Mepe (matrix extracellular phosphoglycoprotein) - Rat Genome Database

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Gene: Mepe (matrix extracellular phosphoglycoprotein) Rattus norvegicus
Analyze
Symbol: Mepe
Name: matrix extracellular phosphoglycoprotein
RGD ID: 71036
Description: Predicted to enable extracellular matrix protein binding activity. Involved in regulation of bone remodeling. Predicted to be located in extracellular region. Predicted to be active in extracellular matrix. Orthologous to human MEPE (matrix extracellular phosphoglycoprotein); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acrylamide.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: matrix extracellular phosphoglycoprotein with ASARM motif; matrix extracellular phosphoglycoprotein with ASARM motif (bone); OF45; osteoblast/osteocyte factor 45; osteoregulin
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8145,725,308 - 5,736,858 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl145,725,175 - 5,736,996 (-)EnsemblGRCr8
mRatBN7.2145,420,634 - 5,432,186 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl145,420,635 - 5,432,183 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx145,383,076 - 5,394,785 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0146,683,285 - 6,694,994 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0145,372,824 - 5,384,370 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0146,782,011 - 6,793,561 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl146,782,012 - 6,793,558 (-)Ensemblrn6Rnor6.0
Rnor_5.0146,770,080 - 6,781,630 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4146,529,356 - 6,540,902 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera145,559,406 - 5,571,012 (-)NCBICelera
RGSC_v3.1146,529,355 - 6,540,902 (-)NCBI
Cytogenetic Map14p22NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Gene Data Set MGD Curation, June 12, 2002
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Identification of osteoblast/osteocyte factor 45 (OF45), a bone-specific cDNA encoding an RGD-containing protein that is highly expressed in osteoblasts and osteocytes. Petersen DN, etal., J Biol Chem 2000 Nov 17;275(46):36172-80.
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12421822   PMID:15843468   PMID:19005008   PMID:19617624   PMID:22766095   PMID:24255709   PMID:27039006  


Genomics

Comparative Map Data
Mepe
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8145,725,308 - 5,736,858 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl145,725,175 - 5,736,996 (-)EnsemblGRCr8
mRatBN7.2145,420,634 - 5,432,186 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl145,420,635 - 5,432,183 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx145,383,076 - 5,394,785 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0146,683,285 - 6,694,994 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0145,372,824 - 5,384,370 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0146,782,011 - 6,793,561 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl146,782,012 - 6,793,558 (-)Ensemblrn6Rnor6.0
Rnor_5.0146,770,080 - 6,781,630 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4146,529,356 - 6,540,902 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera145,559,406 - 5,571,012 (-)NCBICelera
RGSC_v3.1146,529,355 - 6,540,902 (-)NCBI
Cytogenetic Map14p22NCBI
MEPE
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38487,821,398 - 87,846,792 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl487,821,398 - 87,846,814 (+)Ensemblhg38GRCh38
GRCh37488,742,550 - 88,767,944 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36488,973,164 - 88,986,968 (+)NCBIBuild 36Build 36hg18NCBI36
Build 34489,111,317 - 89,125,121NCBI
Celera486,030,825 - 86,056,232 (+)NCBICelera
Cytogenetic Map4q22.1NCBI
HuRef484,488,173 - 84,513,583 (+)NCBIHuRef
CHM1_1488,719,352 - 88,744,756 (+)NCBICHM1_1
T2T-CHM13v2.0491,147,835 - 91,173,227 (+)NCBIT2T-CHM13v2.0
Mepe
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm395104,473,195 - 104,486,477 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl5104,473,195 - 104,486,477 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm385104,325,329 - 104,338,611 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl5104,325,329 - 104,338,611 (+)Ensemblmm10GRCm38
MGSCv375104,754,348 - 104,767,630 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv365101,920,930 - 101,938,649 (+)NCBIMGSCv36mm8
MGSCv365104,565,678 - 104,578,858 (+)NCBIMGSCv36mm8
Cytogenetic Map5E5NCBI
cM Map550.68NCBI
Mepe
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554742,048,883 - 2,064,515 (-)NCBIChiLan1.0ChiLan1.0
MEPE
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2385,839,530 - 85,853,444 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1486,101,962 - 86,115,875 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0480,125,612 - 80,139,539 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1490,838,938 - 90,864,338 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl490,838,938 - 90,864,332 (+)EnsemblpanPan2panpan1.1
MEPE
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.13211,212,531 - 11,222,805 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl3211,212,531 - 11,222,805 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha3230,731,431 - 30,741,705 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.03211,266,584 - 11,276,866 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl3211,264,740 - 11,276,866 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.13211,349,245 - 11,359,519 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.03211,174,915 - 11,185,203 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.03228,767,808 - 28,778,081 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Mepe
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244052851,864,923 - 1,877,532 (-)NCBIHiC_Itri_2
SpeTri2.0NW_004936905284,849 - 297,297 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MEPE
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl8131,186,888 - 131,200,330 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.18131,186,563 - 131,198,418 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.28140,416,700 - 140,430,560 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MEPE
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1736,201,916 - 36,216,446 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603714,922,079 - 14,936,806 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mepe
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248724,345,045 - 4,358,456 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Mepe
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v11114,376,052 - 14,385,593 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Mepe
102 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:163
Count of miRNA genes:127
Interacting mature miRNAs:146
Transcripts:ENSRNOT00000002927
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300114Srn2Serum renin concentration QTL 23.27blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)14395787821572472Rat
70195Mcs8Mammary carcinoma susceptibility QTL 84.28mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)14395787824886169Rat
2293089Iddm31Insulin dependent diabetes mellitus QTL 314.7blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)14395787818558812Rat
7411573Bw139Body weight QTL 1394.70.001body mass (VT:0001259)body weight gain (CMO:0000420)14140068101Rat
9589814Gluco67Glucose level QTL 674.540.001blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14140068101Rat
724541Niddm53Non-insulin dependent diabetes mellitus QTL 530.001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1439578789393298Rat
1331740Bw26Body weight QTL 263.028body mass (VT:0001259)body weight (CMO:0000012)14395787831121464Rat
634352Apr6Acute phase response QTL 63.7blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)14141415516Rat
71115Niddm15Non-insulin dependent diabetes mellitus QTL 154.8blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14111334906Rat
71117Niddm17Non-insulin dependent diabetes mellitus QTL 172.35blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)14117877928Rat
70204Niddm20Non-insulin dependent diabetes mellitus QTL 205.10.000008blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)14131893212Rat

Markers in Region
BE097139  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2145,430,481 - 5,430,676 (+)MAPPERmRatBN7.2
Rnor_6.0146,791,857 - 6,792,051NCBIRnor6.0
Rnor_5.0146,779,926 - 6,780,120UniSTSRnor5.0
RGSC_v3.4146,539,198 - 6,539,392UniSTSRGSC3.4
Celera145,569,308 - 5,569,502UniSTS
RH 3.4 Map14114.9UniSTS
Cytogenetic Map14p22UniSTS
BE107579  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2145,420,679 - 5,420,855 (+)MAPPERmRatBN7.2
Rnor_6.0146,782,057 - 6,782,232NCBIRnor6.0
Rnor_5.0146,770,126 - 6,770,301UniSTSRnor5.0
RGSC_v3.4146,529,398 - 6,529,573UniSTSRGSC3.4
Celera145,559,448 - 5,559,623UniSTS
RH 3.4 Map1488.2UniSTS
Cytogenetic Map14p22UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
2 6 20 97 22 16 1 31 1 4 83 75 11 81 3 47 15 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000002927   ⟹   ENSRNOP00000002927
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl145,725,309 - 5,736,996 (-)Ensembl
mRatBN7.2 Ensembl145,420,635 - 5,432,183 (-)Ensembl
Rnor_6.0 Ensembl146,782,012 - 6,793,558 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091558   ⟹   ENSRNOP00000074247
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl145,725,359 - 5,727,815 (-)Ensembl
mRatBN7.2 Ensembl145,420,635 - 5,424,769 (-)Ensembl
Rnor_6.0 Ensembl146,782,012 - 6,786,144 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000129722   ⟹   ENSRNOP00000102406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl145,725,679 - 5,734,839 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000142563   ⟹   ENSRNOP00000110781
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl145,725,175 - 5,736,825 (-)Ensembl
RefSeq Acc Id: NM_024142   ⟹   NP_077056
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,725,312 - 5,736,858 (-)NCBI
mRatBN7.2145,420,638 - 5,432,186 (-)NCBI
Rnor_6.0146,782,015 - 6,793,561 (-)NCBI
Rnor_5.0146,770,080 - 6,781,630 (-)NCBI
RGSC_v3.4146,529,356 - 6,540,902 (-)RGD
Celera145,559,406 - 5,571,012 (-)RGD
Sequence:
RefSeq Acc Id: XM_006250635   ⟹   XP_006250697
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8145,725,308 - 5,729,461 (-)NCBI
mRatBN7.2145,420,634 - 5,425,054 (-)NCBI
Rnor_6.0146,782,011 - 6,787,954 (-)NCBI
Rnor_5.0146,770,080 - 6,781,630 (-)NCBI
Sequence:
RefSeq Acc Id: NP_077056   ⟸   NM_024142
- Peptide Label: precursor
- UniProtKB: Q9ES02 (UniProtKB/Swiss-Prot),   Q8K3V0 (UniProtKB/Swiss-Prot),   D6C6P2 (UniProtKB/Swiss-Prot),   A0A0G2K7K7 (UniProtKB/Swiss-Prot),   A0A4X0UXX8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006250697   ⟸   XM_006250635
- Peptide Label: isoform X1
- UniProtKB: A0A4X0UXX8 (UniProtKB/TrEMBL),   A0A4X0WLY2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000002927   ⟸   ENSRNOT00000002927
Ensembl Acc Id: ENSRNOP00000074247   ⟸   ENSRNOT00000091558
Ensembl Acc Id: ENSRNOP00000110781   ⟸   ENSRNOT00000142563
Ensembl Acc Id: ENSRNOP00000102406   ⟸   ENSRNOT00000129722

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9ES02-F1-model_v2 AlphaFold Q9ES02 1-435 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13699172
Promoter ID:EPDNEW_R9697
Type:single initiation site
Name:Mepe_1
Description:matrix extracellular phosphoglycoprotein
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0146,793,557 - 6,793,617EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71036 AgrOrtholog
BioCyc Gene G2FUF-16507 BioCyc
Ensembl Genes ENSRNOG00000002154 Ensembl
InterPro Osteoregulin UniProtKB/Swiss-Prot
KEGG Report rno:79110 UniProtKB/Swiss-Prot
NCBI Gene Mepe ENTREZGENE
PANTHER MATRIX EXTRACELLULAR PHOSPHOGLYCOPROTEIN UniProtKB/Swiss-Prot
  PTHR16510 UniProtKB/Swiss-Prot
Pfam Osteoregulin UniProtKB/Swiss-Prot
PhenoGen Mepe PhenoGen
RatGTEx ENSRNOG00000002154 RatGTEx
UniProt A0A0G2K7K7 ENTREZGENE
  A0A4X0UXX8 ENTREZGENE, UniProtKB/TrEMBL
  A0A4X0WLY2 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0LMY9_RAT UniProtKB/TrEMBL
  A0ABK0LWQ7_RAT UniProtKB/TrEMBL
  D6C6P2 ENTREZGENE
  MEPE_RAT UniProtKB/Swiss-Prot
  Q8K3V0 ENTREZGENE
  Q9ES02 ENTREZGENE
UniProt Secondary A0A0G2K7K7 UniProtKB/Swiss-Prot
  D6C6P2 UniProtKB/Swiss-Prot
  Q8K3V0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-11-06 Mepe  matrix extracellular phosphoglycoprotein  Mepe  matrix extracellular phosphoglycoprotein with ASARM motif (bone)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Mepe  matrix extracellular phosphoglycoprotein with ASARM motif (bone)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains a serine/glycine-rich secreted peptide containing numerous potential phosphorylation sites and one RGD sequence motif 70633
gene_expression expressed only in bone 70633