Itga7 (integrin subunit alpha 7) - Rat Genome Database

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Gene: Itga7 (integrin subunit alpha 7) Rattus norvegicus
Analyze
Symbol: Itga7
Name: integrin subunit alpha 7
RGD ID: 71022
Description: Enables integrin binding activity and laminin binding activity. Involved in cell adhesion; integrin-mediated signaling pathway; and skeletal muscle tissue development. Located in cell surface. Part of integrin complex. Used to study cardiomyopathy. Biomarker of arteriosclerosis. Human ortholog(s) of this gene implicated in Duchenne muscular dystrophy; congenital muscular dystrophy due to integrin alpha-7 deficiency; and muscular disease. Orthologous to human ITGA7 (integrin subunit alpha 7); PARTICIPATES IN integrin mediated signaling pathway; arrhythmogenic right ventricular cardiomyopathy pathway; cell-extracellular matrix signaling pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha 7A integrin; H36-alpha7; integrin alpha 7; integrin alpha-7; integrin, alpha 7; MGC105724
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,944,447 - 1,973,347 (+)NCBIGRCr8
mRatBN7.271,360,125 - 1,388,886 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl71,359,940 - 1,388,450 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx74,124,517 - 4,151,033 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.076,000,177 - 6,026,675 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.076,301,622 - 6,327,909 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.073,355,079 - 3,383,886 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl73,355,116 - 3,384,675 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.073,325,268 - 3,354,361 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.472,230,747 - 2,269,403 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.172,230,888 - 2,269,401 (+)NCBI
Celera71,231,167 - 1,259,461 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (EXP)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Allylamine  (EXP)
alpha-Zearalanol  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
butanal  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chrysene  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (EXP)
dexamethasone  (ISO)
dibutyl phthalate  (EXP)
diquat  (ISO)
diuron  (EXP)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (ISO)
fenamidone  (ISO)
fipronil  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
FR900359  (ISO)
gentamycin  (EXP)
hydrogen peroxide  (ISO)
indometacin  (ISO)
lipopolysaccharide  (ISO)
maneb  (ISO)
monosodium L-glutamate  (ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
ochratoxin A  (EXP)
ozone  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentanal  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP)
PhIP  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propanal  (ISO)
rotenone  (EXP)
sevoflurane  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP)
tetraphene  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triptonide  (ISO)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transgenic expression of {alpha}7{beta}1 integrin maintains muscle integrity, increases regenerative capacity, promotes hypertrophy, and reduces cardiomyopathy in dystrophic mice. Burkin DJ, etal., Am J Pathol. 2005 Jan;166(1):253-63.
2. Modulation of alpha7-integrin-mediated adhesion and expression by platelet-derived growth factor in vascular smooth muscle cells. Chao JT, etal., Am J Physiol Cell Physiol. 2006 Apr;290(4):C972-80. Epub 2005 Nov 9.
3. Regulation of alpha7-integrin expression in vascular smooth muscle by injury-induced atherosclerosis. Chao JT, etal., Am J Physiol Heart Circ Physiol. 2004 Jul;287(1):H381-9. Epub 2004 Feb 26.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Mutations in the integrin alpha7 gene cause congenital myopathy. Hayashi YK, etal., Nat Genet. 1998 May;19(1):94-7.
7. AAV-mediated overexpression of human a7 integrin leads to histological and functional improvement in dystrophic mice. Heller KN, etal., Mol Ther. 2013 Mar;21(3):520-5. doi: 10.1038/mt.2012.281. Epub 2013 Jan 15.
8. Absence of integrin alpha 7 causes a novel form of muscular dystrophy. Mayer U, etal., Nat Genet. 1997 Nov;17(3):318-23. doi: 10.1038/ng1197-318.
9. Gene Data Set MGD Curation, June 12, 2002
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. H36-alpha 7 is a novel integrin alpha chain that is developmentally regulated during skeletal myogenesis. Song WK, etal., J Cell Biol 1992 May;117(3):643-57.
18. Expression of alpha 7 integrin cytoplasmic domains during skeletal muscle development: alternate forms, conformational change, and homologies with serine/threonine kinases and tyrosine phosphatases. Song WK, etal., J Cell Sci 1993 Dec;106 ( Pt 4):1139-52.
19. The integrins. Takada Y, etal., Genome Biol. 2007;8(5):215.
20. Cartilage oligomeric matrix protein maintains the contractile phenotype of vascular smooth muscle cells by interacting with alpha(7)beta(1) integrin. Wang L, etal., Circ Res. 2010 Feb 19;106(3):514-25. doi: 10.1161/CIRCRESAHA.109.202762. Epub 2009 Dec 17.
Additional References at PubMed
PMID:1839357   PMID:8626012   PMID:9004048   PMID:12037582   PMID:12477932   PMID:14715956   PMID:16003770   PMID:17598176   PMID:18611855   PMID:18940796   PMID:19796622   PMID:20563599  
PMID:22659335   PMID:23154389  


Genomics

Comparative Map Data
Itga7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,944,447 - 1,973,347 (+)NCBIGRCr8
mRatBN7.271,360,125 - 1,388,886 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl71,359,940 - 1,388,450 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx74,124,517 - 4,151,033 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.076,000,177 - 6,026,675 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.076,301,622 - 6,327,909 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.073,355,079 - 3,383,886 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl73,355,116 - 3,384,675 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.073,325,268 - 3,354,361 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.472,230,747 - 2,269,403 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.172,230,888 - 2,269,401 (+)NCBI
Celera71,231,167 - 1,259,461 (+)NCBICelera
Cytogenetic Map7q11NCBI
ITGA7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381255,684,568 - 55,716,400 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1255,684,568 - 55,716,404 (-)EnsemblGRCh38hg38GRCh38
GRCh371256,078,352 - 56,106,192 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,364,619 - 54,387,894 (-)NCBINCBI36Build 36hg18NCBI36
Build 341254,364,622 - 54,387,894NCBI
Celera1255,730,824 - 55,758,560 (-)NCBICelera
Cytogenetic Map12q13.2NCBI
HuRef1253,117,170 - 53,144,908 (-)NCBIHuRef
CHM1_11256,045,138 - 56,072,879 (-)NCBICHM1_1
T2T-CHM13v2.01255,651,197 - 55,683,036 (-)NCBIT2T-CHM13v2.0
Itga7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,769,633 - 128,794,155 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,769,645 - 128,794,155 (+)EnsemblGRCm39 Ensembl
GRCm3810128,933,421 - 128,958,286 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,933,818 - 128,958,282 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710128,370,869 - 128,395,342 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610128,336,767 - 128,361,231 (+)NCBIMGSCv36mm8
Celera10131,326,513 - 131,351,034 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1077.2NCBI
Itga7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,321,259 - 3,343,275 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,322,735 - 3,343,275 (-)NCBIChiLan1.0ChiLan1.0
ITGA7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21038,612,270 - 38,643,474 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11238,609,040 - 38,640,051 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01233,195,602 - 33,226,796 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11233,923,549 - 33,950,892 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1233,923,549 - 33,950,886 (+)Ensemblpanpan1.1panPan2
ITGA7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11091,782 - 110,839 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1091,391 - 110,817 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10154,177 - 173,232 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01099,047 - 118,100 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1099,047 - 118,145 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11076,762 - 95,812 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010319,641 - 338,710 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010443,742 - 462,792 (-)NCBIUU_Cfam_GSD_1.0
Itga7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,683,840 - 58,709,601 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646161,332 - 179,481 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936646160,661 - 179,454 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGA7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,126,571 - 21,148,776 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,126,565 - 21,150,875 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ITGA7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11151,634,324 - 51,656,251 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037194,338,896 - 194,360,304 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itga7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480212,312,679 - 12,336,587 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480212,303,969 - 12,332,737 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Itga7
384 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:423
Count of miRNA genes:225
Interacting mature miRNAs:262
Transcripts:ENSRNOT00000030453, ENSRNOT00000048267, ENSRNOT00000061657
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat

Markers in Region
D7Uia7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.271,363,523 - 1,363,728 (+)MAPPERmRatBN7.2
Rnor_6.073,358,656 - 3,358,860NCBIRnor6.0
Rnor_5.073,328,840 - 3,329,044UniSTSRnor5.0
RGSC_v3.472,234,144 - 2,234,348UniSTSRGSC3.4
Celera71,234,564 - 1,234,768UniSTS
Cytogenetic Map7q11UniSTS
RH128213  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.271,388,522 - 1,388,731 (+)MAPPERmRatBN7.2
Rnor_6.073,383,523 - 3,383,731NCBIRnor6.0
Rnor_5.073,353,995 - 3,354,203UniSTSRnor5.0
RGSC_v3.472,269,040 - 2,269,248UniSTSRGSC3.4
Celera71,259,098 - 1,259,306UniSTS
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 83 82 51 25 51 6 210 97 93 45 60 31

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001429169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_030842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC097931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X65036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X74293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X74294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000030453   ⟹   ENSRNOP00000028983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl73,355,116 - 3,384,675 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000061657   ⟹   ENSRNOP00000058370
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl71,359,940 - 1,388,450 (+)Ensembl
Rnor_6.0 Ensembl73,355,259 - 3,383,879 (+)Ensembl
RefSeq Acc Id: NM_030842   ⟹   NP_110469
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,944,615 - 1,973,344 (+)NCBI
mRatBN7.271,360,125 - 1,388,886 (+)NCBI
Rnor_6.073,355,259 - 3,383,886 (+)NCBI
Rnor_5.073,325,268 - 3,354,361 (+)NCBI
RGSC_v3.472,230,747 - 2,269,403 (+)RGD
Celera71,231,167 - 1,259,461 (+)RGD
Sequence:
RefSeq Acc Id: XM_063264290   ⟹   XP_063120360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,944,447 - 1,973,347 (+)NCBI
RefSeq Acc Id: XM_063264291   ⟹   XP_063120361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,944,448 - 1,973,347 (+)NCBI
RefSeq Acc Id: XM_063264292   ⟹   XP_063120362
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,944,448 - 1,973,347 (+)NCBI
RefSeq Acc Id: XM_063264293   ⟹   XP_063120363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,952,011 - 1,973,347 (+)NCBI
RefSeq Acc Id: XM_063264294   ⟹   XP_063120364
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,944,450 - 1,973,347 (+)NCBI
RefSeq Acc Id: NP_110469   ⟸   NM_030842
- Peptide Label: precursor
- UniProtKB: Q63026 (UniProtKB/Swiss-Prot),   Q5HZX9 (UniProtKB/Swiss-Prot),   Q63027 (UniProtKB/Swiss-Prot),   Q63258 (UniProtKB/Swiss-Prot),   A0A8L2QS22 (UniProtKB/TrEMBL),   A6KSL0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000058370   ⟸   ENSRNOT00000061657
Ensembl Acc Id: ENSRNOP00000028983   ⟸   ENSRNOT00000030453
RefSeq Acc Id: XP_063120360   ⟸   XM_063264290
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063120361   ⟸   XM_063264291
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063120362   ⟸   XM_063264292
- Peptide Label: isoform X3
RefSeq Acc Id: XP_063120364   ⟸   XM_063264294
- Peptide Label: isoform X5
RefSeq Acc Id: XP_063120363   ⟸   XM_063264293
- Peptide Label: isoform X4
Protein Domains
Integrin alpha first immunoglubulin-like   Integrin alpha second immunoglobulin-like   Integrin alpha third immunoglobulin-like

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q63258-F1-model_v2 AlphaFold Q63258 1-1135 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13694963
Promoter ID:EPDNEW_R5484
Type:initiation region
Name:Itga7_1
Description:integrin subunit alpha 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5485  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.073,355,121 - 3,355,181EPDNEW
RGD ID:13694960
Promoter ID:EPDNEW_R5485
Type:single initiation site
Name:Itga7_2
Description:integrin subunit alpha 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5484  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.073,355,238 - 3,355,298EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:71022 AgrOrtholog
BioCyc Gene G2FUF-35318 BioCyc
Ensembl Genes ENSRNOG00000007905 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000061657.6 UniProtKB/TrEMBL
Gene3D-CATH 2.130.10.130 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Bicelle-embedded integrin alpha(iib) transmembrane segment UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin domains. Chain A, domain 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ntegrin, alpha v. Chain A, domain 4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7313230 IMAGE-MGC_LOAD
InterPro FG-GAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Int_alpha_beta-p UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha-2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha_C_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha_Ig-like_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:81008 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:105724 IMAGE-MGC_LOAD
NCBI Gene 81008 ENTREZGENE
PANTHER INTEGRIN ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTEGRIN ALPHA-7 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam FG-GAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_A_Ig_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_A_Ig_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Integrin_alpha2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Itga7 PhenoGen
PRINTS INTEGRINA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FG_GAP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  INTEGRIN_ALPHA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000007905 RatGTEx
SMART Int_alpha UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF69179 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF69318 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A8L2QS22 ENTREZGENE, UniProtKB/TrEMBL
  A6KSK9 ENTREZGENE, UniProtKB/TrEMBL
  A6KSL0 ENTREZGENE, UniProtKB/TrEMBL
  ITA7_RAT UniProtKB/Swiss-Prot
  Q5HZX9 ENTREZGENE
  Q63026 ENTREZGENE
  Q63027 ENTREZGENE
  Q63258 ENTREZGENE
UniProt Secondary Q5HZX9 UniProtKB/Swiss-Prot
  Q63026 UniProtKB/Swiss-Prot
  Q63027 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Itga7  integrin subunit alpha 7  Itga7  integrin, alpha 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-02-09 Itga7  integrin, alpha 7  Itga7  integrin alpha 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Itga7  integrin alpha 7      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction associated with integrin beta 1 70774
gene_process involved in the development of skeletal muscle 70773