Cox8c (cytochrome c oxidase subunit 8C) - Rat Genome Database

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Gene: Cox8c (cytochrome c oxidase subunit 8C) Rattus norvegicus
Analyze
Symbol: Cox8c
Name: cytochrome c oxidase subunit 8C
RGD ID: 727840
Description: Predicted to be involved in mitochondrial electron transport, cytochrome c to oxygen. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex IV. Predicted to be active in mitochondrion. Orthologous to human COX8C (cytochrome c oxidase subunit 8C); PARTICIPATES IN Alzheimer's disease pathway; Huntington's disease pathway; oxidative phosphorylation pathway; INTERACTS WITH acrylamide; bisphenol A; indole-3-methanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: COX VIII-3; COXVIII-3; cytochrome c oxidase polypeptide 8; cytochrome c oxidase polypeptide VIII; cytochrome c oxidase subunit 8-3; cytochrome c oxidase subunit 8C, mitochondrial; cytochrome c oxidase subunit VIII; cytochrome c oxidase subunit VIII isoform 3; cytochrome c oxidase, subunit 8C; cytochrome c oxidase, subunit VIIIc; LOC360229
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86127,793,379 - 127,794,702 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6127,793,379 - 127,794,702 (+)EnsemblGRCr8
mRatBN7.26122,028,566 - 122,029,889 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6122,028,566 - 122,029,889 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6122,166,956 - 122,168,278 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06122,462,221 - 122,463,543 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06121,798,339 - 121,799,672 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06126,766,967 - 126,768,290 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6126,766,967 - 126,768,290 (+)Ensemblrn6Rnor6.0
Rnor_5.06135,972,917 - 135,974,240 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46127,161,354 - 127,162,677 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6119,515,028 - 119,516,351 (+)NCBICelera
RGSC_v3.16127,165,100 - 127,166,424 (+)NCBI
Cytogenetic Map6q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
3. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
4. GOA pipeline RGD automated data pipeline
5. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12762575   PMID:12909344   PMID:18614015  


Genomics

Comparative Map Data
Cox8c
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86127,793,379 - 127,794,702 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6127,793,379 - 127,794,702 (+)EnsemblGRCr8
mRatBN7.26122,028,566 - 122,029,889 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6122,028,566 - 122,029,889 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx6122,166,956 - 122,168,278 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06122,462,221 - 122,463,543 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06121,798,339 - 121,799,672 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.06126,766,967 - 126,768,290 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6126,766,967 - 126,768,290 (+)Ensemblrn6Rnor6.0
Rnor_5.06135,972,917 - 135,974,240 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.46127,161,354 - 127,162,677 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera6119,515,028 - 119,516,351 (+)NCBICelera
RGSC_v3.16127,165,100 - 127,166,424 (+)NCBI
Cytogenetic Map6q32NCBI
COX8C
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381493,347,182 - 93,348,356 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1493,347,182 - 93,348,356 (+)Ensemblhg38GRCh38
GRCh371493,813,528 - 93,814,702 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361492,883,290 - 92,884,453 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341492,883,289 - 92,884,453NCBI
Celera1473,867,551 - 73,868,714 (+)NCBICelera
Cytogenetic Map14q32.12NCBI
HuRef1473,993,564 - 73,994,727 (+)NCBIHuRef
CHM1_11493,751,557 - 93,752,720 (+)NCBICHM1_1
T2T-CHM13v2.01487,579,055 - 87,580,228 (+)NCBIT2T-CHM13v2.0
Cox8c
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912102,865,565 - 102,866,793 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12102,865,575 - 102,866,785 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm3812102,899,306 - 102,900,534 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12102,899,316 - 102,900,526 (+)Ensemblmm10GRCm38
MGSCv3712104,137,516 - 104,138,744 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv3612103,300,356 - 103,301,584 (+)NCBIMGSCv36mm8
Celera12104,116,515 - 104,117,743 (+)NCBICelera
Cytogenetic Map12ENCBI
cM Map1252.55NCBI
LOC102005637
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495543815,480,509 - 15,481,812 (+)NCBIChiLan1.0ChiLan1.0
LOC100984553
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21594,493,815 - 94,571,864 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11493,707,703 - 93,772,906 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01473,979,629 - 73,984,116 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11493,316,013 - 93,317,217 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1493,316,013 - 93,317,217 (+)EnsemblpanPan2panpan1.1
LOC100856429
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11825,401,351 - 25,402,874 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1825,051,304 - 25,052,818 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01825,928,113 - 25,929,627 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
UMICH_Zoey_3.11825,496,165 - 25,497,679 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01825,140,874 - 25,142,388 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01825,753,536 - 25,755,050 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC100157935
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.17114,727,841 - 114,729,102 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.27121,313,089 - 121,314,323 (+)NCBISscrofa10.2Sscrofa10.2susScr3
COX8C
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12471,098,014 - 71,099,417 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2471,098,346 - 71,099,180 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366605358,339,240 - 58,350,907 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
LOC116904927
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v17114,171,593 - 114,172,893 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Cox8c
8 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:106
Count of miRNA genes:86
Interacting mature miRNAs:91
Transcripts:ENSRNOT00000052296
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331797Bp213Blood pressure QTL 2133.291arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)6114241077147156653Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6112483610147156653Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6110921244147156653Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6106095977147156653Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6118366855147156653Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6122236101147156653Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6101593607138161926Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
12801471Schws9Schwannoma susceptibility QTL 9nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6101593607146593607Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6121444670147156653Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
4 6 6 29 25 29 16 11 16 56 23 25 9 50 13

Sequence


Ensembl Acc Id: ENSRNOT00000052296   ⟹   ENSRNOP00000047295
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6127,793,379 - 127,794,702 (+)Ensembl
mRatBN7.2 Ensembl6122,028,566 - 122,029,889 (+)Ensembl
Rnor_6.0 Ensembl6126,766,967 - 126,768,290 (+)Ensembl
RefSeq Acc Id: NM_183055   ⟹   NP_898878
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86127,793,379 - 127,794,702 (+)NCBI
mRatBN7.26122,028,566 - 122,029,889 (+)NCBI
Rnor_6.06126,766,967 - 126,768,290 (+)NCBI
Rnor_5.06135,972,917 - 135,974,240 (+)NCBI
RGSC_v3.46127,161,354 - 127,162,677 (+)RGD
Celera6119,515,028 - 119,516,351 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_898878 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAO26194 (Get FASTA)   NCBI Sequence Viewer  
  EDL81762 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000047295
  ENSRNOP00000047295.1
GenBank Protein Q7TNN2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_898878   ⟸   NM_183055
- UniProtKB: Q7TNN2 (UniProtKB/Swiss-Prot),   A6JEL8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000047295   ⟸   ENSRNOT00000052296

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TNN2-F1-model_v2 AlphaFold Q7TNN2 1-72 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694789
Promoter ID:EPDNEW_R5313
Type:initiation region
Name:Cox8c_1
Description:cytochrome c oxidase subunit 8C
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.06126,766,994 - 126,767,054EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727840 AgrOrtholog
BioCyc Gene G2FUF-36430 BioCyc
Ensembl Genes ENSRNOG00000031106 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000052296 ENTREZGENE
  ENSRNOT00000052296.2 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.81.10 UniProtKB/Swiss-Prot
InterPro Cyt_c_oxidase_su8 UniProtKB/Swiss-Prot
  Cyt_c_oxidase_su8_sf UniProtKB/Swiss-Prot
KEGG Report rno:360229 UniProtKB/Swiss-Prot
NCBI Gene 360229 ENTREZGENE
PANTHER CYTOCHROME C OXIDASE SUBUNIT 8C, MITOCHONDRIAL UniProtKB/Swiss-Prot
  PTHR16717 UniProtKB/Swiss-Prot
Pfam COX8 UniProtKB/Swiss-Prot
PhenoGen Cox8c PhenoGen
RatGTEx ENSRNOG00000031106 RatGTEx
Superfamily-SCOP SSF81431 UniProtKB/Swiss-Prot
UniProt A6JEL8 ENTREZGENE, UniProtKB/TrEMBL
  COX8C_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-17 Cox8c  cytochrome c oxidase subunit 8C  Cox8c  cytochrome c oxidase, subunit VIIIc  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-02-18 Cox8c  cytochrome c oxidase, subunit VIIIc  Cox8c  cytochrome c oxidase, subunit 8C  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-10 Cox8c  cytochrome c oxidase, subunit 8C  Cox8c  cytochrome c oxidase, subunit 8c  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-03-05 Cox8c  cytochrome c oxidase, subunit 8c  LOC360229  cytochrome c oxidase subunit VIII isoform 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-12-28 LOC360229        Symbol and Name status set to provisional 70820 PROVISIONAL