Itga7 (integrin subunit alpha 7) - Rat Genome Database

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Gene: Itga7 (integrin subunit alpha 7) Rattus norvegicus
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Symbol: Itga7
Name: integrin subunit alpha 7
RGD ID: 71022
Description: Enables integrin binding activity and laminin binding activity. Involved in cell adhesion; integrin-mediated signaling pathway; and skeletal muscle tissue development. Located in cell surface. Part of integrin complex. Used to study cardiomyopathy. Biomarker of arteriosclerosis. Human ortholog(s) of this gene implicated in Duchenne muscular dystrophy; congenital muscular dystrophy due to integrin alpha-7 deficiency; and muscular disease. Orthologous to human ITGA7 (integrin subunit alpha 7); PARTICIPATES IN integrin mediated signaling pathway; arrhythmogenic right ventricular cardiomyopathy pathway; cell-extracellular matrix signaling pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: alpha 7A integrin; H36-alpha7; integrin alpha 7; integrin alpha-7; integrin, alpha 7; MGC105724
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,944,447 - 1,973,347 (+)NCBIGRCr8
mRatBN7.271,360,125 - 1,388,886 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl71,359,940 - 1,388,450 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx74,124,517 - 4,151,033 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.076,000,177 - 6,026,675 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.076,301,622 - 6,327,909 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.073,355,079 - 3,383,886 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl73,355,116 - 3,384,675 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.073,325,268 - 3,354,361 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.472,230,747 - 2,269,403 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.172,230,888 - 2,269,401 (+)NCBI
Celera71,231,167 - 1,259,461 (+)NCBICelera
Cytogenetic Map7q11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Itga7Ratarteriosclerosis  IEP 1600025AtherogenesisRGD 
Itga7Ratcardiomyopathy treatmentIMP 13601980 RGD 
Itga7Ratcongenital muscular dystrophy due to integrin alpha-7 deficiency  ISOItga7 (Mus musculus)13601979 RGD 
Itga7RatCOVID-19  ISOITGA7 (Homo sapiens)9068941mRNA:increased expression:peripheral blood mononuclear cell (human)RGDPMID:32228226 and REF_RGD_ID:28912744
Itga7RatDuchenne muscular dystrophy treatmentISOITGA7 (Homo sapiens)13601981 RGD 
Itga7Ratmuscular disease  ISOITGA7 (Homo sapiens)1600024 RGD 
Object Symbol
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Reference
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Original Reference(s)
Itga7Ratcongenital muscular dystrophy due to integrin alpha-7 deficiency  ISOITGA7 (Homo sapiens)8554872ClinVar more ...ClinVarPMID:12057917 more ...
Object Symbol
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Original Reference(s)
Itga7RatColonic Neoplasms  ISOITGA7 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15059925
Itga7Ratcongenital muscular dystrophy due to integrin alpha-7 deficiency  ISOITGA7 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTD 
Object Symbol
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Reference
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Original Reference(s)
Itga7Ratcongenital muscular dystrophy due to integrin alpha-7 deficiency  ISSItga7 (Mus musculus)13592920OMIM:613204MouseDO 
Object Symbol
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Original Reference(s)
Itga7Ratcongenital muscular dystrophy due to integrin alpha-7 deficiency  ISOITGA7 (Homo sapiens)7240710 OMIM 

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Object Symbol
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Original Reference(s)
Itga7Rat(1->4)-beta-D-glucan multiple interactionsISOItga7 (Mus musculus)6480464[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of ITGA7 mRNACTDPMID:36331819
Itga7Rat1,2-dimethylhydrazine increases expressionISOItga7 (Mus musculus)64804641 and 2-Dimethylhydrazine results in increased expression of ITGA7 mRNACTDPMID:22206623
Itga7Rat17beta-estradiol increases expressionISOItga7 (Mus musculus)6480464Estradiol results in increased expression of ITGA7 mRNACTDPMID:39298647
Itga7Rat2,2',4,4',5,5'-hexachlorobiphenyl multiple interactionsEXP 6480464[3 more ...CTDPMID:16984957
Itga7Rat2,2',5,5'-tetrachlorobiphenyl decreases expressionISOITGA7 (Homo sapiens)64804642 more ...CTDPMID:36804509
Itga7Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsEXP 6480464AHR protein alternative form affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of ITGA7 mRNA]CTDPMID:21215274
Itga7Rat2,3,7,8-tetrachlorodibenzodioxine increases expressionEXP 6480464Tetrachlorodibenzodioxin results in increased expression of ITGA7 mRNACTDPMID:34747641
Itga7Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOItga7 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of ITGA7 mRNACTDPMID:21570461 and PMID:24680724
Itga7Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of ITGA7 mRNACTDPMID:21215274
Itga7Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionEXP 6480464Tetrachlorodibenzodioxin affects the expression of ITGA7 mRNACTDPMID:22298810
Itga7Rat2,3,7,8-Tetrachlorodibenzofuran decreases expressionEXP 64804642 more ...CTDPMID:32109520
Itga7Rat2,4-dibromophenyl 2,4,5-tribromophenyl ether affects expressionISOItga7 (Mus musculus)64804642 more ...CTDPMID:38648751
Itga7Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of ITGA7 mRNACTDPMID:21346803
Itga7Rat3,3',4,4',5-pentachlorobiphenyl multiple interactionsEXP 6480464[3 more ...CTDPMID:16984957
Itga7Rat3,4-methylenedioxymethamphetamine decreases expressionISOItga7 (Mus musculus)6480464N-Methyl-3 and 4-methylenedioxyamphetamine results in decreased expression of ITGA7 mRNACTDPMID:26251327
Itga7Rat3-isobutyl-1-methyl-7H-xanthine multiple interactionsISOITGA7 (Homo sapiens)6480464[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ITGA7 mRNACTDPMID:28628672
Itga7Rat3-methylcholanthrene multiple interactionsISOItga7 (Mus musculus)6480464[Methylcholanthrene co-treated with Tetradecanoylphorbol Acetate] results in increased expression of ITGA7 mRNACTDPMID:23519560
Itga7Rat4,4'-sulfonyldiphenol increases expressionISOITGA7 (Homo sapiens)6480464bisphenol S results in increased expression of ITGA7 mRNACTDPMID:27685785
Itga7Rat4,4'-sulfonyldiphenol increases expressionISOItga7 (Mus musculus)6480464bisphenol S results in increased expression of ITGA7 mRNACTDPMID:39298647
Itga7Rat4-hydroxynon-2-enal decreases expressionISOITGA7 (Homo sapiens)64804644-hydroxy-2-nonenal results in decreased expression of ITGA7 mRNACTDPMID:12419474

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Biological Process
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Object Symbol
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Original Reference(s)
Itga7Ratblood vessel morphogenesis acts_upstream_of_or_withinISOItga7 (Mus musculus)1624291MGI:3512077 PMID:16003770RGDPMID:16003770
Itga7Ratcell adhesion  IDA 70774 RGD 
Itga7Ratcell adhesion involved_inIEAUniProtKB-KW:KW-01301600115GO_REF:0000043UniProtGO_REF:0000043
Itga7Ratcell adhesion involved_inIEAInterPro:IPR0004131600115GO_REF:0000002InterProGO_REF:0000002
Itga7Ratcell adhesion acts_upstream_of_or_withinISOItga7 (Mus musculus)1624291 PMID:9004048RGDPMID:9004048
Itga7Ratcell adhesion  IMP 1600026 RGD 
Itga7Ratcell adhesion mediated by integrin involved_inIBAFB:FBgn0001250 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Itga7Ratcell migration acts_upstream_of_or_withinISOItga7 (Mus musculus)1624291 PMID:9004048RGDPMID:9004048
Itga7Ratcell-cell adhesion involved_inIBAMGI:96602 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Itga7Ratendodermal cell differentiation involved_inISOITGA7 (Homo sapiens)1624291 PMID:23154389RGDPMID:23154389
Itga7Ratheterotypic cell-cell adhesion involved_inISOITGA7 (Homo sapiens)1624291 PMID:20563599RGDPMID:20563599
Itga7Ratintegrin-mediated signaling pathway  IDA 70774 RGD 
Itga7Ratintegrin-mediated signaling pathway involved_inIBAPANTHER:PTN001144284 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Itga7Ratintegrin-mediated signaling pathway involved_inIEAUniProtKB-KW:KW-04011600115GO_REF:0000043UniProtGO_REF:0000043
Itga7Ratleukocyte migration involved_inIBAMGI:96605 and PANTHER:PTN0015068891600115GO_REF:0000033GO_CentralGO_REF:0000033
Itga7Ratregulation of cell shape involved_inIEAUniProtKB-KW:KW-01331600115GO_REF:0000043UniProtGO_REF:0000043
Itga7Ratskeletal muscle tissue development  IEP 70774 RGD 
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Cellular Component
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Object Symbol
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Source
Original Reference(s)
Itga7Ratcell surface  IDA 70774 RGD 
Itga7Ratcytoplasm located_inISOItga7 (Mus musculus)1624291 PMID:19796622RGDPMID:19796622
Itga7Ratexternal side of plasma membrane is_active_inIBAMGI:1298377 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Itga7Ratintegrin alpha7-beta1 complex part_ofISOItga7 (Mus musculus)1624291PR:P09055 PMID:1839357 and PMID:18611855RGDPMID:1839357 and PMID:18611855
Itga7Ratintegrin complex  IDA 70774 RGD 
Itga7Ratintegrin complex part_ofIEAInterPro:IPR0004131600115GO_REF:0000002InterProGO_REF:0000002
Itga7Ratintegrin complex part_ofIBAFB:FBgn0001250 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Itga7Ratmembrane located_inIEAUniProtKB-SubCell:SL-01621600115GO_REF:0000044UniProtGO_REF:0000044
Itga7Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Itga7Ratmuscle tendon junction located_inISOItga7 (Mus musculus)1624291 PMID:18611855RGDPMID:18611855
Itga7Ratneuromuscular junction located_inISOItga7 (Mus musculus)1624291 PMID:18611855RGDPMID:18611855
Itga7Ratplasma membrane located_inIEAARBA:ARBA000278011600115GO_REF:0000117UniProtGO_REF:0000117
Itga7Ratsarcolemma located_inISOItga7 (Mus musculus)1624291 PMID:18611855RGDPMID:18611855
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Molecular Function
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RGD Manual Annotations


  
Object Symbol
Species
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Qualifier
Evidence
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Source
Original Reference(s)
Itga7Ratintegrin mediated signaling pathway   IDA 70774 RGD 
Itga7Ratintegrin mediated signaling pathway   ISOITGA7 (Homo sapiens)5135538 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
Species
Term
Qualifier
Evidence
With
Reference
Notes
Source
Original Reference(s)
Itga7Ratarrhythmogenic right ventricular cardiomyopathy pathway  IEA 6907045 KEGGrno:05412
Itga7Ratcell-extracellular matrix signaling pathway  IEA 6907045 KEGGrno:04512
Itga7Ratdilated cardiomyopathy pathway  IEA 6907045 KEGGrno:05414
Itga7Rathypertrophic cardiomyopathy pathway  IEA 6907045 KEGGrno:05410

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#
Reference Title
Reference Citation
1. Transgenic expression of {alpha}7{beta}1 integrin maintains muscle integrity, increases regenerative capacity, promotes hypertrophy, and reduces cardiomyopathy in dystrophic mice. Burkin DJ, etal., Am J Pathol. 2005 Jan;166(1):253-63.
2. Modulation of alpha7-integrin-mediated adhesion and expression by platelet-derived growth factor in vascular smooth muscle cells. Chao JT, etal., Am J Physiol Cell Physiol. 2006 Apr;290(4):C972-80. Epub 2005 Nov 9.
3. Regulation of alpha7-integrin expression in vascular smooth muscle by injury-induced atherosclerosis. Chao JT, etal., Am J Physiol Heart Circ Physiol. 2004 Jul;287(1):H381-9. Epub 2004 Feb 26.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. Mutations in the integrin alpha7 gene cause congenital myopathy. Hayashi YK, etal., Nat Genet. 1998 May;19(1):94-7.
7. AAV-mediated overexpression of human a7 integrin leads to histological and functional improvement in dystrophic mice. Heller KN, etal., Mol Ther. 2013 Mar;21(3):520-5. doi: 10.1038/mt.2012.281. Epub 2013 Jan 15.
8. Absence of integrin alpha 7 causes a novel form of muscular dystrophy. Mayer U, etal., Nat Genet. 1997 Nov;17(3):318-23. doi: 10.1038/ng1197-318.
9. Gene Data Set MGD Curation, June 12, 2002
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
13. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. H36-alpha 7 is a novel integrin alpha chain that is developmentally regulated during skeletal myogenesis. Song WK, etal., J Cell Biol 1992 May;117(3):643-57.
18. Expression of alpha 7 integrin cytoplasmic domains during skeletal muscle development: alternate forms, conformational change, and homologies with serine/threonine kinases and tyrosine phosphatases. Song WK, etal., J Cell Sci 1993 Dec;106 ( Pt 4):1139-52.
19. The integrins. Takada Y, etal., Genome Biol. 2007;8(5):215.
20. Cartilage oligomeric matrix protein maintains the contractile phenotype of vascular smooth muscle cells by interacting with alpha(7)beta(1) integrin. Wang L, etal., Circ Res. 2010 Feb 19;106(3):514-25. doi: 10.1161/CIRCRESAHA.109.202762. Epub 2009 Dec 17.
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PMID:1839357   PMID:8626012   PMID:9004048   PMID:12037582   PMID:12477932   PMID:14715956   PMID:16003770   PMID:17598176   PMID:18611855   PMID:18940796   PMID:19796622   PMID:20563599  
PMID:22659335   PMID:23154389  



Itga7
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr871,944,447 - 1,973,347 (+)NCBIGRCr8
mRatBN7.271,360,125 - 1,388,886 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl71,359,940 - 1,388,450 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx74,124,517 - 4,151,033 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.076,000,177 - 6,026,675 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.076,301,622 - 6,327,909 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.073,355,079 - 3,383,886 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl73,355,116 - 3,384,675 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.073,325,268 - 3,354,361 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.472,230,747 - 2,269,403 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.172,230,888 - 2,269,401 (+)NCBI
Celera71,231,167 - 1,259,461 (+)NCBICelera
Cytogenetic Map7q11NCBI
ITGA7
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381255,684,568 - 55,716,400 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1255,684,568 - 55,716,404 (-)EnsemblGRCh38hg38GRCh38
GRCh371256,078,352 - 56,106,192 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361254,364,619 - 54,387,894 (-)NCBINCBI36Build 36hg18NCBI36
Build 341254,364,622 - 54,387,894NCBI
Celera1255,730,824 - 55,758,560 (-)NCBICelera
Cytogenetic Map12q13.2NCBI
HuRef1253,117,170 - 53,144,908 (-)NCBIHuRef
CHM1_11256,045,138 - 56,072,879 (-)NCBICHM1_1
T2T-CHM13v2.01255,651,197 - 55,683,036 (-)NCBIT2T-CHM13v2.0
Itga7
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3910128,769,633 - 128,794,155 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl10128,769,645 - 128,794,155 (+)EnsemblGRCm39 Ensembl
GRCm3810128,933,421 - 128,958,286 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl10128,933,818 - 128,958,282 (+)EnsemblGRCm38mm10GRCm38
MGSCv3710128,370,869 - 128,395,342 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3610128,336,767 - 128,361,231 (+)NCBIMGSCv36mm8
Celera10131,326,513 - 131,351,034 (+)NCBICelera
Cytogenetic Map10D3NCBI
cM Map1077.2NCBI
Itga7
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554583,321,259 - 3,343,275 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554583,322,735 - 3,343,275 (-)NCBIChiLan1.0ChiLan1.0
ITGA7
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21038,612,270 - 38,643,474 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11238,609,040 - 38,640,051 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01233,195,602 - 33,226,796 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11233,923,549 - 33,950,892 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1233,923,549 - 33,950,886 (+)Ensemblpanpan1.1panPan2
ITGA7
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11091,782 - 110,839 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1091,391 - 110,817 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha10154,177 - 173,232 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01099,047 - 118,100 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1099,047 - 118,145 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11076,762 - 95,812 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.010319,641 - 338,710 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.010443,742 - 462,792 (-)NCBIUU_Cfam_GSD_1.0
Itga7
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494558,683,840 - 58,709,601 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936646161,332 - 179,481 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936646160,661 - 179,454 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ITGA7
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl521,126,571 - 21,148,776 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1521,126,565 - 21,150,875 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
ITGA7
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11151,634,324 - 51,656,251 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_023666037194,338,896 - 194,360,304 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Itga7
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462480212,312,679 - 12,336,587 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462480212,303,969 - 12,332,737 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Itga7
384 total Variants

Predicted Target Of
Summary Value
Count of predictions:423
Count of miRNA genes:225
Interacting mature miRNAs:262
Transcripts:ENSRNOT00000030453, ENSRNOT00000048267, ENSRNOT00000061657
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7144782185Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)766427026029351Rat
2317047Wbc4White blood cell count QTL 40.01leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)7135342956Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7127829089Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7144822433Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)7924703115097879Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134000259Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7131962314Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7131962314Rat

1 to 9 of 9 rows
D7Uia7  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.271,363,523 - 1,363,728 (+)MAPPERmRatBN7.2
Rnor_6.073,358,656 - 3,358,860NCBIRnor6.0
Rnor_5.073,328,840 - 3,329,044UniSTSRnor5.0
RGSC_v3.472,234,144 - 2,234,348UniSTSRGSC3.4
Celera71,234,564 - 1,234,768UniSTS
Cytogenetic Map7q11UniSTS
RH128213  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.271,388,522 - 1,388,731 (+)MAPPERmRatBN7.2
Rnor_6.073,383,523 - 3,383,731NCBIRnor6.0
Rnor_5.073,353,995 - 3,354,203UniSTSRnor5.0
RGSC_v3.472,269,040 - 2,269,248UniSTSRGSC3.4
Celera71,259,098 - 1,259,306UniSTS
Cytogenetic Map7q11UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 83 82 51 25 51 6 210 97 93 45 60 31


1 to 20 of 20 rows
RefSeq Transcripts NM_001429169 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429170 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429171 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429172 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429174 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_030842 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006240800 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008765044 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264290 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264291 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264292 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063264294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC097931 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC088846 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474104 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000007 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X65036 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X74293 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X74294 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
1 to 20 of 20 rows

Ensembl Acc Id: ENSRNOT00000030453   ⟹   ENSRNOP00000028983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl73,355,116 - 3,384,675 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000061657   ⟹   ENSRNOP00000058370
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl71,359,940 - 1,388,450 (+)Ensembl
Rnor_6.0 Ensembl73,355,259 - 3,383,879 (+)Ensembl
RefSeq Acc Id: NM_030842   ⟹   NP_110469
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,944,615 - 1,973,344 (+)NCBI
mRatBN7.271,360,125 - 1,388,886 (+)NCBI
Rnor_6.073,355,259 - 3,383,886 (+)NCBI
Rnor_5.073,325,268 - 3,354,361 (+)NCBI
RGSC_v3.472,230,747 - 2,269,403 (+)RGD
Celera71,231,167 - 1,259,461 (+)RGD
Sequence:
RefSeq Acc Id: XM_063264290   ⟹   XP_063120360
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,944,447 - 1,973,347 (+)NCBI
RefSeq Acc Id: XM_063264291   ⟹   XP_063120361
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,944,448 - 1,973,347 (+)NCBI
RefSeq Acc Id: XM_063264292   ⟹   XP_063120362
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,944,448 - 1,973,347 (+)NCBI
RefSeq Acc Id: XM_063264293   ⟹   XP_063120363
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,952,011 - 1,973,347 (+)NCBI
RefSeq Acc Id: XM_063264294   ⟹   XP_063120364
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr871,944,450 - 1,973,347 (+)NCBI
RefSeq Acc Id: NP_110469   ⟸   NM_030842
- Peptide Label: precursor
- UniProtKB: Q63026 (UniProtKB/Swiss-Prot),   Q5HZX9 (UniProtKB/Swiss-Prot),   Q63027 (UniProtKB/Swiss-Prot),   Q63258 (UniProtKB/Swiss-Prot),   A0A8L2QS22 (UniProtKB/TrEMBL),   A6KSL0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000058370   ⟸   ENSRNOT00000061657
Ensembl Acc Id: ENSRNOP00000028983   ⟸   ENSRNOT00000030453
RefSeq Acc Id: XP_063120360   ⟸   XM_063264290
- Peptide Label: isoform X1
RefSeq Acc Id: XP_063120361   ⟸   XM_063264291
- Peptide Label: isoform X2
- UniProtKB: A0A8L2QS22 (UniProtKB/TrEMBL)
Name Modeler Protein Id AA Range Protein Structure
AF-Q63258-F1-model_v2 AlphaFold Q63258 1-1135 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13694963
Promoter ID:EPDNEW_R5484
Type:initiation region
Name:Itga7_1
Description:integrin subunit alpha 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5485  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.073,355,121 - 3,355,181EPDNEW
RGD ID:13694960
Promoter ID:EPDNEW_R5485
Type:single initiation site
Name:Itga7_2
Description:integrin subunit alpha 7
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R5484  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.073,355,238 - 3,355,298EPDNEW


1 to 40 of 48 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-35318 BioCyc
Ensembl Genes ENSRNOG00000007905 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000061657 ENTREZGENE
  ENSRNOT00000145353 ENTREZGENE
  ENSRNOT00000146693 ENTREZGENE
Gene3D-CATH 2.130.10.130 UniProtKB/Swiss-Prot
  Bicelle-embedded integrin alpha(iib) transmembrane segment UniProtKB/Swiss-Prot
  Integrin domains. Chain A, domain 2 UniProtKB/Swiss-Prot
  ntegrin, alpha v. Chain A, domain 3 UniProtKB/Swiss-Prot
  ntegrin, alpha v. Chain A, domain 4 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7313230 IMAGE-MGC_LOAD
InterPro FG-GAP UniProtKB/Swiss-Prot
  Int_alpha_beta-p UniProtKB/Swiss-Prot
  Integrin_alpha UniProtKB/Swiss-Prot
  Integrin_alpha-2 UniProtKB/Swiss-Prot
  Integrin_alpha_C_CS UniProtKB/Swiss-Prot
  Integrin_alpha_Ig-like_2 UniProtKB/Swiss-Prot
  Integrin_alpha_Ig-like_3 UniProtKB/Swiss-Prot
  Integrin_alpha_N UniProtKB/Swiss-Prot
  Integrin_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:81008 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105724 IMAGE-MGC_LOAD
NCBI Gene 81008 ENTREZGENE
PANTHER INTEGRIN ALPHA UniProtKB/Swiss-Prot
  INTEGRIN ALPHA-7 UniProtKB/Swiss-Prot
Pfam FG-GAP UniProtKB/Swiss-Prot
  Integrin_A_Ig_2 UniProtKB/Swiss-Prot
  Integrin_A_Ig_3 UniProtKB/Swiss-Prot
  Integrin_alpha2 UniProtKB/Swiss-Prot
PhenoGen Itga7 PhenoGen
PRINTS INTEGRINA UniProtKB/Swiss-Prot
PROSITE FG_GAP UniProtKB/Swiss-Prot
  INTEGRIN_ALPHA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007905 RatGTEx
SMART Int_alpha UniProtKB/Swiss-Prot
Superfamily-SCOP SSF69179 UniProtKB/Swiss-Prot
  SSF69318 UniProtKB/Swiss-Prot
UniProt A0A8L2QS22 ENTREZGENE, UniProtKB/TrEMBL
  A6KSK9 ENTREZGENE, UniProtKB/TrEMBL
  A6KSL0 ENTREZGENE, UniProtKB/TrEMBL
1 to 40 of 48 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-12-23 Itga7  integrin subunit alpha 7  Itga7  integrin, alpha 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-02-09 Itga7  integrin, alpha 7  Itga7  integrin alpha 7  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Itga7  integrin alpha 7      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

Note Type Note Reference
gene_physical_interaction associated with integrin beta 1 70774
gene_process involved in the development of skeletal muscle 70773