aerobic running capacity QTL 40.03exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)1638712345387123Rat
70183BpQTLcluster13Blood pressure QTL cluster 133.654arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)16423421249757901Rat
737826Alc11Alcohol consumption QTL 113.2consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)16423421266955197Rat
1600369Hcas8Hepatocarcinoma susceptibility QTL 8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)161627818427244292Rat
2303566Bw90Body weight QTL 902body mass (VT:0001259)body weight (CMO:0000012)16139568015Rat
2312663Slep9Serum leptin concentration QTL 90.001blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)1683908666195506Rat
2306902Bp339Blood pressure QTL 3390.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16338679049757901Rat
1300133Rf24Renal function QTL 243.64blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)16338679026128267Rat
2312660Bw95Body weight QTL 950.05inguinal fat pad mass (VT:0010424)inguinal fat pad weight to body weight ratio (CMO:0001253)1683908666195506Rat
2312666Insul16Insulin level QTL 160.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1683908666195506Rat
634355Rends4Renal damage susceptibility QTL 40.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)16126734272Rat
70205Gcr3Gastric cancer resistance QTL 32.3stomach morphology trait (VT:0000470)stomach tumor diameter (CMO:0001889)161773081872536785Rat
2293343Glom16Glomerulus QTL 167.4kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1683908652786090Rat
2301406Kidm39Kidney mass QTL 390.002kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)161590580260905802Rat
2312669Stl23Serum triglyceride level QTL 230.01blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1683908666195506Rat
6903319Bw114Body weight QTL 1142.70.0037body mass (VT:0001259)body weight (CMO:0000012)16330168348301683Rat

Markers in Region
RH133923  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21618,217,461 - 18,217,649 (+)MAPPERmRatBN7.2
Rnor_6.01619,938,839 - 19,939,026NCBIRnor6.0
Rnor_5.01619,800,403 - 19,800,590UniSTSRnor5.0
RGSC_v3.41618,698,603 - 18,698,790UniSTSRGSC3.4
Celera1618,422,412 - 18,422,599UniSTS
RH 3.4 Map16190.3UniSTS
Cytogenetic Map16p14UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 156 91 90 59 92 59 6 356 192 11 134 81 92 31 12 12

Sequence


Ensembl Acc Id: ENSRNOT00000087162   ⟹   ENSRNOP00000068951
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1618,251,847 - 18,254,967 (-)Ensembl
mRatBN7.2 Ensembl1618,217,859 - 18,220,979 (-)Ensembl
Rnor_6.0 Ensembl1619,939,236 - 19,942,343 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091906   ⟹   ENSRNOP00000073737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1618,251,847 - 18,254,967 (-)Ensembl
mRatBN7.2 Ensembl1618,217,407 - 18,220,979 (-)Ensembl
Rnor_6.0 Ensembl1619,938,784 - 19,942,353 (-)Ensembl
RefSeq Acc Id: NM_198134   ⟹   NP_937767
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,250,593 - 18,254,967 (-)NCBI
mRatBN7.21618,216,605 - 18,220,979 (-)NCBI
Rnor_6.01619,938,781 - 19,942,353 (-)NCBI
Rnor_5.01619,800,345 - 19,803,919 (-)NCBI
RGSC_v3.41618,698,545 - 18,701,768 (-)RGD
Celera1618,422,354 - 18,425,936 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_937767 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein CAD61869 (Get FASTA)   NCBI Sequence Viewer  
  EDL90784 (Get FASTA)   NCBI Sequence Viewer  
  EDL90785 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000073737.2
GenBank Protein Q811A2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_937767   ⟸   NM_198134
- UniProtKB: Q811A2 (UniProtKB/Swiss-Prot),   A6K9V3 (UniProtKB/TrEMBL),   A0A0G2JU36 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000068951   ⟸   ENSRNOT00000087162
Ensembl Acc Id: ENSRNOP00000073737   ⟸   ENSRNOT00000091906

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q811A2-F1-model_v2 AlphaFold Q811A2 1-172 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700005
Promoter ID:EPDNEW_R10527
Type:multiple initiation site
Name:Bst2_1
Description:bone marrow stromal cell antigen 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01619,942,350 - 19,942,410EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727849 AgrOrtholog
BioCyc Gene G2FUF-11844 BioCyc
Ensembl Genes ENSRNOG00000059900 Ensembl, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000091906.2 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.5.1700 UniProtKB/Swiss-Prot
InterPro BST2 UniProtKB/Swiss-Prot
KEGG Report rno:378947 UniProtKB/Swiss-Prot
NCBI Gene 378947 ENTREZGENE
PANTHER BONE MARROW STROMAL ANTIGEN 2 UniProtKB/Swiss-Prot
  PTHR15190 UniProtKB/Swiss-Prot
Pfam BST2 UniProtKB/Swiss-Prot
PhenoGen Bst2 PhenoGen
RatGTEx ENSRNOG00000059900 RatGTEx
Superfamily-SCOP Sec2 N-terminal region UniProtKB/Swiss-Prot
UniProt A0A0G2JU36 ENTREZGENE, UniProtKB/TrEMBL
  A0A0G2K6A4_RAT UniProtKB/TrEMBL
  A6K9V2_RAT UniProtKB/TrEMBL
  A6K9V3 ENTREZGENE, UniProtKB/TrEMBL
  BST2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-08 Bst2  bone marrow stromal cell antigen 2  Damp1  DAMP-1 protein  Symbol and Name updated 1299863 APPROVED