Klf9 (KLF transcription factor 9) - Rat Genome Database

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Gene: Klf9 (KLF transcription factor 9) Rattus norvegicus
Analyze
Symbol: Klf9
Name: KLF transcription factor 9
RGD ID: 70934
Description: Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to endothelin. Predicted to be located in nucleus. Orthologous to human KLF9 (KLF transcription factor 9); INTERACTS WITH 17beta-estradiol; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Basic transcription element binding protein; basic transcription element binding protein 1; basic transcription element-binding protein 1; BTE-binding protein 1; Bteb; Bteb1; GC-box-binding protein 1; Krueppel-like factor 9; Kruppel-like factor 9; transcription factor BTEB1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81230,126,646 - 230,151,641 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1230,126,646 - 230,151,641 (+)EnsemblGRCr8
mRatBN7.21220,700,108 - 220,725,110 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1220,700,108 - 220,725,037 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1229,139,267 - 229,164,252 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01236,069,326 - 236,094,314 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01228,887,366 - 228,912,356 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01240,908,483 - 240,933,198 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1240,908,483 - 240,933,198 (+)Ensemblrn6Rnor6.0
Rnor_5.01248,193,534 - 248,218,136 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41226,420,949 - 226,446,376 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1217,916,709 - 217,941,816 (+)NCBICelera
RGSC_v3.11226,584,971 - 226,610,399 (+)NCBI
Cytogenetic Map1q51NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,1-dichloroethene  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
3,3',5-triiodo-L-thyronine  (ISO)
3,4-methylenedioxymethamphetamine  (EXP)
3-isobutyl-1-methyl-7H-xanthine  (ISO)
3-methylcholanthrene  (ISO)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-tert-Octylphenol  (EXP)
5-aza-2'-deoxycytidine  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
acetaldehyde  (EXP)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (ISO)
allicin  (ISO)
amitrole  (EXP,ISO)
ammonium chloride  (EXP)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
Aroclor 1254  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
belinostat  (ISO)
benzo[a]pyrene  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP,ISO)
bisphenol A  (EXP,ISO)
bromobenzene  (EXP)
buspirone  (EXP)
buta-1,3-diene  (ISO)
butan-1-ol  (ISO)
C60 fullerene  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
calciol  (ISO)
carbon nanotube  (ISO)
casticin  (ISO)
CGP 52608  (ISO)
chloroprene  (EXP,ISO)
choline  (ISO)
chromium(6+)  (ISO)
ciguatoxin CTX1B  (ISO)
cisplatin  (ISO)
clobetasol  (ISO)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (ISO)
corticosterone  (EXP)
coumestrol  (ISO)
crocidolite asbestos  (ISO)
cyclosporin A  (ISO)
D-glucose  (ISO)
DDE  (ISO)
dexamethasone  (ISO)
diarsenic trioxide  (ISO)
dibutyl phthalate  (ISO)
dieldrin  (EXP)
diethylstilbestrol  (EXP)
dimethoate  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
endosulfan  (EXP)
Enterolactone  (ISO)
entinostat  (ISO)
ethanol  (EXP,ISO)
flavonoids  (EXP)
fluoranthene  (ISO)
flutamide  (EXP)
folic acid  (ISO)
furan  (EXP)
gamma-hexachlorocyclohexane  (EXP)
gentamycin  (EXP)
glucose  (ISO)
GSK-J4  (ISO)
hydrogen peroxide  (ISO)
indometacin  (ISO)
iodoacetic acid  (ISO)
irinotecan  (ISO)
ketamine  (EXP)
L-methionine  (ISO)
lead diacetate  (EXP)
lead(0)  (ISO)
leflunomide  (ISO)
levofloxacin  (EXP)
manganese atom  (ISO)
manganese(0)  (ISO)
manganese(II) chloride  (ISO)
mercury dibromide  (ISO)
metformin  (EXP)
methimazole  (EXP,ISO)
methylmercury chloride  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
niclosamide  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
ozone  (ISO)
p-chloromercuribenzoic acid  (ISO)
p-tert-Amylphenol  (EXP)
paracetamol  (EXP,ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
phenobarbital  (EXP,ISO)
phenylarsine oxide  (ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
progesterone  (EXP)
propiconazole  (ISO)
resveratrol  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
sevoflurane  (EXP)
silicon dioxide  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sulfadimethoxine  (EXP)
sulforaphane  (EXP,ISO)
tamibarotene  (ISO)
tamoxifen  (ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
testosterone  (ISO)
tetrachloroethene  (ISO)
tetrachloromethane  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
Tributyltin oxide  (EXP)
trichloroethene  (EXP)
trichostatin A  (ISO)
triclosan  (ISO)
trimellitic anhydride  (ISO)
triphenyl phosphate  (ISO)
troglitazone  (ISO)
trovafloxacin  (EXP)
tunicamycin  (ISO)
urethane  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vitamin E  (ISO)
vorinostat  (ISO)
zinc atom  (EXP,ISO)
zinc sulfate  (EXP)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
nucleoplasm  (IEA,ISO)
nucleus  (IBA,IEA,ISO,ISS)

References

References - curated
# Reference Title Reference Citation
1. Differential regulation of Kruppel-like factor family transcription factor expression in neonatal rat cardiac myocytes: effects of endothelin-1, oxidative stress and cytokines. Cullingford TE, etal., Biochim Biophys Acta. 2008 Jun;1783(6):1229-36. Epub 2008 Mar 25.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Two regulatory proteins that bind to the basic transcription element (BTE), a GC box sequence in the promoter region of the rat P-4501A1 gene. Imataka H, etal., EMBO J 1992 Oct;11(10):3663-71.
4. Gene Data Set MGD Curation, June 12, 2002
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Molecular markers of endometrial epithelial cell mitogenesis mediated by the Sp/Kruppel-like factor BTEB1. Simmen RC, etal., DNA Cell Biol 2002 Feb;21(2):115-28.
Additional References at PubMed
PMID:9858544   PMID:15117941   PMID:19375645   PMID:22711835   PMID:27561292   PMID:28871032   PMID:29860460   PMID:30315936   PMID:31295469   PMID:36109428   PMID:36359788  


Genomics

Comparative Map Data
Klf9
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81230,126,646 - 230,151,641 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1230,126,646 - 230,151,641 (+)EnsemblGRCr8
mRatBN7.21220,700,108 - 220,725,110 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1220,700,108 - 220,725,037 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1229,139,267 - 229,164,252 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01236,069,326 - 236,094,314 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01228,887,366 - 228,912,356 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01240,908,483 - 240,933,198 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1240,908,483 - 240,933,198 (+)Ensemblrn6Rnor6.0
Rnor_5.01248,193,534 - 248,218,136 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41226,420,949 - 226,446,376 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1217,916,709 - 217,941,816 (+)NCBICelera
RGSC_v3.11226,584,971 - 226,610,399 (+)NCBI
Cytogenetic Map1q51NCBI
KLF9
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38970,384,604 - 70,414,657 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl970,384,604 - 70,414,657 (-)Ensemblhg38GRCh38
GRCh37972,999,520 - 73,029,573 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36972,189,333 - 72,219,393 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34970,229,068 - 70,259,127NCBI
Celera943,589,868 - 43,619,934 (-)NCBICelera
Cytogenetic Map9q21.12NCBI
HuRef942,839,584 - 42,869,749 (-)NCBIHuRef
CHM1_1973,146,053 - 73,176,110 (-)NCBICHM1_1
T2T-CHM13v2.0982,551,421 - 82,581,475 (-)NCBIT2T-CHM13v2.0
Klf9
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391923,118,590 - 23,145,493 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1923,118,590 - 23,145,498 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381923,141,226 - 23,168,129 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1923,141,226 - 23,168,134 (+)Ensemblmm10GRCm38
MGSCv371923,215,716 - 23,241,401 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361923,208,323 - 23,234,008 (+)NCBIMGSCv36mm8
Celera1923,874,123 - 23,899,734 (+)NCBICelera
Cytogenetic Map19BNCBI
cM Map1917.9NCBI
Klf9
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554342,685,416 - 2,716,669 (+)Ensembl
ChiLan1.0NW_0049554342,685,416 - 2,716,669 (+)NCBIChiLan1.0ChiLan1.0
KLF9
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21169,584,860 - 69,617,616 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1969,590,799 - 69,620,489 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0954,387,404 - 54,417,095 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1969,142,283 - 69,170,658 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl969,142,283 - 69,170,664 (-)EnsemblpanPan2panpan1.1
KLF9
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1187,109,310 - 87,164,636 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl187,109,450 - 87,111,525 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha187,581,041 - 87,603,438 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0187,660,844 - 87,683,331 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl187,660,922 - 87,683,173 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1187,315,854 - 87,338,222 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0187,021,569 - 87,044,167 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0187,779,152 - 87,801,513 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Klf9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947134,624,963 - 134,652,341 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365036,517,687 - 6,548,336 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365036,517,748 - 6,553,532 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KLF9
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1223,720,435 - 223,748,621 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.11223,723,613 - 223,747,661 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21250,030,719 - 250,054,070 (+)NCBISscrofa10.2Sscrofa10.2susScr3
KLF9
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11281,451,210 - 81,481,384 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1281,454,394 - 81,480,094 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603869,866,543 - 69,896,756 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Klf9
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247362,654,220 - 2,682,673 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247362,653,336 - 2,682,677 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Klf9
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1223,203,779 - 23,227,088 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Klf9
70 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:139
Count of miRNA genes:99
Interacting mature miRNAs:122
Transcripts:ENSRNOT00000019367
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8693637Alc29Alcohol consumption QTL 292.70.258drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367243666627Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
5508828Leukc3Leukocyte quantity QTL 3eosinophil quantity (VT:0002602)blood eosinophil count (CMO:0000033)1227535119233480676Rat
61455Niddm7Non-insulin dependent diabetes mellitus QTL 75.5blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1223964326248681945Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
8693661Alc34Alcohol consumption QTL 342.20.611drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367238041033Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228180243255849249Rat
1331790Bp201Blood pressure QTL 2013.127arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1221820316234540296Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
634340Hcar5Hepatocarcinoma resistance QTL 58liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1223964326236074012Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
8693618Alc25Alcohol consumption QTL 2530.28drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1217412367238041033Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat

Markers in Region
D1Got222  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21220,720,366 - 220,720,548 (+)MAPPERmRatBN7.2
Rnor_6.01240,928,740 - 240,928,923NCBIRnor6.0
Rnor_5.01248,213,678 - 248,213,861UniSTSRnor5.0
RGSC_v3.41226,441,750 - 226,441,934RGDRGSC3.4
RGSC_v3.41226,441,751 - 226,441,934UniSTSRGSC3.4
Celera1217,937,154 - 217,937,337UniSTS
RGSC_v3.11226,605,773 - 226,605,957RGD
RH 2.0 Map21174.2RGD
Cytogenetic Map1q51UniSTS
RH144179  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21220,708,998 - 220,709,132 (+)MAPPERmRatBN7.2
Rnor_6.01240,917,374 - 240,917,507NCBIRnor6.0
Rnor_5.01248,202,312 - 248,202,445UniSTSRnor5.0
RGSC_v3.41226,430,478 - 226,430,611UniSTSRGSC3.4
Celera1217,925,787 - 217,925,920UniSTS
RH 3.4 Map11614.1UniSTS
Cytogenetic Map1q51UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 165 91 90 59 92 59 6 356 192 11 144 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000019367   ⟹   ENSRNOP00000019367
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1230,126,646 - 230,151,641 (+)Ensembl
mRatBN7.2 Ensembl1220,700,108 - 220,725,037 (+)Ensembl
Rnor_6.0 Ensembl1240,908,483 - 240,933,198 (+)Ensembl
RefSeq Acc Id: NM_057211   ⟹   NP_476559
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81230,126,646 - 230,151,641 (+)NCBI
mRatBN7.21220,700,108 - 220,725,110 (+)NCBI
Rnor_6.01240,908,483 - 240,933,198 (+)NCBI
Rnor_5.01248,193,534 - 248,218,136 (+)NCBI
RGSC_v3.41226,420,949 - 226,446,376 (+)RGD
Celera1217,916,709 - 217,941,816 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_476559 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein BAA02236 (Get FASTA)   NCBI Sequence Viewer  
  EDM13014 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000019367
GenBank Protein Q01713 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_476559   ⟸   NM_057211
- UniProtKB: Q01713 (UniProtKB/Swiss-Prot),   G3V7U5 (UniProtKB/TrEMBL),   A6I0N3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000019367   ⟸   ENSRNOT00000019367
Protein Domains
C2H2-type

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q01713-F1-model_v2 AlphaFold Q01713 1-244 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690819
Promoter ID:EPDNEW_R1343
Type:initiation region
Name:Klf9_1
Description:Kruppel-like factor 9
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01240,908,435 - 240,908,495EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70934 AgrOrtholog
BioCyc Gene G2FUF-56119 BioCyc
Ensembl Genes ENSRNOG00000014215 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000019367 ENTREZGENE
Gene3D-CATH Classic Zinc Finger UniProtKB/Swiss-Prot
InterPro Znf_C2H2_sf UniProtKB/Swiss-Prot
  Znf_C2H2_type UniProtKB/Swiss-Prot
KEGG Report rno:117560 UniProtKB/Swiss-Prot
NCBI Gene 117560 ENTREZGENE
PANTHER KRUEPPEL-LIKE FACTOR 9 UniProtKB/Swiss-Prot
  KRUEPPEL-LIKE TRANSCRIPTION FACTOR UniProtKB/Swiss-Prot
Pfam zf-C2H2 UniProtKB/Swiss-Prot
PhenoGen Klf9 PhenoGen
PROSITE ZINC_FINGER_C2H2_1 UniProtKB/Swiss-Prot
  ZINC_FINGER_C2H2_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000014215 RatGTEx
SMART ZnF_C2H2 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF57667 UniProtKB/Swiss-Prot
UniProt A6I0N3 ENTREZGENE, UniProtKB/TrEMBL
  G3V7U5 ENTREZGENE, UniProtKB/TrEMBL
  KLF9_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2022-10-03 Klf9  KLF transcription factor 9  Klf9  Kruppel-like factor 9  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Klf9  Kruppel-like factor 9  Bteb1  basic transcription element binding protein 1  Symbol and Name updated 1299863 APPROVED
2004-09-10 Bteb1  basic transcription element binding protein 1  Klf9  Kruppel-like factor 9  Symbol and Name updated 1299863 APPROVED
2002-07-09 Klf9  Kruppel-like factor 9      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process regulates transcription to influence cellular homeostasis 633047