Pigm (phosphatidylinositol glycan anchor biosynthesis, class M) - Rat Genome Database

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Pathways
Gene: Pigm (phosphatidylinositol glycan anchor biosynthesis, class M) Rattus norvegicus
Analyze
Symbol: Pigm
Name: phosphatidylinositol glycan anchor biosynthesis, class M
RGD ID: 71041
Description: Enables dol-P-Man:GlcN-acyl-PI alpha-1,4-mannosyltransferase activity. Involved in GPI anchor biosynthetic process. Part of glycosylphosphatidylinositol-mannosyltransferase I complex. Orthologous to human PIGM (phosphatidylinositol glycan anchor biosynthesis class M); PARTICIPATES IN glycosylphosphatidylinositol anchor biosynthetic pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: GPI alpha-1,4-mannosyltransferase I, catalytic subunit; GPI mannosyltransferase 1; GPI mannosyltransferase I; GPI-MT-I; LOC103694910; phosphatidylinositol glycan, class M; phosphatidylinositol-glycan biosynthesis class M protein; PIG-M mRNA for mannosyltransferase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81387,370,693 - 87,374,390 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1387,368,359 - 87,376,206 (+)EnsemblGRCr8
mRatBN7.21384,838,329 - 84,842,026 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1384,838,175 - 84,843,381 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1387,341,646 - 87,345,343 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01388,741,920 - 88,745,617 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01385,926,307 - 85,930,006 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01390,759,260 - 90,762,957 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1390,759,260 - 90,762,957 (+)Ensemblrn6Rnor6.0
Rnor_5.01395,281,187 - 95,284,884 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41388,377,212 - 88,380,909 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1384,448,384 - 84,452,081 (+)NCBICelera
RGSC_v3.11388,566,095 - 88,569,793 (+)NCBI
Cytogenetic Map13q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Mammalian PIG-X and yeast Pbn1p are the essential components of glycosylphosphatidylinositol-mannosyltransferase I. Ashida H, etal., Mol Biol Cell. 2005 Mar;16(3):1439-48. doi: 10.1091/mbc.e04-09-0802. Epub 2005 Jan 5.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. PIG-M transfers the first mannose to glycosylphosphatidylinositol on the lumenal side of the ER. Maeda Y, etal., EMBO J 2001 Jan 15;20(1-2):250-61.
4. Gene Data Set MGD Curation, June 12, 2002
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Comparative Map Data
Pigm
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81387,370,693 - 87,374,390 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1387,368,359 - 87,376,206 (+)EnsemblGRCr8
mRatBN7.21384,838,329 - 84,842,026 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1384,838,175 - 84,843,381 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1387,341,646 - 87,345,343 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01388,741,920 - 88,745,617 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01385,926,307 - 85,930,006 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01390,759,260 - 90,762,957 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1390,759,260 - 90,762,957 (+)Ensemblrn6Rnor6.0
Rnor_5.01395,281,187 - 95,284,884 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41388,377,212 - 88,380,909 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1384,448,384 - 84,452,081 (+)NCBICelera
RGSC_v3.11388,566,095 - 88,569,793 (+)NCBI
Cytogenetic Map13q24NCBI
PIGM
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381160,024,953 - 160,031,990 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1160,024,953 - 160,031,990 (-)Ensemblhg38GRCh38
GRCh371159,994,743 - 160,001,780 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361158,264,086 - 158,268,407 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341156,812,769 - 156,814,821NCBI
Celera1133,065,903 - 133,070,225 (-)NCBICelera
Cytogenetic Map1q23.2NCBI
HuRef1131,354,186 - 131,358,509 (-)NCBIHuRef
CHM1_11161,392,783 - 161,397,106 (-)NCBICHM1_1
T2T-CHM13v2.01159,162,027 - 159,169,067 (-)NCBIT2T-CHM13v2.0
Pigm
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391172,204,098 - 172,211,666 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1172,204,113 - 172,211,666 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381172,376,531 - 172,384,099 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1172,376,546 - 172,384,099 (+)Ensemblmm10GRCm38
MGSCv371174,306,662 - 174,314,230 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361174,213,231 - 174,217,208 (+)NCBIMGSCv36mm8
Celera1175,229,959 - 175,237,523 (+)NCBICelera
Cytogenetic Map1H3NCBI
cM Map179.73NCBI
Pigm
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495546811,818,604 - 11,819,872 (-)Ensembl
ChiLan1.0NW_00495546811,817,647 - 11,820,456 (-)NCBIChiLan1.0ChiLan1.0
PIGM
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2189,820,391 - 89,827,205 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1189,560,492 - 89,567,215 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01135,378,843 - 135,387,789 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11139,303,208 - 139,307,797 (-)NCBIPanPan1.1PanPan1.1panPan2
PIGM
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13822,150,006 - 22,151,589 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha3822,225,395 - 22,230,629 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03822,269,869 - 22,271,417 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3822,269,352 - 22,271,115 (+)EnsemblROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.03822,570,098 - 22,575,352 (+)NCBIUNSW_CanFamBas_1.0
Pigm
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244050586,156,494 - 6,158,603 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936740596,072 - 597,343 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936740595,932 - 597,964 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PIGM
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1490,461,507 - 90,464,500 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2498,432,754 - 98,434,851 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PIGM
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1203,913,163 - 3,914,853 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl203,913,336 - 3,914,607 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660382,969,696 - 2,972,124 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pigm
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247941,220,121 - 1,221,392 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247941,220,004 - 1,222,259 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Pigm
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11051,490,760 - 51,494,205 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Pigm
10 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:206
Count of miRNA genes:151
Interacting mature miRNAs:172
Transcripts:ENSRNOT00000010551
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
7207885Glom27Glomerulus QTL 273.9kidney glomerulus integrity trait (VT:0010546)kidney crescentic glomeruli count to kidney normal glomeruli count ratio (CMO:0002139)1321120177109350286Rat
738027Lnnr6Liver neoplastic nodule remodeling QTL 63.3liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)1365613454109350286Rat
7387280Uae43Urinary albumin excretion QTL 435.690.4174urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1368983334109350286Rat
1298066Bp159Blood pressure QTL 1590.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134863963493639634Rat
738026Lnnr5Liver neoplastic nodule remodeling QTL 53.29liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)136242459288113509Rat
10755495Bp387Blood pressure QTL 3873.78arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)133721624190057603Rat
2293702Bss34Bone structure and strength QTL 344.610.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1367635937109350286Rat
1576318Schws5Schwannoma susceptibility QTL 50.0351nervous system integrity trait (VT:0010566)post-insult time to trigeminal nerve neurilemmoma formation (CMO:0002019)1364497900109350286Rat
1354621Rf47Renal function QTL 473.7kidney renin amount (VT:0010559)kidney renin level (CMO:0002166)1311081740103588154Rat
1581554Pur11Proteinuria QTL 11urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1354655Bp241Blood pressure QTL 2413.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1338975045103588154Rat
8655951Rf63Renal function QTL 6312.2blood urea nitrogen amount (VT:0005265)plasma urea nitrogen level (CMO:0000586)1371610804109350286Rat
4889606Gluco63Glucose level QTL 632.860.003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1383286150109350286Rat
8655945Rf61Renal function QTL 613.6blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)137161080489333251Rat
1331783Bp221Blood pressure QTL 2213.72886arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)137161080489333251Rat
8655959Pur32Proteinuria QTL 328.4urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)137298450699745408Rat
2293687Bss26Bone structure and strength QTL 264.60.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1367635937109350286Rat
1300166Kidm6Kidney mass QTL 63.93kidney mass (VT:0002707)single kidney wet weight to body weight ratio (CMO:0000622)137161080489333251Rat
12879475Bp400Blood pressure QTL 400arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1364375743109350286Rat
1581573Uae36Urinary albumin excretion QTL 36urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)13600200888706694Rat
1354666Bp244Blood pressure QTL 2444.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)131103588154Rat
724564Uae11Urinary albumin excretion QTL 115.7urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)134735425894285672Rat
2293341Glom15Glomerulus QTL 159.1kidney glomerulus integrity trait (VT:0010546)kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)1367635937109350286Rat

Markers in Region
AI644422  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21384,837,936 - 84,838,076 (+)MAPPERmRatBN7.2
Rnor_6.01390,758,868 - 90,759,007NCBIRnor6.0
Rnor_5.01395,280,795 - 95,280,934UniSTSRnor5.0
RGSC_v3.41388,376,820 - 88,376,959UniSTSRGSC3.4
Celera1384,447,992 - 84,448,131UniSTS
Cytogenetic Map13q24UniSTS
RH141295  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21384,840,451 - 84,840,642 (+)MAPPERmRatBN7.2
Rnor_6.01390,761,383 - 90,761,573NCBIRnor6.0
Rnor_5.01395,283,310 - 95,283,500UniSTSRnor5.0
RGSC_v3.41388,379,335 - 88,379,525UniSTSRGSC3.4
Celera1384,450,507 - 84,450,697UniSTS
RH 3.4 Map13556.9UniSTS
Cytogenetic Map13q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 12 61 132 57 60 41 86 41 298 168 11 123 71 73 19 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000010551   ⟹   ENSRNOP00000010551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1387,370,315 - 87,375,718 (+)Ensembl
mRatBN7.2 Ensembl1384,838,175 - 84,843,381 (+)Ensembl
Rnor_6.0 Ensembl1390,759,260 - 90,762,957 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000150620   ⟹   ENSRNOP00000109897
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1387,370,606 - 87,375,532 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000163100   ⟹   ENSRNOP00000099598
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1387,368,359 - 87,376,206 (+)Ensembl
RefSeq Acc Id: NM_024144   ⟹   NP_077058
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81387,370,693 - 87,374,390 (+)NCBI
mRatBN7.21384,838,329 - 84,842,026 (+)NCBI
Rnor_6.01390,759,260 - 90,762,957 (+)NCBI
Rnor_5.01395,281,187 - 95,284,884 (+)NCBI
RGSC_v3.41388,377,212 - 88,380,909 (+)RGD
Celera1384,448,384 - 84,452,081 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_077058 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAB18566 (Get FASTA)   NCBI Sequence Viewer  
  EDL94711 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000010551
  ENSRNOP00000010551.3
GenBank Protein Q9EQY6 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_077058   ⟸   NM_024144
- UniProtKB: Q9EQY6 (UniProtKB/Swiss-Prot),   A6JG55 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000010551   ⟸   ENSRNOT00000010551
Ensembl Acc Id: ENSRNOP00000099598   ⟸   ENSRNOT00000163100
Ensembl Acc Id: ENSRNOP00000109897   ⟸   ENSRNOT00000150620

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EQY6-F1-model_v2 AlphaFold Q9EQY6 1-423 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699025
Promoter ID:EPDNEW_R9550
Type:initiation region
Name:Pigm_1
Description:phosphatidylinositol glycan anchor biosynthesis, class M
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01390,759,198 - 90,759,258EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71041 AgrOrtholog
BioCyc Gene G2FUF-17322 BioCyc
Ensembl Genes ENSRNOG00000007735 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000010551 ENTREZGENE
  ENSRNOT00000010551.4 UniProtKB/Swiss-Prot
InterPro PIG-M UniProtKB/Swiss-Prot
KEGG Report rno:79112 UniProtKB/Swiss-Prot
NCBI Gene 79112 ENTREZGENE
PANTHER GPI MANNOSYLTRANSFERASE 1 UniProtKB/Swiss-Prot
  PTHR12886 UniProtKB/Swiss-Prot
Pfam Mannosyl_trans UniProtKB/Swiss-Prot
PhenoGen Pigm PhenoGen
RatGTEx ENSRNOG00000007735 RatGTEx
UniProt A6JG55 ENTREZGENE, UniProtKB/TrEMBL
  PIGM_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Pigm  phosphatidylinositol glycan anchor biosynthesis, class M  LOC103694910  GPI mannosyltransferase 1  Data merged from RGD:9267318 737654 PROVISIONAL
2014-08-25 LOC103694910  GPI mannosyltransferase 1      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-02-18 Pigm  phosphatidylinositol glycan anchor biosynthesis, class M  Pigm  phosphatidylinositol glycan, class M  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Pigm  phosphatidylinositol glycan, class M      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference