Rtn4rl2 (reticulon 4 receptor-like 2) - Rat Genome Database

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Gene: Rtn4rl2 (reticulon 4 receptor-like 2) Rattus norvegicus
Analyze
Symbol: Rtn4rl2
Name: reticulon 4 receptor-like 2
RGD ID: 727797
Description: Enables signaling receptor activity. Involved in cell surface receptor signaling pathway and negative regulation of neuron projection development. Located in several cellular components, including external side of plasma membrane; membrane raft; and perikaryon. Orthologous to human RTN4RL2 (reticulon 4 receptor like 2); INTERACTS WITH 17beta-estradiol; acetamide; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: ngR2; Ngrh1; nogo receptor-like 3; Nogo-66 receptor homolog 1; nogo-66 receptor-related protein 2; reticulon-4 receptor-like 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8390,361,234 - 90,377,775 (-)NCBIGRCr8
mRatBN7.2369,954,557 - 69,971,108 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl369,955,169 - 69,971,488 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx373,336,652 - 73,353,243 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0381,935,323 - 81,951,912 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0379,693,746 - 79,710,228 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0372,272,814 - 72,289,310 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl372,273,424 - 72,289,310 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0378,792,727 - 78,809,760 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4368,098,435 - 68,113,874 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1367,994,806 - 68,010,246 (-)NCBI
Celera369,310,032 - 69,324,497 (-)NCBICelera
Cytogenetic Map3q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function
protein binding  (IPI)
signaling receptor activity  (IBA,IEA,IMP,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
4. Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor. Pignot V, etal., J Neurochem 2003 May;85(3):717-28.
5. GOA pipeline RGD automated data pipeline
6. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
7. Molecular basis of the interactions of the Nogo-66 receptor and its homolog NgR2 with myelin-associated glycoprotein: development of NgROMNI-Fc, a novel antagonist of CNS myelin inhibition. Robak LA, etal., J Neurosci. 2009 May 6;29(18):5768-83. doi: 10.1523/JNEUROSCI.4935-08.2009.
8. The Nogo-66 receptor homolog NgR2 is a sialic acid-dependent receptor selective for myelin-associated glycoprotein. Venkatesh K, etal., J Neurosci. 2005 Jan 26;25(4):808-22.
Additional References at PubMed
PMID:12658441   PMID:18056009   PMID:19063867   PMID:20463223   PMID:21308849   PMID:22406547   PMID:23376485   PMID:23533145   PMID:27339102   PMID:34544340   PMID:34643252  


Genomics

Comparative Map Data
Rtn4rl2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8390,361,234 - 90,377,775 (-)NCBIGRCr8
mRatBN7.2369,954,557 - 69,971,108 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl369,955,169 - 69,971,488 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx373,336,652 - 73,353,243 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0381,935,323 - 81,951,912 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0379,693,746 - 79,710,228 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0372,272,814 - 72,289,310 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl372,273,424 - 72,289,310 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0378,792,727 - 78,809,760 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4368,098,435 - 68,113,874 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1367,994,806 - 68,010,246 (-)NCBI
Celera369,310,032 - 69,324,497 (-)NCBICelera
Cytogenetic Map3q24NCBI
RTN4RL2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381157,460,528 - 57,477,534 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1157,460,528 - 57,477,534 (+)EnsemblGRCh38hg38GRCh38
GRCh371157,228,001 - 57,245,007 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361156,984,915 - 57,000,960 (+)NCBINCBI36Build 36hg18NCBI36
Build 341156,984,914 - 57,000,960NCBI
Celera1154,584,904 - 54,600,951 (+)NCBICelera
Cytogenetic Map11q12.1NCBI
HuRef1153,577,332 - 53,593,249 (+)NCBIHuRef
CHM1_11157,094,644 - 57,110,689 (+)NCBICHM1_1
T2T-CHM13v2.01157,410,743 - 57,427,752 (+)NCBIT2T-CHM13v2.0
Rtn4rl2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39284,701,653 - 84,718,985 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl284,702,268 - 84,717,054 (-)EnsemblGRCm39 Ensembl
GRCm38284,871,297 - 84,888,641 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl284,871,924 - 84,886,710 (-)EnsemblGRCm38mm10GRCm38
MGSCv37284,712,103 - 84,726,849 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36284,672,785 - 84,687,531 (-)NCBIMGSCv36mm8
Celera286,470,110 - 86,484,840 (-)NCBICelera
Cytogenetic Map2DNCBI
cM Map249.45NCBI
Rtn4rl2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049555112,463,006 - 2,474,045 (+)NCBIChiLan1.0ChiLan1.0
RTN4RL2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2958,616,869 - 58,633,957 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11159,633,959 - 59,650,954 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01152,701,378 - 52,718,385 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11156,174,245 - 56,190,508 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1156,174,358 - 56,190,410 (+)Ensemblpanpan1.1panPan2
RTN4RL2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11838,681,742 - 38,696,661 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1838,689,025 - 38,690,234 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1838,228,356 - 38,242,033 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01839,364,300 - 39,377,991 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1839,363,300 - 39,378,515 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11838,946,827 - 38,960,492 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01838,520,507 - 38,534,147 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01839,150,891 - 39,164,583 (-)NCBIUU_Cfam_GSD_1.0
Rtn4rl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494714,902,687 - 14,936,583 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365815,016,499 - 5,031,676 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365815,016,521 - 5,050,405 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RTN4RL2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl213,442,349 - 13,458,875 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1213,442,716 - 13,459,063 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
RTN4RL2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1115,757,790 - 15,775,804 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666038113,106,708 - 113,123,856 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rtn4rl2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248643,152,958 - 3,186,043 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:53
Count of miRNA genes:51
Interacting mature miRNAs:52
Transcripts:ENSRNOT00000038250
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2303593Gluco46Glucose level QTL 463blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)34887661993876619Rat
1354590Despr11Despair related QTL 110.000031locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)34887661993876619Rat
2298542Neuinf11Neuroinflammation QTL 113.9nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)33540319997383526Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
631832Sach1Saccharin preference QTL 12.70.02consumption behavior trait (VT:0002069)calculated saccharin drink intake volume (CMO:0001600)34790417292904172Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
631647Bp122Blood pressure QTL 1226.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)35109256196092561Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
9590286Uminl1Urine mineral level QTL 13.50.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)34865774493657744Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
9590136Scort3Serum corticosterone level QTL 323.370.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)34865774493657744Rat
61419Cia11Collagen induced arthritis QTL 115.6joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)35076614595766145Rat
61356Bp37Blood pressure QTL 373blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)35109256196092561Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1558650Cm48Cardiac mass QTL 4840.0001heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)35076614595766145Rat
8694196Abfw2Abdominal fat weight QTL 216.580.001visceral adipose mass (VT:0010063)abdominal fat pad weight to body weight ratio (CMO:0000095)34865774493657744Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
8552950Pigfal12Plasma insulin-like growth factor 1 level QTL 127.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)34865774493657744Rat
8694386Bw159Body weight QTL 1594.520.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)34865774493657744Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat

Markers in Region
AU048821  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2369,971,627 - 69,971,763 (+)MAPPERmRatBN7.2
Rnor_6.0372,289,807 - 72,289,942NCBIRnor6.0
RGSC_v3.4368,114,250 - 68,114,385UniSTSRGSC3.4
Celera369,324,931 - 69,325,066UniSTS
Cytogenetic Map3q24UniSTS
BE113531  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2369,956,871 - 69,957,070 (+)MAPPERmRatBN7.2
Rnor_6.0372,275,139 - 72,275,337NCBIRnor6.0
Rnor_5.0378,795,062 - 78,795,260UniSTSRnor5.0
RGSC_v3.4368,100,175 - 68,100,373UniSTSRGSC3.4
Celera369,312,156 - 69,312,354UniSTS
Cytogenetic Map3q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 5 49 113 79 76 53 19 53 6 194 90 93 39 59 23

Sequence


Ensembl Acc Id: ENSRNOT00000038250   ⟹   ENSRNOP00000032922
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl369,955,169 - 69,965,514 (-)Ensembl
Rnor_6.0 Ensembl372,273,424 - 72,289,310 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000105407   ⟹   ENSRNOP00000095119
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl369,955,169 - 69,971,488 (-)Ensembl
RefSeq Acc Id: NM_181380   ⟹   NP_852045
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8390,361,839 - 90,377,775 (-)NCBI
mRatBN7.2369,955,169 - 69,971,108 (-)NCBI
Rnor_6.0372,273,424 - 72,289,310 (-)NCBI
Rnor_5.0378,792,727 - 78,809,760 (-)NCBI
RGSC_v3.4368,098,435 - 68,113,874 (-)RGD
Celera369,310,032 - 69,324,497 (-)RGD
Sequence:
RefSeq Acc Id: XM_006234465   ⟹   XP_006234527
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8390,361,234 - 90,377,550 (-)NCBI
mRatBN7.2369,954,557 - 69,970,880 (-)NCBI
Rnor_6.0372,272,814 - 72,289,193 (-)NCBI
Rnor_5.0378,792,727 - 78,809,760 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006234466   ⟹   XP_006234528
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8390,361,234 - 90,376,878 (-)NCBI
mRatBN7.2369,954,557 - 69,970,224 (-)NCBI
Rnor_6.0372,272,814 - 72,288,866 (-)NCBI
Rnor_5.0378,792,727 - 78,809,760 (-)NCBI
Sequence:
RefSeq Acc Id: NP_852045   ⟸   NM_181380
- Peptide Label: precursor
- UniProtKB: Q80WD1 (UniProtKB/Swiss-Prot),   A6HMS2 (UniProtKB/TrEMBL),   A0A8I6AME5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234527   ⟸   XM_006234465
- Peptide Label: isoform X1
- UniProtKB: A6HMS3 (UniProtKB/TrEMBL),   A0A8L2QGV6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234528   ⟸   XM_006234466
- Peptide Label: isoform X1
- UniProtKB: A6HMS3 (UniProtKB/TrEMBL),   A0A8L2QGV6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000032922   ⟸   ENSRNOT00000038250
Ensembl Acc Id: ENSRNOP00000095119   ⟸   ENSRNOT00000105407
Protein Domains
LRRCT   LRRNT

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q80WD1-F1-model_v2 AlphaFold Q80WD1 1-420 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727797 AgrOrtholog
BioCyc Gene G2FUF-49149 BioCyc
Ensembl Genes ENSRNOG00000021513 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000038250.2 UniProtKB/TrEMBL
  ENSRNOT00000105407.1 UniProtKB/TrEMBL
Gene3D-CATH 3.80.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Dev_Immune_Receptor UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:311169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 311169 ENTREZGENE
PANTHER RETICULON-4 RECEPTOR-LIKE 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SLIT RELATED LEUCINE-RICH REPEAT NEURONAL PROTEIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam LRR_8 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rtn4rl2 PhenoGen
RatGTEx ENSRNOG00000021513 RatGTEx
SMART LRR_TYP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LRRCT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP L domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8I6AME5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8L2QGV6 ENTREZGENE, UniProtKB/TrEMBL
  A6HMS2 ENTREZGENE, UniProtKB/TrEMBL
  A6HMS3 ENTREZGENE, UniProtKB/TrEMBL
  Q80WD1 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Rtn4rl2  reticulon 4 receptor-like 2  Ngrh1  Nogo-66 receptor homolog 1  Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization protein is detected as a cell surface, N-glycosylated, GPI-anchored protein localized within the lipid rafts of the plasma membrane 1299553
gene_domains protein contains eight leucine-rich repeats, a leucine-rich repeat C-terminus and a leucine-rich repeat N-terminus as well as a C-terminal GPI signal sequence 1299553
gene_expression predominant expression in the brain particularly in all cortical layers except layer 1 and in neurons of the hippocampus; little or no expression was observed in the cerebellum, thalamus or striatum 1299553