Gpr6 (G protein-coupled receptor 6)

Gene: Gpr6 (G protein-coupled receptor 6) Rattus norvegicus

Analyze

Symbol:

Gpr6

Name:

G protein-coupled receptor 6

RGD ID:

70939

Description:

Predicted to enable sphingosine-1-phosphate receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of metabolic process. Predicted to act upstream of or within positive regulation of cytosolic calcium ion concentration and sphingosine-1-phosphate receptor signaling pathway. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human GPR6 (G protein-coupled receptor 6); INTERACTS WITH 6-propyl-2-thiouracil; bisphenol A; glycidol.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

G-protein coupled receptor 6; putative G protein-coupled receptor (CNL3); sphingosine 1-phosphate receptor GPR6

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	GPR6 (G protein-coupled receptor 6)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):	Gpr6 (G protein-coupled receptor 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Gpr6 (G protein-coupled receptor 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	GPR6 (G protein-coupled receptor 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	GPR6 (G protein-coupled receptor 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Gpr6 (G protein-coupled receptor 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	GPR6 (G protein-coupled receptor 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	GPR6 (G protein-coupled receptor 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Gpr6 (G protein-coupled receptor 6)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	GPR6 (G protein-coupled receptor 6)	Alliance	DIOPT (HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Gpr6 (G protein-coupled receptor 6)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	gpr6	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	46,072,480 - 46,075,251 (-)	NCBI		GRCr8
mRatBN7.2	20	44,489,853 - 44,492,624 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	44,489,853 - 44,492,624 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	46,274,495 - 46,277,282 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	45,933,647 - 45,936,434 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	46,658,987 - 46,661,774 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	45,813,169 - 45,815,940 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	45,813,169 - 45,815,940 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	47,518,790 - 47,521,561 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	20	45,290,688 - 45,293,459 (-)	NCBI		Celera
Cytogenetic Map	20	q12	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (ISO)

2-butan-2-yl-4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]phenyl]-1,2,4-triazol-3-one (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP)

CGP 52608 (ISO)

choline (ISO)

ethanol (ISO)

folic acid (ISO)

glycidol (EXP)

itraconazole (ISO)

ketoconazole (ISO)

L-methionine (ISO)

morphine (ISO)

nicotine (ISO)

paraquat (EXP)

Soman (EXP)

valproic acid (EXP)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating G protein-coupled receptor signaling pathway (IBA)

G protein-coupled receptor signaling pathway (TAS)

positive regulation of cytosolic calcium ion concentration (ISO)

regulation of metabolic process (IBA)

sphingosine-1-phosphate receptor signaling pathway (ISO)

Cellular Component

cytoplasm (IBA)

plasma membrane (IBA)

Molecular Function

sphingosine-1-phosphate receptor activity (IBA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Temporally and spatially regulated expression of a candidate G-protein-coupled receptor during cerebral cortical development.	Chenn A, etal., J Neurobiol 2001 Feb 15;46(3):167-77.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
4.	Gene Data Set	MGD Curation, June 12, 2002
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	GOA pipeline	RGD automated data pipeline
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Molecular cloning of a novel candidate G protein-coupled receptor from rat brain.	Song ZH, etal., FEBS Lett 1994 Sep 12;351(3):375-9.

Additional References at PubMed

PMID:14592418	PMID:19059244	PMID:23150673	PMID:30376752

Genomics

Comparative Map Data

Gpr6
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	20	46,072,480 - 46,075,251 (-)	NCBI		GRCr8
mRatBN7.2	20	44,489,853 - 44,492,624 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	20	44,489,853 - 44,492,624 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	20	46,274,495 - 46,277,282 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	20	45,933,647 - 45,936,434 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	20	46,658,987 - 46,661,774 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	20	45,813,169 - 45,815,940 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	20	45,813,169 - 45,815,940 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	20	47,518,790 - 47,521,561 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	20	45,290,688 - 45,293,459 (-)	NCBI		Celera
Cytogenetic Map	20	q12	NCBI

GPR6
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	109,978,311 - 109,980,720 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	6	109,978,256 - 109,980,720 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	110,299,514 - 110,301,923 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	110,406,991 - 110,408,616 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	110,406,989 - 110,408,615	NCBI
Celera	6	111,046,984 - 111,048,609 (+)	NCBI		Celera
Cytogenetic Map	6	q21	NCBI
HuRef	6	107,866,913 - 107,868,538 (+)	NCBI		HuRef
CHM1_1	6	110,563,521 - 110,565,146 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	111,156,757 - 111,159,166 (+)	NCBI		T2T-CHM13v2.0

Gpr6
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	40,945,973 - 40,948,286 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	40,945,973 - 40,948,281 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	41,069,977 - 41,072,290 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	41,069,977 - 41,072,285 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	10	40,790,299 - 40,791,390 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	10	40,758,908 - 40,759,999 (-)	NCBI		MGSCv36	mm8
Celera	10	41,965,591 - 41,966,682 (-)	NCBI		Celera
Cytogenetic Map	10	B1	NCBI
cM Map	10	22.08	NCBI

Gpr6
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955411	34,781,598 - 34,783,926 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955411	34,781,598 - 34,783,926 (+)	NCBI	ChiLan1.0	ChiLan1.0

GPR6
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	5	129,988,862 - 129,991,268 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	6	127,875,740 - 127,879,745 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	6	107,783,260 - 107,785,662 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	6	111,825,742 - 111,828,202 (+)	NCBI	panpan1.1	PanPan1.1	panPan2

GPR6
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	12	66,721,466 - 66,723,153 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	12	66,720,606 - 66,723,157 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	12	66,541,151 - 66,542,732 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	12	67,606,543 - 67,608,124 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	12	66,954,314 - 66,955,894 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	12	66,803,410 - 66,804,991 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	12	67,075,134 - 67,076,715 (+)	NCBI		UU_Cfam_GSD_1.0

Gpr6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404946	101,660,014 - 101,663,023 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936564	5,935,216 - 5,937,647 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936564	5,935,216 - 5,937,647 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GPR6
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1	1	75,979,360 - 75,982,036 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	1	85,202,296 - 85,204,602 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GPR6
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	63,909,222 - 63,911,725 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	63,909,793 - 63,910,881 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666040	36,193,313 - 36,196,044 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gpr6
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624916	1,042,798 - 1,045,180 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624916	1,042,193 - 1,045,191 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Gpr6
8 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	124
Count of miRNA genes:	106
Interacting mature miRNAs:	110
Transcripts:	ENSRNOT00000073276
Prediction methods:	Miranda, Rnahybrid
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2305926	Iddm37	Insulin dependent diabetes mellitus QTL 37	6		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	20	1527842	46527842	Rat
1641915	Colcr9	Colorectal carcinoma resistance QTL 9	2.97	0.0024	intestine integrity trait (VT:0010554)	benign colorectal tumor number (CMO:0001795)	20	1530655	46530655	Rat
1598816	Memor12	Memory QTL 12	2.4		exploratory behavior trait (VT:0010471)	average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)	20	2606836	47606836	Rat
7411652	Foco24	Food consumption QTL 24		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	20	11757515	54435887	Rat
9590092	Insglur9	Insulin/glucose ratio QTL 9	18.38	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	20	11757515	54435887	Rat
4889610	Pancm3	Pancreatic morphology QTL 3	3.75	0.001	pancreas mass (VT:0010144)	pancreas wet weight (CMO:0000626)	20	17617832	47606836	Rat
2317880	Alcrsp25	Alcohol response QTL 25	2.3		response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	20	17697550	54435887	Rat
2303626	Vencon10	Ventilatory control QTL 10		0.001	respiration trait (VT:0001943)	respiration rate (CMO:0000289)	20	19190721	54435887	Rat
2303578	Gluco50	Glucose level QTL 50	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	20	25106722	54435887	Rat
2303587	Bw93	Body weight QTL 93	13		body mass (VT:0001259)	body weight (CMO:0000012)	20	25106722	54435887	Rat
2300188	Bmd68	Bone mineral density QTL 68	6.4	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	20	25106722	54435887	Rat
1331747	Hrtrt16	Heart rate QTL 16	3.163		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	20	25209734	54435887	Rat
1598869	Memor6	Memory QTL 6	3.1		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	20	29244388	54435887	Rat

Markers in Region

RH70579

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	44,490,664 - 44,490,896 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	45,813,981 - 45,814,212	NCBI	Rnor6.0
Rnor_5.0	20	47,519,602 - 47,519,833	UniSTS	Rnor5.0
Celera	20	45,291,500 - 45,291,731	UniSTS

Gpr6

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	44,490,925 - 44,491,207 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	45,814,242 - 45,814,523	NCBI	Rnor6.0
Rnor_5.0	20	47,519,863 - 47,520,144	UniSTS	Rnor5.0
Celera	20	45,291,761 - 45,292,042	UniSTS

UniSTS:489566

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	44,490,848 - 44,491,940 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	45,814,165 - 45,815,256	NCBI	Rnor6.0
Rnor_5.0	20	47,519,786 - 47,520,877	UniSTS	Rnor5.0
Celera	20	45,291,684 - 45,292,775	UniSTS

UniSTS:495955

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	20	44,491,146 - 44,491,255 (+)	MAPPER	mRatBN7.2
Rnor_6.0	20	45,814,463 - 45,814,571	NCBI	Rnor6.0
Rnor_5.0	20	47,520,084 - 47,520,192	UniSTS	Rnor5.0
Celera	20	45,291,982 - 45,292,090	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	endocrine system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	appendage
High
Medium				4
Low				36
Below cutoff	2	1	1	18	4	13	1

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031806	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF064706	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474119	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000020	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U12006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000073276 ⟹ ENSRNOP00000067254

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	20	44,489,853 - 44,492,624 (-)	Ensembl
Rnor_6.0 Ensembl	20	45,813,169 - 45,815,940 (-)	Ensembl

RefSeq Acc Id:

NM_031806 ⟹ NP_113994

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	20	46,072,480 - 46,075,251 (-)	NCBI
mRatBN7.2	20	44,489,853 - 44,492,624 (-)	NCBI
Rnor_6.0	20	45,813,169 - 45,815,940 (-)	NCBI
Rnor_5.0	20	47,518,790 - 47,521,561 (-)	NCBI
Celera	20	45,290,688 - 45,293,459 (-)	RGD

Sequence:

show sequence

CTCAGGGACAGGAGACCAGTACTTTCCTCTTCGACGCGGGGCAGCCTCCTGCAGGCAGCTGCTC
GGACCGCGTAGGGCACACAGCCGCGGAGCGCATGACCAGAGACTCCCGGGAGCCCTGACTCCTC
AGGGAGCAGCATCTGGCGGCGATGAACGCTAGCGCCGCCGCGCTCAACGAGTCCCAGGTGGTGG
CAGTAGCGGCCGAGGGAGCGGCAGCTGCGGCTACAGCAGCAGGGACACCGGACACCAGCGAATG
GGGACCTCCGGCAGCATCCGCGGCGCTGGGAGGCGGCGGAGGACCTAACGGGTCACTGGAGCTG
TCTTCGCAGCTGCCCGCAGGACCCTCAGGACTTCTGCTTTCGGCAGTGAATCCCTGGGATGTGC
TGCTGTGCGTGTCGGGGACTGTGATCGCAGGCGAAAATGCGCTGGTGGTGGCGCTCATCGCATC
CACTCCCGCGCTGCGCACGCCCATGTTTGTGCTCGTGGGTAGTCTGGCCACTGCTGACCTGCTG
GCGGGCTGTGGCCTCATCCTACACTTCGTGTTCCAGTACGTGGTGCCCTCGGAGACTGTGAGCC
TGCTCATGGTGGGCTTCCTGGTGGCGTCCTTCGCCGCCTCAGTCAGCAGCCTGCTCGCTATCAC
AGTGGACCGTTACCTGTCCCTTTACAACGCGCTCACCTACTACTCGCGCCGGACCCTGTTGGGC
GTGCACCTCTTGCTAGCAGCCACCTGGACAGTGTCCCTCGGGTTGGGGTTGCTGCCCGTTCTAG
GCTGGAACTGCTTGGCTGACCGCGCGTCCTGCAGCGTGGTGCGCCCCCTGACACGCAGCCATGT
GGCGTTGCTCTCCACTTCCTTCTTTGTGGTCTTTGGCATCATGCTACACTTGTACGTGCGCATC
TGCCAGGTGGTCTGGCGCCACGCCCACCAGATCGCTTTGCAACAGCACTGCCTAGCACCACCAC
ACTTAGCAGCCACCAGAAAGGGTGTGGGAACTTTGGCCGTGGTGCTAGGCACTTTTGGGGCCAG
CTGGCTGCCCTTCGCCATCTATTGTGTGGTGGGTAGCCAAGAGGACCCGGCCATCTACACCTAT
GCCACCCTGCTGCCTGCCACCTATAACTCCATGATCAATCCCATCATCTATGCCTTCCGCAACC
AGGAGATCCAGCGTGCCTTGTGGCTCCTGTTCTGTGGCTGTTTCCAATCCAAAGTGCCCTTCCG
CTCCAGGTCCCCCAGTGAGGTCTGAAGGGCTCCTCCGTGTCTCCTCACCCACATCACAAATCCA
ACATGCCGGCCTTTGGTGAGCTTCTAGGTGCCTGCTGATGAACTCTTGAGGACTCAGTGGTTCG
GCGCGAGTCTGACTGCCCCGCAAAGGGACTGGATGTGAACGCAACAAACTGACTCAGACAAAGA
GGCTTGTTGGCATTTTACATATACAGTGTATACACGTGTACATATATATACAAATATTTGTATC
TTCTGGAGGTGTTCAGGGCCTGGAGCTTCCCGTTCTGTGAAAAAAACTAACAAAATGTGGTTGT
ATACTCAATCGTACATCACATTTGTCAAGTGAAGACATTCCAATACTGCTTAATAATAGCACTT
TATTTTTAGCTGCTGAAATGCCAAGACAGTGTTGCCATCCCCAAGAGCAGGAGAAAGGGAGTCA
GAGATGTATTTTTGTTGTATGTGATAGAATATTTTGCTGCACATGCATCAGTAAACTACAACAT
ATTTTGTACACAAATAAACACATTATAAAAGTATGATCTTGGGTATGTGATAAATTGTGGCATT
GTTTGGAATCTGAATTGTGAGTGTGTTTATTTTAAAAGTCTACTGCACATCTATCTATCATCTG
TCCCAGGGAGAGCCACATGAAATACCAGATCTAAACCATGGGATGAGGCAGTAACATTCATGAG
TCATGGAGGAAGTAACATTCACACGTGGCATCCCCAGAACACGAGAAGGAAGGCTGTTACTGGT
GCAAGTTAATGTGCTCTCTTGGTGGCCGGGTTGGGAAGACATGTTTCAGAGGTCAAAACAATTC
AAGTCACATAGGCACAGGTGTAAACTCTGAAGCCACAACTTACCAGCATAACTTTACAAACATG
CCAAGATTTCTCAACATGGCTTATTCAGACTGTTGCTACCCAGGTCTGGTAGCCAGGTGCAGAG
CCCAATAAAACCAATAAAATTCTCCTAAAGCAGGATTCCCAGATCTTCATGGGGTAACTG

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Protein Sequences


Protein RefSeqs	NP_113994	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA21870	(Get FASTA)	NCBI Sequence Viewer
	AAC16886	(Get FASTA)	NCBI Sequence Viewer
	EDL83244	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000067254
	ENSRNOP00000067254.1
	ENSRNOP00055000913
	ENSRNOP00060008654
	ENSRNOP00065010239
GenBank Protein	P51651	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_113994 ⟸ NM_031806

- UniProtKB:

P51651 (UniProtKB/Swiss-Prot), A6KTC7 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MNASAAALNESQVVAVAAEGAAAAATAAGTPDTSEWGPPAASAALGGGGGPNGSLELSSQLPAG
PSGLLLSAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLIL
HFVFQYVVPSETVSLLMVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLAA
TWTVSLGLGLLPVLGWNCLADRASCSVVRPLTRSHVALLSTSFFVVFGIMLHLYVRICQVVWRH
AHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCVVGSQEDPAIYTYATLLPAT
YNSMINPIIYAFRNQEIQRALWLLFCGCFQSKVPFRSRSPSEV

hide sequence

RefSeq Acc Id:

ENSRNOP00000067254 ⟸ ENSRNOT00000073276

Protein Domains

G-protein coupled receptors family 1 profile

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P51651-F1-model_v2	AlphaFold	P51651	1-363	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:70939	AgrOrtholog
BioCyc Gene	G2FUF-3410	BioCyc
Ensembl Genes	ENSRNOG00000049580	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
	ENSRNOG00055000679	UniProtKB/Swiss-Prot
	ENSRNOG00060007021	UniProtKB/Swiss-Prot
	ENSRNOG00065008683	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000073276	ENTREZGENE
	ENSRNOT00000073276.2	UniProtKB/Swiss-Prot
	ENSRNOT00055001158	UniProtKB/Swiss-Prot
	ENSRNOT00060011533	UniProtKB/Swiss-Prot
	ENSRNOT00065013790	UniProtKB/Swiss-Prot
Gene3D-CATH	Rhodopsin 7-helix transmembrane proteins	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	GPCR_Rhodpsn	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPCR_Rhodpsn_7TM	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPR6	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPR_3/6/12_orphan	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:83683	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	83683	ENTREZGENE
PANTHER	G-PROTEIN COUPLED RECEPTOR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G-PROTEIN COUPLED RECEPTOR 6	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	7tm_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Gpr6	PhenoGen
PRINTS	GPCRRHODOPSN	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPR6ORPHANR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	GPRORPHANR	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	G_PROTEIN_RECEP_F1_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	G_PROTEIN_RECEP_F1_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000049580	RatGTEx
	ENSRNOG00055000679	RatGTEx
	ENSRNOG00060007021	RatGTEx
	ENSRNOG00065008683	RatGTEx
SMART	7TM_GPCR_Srsx	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	Family A G protein-coupled receptor-like	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A6KTC7	ENTREZGENE, UniProtKB/TrEMBL
	GPR6_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-07-09	Gpr6	G protein-coupled receptor 6			Symbol and Name updated to reflect Human and Mouse nomenclature	70877	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	enriched in layers 2-4 of the young cortex and in the developing and adult striatum	70753

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar