Bbs2 (Bardet-Biedl syndrome 2) - Rat Genome Database

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Advanced Search (OLGA)
Gene: Bbs2 (Bardet-Biedl syndrome 2) Rattus norvegicus
Analyze
Symbol: Bbs2
Name: Bardet-Biedl syndrome 2
RGD ID: 71091
Description: Predicted to enable RNA polymerase II-specific DNA-binding transcription factor binding activity. Predicted to be involved in several processes, including negative regulation of appetite by leptin-mediated signaling pathway; regulation of cilium beat frequency involved in ciliary motility; and visual perception. Predicted to act upstream of or within several processes, including blood vessel diameter maintenance; brain development; and cilium assembly. Predicted to be located in ciliary membrane; microvillus; and stereocilium. Predicted to be part of BBSome. Predicted to be active in several cellular components, including ciliary basal body; motile cilium; and neuron projection. Human ortholog(s) of this gene implicated in Bardet-Biedl syndrome; Bardet-Biedl syndrome 2; obesity; and retinitis pigmentosa 74. Orthologous to human BBS2 (Bardet-Biedl syndrome 2); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,3',4,4',5-pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: bardet-biedl syndrome 2 (human); Bardet-Biedl syndrome 2 homolog; Bardet-Biedl syndrome 2 homolog (human); bardet-Biedl syndrome 2 protein homolog; BBSome complex member BBS2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,915,566 - 10,950,911 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1910,915,476 - 10,950,921 (+)EnsemblGRCr8
mRatBN7.21910,909,653 - 10,944,998 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,909,619 - 10,944,993 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1910,879,554 - 10,915,000 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01911,644,727 - 11,680,171 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,931,731 - 10,967,176 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01911,385,921 - 11,421,523 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1911,386,024 - 11,421,498 (+)Ensemblrn6Rnor6.0
Rnor_5.01911,360,477 - 11,395,956 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41911,347,432 - 11,382,830 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1910,794,343 - 10,829,641 (+)NCBICelera
RGSC_v3.11911,352,257 - 11,387,656 (+)NCBI
Cytogenetic Map19p12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-epigallocatechin 3-gallate  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2-hydroxypropanoic acid  (ISO)
2-methylcholine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
Aroclor 1254  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
benzo[a]pyrene  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
Dibutyl phosphate  (ISO)
disulfiram  (ISO)
doxorubicin  (ISO)
finasteride  (EXP)
flavonoids  (EXP)
fulvestrant  (ISO)
glafenine  (EXP)
leflunomide  (EXP)
lipopolysaccharide  (ISO)
menadione  (ISO)
methapyrilene  (EXP)
methimazole  (EXP)
methyl methanesulfonate  (ISO)
niclosamide  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
perfluorooctanoic acid  (EXP)
pirinixic acid  (EXP)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulfadimethoxine  (EXP)
sunitinib  (ISO)
tamoxifen  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
tributylstannane  (EXP)
triphenyl phosphate  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
BBSome  (IBA,IEA,ISO)
centriolar satellite  (IEA)
ciliary basal body  (IBA,IEA,ISO)
ciliary membrane  (IEA,ISO)
ciliary transition zone  (IEA,ISO)
cytoplasm  (IEA)
cytoskeleton  (IEA)
membrane  (IBA,IEA,ISO)
microvillus  (IEA,ISO)
motile cilium  (IBA,IEA,ISO)
neuron projection  (IBA)
stereocilium  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Bardet-Biedl syndrome gene variants are associated with both childhood and adult common obesity in French Caucasians. Benzinou M, etal., Diabetes. 2006 Oct;55(10):2876-82.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Linkage of Bardet-Biedl syndrome to chromosome 16q and evidence for non-allelic genetic heterogeneity. Kwitek-Black AE, etal., Nat Genet 1993 Dec;5(4):392-6.
4. Gene Data Set MGD Curation, June 12, 2002
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. Positional cloning of a novel gene on chromosome 16q causing Bardet-Biedl syndrome (BBS2). Nishimura DY, etal., Hum Mol Genet 2001 Apr 1;10(8):865-74.
8. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. Targeting of vasoactive intestinal peptide receptor 2, VPAC2, a secretin family G-protein coupled receptor, to primary cilia. Soetedjo L, etal., Biol Open. 2013 May 23;2(7):686-94. doi: 10.1242/bio.20134747. Print 2013 Jul 15.
Additional References at PubMed
PMID:15539463   PMID:17379567   PMID:17574030   PMID:18032602   PMID:18299575   PMID:18317593   PMID:18334641   PMID:19150989   PMID:19195025   PMID:20080638   PMID:20852044   PMID:22072986  
PMID:22139371   PMID:22228099   PMID:22302990   PMID:22500027   PMID:24550735   PMID:25541840   PMID:25605782  


Genomics

Comparative Map Data
Bbs2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81910,915,566 - 10,950,911 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1910,915,476 - 10,950,921 (+)EnsemblGRCr8
mRatBN7.21910,909,653 - 10,944,998 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1910,909,619 - 10,944,993 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1910,879,554 - 10,915,000 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01911,644,727 - 11,680,171 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01910,931,731 - 10,967,176 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01911,385,921 - 11,421,523 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1911,386,024 - 11,421,498 (+)Ensemblrn6Rnor6.0
Rnor_5.01911,360,477 - 11,395,956 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41911,347,432 - 11,382,830 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1910,794,343 - 10,829,641 (+)NCBICelera
RGSC_v3.11911,352,257 - 11,387,656 (+)NCBI
Cytogenetic Map19p12NCBI
BBS2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381656,470,403 - 56,520,024 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1656,465,640 - 56,582,667 (-)Ensemblhg38GRCh38
GRCh371656,504,315 - 56,553,936 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,075,798 - 55,111,696 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341655,075,798 - 55,111,696NCBI
Celera1641,016,278 - 41,052,025 (-)NCBICelera
Cytogenetic Map16q13NCBI
HuRef1642,388,684 - 42,424,427 (-)NCBIHuRef
CHM1_11657,925,275 - 57,961,074 (-)NCBICHM1_1
T2T-CHM13v2.01662,265,473 - 62,315,098 (-)NCBIT2T-CHM13v2.0
Bbs2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39894,794,580 - 94,825,997 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl894,794,582 - 94,825,556 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38894,067,952 - 94,099,369 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl894,067,954 - 94,098,928 (-)Ensemblmm10GRCm38
MGSCv37896,591,854 - 96,622,711 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36896,957,083 - 96,987,940 (-)NCBIMGSCv36mm8
Celera898,399,207 - 98,430,064 (-)NCBICelera
Cytogenetic Map8C5NCBI
cM Map846.14NCBI
Bbs2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543314,266,190 - 14,296,929 (-)Ensembl
ChiLan1.0NW_00495543314,266,190 - 14,321,780 (-)NCBIChiLan1.0ChiLan1.0
BBS2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21865,952,091 - 66,003,137 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11671,871,011 - 71,921,964 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01636,756,699 - 36,807,652 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11655,902,945 - 55,940,053 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1655,902,945 - 55,940,053 (-)EnsemblpanPan2panpan1.1
BBS2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1259,650,439 - 59,705,728 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl259,677,216 - 59,705,730 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha256,308,316 - 56,339,418 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0260,219,421 - 60,250,791 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl260,219,416 - 60,250,791 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1257,050,041 - 57,081,142 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0258,058,880 - 58,089,986 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0258,951,859 - 58,982,967 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Bbs2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934950,759,978 - 50,803,324 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364758,785,154 - 8,810,541 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364758,785,914 - 8,810,490 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BBS2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl618,542,386 - 18,575,514 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1618,542,383 - 18,575,338 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2626,446,675 - 26,473,875 (+)NCBISscrofa10.2Sscrofa10.2susScr3
BBS2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1542,395,387 - 42,430,204 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl542,395,230 - 42,430,154 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604733,933,967 - 33,969,228 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bbs2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475755,811 - 88,562 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462475755,861 - 88,703 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Bbs2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v117977,093 - 1,011,966 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Bbs2
130 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:40
Count of miRNA genes:34
Interacting mature miRNAs:39
Transcripts:ENSRNOT00000026076
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1549847Bss8Bone structure and strength QTL 84lumbar vertebra strength trait (VT:0010574)vertebra ultimate force (CMO:0001678)19131969901Rat
8552935Pigfal10Plasma insulin-like growth factor 1 level QTL 105.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)19799775052997750Rat
9590298Uminl5Urine mineral level QTL 53.590.001urine mineral amount (VT:0015086)urine electrolyte level (CMO:0000593)19799775052997750Rat
631840Niddm38Non-insulin dependent diabetes mellitus QTL 383.86blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)191032907674246245Rat
1358200Insglur2Insulin/glucose ratio QTL 24.1blood glucose amount (VT:0000188)serum glucose level (CMO:0000543)19574806450748064Rat
10054132Srcrt9Stress Responsive Cort QTL 92.870.0017blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19127361636Rat
1331737Uae29Urinary albumin excretion QTL 295.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)193628974246245Rat
61423Cia14Collagen induced arthritis QTL 143joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)191083361874246245Rat
7411590Foco7Food consumption QTL 76.80.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)19124694445Rat
9590090Insglur8Insulin/glucose ratio QTL 810.810.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)19799775052997750Rat
9590250Scort11Serum corticosterone level QTL 1123.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)19799775052997750Rat
7247442Uae39Urinary albumin excretion QTL 39urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)19219431774246245Rat
724566Uae12Urinary albumin excretion QTL 125urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)19219431774246245Rat

Markers in Region
RH131221  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21910,945,176 - 10,945,387 (+)MAPPERmRatBN7.2
Rnor_6.01911,421,700 - 11,421,910NCBIRnor6.0
Rnor_5.01911,396,133 - 11,396,343UniSTSRnor5.0
RGSC_v3.41911,383,032 - 11,383,242UniSTSRGSC3.4
Celera1910,829,843 - 10,830,053UniSTS
RH 3.4 Map19111.9UniSTS
Cytogenetic Map19p12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000026076   ⟹   ENSRNOP00000026076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1910,915,587 - 10,950,921 (+)Ensembl
mRatBN7.2 Ensembl1910,909,653 - 10,944,975 (+)Ensembl
Rnor_6.0 Ensembl1911,386,024 - 11,421,498 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000106411   ⟹   ENSRNOP00000087643
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1910,915,476 - 10,950,920 (+)Ensembl
mRatBN7.2 Ensembl1910,909,619 - 10,944,993 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114302   ⟹   ENSRNOP00000087717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1910,910,519 - 10,944,993 (+)Ensembl
RefSeq Acc Id: NM_053618   ⟹   NP_446070
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81910,915,566 - 10,950,894 (+)NCBI
mRatBN7.21910,909,653 - 10,944,975 (+)NCBI
Rnor_6.01911,386,024 - 11,421,498 (+)NCBI
Rnor_5.01911,360,477 - 11,395,956 (+)NCBI
RGSC_v3.41911,347,432 - 11,382,830 (+)RGD
Celera1910,794,343 - 10,829,641 (+)RGD
Sequence:
RefSeq Acc Id: XM_006255131   ⟹   XP_006255193
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81910,915,648 - 10,950,911 (+)NCBI
mRatBN7.21910,909,715 - 10,944,998 (+)NCBI
Rnor_6.01911,385,921 - 11,421,523 (+)NCBI
Rnor_5.01911,360,477 - 11,395,956 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039097425   ⟹   XP_038953353
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81910,915,651 - 10,950,911 (+)NCBI
mRatBN7.21910,909,735 - 10,944,998 (+)NCBI
RefSeq Acc Id: XM_063277732   ⟹   XP_063133802
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81910,925,911 - 10,950,911 (+)NCBI
RefSeq Acc Id: NP_446070   ⟸   NM_053618
- UniProtKB: Q99MH9 (UniProtKB/Swiss-Prot),   A6JY76 (UniProtKB/TrEMBL),   A0A8I6A3J2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006255193   ⟸   XM_006255131
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A3J2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026076   ⟸   ENSRNOT00000026076
RefSeq Acc Id: XP_038953353   ⟸   XM_039097425
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A6C7 (UniProtKB/TrEMBL),   A0A8I6A3J2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000087717   ⟸   ENSRNOT00000114302
Ensembl Acc Id: ENSRNOP00000087643   ⟸   ENSRNOT00000106411
RefSeq Acc Id: XP_063133802   ⟸   XM_063277732
- Peptide Label: isoform X2
- UniProtKB: A0A8I6A3J2 (UniProtKB/TrEMBL),   A0A8I6A6C7 (UniProtKB/TrEMBL)
Protein Domains
BBS2 C-terminal helix bundle   BBS2 GAE   BBS2 hairpin   BBS2 platform   Ciliary BBSome complex subunit 2 middle region   Ciliary BBSome complex subunit 2 N-terminal

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99MH9-F1-model_v2 AlphaFold Q99MH9 1-721 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13700953
Promoter ID:EPDNEW_R11477
Type:initiation region
Name:Bbs2_1
Description:Bardet-Biedl syndrome 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01911,386,092 - 11,386,152EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71091 AgrOrtholog
BioCyc Gene G2FUF-6471 BioCyc
Ensembl Genes ENSRNOG00000019020 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026076 ENTREZGENE
  ENSRNOT00000026076.4 UniProtKB/Swiss-Prot
  ENSRNOT00000106411 ENTREZGENE
InterPro Bardet-Biedl_syndrome_2_prot UniProtKB/Swiss-Prot
  BBS2_C UniProtKB/Swiss-Prot
  BBS2_CtH_dom UniProtKB/Swiss-Prot
  BBS2_hp_dom UniProtKB/Swiss-Prot
  BBS2_Mid UniProtKB/Swiss-Prot
  BBS2_N UniProtKB/Swiss-Prot
  BBS2_pf_dom UniProtKB/Swiss-Prot
  WD40_repeat_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:113948 UniProtKB/Swiss-Prot
NCBI Gene 113948 ENTREZGENE
PANTHER BARDET-BIEDL SYNDROME 2 PROTEIN UniProtKB/Swiss-Prot
  PTHR32465 UniProtKB/Swiss-Prot
Pfam BBS2_C UniProtKB/Swiss-Prot
  BBS2_CtH UniProtKB/Swiss-Prot
  BBS2_hp UniProtKB/Swiss-Prot
  BBS2_Mid UniProtKB/Swiss-Prot
  BBS2_N UniProtKB/Swiss-Prot
  BBS2_pf UniProtKB/Swiss-Prot
PhenoGen Bbs2 PhenoGen
PIRSF BBS2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019020 RatGTEx
Superfamily-SCOP SSF50978 UniProtKB/Swiss-Prot
UniProt A0A8I6A3J2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A6C7 ENTREZGENE
  A6JY76 ENTREZGENE, UniProtKB/TrEMBL
  BBS2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2009-11-05 Bbs2  Bardet-Biedl syndrome 2  Bbs2  Bardet-Biedl syndrome 2 homolog (human)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-02   Bardet-Biedl syndrome 2 homolog (human)  Bbs2  Bardet-Biedl syndrome 2 (human)  Name updated 1299863 APPROVED
2002-07-09 Bbs2  Bardet-Biedl syndrome 2 (human)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference