Akap12 (A-kinase anchoring protein 12) - Rat Genome Database

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Gene: Akap12 (A-kinase anchoring protein 12) Rattus norvegicus
Analyze
Symbol: Akap12
Name: A-kinase anchoring protein 12
RGD ID: 70988
Description: Predicted to enable adenylate cyclase binding activity. Involved in several processes, including cellular response to cytokine stimulus; hepatic stellate cell activation; and positive regulation of ERK1 and ERK2 cascade. Located in neuronal cell body. Biomarker of brain ischemia; liver cirrhosis; osteosarcoma; and sciatic neuropathy. Human ortholog(s) of this gene implicated in chronic kidney disease; colorectal carcinoma; and juvenile myelomonocytic leukemia. Orthologous to human AKAP12 (A-kinase anchoring protein 12); PARTICIPATES IN protein kinase A (PKA) signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A kinase (PRKA) anchor protein (gravin) 12; A kinase (PRKA) anchor protein 12; A kinase anchoring protein 12 alpha; A kinase anchoring protein 12 beta; A kinase anchoring protein 12 gamma; A-kinase anchor protein 12; AKAP-12; AKAP12A; AKAP12B; AKAP12G; SSeCKS, Gravin, AKAP250
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8143,135,515 - 43,225,245 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl143,199,008 - 43,225,557 (+)EnsemblGRCr8
mRatBN7.2140,730,123 - 40,819,863 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl140,730,123 - 40,819,886 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx141,257,330 - 41,347,044 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0147,244,521 - 47,334,234 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0141,332,883 - 41,422,632 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0140,816,130 - 40,906,582 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl140,816,107 - 40,906,581 (+)Ensemblrn6Rnor6.0
Rnor_5.0142,162,163 - 42,252,615 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4134,979,039 - 35,068,763 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera136,421,269 - 36,510,639 (+)NCBICelera
RGSC_v3.1134,982,110 - 35,070,840 (+)NCBI
Cytogenetic Map1q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (ISO)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,3-dimethoxynaphthalene-1,4-dione  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,4-dinitrotoluene  (EXP)
2-butoxyethanol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,3',5-triiodo-L-thyronine  (ISO)
3,7-dihydropurine-6-thione  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
5-aza-2'-deoxycytidine  (ISO)
5-fluorouracil  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP,ISO)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
aristolochic acids  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
Azoxymethane  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
butan-1-ol  (ISO)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cadmium sulfate  (ISO)
caffeine  (ISO)
calcitriol  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
copper(II) chloride  (ISO)
copper(II) sulfate  (ISO)
coumarin  (ISO)
cumene  (ISO)
cyclosporin A  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP)
diethylstilbestrol  (EXP,ISO)
dioxygen  (EXP,ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
enzyme inhibitor  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
etoposide  (ISO)
Evodiamine  (ISO)
folic acid  (ISO)
FR900359  (ISO)
fulvestrant  (ISO)
genistein  (EXP,ISO)
glycidyl methacrylate  (ISO)
hydrogen cyanide  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
isobutanol  (ISO)
ivermectin  (ISO)
ketoconazole  (ISO)
lead diacetate  (ISO)
leflunomide  (ISO)
lipopolysaccharide  (ISO)
menadione  (ISO)
mercaptopurine  (EXP)
metacetamol  (ISO)
methylmercury chloride  (ISO)
methylparaben  (ISO)
methylseleninic acid  (ISO)
mitomycin C  (ISO)
N-nitrosodimethylamine  (ISO)
N-Nitrosopyrrolidine  (ISO)
nickel atom  (ISO)
O-methyleugenol  (ISO)
ochratoxin A  (EXP)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
panobinostat  (ISO)
paracetamol  (EXP,ISO)
paraoxon  (ISO)
PD 0325901  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
phenobarbital  (ISO)
PhIP  (ISO)
pirinixic acid  (ISO)
piroxicam  (ISO)
potassium cyanide  (ISO)
progesterone  (ISO)
purine-6-thiol  (EXP)
quercetin  (ISO)
resorcinol  (ISO)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
S-nitrosoglutathione  (ISO)
SB 431542  (ISO)
senecionine  (ISO)
serpentine asbestos  (ISO)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium fluoride  (ISO)
sulindac sulfide  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
trichloroethene  (EXP)
trichostatin A  (EXP,ISO)
triphenyl phosphate  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (ISO)
tungsten  (ISO)
valproic acid  (ISO)
vancomycin  (ISO)
vinclozolin  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. A-kinase anchoring proteins: from protein complexes to physiology and disease. Carnegie GK, etal., IUBMB Life. 2009 Apr;61(4):394-406.
2. Identification of a major protein kinase C-binding protein and substrate in rat embryo fibroblasts. Decreased expression in transformed cells. Chapline C, etal., J Biol Chem 1996 Mar 15;271(11):6417-22.
3. Vagal efferent fiber stimulation ameliorates pulmonary microvascular endothelial cell injury by downregulating inflammatory responses. Chen C, etal., Inflammation. 2013 Dec;36(6):1567-75. doi: 10.1007/s10753-013-9701-4.
4. Ligand-specific control of src-suppressed C kinase substrate gene expression. Coats SR, etal., Biochem Biophys Res Commun 2002 Oct 11;297(5):1112-20.
5. Silencing of Cited2 and Akap12 genes in radiation-induced rat osteosarcomas. Daino K, etal., Biochem Biophys Res Commun. 2009 Dec 18;390(3):654-8. Epub 2009 Oct 13.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
8. The scaffold protein muscle A-kinase anchoring protein beta orchestrates cardiac myocyte hypertrophic signaling required for the development of heart failure. Kritzer MD, etal., Circ Heart Fail. 2014 Jul;7(4):663-72. doi: 10.1161/CIRCHEARTFAILURE.114.001266. Epub 2014 May 8.
9. Involvement of Src-suppressed C kinase substrate in experimental autoimmune encephalomyelitis: a link between release of astrocyte proinflammatory factor and oligodendrocyte apoptosis. Li X, etal., J Neurosci Res. 2010 Jul;88(9):1858-71. doi: 10.1002/jnr.22355.
10. Isolation and characterization of a novel mitogenic regulatory gene, 322, which is transcriptionally suppressed in cells transformed by src and ras. Lin X, etal., Mol Cell Biol 1995 May;15(5):2754-62.
11. Re-expression of AKAP12 inhibits progression and metastasis potential of colorectal carcinoma in vivo and in vitro. Liu W, etal., PLoS One. 2011;6(8):e24015. doi: 10.1371/journal.pone.0024015. Epub 2011 Aug 30.
12. Gene Data Set MGD Curation, June 12, 2002
13. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
14. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
15. GOA pipeline RGD automated data pipeline
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. SSeCKS immunolabeling in rat primary sensory neurons. Siegel SM, etal., Brain Res. 2002 Feb 1;926(1-2):126-36.
18. Multiple promoters direct expression of three AKAP12 isoforms with distinct subcellular and tissue distribution profiles. Streb JW, etal., J Biol Chem 2004 Dec 31;279(53):56014-23. Epub 2004 Oct 20.
19. Src suppressed C kinase substrate regulates the lipopolysaccharide-induced TNF-alpha biosynthesis in rat astrocytes. Sun LL, etal., J Mol Neurosci. 2007;32(1):16-24.
20. Localized effects of cAMP mediated by distinct routes of protein kinase A. Tasken K and Aandahl EM, Physiol Rev. 2004 Jan;84(1):137-67.
21. Epigenetic silencing of AKAP12 in juvenile myelomonocytic leukemia. Wilhelm T, etal., Epigenetics. 2016;11(2):110-9. doi: 10.1080/15592294.2016.1145327. Epub 2016 Feb 18.
22. Mitogen-induced, FAK-dependent tyrosine phosphorylation of the SSeCKS scaffolding protein. Xia W and Gelman IH, Exp Cell Res 2002 Jul 15;277(2):139-51.
23. A critical role of SRC-suppressed C kinase substrate in rat astrocytes after chronic constriction injury. Xia Y, etal., Neuromolecular Med. 2010 Sep;12(3):205-16. doi: 10.1007/s12017-009-8093-y. Epub 2009 Nov 25.
24. Expression of SRC suppressed C kinase substrate in rat neural tissues during inflammation. Yan M, etal., Neurochem Res. 2014 Apr;39(4):748-57. doi: 10.1007/s11064-014-1265-7. Epub 2014 Mar 13.
25. Association of gene polymorphisms with chronic kidney disease in Japanese individuals. Yoshida T, etal., Int J Mol Med. 2009 Oct;24(4):539-47.
26. Role of src-suppressed C kinase substrate in rat pulmonary microvascular endothelial hyperpermeability stimulated by inflammatory cytokines. You QH, etal., Inflamm Res. 2010 Nov;59(11):949-58. doi: 10.1007/s00011-010-0207-3. Epub 2010 May 8.
27. Increased SSeCKS expression in rat hepatic stellate cells upon activation in vitro and in vivo. You T, etal., Inflammation. 2013 Dec;36(6):1415-23. doi: 10.1007/s10753-013-9681-4.
28. Temporal profile of Src, SSeCKS, and angiogenic factors after focal cerebral ischemia: correlations with angiogenesis and cerebral edema. Zan L, etal., Neurochem Int. 2011 Jul;58(8):872-9. doi: 10.1016/j.neuint.2011.02.014. Epub 2011 Feb 18.
Additional References at PubMed
PMID:12060780   PMID:15923193   PMID:16638134   PMID:17081159   PMID:17482576   PMID:17551670   PMID:17592532   PMID:17873283   PMID:18279585   PMID:18384053   PMID:18979197   PMID:19577259  
PMID:19757038   PMID:20111901   PMID:20204485   PMID:20232114   PMID:20367900   PMID:21423176   PMID:21573722   PMID:23238728   PMID:28281242   PMID:30053369   PMID:32357304  


Genomics

Comparative Map Data
Akap12
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8143,135,515 - 43,225,245 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl143,199,008 - 43,225,557 (+)EnsemblGRCr8
mRatBN7.2140,730,123 - 40,819,863 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl140,730,123 - 40,819,886 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx141,257,330 - 41,347,044 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0147,244,521 - 47,334,234 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0141,332,883 - 41,422,632 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0140,816,130 - 40,906,582 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl140,816,107 - 40,906,581 (+)Ensemblrn6Rnor6.0
Rnor_5.0142,162,163 - 42,252,615 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4134,979,039 - 35,068,763 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera136,421,269 - 36,510,639 (+)NCBICelera
RGSC_v3.1134,982,110 - 35,070,840 (+)NCBI
Cytogenetic Map1q11NCBI
AKAP12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh386151,239,967 - 151,358,559 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl6151,239,936 - 151,358,563 (+)Ensemblhg38GRCh38
GRCh376151,561,102 - 151,679,694 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 366151,603,202 - 151,719,602 (+)NCBIBuild 36Build 36hg18NCBI36
Build 346151,738,936 - 151,770,022NCBI
Celera6152,295,018 - 152,413,580 (+)NCBICelera
Cytogenetic Map6q25.1NCBI
HuRef6149,123,664 - 149,241,939 (+)NCBIHuRef
CHM1_16151,825,190 - 151,943,865 (+)NCBICHM1_1
T2T-CHM13v2.06152,440,587 - 152,559,135 (+)NCBIT2T-CHM13v2.0
Akap12
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39104,216,329 - 4,309,471 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl104,216,380 - 4,309,470 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38104,266,329 - 4,359,471 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl104,266,380 - 4,359,470 (+)Ensemblmm10GRCm38
MGSCv37105,987,070 - 6,080,212 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36105,987,070 - 6,080,163 (-)NCBIMGSCv36mm8
Celera104,190,840 - 4,288,877 (+)NCBICelera
Cytogenetic Map10A1NCBI
cM Map102.06NCBI
Akap12
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495543910,238,664 - 10,263,081 (-)Ensembl
ChiLan1.0NW_00495543910,241,298 - 10,262,416 (-)NCBIChiLan1.0ChiLan1.0
AKAP12
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v25171,264,561 - 171,383,191 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan16169,155,859 - 169,273,390 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v06149,058,350 - 149,176,710 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.16153,839,496 - 153,873,925 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl6153,757,081 - 153,873,925 (+)EnsemblpanPan2panpan1.1
AKAP12
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1141,614,893 - 41,712,350 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl141,614,714 - 41,709,798 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha142,456,089 - 42,553,626 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0141,799,868 - 41,897,347 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl141,799,970 - 41,895,674 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1141,673,111 - 41,770,835 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0141,517,208 - 41,614,636 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0142,023,588 - 42,121,300 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Akap12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404946136,985,500 - 137,006,417 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364894,237,439 - 4,261,141 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364894,237,466 - 4,258,408 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
AKAP12
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl114,904,116 - 15,016,997 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1114,904,109 - 15,017,016 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2117,314,971 - 17,428,055 (-)NCBISscrofa10.2Sscrofa10.2susScr3
AKAP12
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11378,691,588 - 78,812,333 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1378,691,816 - 78,812,834 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604051,020,791 - 51,143,055 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Akap12
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247856,897,561 - 6,988,287 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247856,900,252 - 6,987,712 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Akap12
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v12199,045,721 - 199,135,007 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Akap12
729 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:266
Count of miRNA genes:159
Interacting mature miRNAs:201
Transcripts:ENSRNOT00000026482, ENSRNOT00000060767
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631688Hcas2Hepatocarcinoma susceptibility QTL 230.0001liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1774611852746118Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
4889451Eae29Experimental allergic encephalomyelitis QTL 295.51nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis severity score (CMO:0001419)1774612152746121Rat
70179Xhs2X-ray hypersensitivity QTL 23.2intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)1143965634Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
1558642Prcr2Prostate cancer resistance QTL 24.3prostate integrity trait (VT:0010571)area of ventral prostate occupied by tumorous lesions to total ventral prostate area ratio (CMO:0000899)11037949255379492Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
7421626Bp360Blood pressure QTL 3600.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1694102251941022Rat
1357401Bw43Body weight QTL 433.75body mass (VT:0001259)body weight (CMO:0000012)1690935351909353Rat
631494Bp95Blood pressure QTL 95400.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)11731537851816258Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
5684998Bss101Bone structure and strength QTL 1013.6tibia strength trait (VT:1000284)tibia ultimate force (CMO:0001734)1690935351909353Rat
5684999Bss102Bone structure and strength QTL 1025.57e-07tibia strength trait (VT:1000284)tibia stiffness (CMO:0001735)1690935351909353Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2302038Pia31Pristane induced arthritis QTL 315.50.001blood autoantibody amount (VT:0003725)serum immunoglobulin M-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002111)11282049457820494Rat
634353Rends2Renal damage susceptibility QTL 20.05kidney blood vessel morphology trait (VT:0000530)organ lesion measurement (CMO:0000677)12065642065656420Rat
1578756Iddm22Insulin dependent diabetes mellitus QTL 222.7blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)12050832665508326Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
631508Sald1Serum aldosterone level QTL 13.7blood aldosterone amount (VT:0005346)serum aldosterone level (CMO:0000487)11168446456684464Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat

Markers in Region
D1Rat13  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2140,795,189 - 40,795,347 (+)MAPPERmRatBN7.2
Rnor_6.0140,881,280 - 40,881,437NCBIRnor6.0
Rnor_5.0142,227,313 - 42,227,470UniSTSRnor5.0
RGSC_v3.4135,044,092 - 35,044,250RGDRGSC3.4
RGSC_v3.4135,044,093 - 35,044,250UniSTSRGSC3.4
Celera136,485,613 - 36,485,766UniSTS
RGSC_v3.1135,047,037 - 35,047,195RGD
SHRSP x BN Map118.27UniSTS
SHRSP x BN Map118.27RGD
Cytogenetic Map1p11UniSTS
D1Rat401  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.0142,227,253 - 42,227,471UniSTSRnor5.0
RGSC_v3.4135,044,032 - 35,044,251RGDRGSC3.4
RGSC_v3.4135,044,033 - 35,044,251UniSTSRGSC3.4
Celera136,485,553 - 36,485,767UniSTS
RGSC_v3.1135,046,977 - 35,047,196RGD
SHRSP x BN Map118.27UniSTS
SHRSP x BN Map118.27RGD
Cytogenetic Map1p11UniSTS
D1Rat397  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2140,795,163 - 40,795,374 (+)MAPPERmRatBN7.2
Rnor_6.0140,881,254 - 40,881,464NCBIRnor6.0
Rnor_5.0142,227,287 - 42,227,497UniSTSRnor5.0
RGSC_v3.4135,044,067 - 35,044,277UniSTSRGSC3.4
Celera136,485,587 - 36,485,793UniSTS
RGSC_v3.1135,047,011 - 35,047,222RGD
SHRSP x BN Map118.19UniSTS
SHRSP x BN Map118.19RGD
SHRSP x BN Map118.27UniSTS
Cytogenetic Map1p11UniSTS
D1Rat400  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2140,795,129 - 40,795,348 (+)MAPPERmRatBN7.2
Rnor_6.0140,881,220 - 40,881,438NCBIRnor6.0
Rnor_5.0142,227,252 - 42,227,471NCBIRnor5.0
Rnor_5.0142,227,253 - 42,227,471UniSTSRnor5.0
RGSC_v3.4135,044,033 - 35,044,251UniSTSRGSC3.4
Celera136,485,553 - 36,485,767UniSTS
RGSC_v3.1135,046,977 - 35,047,196RGD
SHRSP x BN Map118.27UniSTS
SHRSP x BN Map118.27RGD
Cytogenetic Map1p11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 91 59 6 355 191 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000026482   ⟹   ENSRNOP00000026483
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl143,206,863 - 43,225,557 (+)Ensembl
mRatBN7.2 Ensembl140,804,110 - 40,819,486 (+)Ensembl
Rnor_6.0 Ensembl140,891,597 - 40,906,573 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000060767   ⟹   ENSRNOP00000057494
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl143,206,878 - 43,225,557 (+)Ensembl
mRatBN7.2 Ensembl140,730,123 - 40,819,862 (+)Ensembl
Rnor_6.0 Ensembl140,816,107 - 40,906,581 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083702   ⟹   ENSRNOP00000070062
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl143,199,008 - 43,225,243 (+)Ensembl
mRatBN7.2 Ensembl140,793,657 - 40,819,862 (+)Ensembl
Rnor_6.0 Ensembl140,879,747 - 40,906,581 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000099245   ⟹   ENSRNOP00000087138
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl140,804,279 - 40,819,886 (+)Ensembl
RefSeq Acc Id: NM_001033653   ⟹   NP_001028825
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,199,042 - 43,225,245 (+)NCBI
mRatBN7.2140,793,657 - 40,819,863 (+)NCBI
Rnor_6.0140,879,747 - 40,906,582 (+)NCBI
Rnor_5.0142,162,163 - 42,252,615 (+)NCBI
RGSC_v3.4134,979,039 - 35,068,763 (+)RGD
Celera136,484,080 - 36,510,639 (+)NCBI
Sequence:
RefSeq Acc Id: NM_057103   ⟹   NP_476444
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,135,515 - 43,225,245 (+)NCBI
mRatBN7.2140,730,123 - 40,819,863 (+)NCBI
Rnor_6.0140,816,130 - 40,906,582 (+)NCBI
Rnor_5.0142,162,163 - 42,252,615 (+)NCBI
RGSC_v3.4134,979,039 - 35,068,763 (+)RGD
Celera136,421,269 - 36,510,639 (+)RGD
Sequence:
RefSeq Acc Id: XM_006227847   ⟹   XP_006227909
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,204,701 - 43,225,245 (+)NCBI
mRatBN7.2140,804,074 - 40,819,863 (+)NCBI
Rnor_6.0140,890,061 - 40,906,582 (+)NCBI
Rnor_5.0142,162,163 - 42,252,615 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006227848   ⟹   XP_006227910
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8143,210,509 - 43,225,245 (+)NCBI
mRatBN7.2140,805,102 - 40,819,863 (+)NCBI
Rnor_6.0140,891,139 - 40,906,582 (+)NCBI
Rnor_5.0142,162,163 - 42,252,615 (+)NCBI
Sequence:
RefSeq Acc Id: NP_476444   ⟸   NM_057103
- Peptide Label: isoform alpha
- UniProtKB: Q5QD50 (UniProtKB/Swiss-Prot),   Q5QD49 (UniProtKB/Swiss-Prot),   Q9Z1F7 (UniProtKB/Swiss-Prot),   Q5QD51 (UniProtKB/Swiss-Prot),   A6KIK8 (UniProtKB/TrEMBL),   Q62766 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001028825   ⟸   NM_001033653
- Peptide Label: isoform beta
- UniProtKB: Q62766 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006227909   ⟸   XM_006227847
- Peptide Label: isoform X1
- UniProtKB: A0A8L2QEC9 (UniProtKB/TrEMBL),   A6KIK9 (UniProtKB/TrEMBL),   Q62766 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006227910   ⟸   XM_006227848
- Peptide Label: isoform X2
- UniProtKB: A6KIL0 (UniProtKB/TrEMBL),   Q62766 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000057494   ⟸   ENSRNOT00000060767
Ensembl Acc Id: ENSRNOP00000026483   ⟸   ENSRNOT00000026482
Ensembl Acc Id: ENSRNOP00000070062   ⟸   ENSRNOT00000083702
Ensembl Acc Id: ENSRNOP00000087138   ⟸   ENSRNOT00000099245
Protein Domains
A kinase-anchoring proteins AKAP-5 and AKAP-12

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5QD51-F1-model_v2 AlphaFold Q5QD51 1-1687 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13689584
Promoter ID:EPDNEW_R109
Type:multiple initiation site
Name:Akap12_2
Description:A-kinase anchoring protein 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R110  EPDNEW_R111  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0140,816,133 - 40,816,193EPDNEW
RGD ID:13689585
Promoter ID:EPDNEW_R110
Type:single initiation site
Name:Akap12_1
Description:A-kinase anchoring protein 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R109  EPDNEW_R111  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0140,879,753 - 40,879,813EPDNEW
RGD ID:13689592
Promoter ID:EPDNEW_R111
Type:initiation region
Name:Akap12_3
Description:A-kinase anchoring protein 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R109  EPDNEW_R110  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0140,891,626 - 40,891,686EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70988 AgrOrtholog
BioCyc Gene G2FUF-61720 BioCyc
Ensembl Genes ENSRNOG00000019549 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000026482 ENTREZGENE
  ENSRNOT00000060767.5 UniProtKB/Swiss-Prot
  ENSRNOT00000083702 ENTREZGENE
  ENSRNOT00000083702.2 UniProtKB/Swiss-Prot
  ENSRNOT00000099245.1 UniProtKB/Swiss-Prot
InterPro AKAP12 UniProtKB/Swiss-Prot
  Pkinase-A_anch_WSK-motif UniProtKB/Swiss-Prot
KEGG Report rno:83425 UniProtKB/Swiss-Prot
NCBI Gene 83425 ENTREZGENE
PANTHER A-KINASE ANCHOR PROTEIN 12 UniProtKB/Swiss-Prot
  PTHR23209 UniProtKB/Swiss-Prot
Pfam WSK UniProtKB/Swiss-Prot
PhenoGen Akap12 PhenoGen
PROSITE AKAP_CAM_BD UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000019549 RatGTEx
UniProt A0A8L2QEC9 ENTREZGENE, UniProtKB/TrEMBL
  A6KIK8 ENTREZGENE, UniProtKB/TrEMBL
  A6KIK9 ENTREZGENE, UniProtKB/TrEMBL
  A6KIL0 ENTREZGENE, UniProtKB/TrEMBL
  AKA12_RAT UniProtKB/Swiss-Prot
  Q5QD49 ENTREZGENE
  Q5QD50 ENTREZGENE
  Q5QD51 ENTREZGENE
  Q62766 ENTREZGENE, UniProtKB/TrEMBL
  Q9Z1F7 ENTREZGENE
UniProt Secondary Q5QD49 UniProtKB/Swiss-Prot
  Q5QD50 UniProtKB/Swiss-Prot
  Q9Z1F7 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-11-25 Akap12  A-kinase anchoring protein 12  Akap12  A kinase (PRKA) anchor protein 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-26 Akap12  A kinase (PRKA) anchor protein 12  Akap12  A kinase (PRKA) anchor protein (gravin) 12  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Akap12  A kinase (PRKA) anchor protein (gravin) 12      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization after 24 hours of sodium butyrate treatment of transformed rat kidney fibroblasts, as cells spread and attach, Akap12 staining is strongest in the lamellipodia and at the edges of spreading cells; by 48 hours the Akap12 protein staining is highest in the perinuclear region 631986
gene_expression highest mRNA expression in testes, heart, skin and brain; highest protein levels in testes and brain 70657
gene_expression progressive transformation of REF52 cells is accompanied by progressive loss of Akap12 expression 70657
gene_pathway involved in PDGF-BB-, LPA-, EPA-, and NaB-mediated cell signaling 631986
gene_physical_interaction interacts with protein kinase C 70657
gene_process may play a role in mitogen-induced cytoskeletal reorganization 631987
gene_protein approximately 200 kDa 70657
gene_regulation transcription suppressed by transformation of Rat-6 fibroblasts by src, ras, fos and myc, but not by raf, mos or neu 70666
gene_regulation platelet-derived growth factor-BB (PDGF-BB) and lysophosphatidic acid (LPA) upregulate Akap12 in rat smooth muscle cells; eicosapentaenoic acid (EPA) induces Akap12 at lower concentrations, but at higher doses it is antagonistic to Angiotensin II induced upregulation 631986
gene_transcript three isoforms sharing >95% amino acid identity except at their N-termini are the result of tissue specific transcription from three separate but overlapping transcription units with non-redundant promoters 1358132