Ddah1 (dimethylarginine dimethylaminohydrolase 1) - Rat Genome Database

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Gene: Ddah1 (dimethylarginine dimethylaminohydrolase 1) Rattus norvegicus
Analyze
Symbol: Ddah1
Name: dimethylarginine dimethylaminohydrolase 1
RGD ID: 70968
Description: Enables amino acid binding activity and dimethylargininase activity. Involved in arginine metabolic process; positive regulation of angiogenesis; and positive regulation of nitric oxide biosynthetic process. Human ortholog(s) of this gene implicated in cardiovascular system disease; coronary artery disease; and hypertension. Orthologous to human DDAH1 (dimethylarginine dimethylaminohydrolase 1); INTERACTS WITH 1-nitropropane; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: DDAH-1; DDAHI; dimethylargininase-1; n(G),N(G)-dimethylarginine dimethylaminohydrolase 1; NG,NG dimethylarginine dimethylaminohydrolase; NGNG dimethylarginine dimethylaminohydrolase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Ddah1em1Ywxu
Genetic Models: SD-Ddah1em1Ywxu
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82237,327,812 - 237,460,624 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2237,327,766 - 237,460,626 (+)EnsemblGRCr8
mRatBN7.22234,667,499 - 234,800,322 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2234,667,491 - 234,799,339 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2242,465,212 - 242,597,798 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02240,356,099 - 240,488,167 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02235,222,839 - 235,355,419 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02251,634,368 - 251,766,009 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2251,634,431 - 251,766,014 (+)Ensemblrn6Rnor6.0
Rnor_5.02270,160,842 - 270,289,319 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42243,932,221 - 244,069,832 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2226,655,820 - 226,787,619 (+)NCBICelera
RGSC_v3.12243,918,960 - 244,056,573 (+)NCBI
Cytogenetic Map2q44NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1-nitropropane  (EXP)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
2,3,4,7,8-Pentachlorodibenzofuran  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-diaminotoluene  (EXP)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (EXP)
2-nitro-p-phenylenediamine  (EXP)
2-nitrofluorene  (EXP)
2-nitropropane  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-chloropropane-1,2-diol  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one  (EXP)
4-acetylaminofluorene  (EXP)
4-amino-2,6-dinitrotoluene  (EXP)
4-hydroxyphenyl retinamide  (ISO)
4-nitro-1,2-phenylenediamine  (EXP)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
Allylamine  (EXP)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
atrazine  (EXP)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
benzo[b]fluoranthene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (EXP)
butan-1-ol  (ISO)
Butylbenzyl phthalate  (ISO)
cadmium dichloride  (ISO)
carbamazepine  (ISO)
carbon nanotube  (ISO)
chromium trinitrate  (ISO)
chromium(6+)  (ISO)
chrysene  (ISO)
cisplatin  (ISO)
clofibrate  (EXP)
cobalt dichloride  (EXP,ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
dexamethasone  (ISO)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
diethylstilbestrol  (EXP)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
folic acid  (ISO)
formaldehyde  (ISO)
furan  (EXP)
glyphosate  (ISO)
hydroquinone  (ISO)
indometacin  (EXP)
inulin  (ISO)
irbesartan  (EXP)
ivermectin  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (ISO)
maneb  (ISO)
manganese atom  (ISO)
manganese(0)  (ISO)
melatonin  (EXP)
methamphetamine  (EXP)
methapyrilene  (EXP)
methotrexate  (EXP)
methylmercury chloride  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
monoethyl phthalate  (ISO)
N-nitrosodimethylamine  (EXP)
N-nitrosomorpholine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (EXP)
nitrobenzenes  (EXP)
p-toluidine  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paroxetine  (ISO)
perfluorododecanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
pioglitazone  (ISO)
piperonyl butoxide  (EXP)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
ranitidine  (EXP)
rotenone  (EXP)
sarin  (EXP)
SB 431542  (ISO)
simvastatin  (EXP)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sulforaphane  (ISO)
taurine  (ISO)
temozolomide  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
tetraphene  (ISO)
thapsigargin  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
triphenyl phosphate  (EXP)
valproic acid  (ISO)
venlafaxine hydrochloride  (EXP)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. AGXT2 and DDAH-1 genetic variants are highly correlated with serum ADMA and SDMA levels and with incidence of coronary artery disease in Egyptians. Amir M, etal., Mol Biol Rep. 2018 Dec;45(6):2411-2419. doi: 10.1007/s11033-018-4407-1. Epub 2018 Oct 3.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Cloning and sequencing of cDNA encoding NG,NG-dimethylarginine dimethylaminohydrolase from rat kidney. Kimoto M, etal., Biochim Biophys Acta 1997 Jan 4;1337(1):6-10.
5. Dimethylarginine dimethylaminohydrolase I enhances tumour growth and angiogenesis. Kostourou V, etal., Br J Cancer 2002 Sep 9;87(6):673-80.
6. Gene Data Set MGD Curation, June 12, 2002
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. GOA pipeline RGD automated data pipeline
9. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
10. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
11. Roles of accumulated endogenous nitric oxide synthase inhibitors, enhanced arginase activity, and attenuated nitric oxide synthase activity in endothelial cells for pulmonary hypertension in rats. Sasaki A, etal., Am J Physiol Lung Cell Mol Physiol. 2007 Jun;292(6):L1480-7. Epub 2007 Feb 23.
12. DDAH gene and cardiovascular risk. Valkonen VP, etal., Vasc Med. 2005 Jul;10 Suppl 1:S45-8.
13. Dimethylarginine dimethylaminohydrolase 1 deficiency aggravates monocrotaline-induced pulmonary oxidative stress, pulmonary arterial hypertension and right heart failure in rats. Wang D, etal., Int J Cardiol. 2019 Nov 15;295:14-20. doi: 10.1016/j.ijcard.2019.07.078. Epub 2019 Jul 27.
Additional References at PubMed
PMID:14766200   PMID:15256062   PMID:16533509   PMID:16959216   PMID:17409314   PMID:17673667   PMID:17909098   PMID:18614015   PMID:19056867   PMID:19156866   PMID:19481782   PMID:19528264  
PMID:19663506   PMID:21408057   PMID:21493890   PMID:21590769   PMID:22785485   PMID:22995517   PMID:23376485   PMID:23533145   PMID:24455716   PMID:24895913   PMID:25013773   PMID:26375520  
PMID:29263339   PMID:29513072   PMID:29721731   PMID:31870966   PMID:33574439   PMID:35509834   PMID:37116560  


Genomics

Comparative Map Data
Ddah1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr82237,327,812 - 237,460,624 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl2237,327,766 - 237,460,626 (+)EnsemblGRCr8
mRatBN7.22234,667,499 - 234,800,322 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2234,667,491 - 234,799,339 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx2242,465,212 - 242,597,798 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.02240,356,099 - 240,488,167 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.02235,222,839 - 235,355,419 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.02251,634,368 - 251,766,009 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2251,634,431 - 251,766,014 (+)Ensemblrn6Rnor6.0
Rnor_5.02270,160,842 - 270,289,319 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.42243,932,221 - 244,069,832 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera2226,655,820 - 226,787,619 (+)NCBICelera
RGSC_v3.12243,918,960 - 244,056,573 (+)NCBI
Cytogenetic Map2q44NCBI
DDAH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38185,318,485 - 85,578,200 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl185,318,481 - 85,578,363 (-)Ensemblhg38GRCh38
GRCh37185,784,168 - 86,043,883 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36185,556,756 - 85,703,411 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34185,496,189 - 85,642,844NCBI
Celera184,028,261 - 84,288,153 (-)NCBICelera
Cytogenetic Map1p22.3NCBI
HuRef183,894,842 - 84,154,833 (-)NCBIHuRef
CHM1_1185,899,643 - 86,159,483 (-)NCBICHM1_1
T2T-CHM13v2.0185,159,290 - 85,419,019 (-)NCBIT2T-CHM13v2.0
Ddah1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm393145,464,447 - 145,600,032 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl3145,464,430 - 145,600,032 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm383145,758,692 - 145,894,277 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl3145,758,675 - 145,894,277 (+)Ensemblmm10GRCm38
MGSCv373145,421,656 - 145,557,241 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv363145,696,113 - 145,829,059 (+)NCBIMGSCv36mm8
Celera3152,212,383 - 152,347,807 (+)NCBICelera
Cytogenetic Map3H2NCBI
cM Map370.63NCBI
Ddah1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554238,636,756 - 8,676,790 (+)Ensembl
ChiLan1.0NW_0049554238,637,116 - 8,673,881 (+)NCBIChiLan1.0ChiLan1.0
DDAH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21141,354,493 - 141,614,910 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11140,509,872 - 140,770,243 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01117,875,875 - 118,136,304 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1186,732,327 - 86,991,596 (-)NCBIPanPan1.1PanPan1.1panPan2
DDAH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1662,548,852 - 62,683,687 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl662,549,152 - 62,683,729 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha665,198,038 - 65,332,811 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0663,091,600 - 63,223,617 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl663,092,081 - 63,223,617 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1662,619,548 - 62,750,820 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0662,587,035 - 62,721,493 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0663,093,978 - 63,228,831 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Ddah1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505895,908,280 - 96,043,352 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936608262,445 - 397,762 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936608262,653 - 397,753 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DDAH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl4130,579,729 - 130,617,531 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.14130,485,305 - 130,617,534 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24143,081,555 - 143,209,100 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DDAH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12047,788,410 - 48,031,868 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2047,891,289 - 48,032,343 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603369,777,494 - 70,020,724 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ddah1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462474212,026,248 - 12,170,147 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462474212,027,450 - 12,170,003 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Ddah1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1314,997,412 - 15,122,776 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Ddah1
1086 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:191
Count of miRNA genes:130
Interacting mature miRNAs:158
Transcripts:ENSRNOT00000045016
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2170656145239614549Rat
1331767Hrtrt12Heart rate QTL 123.373heart pumping trait (VT:2000009)heart rate (CMO:0000002)2221088977243501206Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2210956252251712708Rat
8693697Alc36Alcohol consumption QTL 3620.592drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2219814164239320906Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2143344967251712708Rat
1298075Scl17Serum cholesterol level QTL 173.4blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)2214404877251712708Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2143344967251712708Rat
2293833Kiddil8Kidney dilation QTL 82.9kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat
1598835Anxrr18Anxiety related response QTL 182.98body movement coordination trait (VT:0005424)number of rearing movements in an experimental apparatus (CMO:0001752)2203664411248664411Rat
1300126Bp175Blood pressure QTL 1753.46arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2204795005249795005Rat
7207490Bss111Bone structure and strength QTL 1116.4femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)2214404877251712708Rat
7207484Bss108Bone structure and strength QTL 1085.3femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)2214404877251712708Rat
2313073Bmd75Bone mineral density QTL 754.10.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)2218051934251712708Rat
8693622Alc26Alcohol consumption QTL 262.40.667drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)2223810546243965570Rat
7207482Bss107Bone structure and strength QTL 1077femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)2214404877251712708Rat
2293844Kiddil7Kidney dilation QTL 73.5kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)2220274283249795005Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2151869660251712708Rat
2317752Glom23Glomerulus QTL 233.6urine protein amount (VT:0005160)urine protein level (CMO:0000591)2196140964251540988Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2205135267250135267Rat
1549836Bss2Bone structure and strength QTL 27.5femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)2214404877251712708Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2205135267250135267Rat

Markers in Region
D2Got166  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22234,670,004 - 234,670,280 (+)MAPPERmRatBN7.2
Rnor_6.02251,636,874 - 251,637,149NCBIRnor6.0
Rnor_5.02270,163,348 - 270,163,623UniSTSRnor5.0
RGSC_v3.42243,934,775 - 243,935,051RGDRGSC3.4
RGSC_v3.42243,934,776 - 243,935,051UniSTSRGSC3.4
Celera2226,658,326 - 226,658,601UniSTS
RGSC_v3.12243,921,515 - 243,921,791RGD
Cytogenetic Map2q44UniSTS
RH140029  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22234,798,808 - 234,799,010 (+)MAPPERmRatBN7.2
Rnor_6.02251,764,496 - 251,764,697NCBIRnor6.0
Rnor_5.02270,288,789 - 270,288,990UniSTSRnor5.0
RGSC_v3.42244,069,535 - 244,069,736UniSTSRGSC3.4
Celera2226,787,089 - 226,787,290UniSTS
Cytogenetic Map2q44UniSTS


Genetic Models
This gene Ddah1 is modified in the following models/strains:
SD-Ddah1em1Ywxu    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000045016   ⟹   ENSRNOP00000044971
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl2237,327,766 - 237,460,626 (+)Ensembl
mRatBN7.2 Ensembl2234,667,491 - 234,799,339 (+)Ensembl
Rnor_6.0 Ensembl2251,634,431 - 251,766,014 (+)Ensembl
RefSeq Acc Id: NM_022297   ⟹   NP_071633
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82237,327,812 - 237,459,641 (+)NCBI
mRatBN7.22234,667,499 - 234,799,339 (+)NCBI
Rnor_6.02251,634,368 - 251,765,026 (+)NCBI
Rnor_5.02270,160,842 - 270,289,319 (+)NCBI
RGSC_v3.42243,932,221 - 244,069,832 (+)RGD
Celera2226,655,820 - 226,787,619 (+)RGD
Sequence:
RefSeq Acc Id: XM_017591068   ⟹   XP_017446557
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82237,345,379 - 237,460,624 (+)NCBI
mRatBN7.22234,684,993 - 234,800,322 (+)NCBI
Rnor_6.02251,651,493 - 251,766,009 (+)NCBI
Sequence:
RefSeq Acc Id: XM_063282450   ⟹   XP_063138520
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr82237,418,023 - 237,460,624 (+)NCBI
Protein Sequences
Protein RefSeqs NP_071633 (Get FASTA)   NCBI Sequence Viewer  
  XP_017446557 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138520 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL82408 (Get FASTA)   NCBI Sequence Viewer  
  EDL82409 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000044971
  ENSRNOP00000044971.3
GenBank Protein O08557 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_071633   ⟸   NM_022297
- UniProtKB: O08557 (UniProtKB/Swiss-Prot),   A6HWC2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_017446557   ⟸   XM_017591068
- Peptide Label: isoform X1
- UniProtKB: A6HWC3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000044971   ⟸   ENSRNOT00000045016
RefSeq Acc Id: XP_063138520   ⟸   XM_063282450
- Peptide Label: isoform X2

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08557-F1-model_v2 AlphaFold O08557 1-285 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691809
Promoter ID:EPDNEW_R2334
Type:initiation region
Name:Ddah1_1
Description:dimethylarginine dimethylaminohydrolase 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.02251,634,348 - 251,634,408EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70968 AgrOrtholog
BioCyc Gene G2FUF-50919 BioCyc
Ensembl Genes ENSRNOG00000014613 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000045016 ENTREZGENE
  ENSRNOT00000045016.5 UniProtKB/Swiss-Prot
Gene3D-CATH L-arginine/glycine Amidinotransferase, Chain A UniProtKB/Swiss-Prot
InterPro DDAH UniProtKB/Swiss-Prot
KEGG Report rno:64157 UniProtKB/Swiss-Prot
NCBI Gene 64157 ENTREZGENE
PANTHER PTHR12737 UniProtKB/Swiss-Prot
  PTHR12737:SF17 UniProtKB/Swiss-Prot
Pfam DDAH_eukar UniProtKB/Swiss-Prot
PhenoGen Ddah1 PhenoGen
RatGTEx ENSRNOG00000014613 RatGTEx
Superfamily-SCOP Pentein UniProtKB/Swiss-Prot
UniProt A6HWC2 ENTREZGENE, UniProtKB/TrEMBL
  A6HWC3 ENTREZGENE, UniProtKB/TrEMBL
  DDAH1_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Ddah1  dimethylarginine dimethylaminohydrolase 1      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_function catalyzes the conversion of N(G), N(G)-dimethyl-L-arginine and H(2)O to dimethylamine and L-citrulline 70711
gene_mutations_overexpression overexpression induces increased nitric oxide synthesis and angiogenesis 727432
gene_protein protein is 285 amino acids with a M(r) of 3,1414 727432