Slc29a3 (solute carrier family 29 member 3) - Rat Genome Database

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Gene: Slc29a3 (solute carrier family 29 member 3) Rattus norvegicus
Analyze
Symbol: Slc29a3
Name: solute carrier family 29 member 3
RGD ID: 727811
Description: Enables nucleoside transmembrane transporter activity. Involved in nucleoside transport. Predicted to be located in late endosome membrane and lysosomal membrane. Predicted to be active in Golgi apparatus and plasma membrane. Human ortholog(s) of this gene implicated in histiocytosis-lymphadenopathy plus syndrome. Orthologous to human SLC29A3 (solute carrier family 29 member 3); INTERACTS WITH (+)-schisandrin B; 2,3,7,8-tetrachlorodibenzodioxine; acetamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Ent3; equilibrative nucleoside transporter 3; rENT3; solute carrier family 29 (equilibrative nucleoside transporter), member 3; solute carrier family 29 (nucleoside transporters), member 3
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82029,191,086 - 29,228,299 (-)NCBIGRCr8
mRatBN7.22028,645,265 - 28,685,388 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2028,647,391 - 28,685,388 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2029,663,398 - 29,700,733 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02029,049,711 - 29,087,046 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02029,792,189 - 29,829,528 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02030,289,527 - 30,327,343 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2030,287,424 - 30,327,361 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02032,099,754 - 32,135,978 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42028,041,914 - 28,080,232 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12028,055,735 - 28,094,032 (-)NCBI
Celera2030,085,647 - 30,123,276 (-)NCBICelera
Cytogenetic Map20q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Nucleoside transporter subtype expression and function in rat skeletal muscle microvascular endothelial cells. Archer RG, etal., Br J Pharmacol 2004 Sep;143(1):202-14. Epub 2004 Aug 02.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
5. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
6. GOA pipeline RGD automated data pipeline
7. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:17897319  


Genomics

Comparative Map Data
Slc29a3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82029,191,086 - 29,228,299 (-)NCBIGRCr8
mRatBN7.22028,645,265 - 28,685,388 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2028,647,391 - 28,685,388 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2029,663,398 - 29,700,733 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02029,049,711 - 29,087,046 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02029,792,189 - 29,829,528 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.02030,289,527 - 30,327,343 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2030,287,424 - 30,327,361 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02032,099,754 - 32,135,978 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42028,041,914 - 28,080,232 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12028,055,735 - 28,094,032 (-)NCBI
Celera2030,085,647 - 30,123,276 (-)NCBICelera
Cytogenetic Map20q11NCBI
SLC29A3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381071,319,259 - 71,381,423 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1071,319,259 - 71,381,423 (+)EnsemblGRCh38hg38GRCh38
GRCh371073,079,016 - 73,123,142 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361072,749,016 - 72,793,153 (+)NCBINCBI36Build 36hg18NCBI36
Build 341072,749,037 - 72,793,146NCBI
Celera1066,361,811 - 66,405,947 (+)NCBICelera
Cytogenetic Map10q22.1NCBI
HuRef1067,073,050 - 67,117,221 (+)NCBIHuRef
CHM1_11073,361,676 - 73,405,808 (+)NCBICHM1_1
T2T-CHM13v2.01072,188,806 - 72,250,962 (+)NCBIT2T-CHM13v2.0
Slc29a3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391060,547,851 - 60,588,624 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1060,547,851 - 60,588,573 (-)EnsemblGRCm39 Ensembl
GRCm381060,712,072 - 60,752,849 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1060,712,072 - 60,752,794 (-)EnsemblGRCm38mm10GRCm38
MGSCv371060,174,820 - 60,215,530 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361060,107,430 - 60,148,134 (-)NCBIMGSCv36mm8
Celera1061,812,213 - 61,853,590 (-)NCBICelera
Cytogenetic Map10B4NCBI
cM Map1031.38NCBI
Slc29a3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543720,071,742 - 20,108,558 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495543720,072,915 - 20,108,342 (-)NCBIChiLan1.0ChiLan1.0
SLC29A3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2883,469,319 - 83,513,487 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11083,474,640 - 83,537,500 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01067,789,060 - 67,833,278 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11070,314,373 - 70,358,482 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1070,317,882 - 70,358,482 (+)Ensemblpanpan1.1panPan2
SLC29A3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1422,094,899 - 22,135,066 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl422,097,764 - 22,133,197 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha422,230,842 - 22,271,406 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0422,372,705 - 22,413,264 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl422,372,710 - 22,412,024 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1422,270,416 - 22,310,582 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0422,475,894 - 22,516,436 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0422,828,522 - 22,869,050 (+)NCBIUU_Cfam_GSD_1.0
Slc29a3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721358,925,189 - 58,959,705 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365217,418,184 - 7,452,695 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365217,417,914 - 7,452,695 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC29A3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1474,223,115 - 74,274,646 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11474,222,988 - 74,267,527 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21480,113,925 - 80,157,505 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC29A3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1959,927,957 - 59,979,570 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl959,927,964 - 59,975,174 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604820,572,326 - 20,701,433 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc29a3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247545,296,173 - 5,329,778 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247545,296,083 - 5,330,445 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Slc29a3
412 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:134
Count of miRNA genes:108
Interacting mature miRNAs:120
Transcripts:ENSRNOT00000000689
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8694189Bw153Body weight QTL 1533.130.001body mass (VT:0001259)body weight gain (CMO:0000420)20129191651Rat
9590275Scort15Serum corticosterone level QTL 153.480.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20129191651Rat
7411650Foco23Food consumption QTL 2320.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20129191651Rat
9590109Sffal8Serum free fatty acids level QTL 85.320.01blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)20129191651Rat
9589155Insul32Insulin level QTL 326.380.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)20129191651Rat
6893685Bw111Body weight QTL 1112.70.004body mass (VT:0001259)body weight (CMO:0000012)20132578807Rat
7411668Foco32Food consumption QTL 3280.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)20136600972Rat
9590252Scort12Serum corticosterone level QTL 1220.460.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)20136600972Rat
2305926Iddm37Insulin dependent diabetes mellitus QTL 376blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)20152784246527842Rat
1641915Colcr9Colorectal carcinoma resistance QTL 92.970.0024intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)20153065546530655Rat
1598816Memor12Memory QTL 122.4exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)20260683647606836Rat
4889870Pur30Proteinuria QTL 30190.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)20804241029322208Rat
7411652Foco24Food consumption QTL 240.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)201175751554435887Rat
9590092Insglur9Insulin/glucose ratio QTL 918.380.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)201175751554435887Rat
4889610Pancm3Pancreatic morphology QTL 33.750.001pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)201761783247606836Rat
2317880Alcrsp25Alcohol response QTL 252.3response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)201769755054435887Rat
2303626Vencon10Ventilatory control QTL 100.001respiration trait (VT:0001943)respiration rate (CMO:0000289)201919072154435887Rat
2303578Gluco50Glucose level QTL 502blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)202510672254435887Rat
2303587Bw93Body weight QTL 9313body mass (VT:0001259)body weight (CMO:0000012)202510672254435887Rat
2300188Bmd68Bone mineral density QTL 686.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)202510672254435887Rat
1331747Hrtrt16Heart rate QTL 163.163heart pumping trait (VT:2000009)heart rate (CMO:0000002)202520973454435887Rat

Markers in Region
RH133171  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22028,648,280 - 28,648,491 (+)MAPPERmRatBN7.2
Rnor_6.02030,289,617 - 30,289,827NCBIRnor6.0
Rnor_5.02032,099,844 - 32,100,054UniSTSRnor5.0
RGSC_v3.42028,042,004 - 28,042,214UniSTSRGSC3.4
Celera2030,085,737 - 30,085,947UniSTS
Cytogenetic Map20q11UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 2 5 9 29 23 3
Low 1 43 57 41 14 41 8 11 65 6 18 8 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000000689   ⟹   ENSRNOP00000000689
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2028,649,160 - 28,685,388 (-)Ensembl
Rnor_6.0 Ensembl2030,287,424 - 30,327,361 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000107399   ⟹   ENSRNOP00000095273
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2028,647,391 - 28,683,333 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000113968   ⟹   ENSRNOP00000082643
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2028,648,195 - 28,685,341 (-)Ensembl
RefSeq Acc Id: NM_181639   ⟹   NP_853670
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82029,191,103 - 29,228,299 (-)NCBI
mRatBN7.22028,648,191 - 28,685,388 (-)NCBI
Rnor_6.02030,289,527 - 30,327,343 (-)NCBI
Rnor_5.02032,099,754 - 32,135,978 (-)NCBI
RGSC_v3.42028,041,914 - 28,080,232 (-)RGD
Celera2030,085,647 - 30,123,276 (-)RGD
Sequence:
RefSeq Acc Id: XM_039098779   ⟹   XP_038954707
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82029,191,086 - 29,197,385 (-)NCBI
mRatBN7.22028,645,265 - 28,654,471 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_853670   ⟸   NM_181639
- UniProtKB: Q6AZ86 (UniProtKB/Swiss-Prot),   Q80WK7 (UniProtKB/Swiss-Prot),   A6K3Y0 (UniProtKB/TrEMBL),   A0A8I6GLJ6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000000689   ⟸   ENSRNOT00000000689
RefSeq Acc Id: XP_038954707   ⟸   XM_039098779
- Peptide Label: isoform X1
RefSeq Acc Id: ENSRNOP00000095273   ⟸   ENSRNOT00000107399
RefSeq Acc Id: ENSRNOP00000082643   ⟸   ENSRNOT00000113968

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80WK7-F1-model_v2 AlphaFold Q80WK7 1-475 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13701598
Promoter ID:EPDNEW_R12121
Type:initiation region
Name:Slc29a3_1
Description:solute carrier family 29 member 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02030,327,296 - 30,327,356EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727811 AgrOrtholog
BioCyc Gene G2FUF-3739 BioCyc
Ensembl Genes ENSRNOG00000000568 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055009182 UniProtKB/Swiss-Prot
  ENSRNOG00060002821 UniProtKB/Swiss-Prot
  ENSRNOG00065023841 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000000689.6 UniProtKB/TrEMBL
  ENSRNOT00000107399.1 UniProtKB/TrEMBL
  ENSRNOT00000113968 ENTREZGENE
  ENSRNOT00000113968.1 UniProtKB/Swiss-Prot
  ENSRNOT00055015544 UniProtKB/Swiss-Prot
  ENSRNOT00060004545 UniProtKB/Swiss-Prot
  ENSRNOT00065040902 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7132846 IMAGE-MGC_LOAD
InterPro Eqnu_transpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:353307 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:93033 IMAGE-MGC_LOAD
NCBI Gene 353307 ENTREZGENE
PANTHER PTHR10332 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR10332:SF17 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Nucleoside_tran UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Slc29a3 PhenoGen
PIRSF ENT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS DERENTRNSPRT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000000568 RatGTEx
  ENSRNOG00055009182 RatGTEx
  ENSRNOG00060002821 RatGTEx
  ENSRNOG00065023841 RatGTEx
UniProt A0A8I6GLJ6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2Q0D9_RAT UniProtKB/TrEMBL
  A6K3Y0 ENTREZGENE, UniProtKB/TrEMBL
  Q6AZ86 ENTREZGENE
  Q80WK7 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q6AZ86 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc29a3  solute carrier family 29 member 3  Slc29a3  solute carrier family 29 (equilibrative nucleoside transporter), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc29a3  solute carrier family 29 (equilibrative nucleoside transporter), member 3  Slc29a3  solute carrier family 29 (nucleoside transporters), member 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc29a3  solute carrier family 29 (nucleoside transporters), member 3      Symbol and Name status set to approved 1299863 APPROVED