Gpx2 (glutathione peroxidase 2) - Rat Genome Database

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Gene: Gpx2 (glutathione peroxidase 2) Rattus norvegicus
Analyze
Symbol: Gpx2
Name: glutathione peroxidase 2
RGD ID: 727780
Description: Enables glutathione peroxidase activity. Involved in response to salicylic acid and response to selenium ion. Predicted to be located in cytosol. Orthologous to human GPX2 (glutathione peroxidase 2); PARTICIPATES IN arachidonic acid metabolic pathway; glutathione metabolic pathway; INTERACTS WITH (+)-schisandrin B; (R)-lipoic acid; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane.
Type: protein-coding
RefSeq Status: REVIEWED
Previously known as: glutathione peroxidase-gastrointestinal; GPx-2; GPX-GI; GSHPx-2; GSHPx-GI; phospholipid hydroperoxide glutathione peroxidase GPX2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Related Pseudogenes: Gpx2-ps1   Gpx2-ps2  
Candidate Gene For: Schws4
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86101,226,745 - 101,230,033 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6101,226,745 - 101,230,862 (-)EnsemblGRCr8
mRatBN7.2695,493,589 - 95,496,877 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl695,493,589 - 95,496,877 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx695,882,234 - 95,885,509 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0696,180,771 - 96,184,046 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0695,609,574 - 95,612,849 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0699,839,960 - 99,843,245 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl699,839,960 - 99,843,245 (-)Ensemblrn6Rnor6.0
Rnor_5.06109,236,420 - 109,239,718 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4699,372,418 - 99,376,230 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera693,912,759 - 93,916,226 (-)NCBICelera
RGSC_v3.1699,375,879 - 99,379,686 (-)NCBI
Cytogenetic Map6q24NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
(R)-lipoic acid  (EXP)
(S)-naringenin  (ISO)
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP)
1,2-dimethylhydrazine  (EXP,ISO)
1-chloro-2,4-dinitrobenzene  (ISO)
1-naphthyl isothiocyanate  (EXP,ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-trinitrobenzenesulfonic acid  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-acetamidofluorene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,4-methylenedioxymethamphetamine  (ISO)
3,7-dihydropurine-6-thione  (ISO)
3-phenylprop-2-enal  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxy-TEMPO  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
4-nitroquinoline N-oxide  (ISO)
5-fluorouracil  (ISO)
5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole  (EXP)
6-propyl-2-thiouracil  (EXP)
7,12-dimethyltetraphene  (EXP)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (ISO)
9-cis-retinoic acid  (ISO)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
all-trans-retinoic acid  (ISO)
allopurinol  (ISO)
alpha-hexachlorocyclohexane  (EXP)
antimonite  (ISO)
aristolochic acid A  (EXP)
arotinoid acid  (ISO)
arsane  (ISO)
arsenic acid  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atazanavir sulfate  (ISO)
atrazine  (ISO)
Augmentin  (ISO)
azathioprine  (ISO)
Bardoxolone methyl  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (EXP)
bifenthrin  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromobenzene  (EXP)
buta-1,3-diene  (ISO)
butanal  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
calcitriol  (ISO)
cannabidiol  (ISO)
carbamazepine  (EXP,ISO)
cefaloridine  (EXP)
ceric oxide  (EXP)
cerium trichloride  (ISO)
CGP 52608  (ISO)
chenodeoxycholic acid  (ISO)
CHIR 99021  (ISO)
chloroprene  (ISO)
chlorpyrifos  (EXP,ISO)
cholesterol  (EXP)
choline  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clavulanic acid  (ISO)
cobalt atom  (ISO)
cobalt dichloride  (ISO)
cobicistat  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
cortisol  (ISO)
CU-O LINKAGE  (ISO)
cumene hydroperoxide  (ISO)
cyclosporin A  (ISO)
cyfluthrin  (ISO)
cylindrospermopsin  (ISO)
cypermethrin  (ISO)
cyproconazole  (EXP,ISO)
D-glucose  (EXP,ISO)
deoxycholic acid  (ISO)
dextran sulfate  (ISO)
diallyl disulfide  (EXP)
diazinon  (EXP)
Dibutyl phosphate  (ISO)
diclofenac  (ISO)
dicyclanil  (ISO)
diethyl maleate  (ISO)
dimethyl sulfoxide  (ISO)
dimethylarsinic acid  (EXP)
dioxygen  (ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (ISO)
diquat  (ISO)
disodium selenite  (ISO)
doramapimod  (ISO)
elemental selenium  (ISO)
emodin  (ISO)
endosulfan  (ISO)
enilconazole  (ISO)
epoxiconazole  (EXP)
erythromycin estolate  (EXP)
ethanol  (EXP)
Evodiamine  (ISO)
fenofibrate  (EXP,ISO)
flutamide  (EXP)
folic acid  (ISO)
folpet  (ISO)
furan  (EXP)
genistein  (ISO)
glucobrassicin  (ISO)
glucoraphanin  (EXP,ISO)
glucose  (EXP,ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
hexadecanoic acid  (EXP,ISO)
hydrogen peroxide  (ISO)
hydroquinone  (ISO)
hydroxytyrosol  (ISO)
indole-3-methanol  (EXP)
iron atom  (EXP)
iron(0)  (EXP)
isotretinoin  (ISO)
L-ascorbic acid  (ISO)
L-ascorbic acid 2-phosphate  (ISO)
L-methionine  (ISO)
lead(II) chloride  (ISO)
linoleic acid hydroperoxide  (ISO)
lipoic acid  (EXP)
lipopolysaccharide  (ISO)
lutein  (ISO)
lycopene  (ISO)
melatonin  (EXP)
menadione  (ISO)
mercaptopurine  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methylmercury chloride  (ISO)
microcystin-LR  (EXP,ISO)
Mitotane  (EXP)
monocrotaline  (ISO)
monosodium L-glutamate  (ISO)
morin  (EXP)
N-acetyl-L-cysteine  (EXP)
N-methyl-N-nitrosourea  (EXP)
N-nitrosodiethylamine  (EXP,ISO)
N-nitrosomorpholine  (EXP)
nefazodone  (ISO)
nickel atom  (EXP,ISO)
nitric oxide  (ISO)
obeticholic acid  (ISO)
ochratoxin A  (EXP)
omeprazole  (EXP)
orphenadrine  (EXP)
oxfendazole  (EXP)
ozone  (ISO)
p-toluidine  (EXP)
paclitaxel  (EXP)
paracetamol  (EXP,ISO)
paraquat  (ISO)
parthenolide  (EXP)
pentane-2,3-dione  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (EXP,ISO)
phenytoin  (ISO)
PhIP  (EXP)
phosgene  (ISO)
phoxim  (EXP)
piperonyl butoxide  (EXP)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (ISO)
propanal  (ISO)
prostaglandin E2  (ISO)
purine-6-thiol  (ISO)
quercetin  (EXP,ISO)
quercetin 3-O-beta-D-glucofuranoside  (EXP)
quercetin 3-O-beta-D-glucopyranoside  (EXP)
resveratrol  (EXP,ISO)
rifampicin  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
salicylic acid  (EXP)
SB 431542  (ISO)
selenium atom  (ISO)
selenium ion  (EXP)
silicon dioxide  (EXP,ISO)
silver atom  (ISO)
silver(0)  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium cholate  (EXP)
sodium dichromate  (EXP,ISO)
streptozocin  (EXP,ISO)
sulforaphane  (ISO)
Sunset Yellow FCF  (ISO)
T-2 toxin  (EXP)
tert-butyl hydroperoxide  (ISO)
testosterone  (EXP,ISO)
Tetrachlorobisphenol A  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
toluene  (EXP)
Tributyltin oxide  (ISO)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
tris(2-chloroethyl) phosphate  (ISO)
troglitazone  (ISO)
valdecoxib  (EXP)
valproic acid  (ISO)
vinclozolin  (EXP)
vitamin E  (EXP)
XAV939  (ISO)
zinc dichloride  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA,ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. GPx2 counteracts PGE2 production by dampening COX-2 and mPGES-1 expression in human colon cancer cells. Banning A, etal., Antioxid Redox Signal. 2008 Sep;10(9):1491-500. doi: 10.1089/ars.2008.2047.
2. Feeding of selenium alone or in combination with glucoraphanin differentially affects intestinal and hepatic antioxidant and phase II enzymes in growing rats. Blum NM, etal., Biol Trace Elem Res. 2013 Mar;151(3):384-99. doi: 10.1007/s12011-012-9567-6. Epub 2012 Dec 29.
3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, etal., Genome Res 1996 Sep;6(9):791-806.
4. Salicylic acid modulates oxidative stress and glutathione peroxidase activity in the rat colon. Drew JE, etal., Biochem Pharmacol. 2005 Sep 15;70(6):888-93. doi: 10.1016/j.bcp.2005.06.011.
5. Selenium-dependent glutathione peroxidase-GI is a major glutathione peroxidase activity in the mucosal epithelium of rodent intestine. Esworthy RS, etal., Biochim Biophys Acta 1998 Jul 23;1381(2):213-26.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Protective Effects of Ammannia baccifera Against CCl4-Induced Oxidative Stress in Rats. Goodla L, etal., Int J Environ Res Public Health. 2019 Apr 23;16(8):1440. doi: 10.3390/ijerph16081440.
8. Expression of Selenoprotein Genes and Association with Selenium Status in Colorectal Adenoma and Colorectal Cancer. Hughes DJ, etal., Nutrients. 2018 Nov 21;10(11). pii: nu10111812. doi: 10.3390/nu10111812.
9. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
10. Effect of diallyl disulfide on acute gastric mucosal damage induced by alcohol in rats. Lee IC, etal., Hum Exp Toxicol. 2015 Mar;34(3):227-39. doi: 10.1177/0960327114537095. Epub 2014 Jun 27.
11. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
12. NCBI rat LocusLink and RefSeq merged data October 15, 2003 NCBI rat LocusLink and RefSeq merged data October 15, 2003
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Dietary selenium protects adiponectin knockout mice against chronic inflammation induced colon cancer. Saxena A, etal., Cancer Biol Ther. 2017 Apr 3;18(4):257-267. doi: 10.1080/15384047.2016.1276130. Epub 2017 Jan 3.
17. Identification of gene expression profile of dorsal root ganglion in the rat peripheral axotomy model of neuropathic pain. Xiao HS, etal., Proc Natl Acad Sci U S A 2002 Jun 11;99(12):8360-5.
Additional References at PubMed
PMID:11518697   PMID:12751789   PMID:16229841   PMID:17993721   PMID:18056462   PMID:23376485   PMID:23867582   PMID:24962481   PMID:26192016   PMID:37761814  


Genomics

Comparative Map Data
Gpx2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86101,226,745 - 101,230,033 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl6101,226,745 - 101,230,862 (-)EnsemblGRCr8
mRatBN7.2695,493,589 - 95,496,877 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl695,493,589 - 95,496,877 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx695,882,234 - 95,885,509 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0696,180,771 - 96,184,046 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0695,609,574 - 95,612,849 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0699,839,960 - 99,843,245 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl699,839,960 - 99,843,245 (-)Ensemblrn6Rnor6.0
Rnor_5.06109,236,420 - 109,239,718 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4699,372,418 - 99,376,230 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera693,912,759 - 93,916,226 (-)NCBICelera
RGSC_v3.1699,375,879 - 99,379,686 (-)NCBI
Cytogenetic Map6q24NCBI
GPX2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381464,939,158 - 64,942,745 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1464,939,152 - 64,942,746 (-)Ensemblhg38GRCh38
GRCh371465,405,876 - 65,409,463 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361464,475,625 - 64,479,284 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341464,475,624 - 64,479,284NCBI
Celera1445,460,457 - 45,464,116 (-)NCBICelera
Cytogenetic Map14q23.3NCBI
HuRef1445,575,494 - 45,579,247 (-)NCBIHuRef
CHM1_11465,344,036 - 65,347,793 (-)NCBICHM1_1
T2T-CHM13v2.01459,144,027 - 59,147,614 (-)NCBIT2T-CHM13v2.0
Gpx2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391276,839,109 - 76,842,328 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1276,839,107 - 76,842,273 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381276,792,335 - 76,795,554 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1276,792,333 - 76,795,554 (-)Ensemblmm10GRCm38
MGSCv371277,893,322 - 77,896,541 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361277,711,177 - 77,714,346 (-)NCBIMGSCv36mm8
Celera1277,874,684 - 77,877,908 (-)NCBICelera
Cytogenetic Map12C3NCBI
cM Map1233.73NCBI
Gpx2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554664,984,631 - 4,987,457 (+)Ensembl
ChiLan1.0NW_0049554664,983,532 - 4,987,780 (+)NCBIChiLan1.0ChiLan1.0
GPX2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21566,048,329 - 66,056,792 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11465,264,842 - 65,273,236 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01445,522,558 - 45,526,678 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11464,401,921 - 64,405,720 (-)NCBIPanPan1.1PanPan1.1panPan2
GPX2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1839,322,040 - 39,325,833 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl839,322,034 - 39,325,817 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha839,014,111 - 39,017,902 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0839,544,781 - 39,548,609 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl839,544,775 - 39,548,593 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1839,166,063 - 39,169,883 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0839,238,883 - 39,242,643 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0839,597,955 - 39,601,701 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Gpx2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440864065,598,245 - 65,601,474 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364958,590,556 - 8,593,367 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364958,590,225 - 8,593,511 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GPX2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl789,007,375 - 89,011,620 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1789,007,636 - 89,011,620 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2795,388,550 - 95,392,539 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GPX2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12442,151,205 - 42,155,335 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605330,321,541 - 30,325,285 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Gpx2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473436,086,902 - 36,089,855 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473436,086,831 - 36,090,180 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Gpx2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1790,925,119 - 90,928,234 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Gpx2
21 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
4145119Mcs25Mammary carcinoma susceptibility QTL 250.0001mammary gland integrity trait (VT:0010552)ratio of deaths to total study population during a period of time (CMO:0001023)671278722116278722Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)6100704576101593851Rat
70176Mcsm1Mammary carcinoma susceptibility modifier QTL 1mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)664367996109367996Rat
2293088Iddm28Insulin dependent diabetes mellitus QTL 285.21blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)668767270135411972Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)688019181136741135Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)690871046135871046Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)693560258136550638Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)698944780143944780Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)6100704576136029228Rat
724524Uae2Urinary albumin excretion QTL 22.70.0005urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)679198463144254945Rat
737827Hcar11Hepatocarcinoma resistance QTL 114.4liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)646050607116278722Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)693778632138778632Rat
1576309Emca7Estrogen-induced mammary cancer QTL 74mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)620859430113082285Rat
2293837Kiddil1Kidney dilation QTL 13.7kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)684490437129490437Rat
2293842Kiddil3Kidney dilation QTL 34.3kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)686867923110125012Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)690871046135871046Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)693560258136550638Rat
1576302Schws4Schwannoma susceptibility QTL 40.0078nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)678204640123204640Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)693560258136550638Rat
1300075Glom7Glomerulus QTL 75.60.0000002kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)676937178121937178Rat
1331789Rf37Renal function QTL 373.224kidney blood vessel physiology trait (VT:0100012)absolute change in renal vascular resistance (CMO:0001900)686494122112380234Rat
1331725Bp212Blood pressure QTL 2123.52475arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)699437079125323237Rat
1331722Thshl1Thyroid stimulating hormone level QTL 111.70.0001blood thyroid-stimulating hormone amount (VT:0005119)serum thyroid stimulating hormone level (CMO:0001248)699708426112483760Rat

Markers in Region
RH130461  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2695,493,588 - 95,493,777 (+)MAPPERmRatBN7.2
Rnor_6.0699,839,960 - 99,840,148NCBIRnor6.0
Rnor_5.06109,236,420 - 109,236,608UniSTSRnor5.0
RGSC_v3.4699,372,418 - 99,372,606UniSTSRGSC3.4
Celera693,912,759 - 93,912,947UniSTS
RH 3.4 Map6677.1UniSTS
Cytogenetic Map6q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 10 54 130 91 90 59 40 59 6 286 122 8 110 81 91 31 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000080270   ⟹   ENSRNOP00000072136
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6101,226,745 - 101,230,033 (-)Ensembl
mRatBN7.2 Ensembl695,493,589 - 95,496,877 (-)Ensembl
Rnor_6.0 Ensembl699,839,960 - 99,843,245 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000134107   ⟹   ENSRNOP00000098737
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl6101,226,745 - 101,230,862 (-)Ensembl
RefSeq Acc Id: NM_183403   ⟹   NP_899653
RefSeq Status: REVIEWED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86101,226,745 - 101,230,033 (-)NCBI
mRatBN7.2695,493,589 - 95,496,877 (-)NCBI
Rnor_6.0699,839,960 - 99,843,245 (-)NCBI
Rnor_5.06109,236,420 - 109,239,718 (-)NCBI
RGSC_v3.4699,372,418 - 99,376,230 (-)RGD
Celera693,912,759 - 93,916,226 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_899653 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072136
GenBank Protein P83645 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_899653   ⟸   NM_183403
- UniProtKB: P83645 (UniProtKB/Swiss-Prot),   A0A0G2K278 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000072136   ⟸   ENSRNOT00000080270
Ensembl Acc Id: ENSRNOP00000098737   ⟸   ENSRNOT00000134107

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694680
Promoter ID:EPDNEW_R5205
Type:multiple initiation site
Name:Gpx2_1
Description:glutathione peroxidase 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0699,843,141 - 99,843,201EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:727780 AgrOrtholog
BioCyc Gene G2FUF-37047 BioCyc
BioCyc Pathway DETOX1-PWY-1 [reactive oxygen species degradation] BioCyc
  PWY-4081 [glutathione-peroxide redox reactions] BioCyc
BioCyc Pathway Image DETOX1-PWY-1 BioCyc
  PWY-4081 BioCyc
Ensembl Genes ENSRNOG00000055672 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000080270 ENTREZGENE
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot
InterPro Glutathione_peroxidase UniProtKB/Swiss-Prot
  GPX_AS UniProtKB/Swiss-Prot
  GPX_CS UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
NCBI Gene 29326 ENTREZGENE
PANTHER Glut_peroxidase UniProtKB/Swiss-Prot
  GLUTATHIONE PEROXIDASE 2 UniProtKB/Swiss-Prot
Pfam GSHPx UniProtKB/Swiss-Prot
PhenoGen Gpx2 PhenoGen
PIRSF Glutathion_perox UniProtKB/Swiss-Prot
PRINTS GLUTPROXDASE UniProtKB/Swiss-Prot
PROSITE GLUTATHIONE_PEROXID_1 UniProtKB/Swiss-Prot
  GLUTATHIONE_PEROXID_2 UniProtKB/Swiss-Prot
  GLUTATHIONE_PEROXID_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000055672 RatGTEx
Superfamily-SCOP Thiordxn-like_fd UniProtKB/Swiss-Prot
UniProt A0A0G2K278 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0L4D8_RAT UniProtKB/TrEMBL
  GPX2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-12-14 Gpx2  glutathione peroxidase 2      Symbol and Name status set to approved 1299863 APPROVED