Kir3dl1 (killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1) - Rat Genome Database

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Gene: Kir3dl1 (killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1) Rattus norvegicus
Analyze
Symbol: Kir3dl1
Name: killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1
RGD ID: 727836
Description: Predicted to enable molecular adaptor activity. Predicted to be involved in immune response-regulating signaling pathway and natural killer cell mediated cytotoxicity. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Polyomavirus-associated nephropathy; West Nile fever; human immunodeficiency virus infectious disease (multiple); liver disease (multiple); and tuberculosis (multiple). Orthologous to several human genes including KIR3DL1 (killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1); PARTICIPATES IN antigen processing and presentation pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; ammonium chloride; bromobenzene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: killer cell immunoglobulin-like receptor 3DL1; killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1
RGD Orthologs
Human
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,756,035 - 78,796,961 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl178,757,394 - 78,796,715 (-)EnsemblGRCr8
mRatBN7.2169,715,529 - 69,754,050 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,715,535 - 69,754,050 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx175,074,414 - 75,112,931 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0183,638,727 - 83,677,248 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,788,798 - 76,827,305 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0173,306,564 - 73,345,009 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl173,307,569 - 73,344,955 (-)Ensemblrn6Rnor6.0
Rnor_5.0175,204,288 - 75,241,680 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4169,071,642 - 69,110,751 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera167,391,750 - 67,430,271 (+)NCBICelera
RGSC_v3.1169,149,754 - 69,188,862 (-)NCBI
Cytogenetic Map1q12NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
plasma membrane  (IBA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Cutting edge: molecular cloning of a killer cell Ig-like receptor in the mouse and rat. Hoelsbrekken SE, etal., J Immunol 2003 Mar 1;170(5):2259-63.
3. Differential association of KIR gene loci to risk of malaria in ethnic groups of Assam, Northeast India. Lourembam SD, etal., Infect Genet Evol. 2011 Dec;11(8):1921-8. doi: 10.1016/j.meegid.2011.08.017. Epub 2011 Aug 25.
4. Killer cell immunoglobulin-like receptor 3DL1 variation modifies HLA-B*57 protection against HIV-1. Martin MP, etal., J Clin Invest. 2018 May 1;128(5):1903-1912. doi: 10.1172/JCI98463. Epub 2018 Apr 3.
5. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
6. Natural killer cell functional dichotomy in chronic hepatitis B and chronic hepatitis C virus infections. Oliviero B, etal., Gastroenterology. 2009 Sep;137(3):1151-60, 1160.e1-7. doi: 10.1053/j.gastro.2009.05.047. Epub 2009 May 24.
7. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. Killer cell immunoglobulin like receptor gene association with tuberculosis. Pydi SS, etal., Hum Immunol. 2013 Jan;74(1):85-92. doi: 10.1016/j.humimm.2012.10.006. Epub 2012 Oct 13.
10. GOA pipeline RGD automated data pipeline
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Influence of HLA class I, HLA class II and KIRs on vertical transmission and chronicity of hepatitis C virus in children. Ruiz-Extremera A, etal., PLoS One. 2017 Feb 22;12(2):e0172527. doi: 10.1371/journal.pone.0172527. eCollection 2017.
13. Role of Killer cell immunoglobulin-like receptors (KIR) genes in stages of HIV-1 infection among patients from Burkina Faso. Sorgho PA, etal., Biomol Concepts. 2019 Dec 19;10(1):226-236. doi: 10.1515/bmc-2019-0024.
14. Immunological changes in different patient populations with chronic hepatitis C virus infection. Szereday L, etal., World J Gastroenterol. 2016 May 28;22(20):4848-59. doi: 10.3748/wjg.v22.i20.4848.
Additional References at PubMed
PMID:26385514  


Genomics

Comparative Map Data
Kir3dl1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8178,756,035 - 78,796,961 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl178,757,394 - 78,796,715 (-)EnsemblGRCr8
mRatBN7.2169,715,529 - 69,754,050 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl169,715,535 - 69,754,050 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx175,074,414 - 75,112,931 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0183,638,727 - 83,677,248 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0176,788,798 - 76,827,305 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0173,306,564 - 73,345,009 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl173,307,569 - 73,344,955 (-)Ensemblrn6Rnor6.0
Rnor_5.0175,204,288 - 75,241,680 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4169,071,642 - 69,110,751 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera167,391,750 - 67,430,271 (+)NCBICelera
RGSC_v3.1169,149,754 - 69,188,862 (-)NCBI
Cytogenetic Map1q12NCBI
KIR3DL1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381954,816,468 - 54,830,778 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1954,816,468 - 54,830,778 (+)Ensemblhg38GRCh38
GRCh371955,327,923 - 55,342,233 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361960,019,705 - 60,034,045 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341959,989,604 - 60,034,044NCBI
Celera1952,368,593 - 52,382,933 (+)NCBICelera
Cytogenetic Map19q13.42NCBI
HuRef1951,650,580 - 51,664,920 (+)NCBIHuRef
CHM1_11955,321,458 - 55,335,798 (+)NCBICHM1_1
T2T-CHM13v2.01957,880,595 - 57,925,086 (+)NCBIT2T-CHM13v2.0

Variants

.
Variants in Kir3dl1
164 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:87
Count of miRNA genes:76
Interacting mature miRNAs:79
Transcripts:ENSRNOT00000039823
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
11 7 21 42 55 54 23 67 23 6 165 107 22 17 35 31

Sequence


Ensembl Acc Id: ENSRNOT00000039823   ⟹   ENSRNOP00000031521
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl178,757,394 - 78,796,715 (-)Ensembl
mRatBN7.2 Ensembl169,715,535 - 69,754,050 (-)Ensembl
Rnor_6.0 Ensembl173,307,569 - 73,344,955 (-)Ensembl
RefSeq Acc Id: NM_181479   ⟹   NP_852144
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,758,194 - 78,796,715 (-)NCBI
mRatBN7.2169,715,529 - 69,754,050 (-)NCBI
Rnor_6.0173,307,563 - 73,344,955 (-)NCBI
Rnor_5.0175,204,288 - 75,241,680 (+)NCBI
RGSC_v3.4169,071,642 - 69,110,751 (-)RGD
Celera167,391,750 - 67,430,271 (+)RGD
Sequence:
RefSeq Acc Id: XM_063265848   ⟹   XP_063121918
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,756,035 - 78,796,961 (-)NCBI
RefSeq Acc Id: XM_063265852   ⟹   XP_063121922
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8178,756,035 - 78,796,961 (-)NCBI
Protein Sequences
Protein RefSeqs NP_852144 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121918 (Get FASTA)   NCBI Sequence Viewer  
  XP_063121922 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAO47865 (Get FASTA)   NCBI Sequence Viewer  
  EDL75824 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000031521
  ENSRNOP00000031521.3
GenBank Protein P83556 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_852144   ⟸   NM_181479
- Peptide Label: precursor
- UniProtKB: P83556 (UniProtKB/Swiss-Prot),   A6KNK5 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000031521   ⟸   ENSRNOT00000039823
RefSeq Acc Id: XP_063121922   ⟸   XM_063265852
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063121918   ⟸   XM_063265848
- Peptide Label: isoform X1
Protein Domains
Ig-like   Ig-like C2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P83556-F1-model_v2 AlphaFold P83556 1-422 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727836 AgrOrtholog
BioCyc Gene G2FUF-60828 BioCyc
Ensembl Genes ENSRNOG00000027843 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000039823 ENTREZGENE
  ENSRNOT00000039823.4 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
InterPro Ig-like UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig-like_Receptors_ImmuneReg UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_sub2 UniProtKB/Swiss-Prot
  Immunoglobulin UniProtKB/Swiss-Prot
KEGG Report rno:353253 UniProtKB/Swiss-Prot
NCBI Gene 353253 ENTREZGENE
PANTHER KIR2DL PROTEIN-RELATED UniProtKB/Swiss-Prot
  MHC CLASS I NK CELL RECEPTOR UniProtKB/Swiss-Prot
Pfam PF00047 UniProtKB/Swiss-Prot
PhenoGen Kir3dl1 PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000027843 RatGTEx
SMART IGc2 UniProtKB/Swiss-Prot
  SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt A6KNK5 ENTREZGENE, UniProtKB/TrEMBL
  KI3L1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-04-29 Kir3dl1  killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1  Kir3dl1  killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Kir3dl1  killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1      Symbol and Name status set to approved 1299863 APPROVED