Dgkz (diacylglycerol kinase zeta) - Rat Genome Database

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Gene: Dgkz (diacylglycerol kinase zeta) Rattus norvegicus
Analyze
Symbol: Dgkz
Name: diacylglycerol kinase zeta
RGD ID: 70929
Description: Enables ATP-dependent diacylglycerol kinase activity. Predicted to be involved in several processes, including glycerolipid metabolic process; lipid phosphorylation; and maintenance of postsynaptic density structure. Predicted to act upstream of or within negative regulation of Ras protein signal transduction. Is active in glutamatergic synapse and postsynaptic density. Orthologous to human DGKZ (diacylglycerol kinase zeta); PARTICIPATES IN glycerolipid metabolic pathway; glycerophospholipid metabolic pathway; phosphatidylinositol 3-kinase signaling pathway; INTERACTS WITH 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 104 kDa diacylglycerol kinase; DAG kinase zeta; DGK-IV; DGK-zeta; diglyceride kinase zeta
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8398,359,804 - 98,401,847 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl398,359,804 - 98,401,951 (-)EnsemblGRCr8
mRatBN7.2377,904,149 - 77,946,114 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,904,150 - 77,946,099 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx381,379,328 - 81,409,244 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,978,358 - 90,008,274 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,829,580 - 87,859,521 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0380,844,002 - 80,886,487 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl380,844,005 - 80,875,817 (-)Ensemblrn6Rnor6.0
Rnor_5.0387,542,666 - 87,584,698 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4376,312,721 - 76,342,603 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera377,106,807 - 77,136,681 (-)NCBICelera
RGSC_v3.1376,209,092 - 76,238,975 (-)NCBI
Cytogenetic Map3q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,6-dinitrotoluene  (EXP)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3,4-methylenedioxymethamphetamine  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
aristolochic acid A  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
benzo[a]pyrene  (ISO)
benzo[e]pyrene  (ISO)
beta-lapachone  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Butylbenzyl phthalate  (EXP)
caffeine  (ISO)
camptothecin  (ISO)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloroprene  (ISO)
chlorpyrifos  (ISO)
copper(II) chloride  (ISO)
Cuprizon  (EXP)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (ISO)
disodium selenite  (ISO)
doxorubicin  (ISO)
ethanol  (ISO)
flutamide  (EXP)
fulvestrant  (ISO)
gentamycin  (EXP)
indometacin  (EXP)
lead diacetate  (ISO)
lead(0)  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methoxychlor  (EXP)
N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine  (ISO)
nefazodone  (EXP)
nitrates  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
paracetamol  (EXP,ISO)
phenylephrine  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP)
propiconazole  (ISO)
resveratrol  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
Soman  (EXP)
taurine  (ISO)
tetrachloromethane  (ISO)
titanium dioxide  (ISO)
Tributyltin oxide  (EXP)
triphenyl phosphate  (ISO)
valproic acid  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (IEA,ISO,ISS)
glutamatergic synapse  (IBA,IDA,IEP,ISO)
lamellipodium  (IEA,ISO)
nuclear speck  (IEA,ISO)
nucleus  (IEA,ISO)
plasma membrane  (IBA,IEA)
postsynaptic density  (IDA,IEP)
Schaffer collateral - CA1 synapse  (ISO)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. A 104-kDa diacylglycerol kinase containing ankyrin-like repeats localizes in the cell nucleus. Goto K and Kondo H, Proc Natl Acad Sci U S A 1996 Oct 1;93(20):11196-201.
4. Gene cloning, sequence, expression and in situ localization of 80 kDa diacylglycerol kinase specific to oligodendrocyte of rat brain. Goto K, etal., Brain Res Mol Brain Res 1992 Nov;16(1-2):75-87.
5. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
6. Synaptic removal of diacylglycerol by DGKzeta and PSD-95 regulates dendritic spine maintenance. Kim K, etal., EMBO J. 2009 Apr 22;28(8):1170-9. doi: 10.1038/emboj.2009.44. Epub 2009 Feb 19.
7. Diacylglycerol kinase zeta regulates phosphatidylinositol 4-phosphate 5-kinase Ialpha by a novel mechanism. Luo B, etal., Cell Signal. 2004 Aug;16(8):891-7. doi: 10.1016/j.cellsig.2004.01.010.
8. Gene Data Set MGD Curation, June 12, 2002
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Cellular expression and localization of DGKzeta-interacting NAP1-like proteins in the brain and functional implications under hypoxic stress. Takahashi N, etal., Histochem Cell Biol. 2014 Nov;142(5):461-71. doi: 10.1007/s00418-014-1226-x. Epub 2014 Jun 4.
Additional References at PubMed
PMID:12477932   PMID:14511325   PMID:15542238   PMID:15544348   PMID:15781737   PMID:15894621   PMID:16286473   PMID:16380548   PMID:17664281   PMID:18004883   PMID:19520144   PMID:19744926  
PMID:21183507   PMID:21362459   PMID:21938675   PMID:22234382   PMID:22627129   PMID:23467923   PMID:27739494   PMID:30053369   PMID:34312706  


Genomics

Comparative Map Data
Dgkz
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8398,359,804 - 98,401,847 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl398,359,804 - 98,401,951 (-)EnsemblGRCr8
mRatBN7.2377,904,149 - 77,946,114 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl377,904,150 - 77,946,099 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx381,379,328 - 81,409,244 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0389,978,358 - 90,008,274 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0387,829,580 - 87,859,521 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0380,844,002 - 80,886,487 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl380,844,005 - 80,875,817 (-)Ensemblrn6Rnor6.0
Rnor_5.0387,542,666 - 87,584,698 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4376,312,721 - 76,342,603 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera377,106,807 - 77,136,681 (-)NCBICelera
RGSC_v3.1376,209,092 - 76,238,975 (-)NCBI
Cytogenetic Map3q24NCBI
DGKZ
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381146,332,926 - 46,380,554 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1146,332,905 - 46,380,554 (+)Ensemblhg38GRCh38
GRCh371146,354,476 - 46,402,104 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361146,311,315 - 46,358,680 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341146,323,562 - 46,358,680NCBI
Celera1146,502,317 - 46,549,682 (+)NCBICelera
Cytogenetic Map11p11.2NCBI
HuRef1146,061,412 - 46,109,062 (+)NCBIHuRef
CHM1_11146,352,750 - 46,400,540 (+)NCBICHM1_1
T2T-CHM13v2.01146,489,001 - 46,536,630 (+)NCBIT2T-CHM13v2.0
Dgkz
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39291,763,167 - 91,806,788 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl291,763,169 - 91,806,209 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38291,932,822 - 91,976,443 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl291,932,824 - 91,975,864 (-)Ensemblmm10GRCm38
MGSCv37291,772,979 - 91,803,720 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36291,733,665 - 91,764,438 (-)NCBIMGSCv36mm8
Celera293,323,226 - 93,354,092 (-)NCBICelera
Cytogenetic Map2E1NCBI
cM Map250.63NCBI
Dgkz
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554221,657,926 - 1,695,404 (-)Ensembl
ChiLan1.0NW_0049554221,658,237 - 1,687,000 (-)NCBIChiLan1.0ChiLan1.0
DGKZ
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2948,546,486 - 48,593,658 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11148,553,316 - 48,600,485 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01146,291,592 - 46,339,127 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11146,841,605 - 46,889,763 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1146,841,605 - 46,889,763 (+)EnsemblpanPan2panpan1.1
DGKZ
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11843,088,169 - 43,103,820 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1843,088,525 - 43,129,294 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1841,816,433 - 41,857,562 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01843,743,999 - 43,785,151 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1843,744,000 - 43,785,151 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11843,228,986 - 43,270,069 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01842,780,862 - 42,821,933 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01843,514,095 - 43,555,174 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Dgkz
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494720,579,265 - 20,621,717 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365622,690,858 - 2,733,620 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365622,690,907 - 2,733,455 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DGKZ
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl216,134,048 - 16,176,238 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1216,134,046 - 16,176,043 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2217,480,094 - 17,495,716 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DGKZ
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1118,949,360 - 18,997,957 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl118,948,425 - 18,982,354 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038116,234,046 - 116,283,086 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Dgkz
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247672,173,272 - 2,210,279 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046247672,173,774 - 2,210,304 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Dgkz
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1566,077,198 - 66,118,831 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Dgkz
197 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:256
Count of miRNA genes:168
Interacting mature miRNAs:192
Transcripts:ENSRNOT00000024280
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300178Hrtrt4Heart rate QTL 43.74heart pumping trait (VT:2000009)heart rate (CMO:0000002)351490129111359995Rat
1358293Bw38Body weight QTL 3860.0000031body mass (VT:0001259)body weight (CMO:0000012)374364268119364268Rat
61377Edpm3Estrogen-dependent pituitary mass QTL 37.050.038pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)373592611110333156Rat
2301414Kidm37Kidney mass QTL 370.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)396509147141509147Rat
1582238Bw68Body weight QTL 683.20.0064body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582239Epfw1Epididymal fat weight QTL 14.50.0006epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)373592512136118980Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
1354589Bw31Body weight QTL 313.3body mass (VT:0001259)body weight (CMO:0000012)35365182698651826Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1358362Srcrt2Stress Responsive Cort QTL 22.78blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)358601291153936591Rat
737818Hcar12Hepatocarcinoma resistance QTL 122.6liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)349872657138829559Rat
1582218Bw74Body weight QTL 743.90.0021body mass (VT:0001259)body weight (CMO:0000012)373592512136118980Rat
1582221Kidm30Kidney mass QTL 303.50.0008kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)385062224136118980Rat
1582210Bw71Body weight QTL 713.30.0012body mass (VT:0001259)body weight (CMO:0000012)385062224136118980Rat
1300111Rf12Renal function QTL 123.78renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)381425008141509147Rat
724523Tsu1Thymus enlargement suppressive QTL 13.84thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)370845569136091483Rat
1600376Arunc5Aerobic running capacity QTL 50.21exercise endurance trait (VT:0002332)longest distance run on treadmill (CMO:0001406)393829559138829559Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1581503Cm58Cardiac mass QTL 582.70.05heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)396509147141509147Rat
2292613Ept16Estrogen-induced pituitary tumorigenesis QTL 168.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat
738019Anxrr10Anxiety related response QTL 103.9exploratory behavior trait (VT:0010471)number of entries into a discrete space in an experimental apparatus (CMO:0000960)358925062103925062Rat
631841Niddm39Non-insulin dependent diabetes mellitus QTL 393.36blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)370311536115311536Rat
631200Cm25Cardiac mass QTL 254.80.0001heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)381541464126563126Rat
12879848Bw181Body weght QTL 1810.015body mass (VT:0001259)body weight (CMO:0000012)390755164141509147Rat
1358905Hrtrt17Heart rate QTL 175.90.000014heart pumping trait (VT:2000009)heart rate (CMO:0000002)336721849110333156Rat
1354597Kidm13Kidney mass QTL 132.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)342158111124558371Rat
1358885Bp251Blood pressure QTL 2513.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)31141509147Rat
1354604Bw36Body weight QTL 362.9body mass (VT:0001259)body weight (CMO:0000012)342158111124558371Rat
1358888Bp264Blood pressure QTL 2644.43arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)35675975141509147Rat
1358186Ept2Estrogen-induced pituitary tumorigenesis QTL 28.3pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)367641995130815812Rat

Markers in Region
RH141843  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2377,904,240 - 77,904,422 (+)MAPPERmRatBN7.2
Rnor_6.0380,844,088 - 80,844,269NCBIRnor6.0
Rnor_5.0387,542,756 - 87,542,937UniSTSRnor5.0
RGSC_v3.4376,312,804 - 76,312,985UniSTSRGSC3.4
Celera377,106,890 - 77,107,071UniSTS
Cytogenetic Map3q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 164 91 90 59 92 59 6 356 192 11 143 81 92 31 17 17

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001415152 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429512 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001429513 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_031143 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006234594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008762037 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592062 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105924 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039105926 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063284642 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005501992 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC135645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC169029 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473949 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D78588 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ228570 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000024280   ⟹   ENSRNOP00000024280
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl398,359,804 - 98,389,702 (-)Ensembl
mRatBN7.2 Ensembl377,904,158 - 77,934,040 (-)Ensembl
Rnor_6.0 Ensembl380,844,005 - 80,873,887 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000091265   ⟹   ENSRNOP00000074012
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl398,359,804 - 98,391,810 (-)Ensembl
mRatBN7.2 Ensembl377,904,150 - 77,936,017 (-)Ensembl
Rnor_6.0 Ensembl380,844,033 - 80,875,817 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000095998   ⟹   ENSRNOP00000087400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl398,359,804 - 98,377,008 (-)Ensembl
mRatBN7.2 Ensembl377,904,150 - 77,921,396 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000112973   ⟹   ENSRNOP00000090177
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl398,359,804 - 98,389,702 (-)Ensembl
mRatBN7.2 Ensembl377,904,158 - 77,934,040 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000117598   ⟹   ENSRNOP00000097565
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl398,359,804 - 98,401,951 (-)Ensembl
mRatBN7.2 Ensembl377,904,150 - 77,946,099 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000142538   ⟹   ENSRNOP00000111485
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl398,359,804 - 98,391,658 (-)Ensembl
RefSeq Acc Id: NM_001415152   ⟹   NP_001402081
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8398,359,804 - 98,391,810 (-)NCBI
mRatBN7.2377,904,149 - 77,936,156 (-)NCBI
RefSeq Acc Id: NM_031143   ⟹   NP_112405
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8398,359,804 - 98,389,702 (-)NCBI
mRatBN7.2377,904,149 - 77,934,047 (-)NCBI
Rnor_6.0380,844,005 - 80,873,887 (-)NCBI
Rnor_5.0387,542,666 - 87,584,698 (-)NCBI
RGSC_v3.4376,312,721 - 76,342,603 (-)RGD
Celera377,106,807 - 77,136,681 (-)RGD
Sequence:
RefSeq Acc Id: XM_006234594   ⟹   XP_006234656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8398,359,812 - 98,377,089 (-)NCBI
mRatBN7.2377,904,157 - 77,921,306 (-)NCBI
Rnor_6.0380,844,002 - 80,861,262 (-)NCBI
Rnor_5.0387,542,666 - 87,584,698 (-)NCBI
Sequence:
RefSeq Acc Id: XM_017592062   ⟹   XP_017447551
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8398,359,812 - 98,401,847 (-)NCBI
mRatBN7.2377,904,151 - 77,946,114 (-)NCBI
Rnor_6.0380,844,002 - 80,886,487 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039105924   ⟹   XP_038961852
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8398,361,252 - 98,373,328 (-)NCBI
mRatBN7.2377,905,553 - 77,918,115 (-)NCBI
RefSeq Acc Id: XM_039105926   ⟹   XP_038961854
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8398,359,812 - 98,391,604 (-)NCBI
mRatBN7.2377,904,151 - 77,935,942 (-)NCBI
RefSeq Acc Id: XM_063284642   ⟹   XP_063140712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8398,359,812 - 98,377,072 (-)NCBI
RefSeq Acc Id: XR_005501992
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8398,365,697 - 98,373,764 (-)NCBI
mRatBN7.2377,910,042 - 77,918,119 (-)NCBI
RefSeq Acc Id: NP_112405   ⟸   NM_031143
- Peptide Label: isoform 2
- UniProtKB: O08560 (UniProtKB/Swiss-Prot),   A6HNF1 (UniProtKB/TrEMBL),   A0A8I6AMI5 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006234656   ⟸   XM_006234594
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_017447551   ⟸   XM_017592062
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSRNOP00000024280   ⟸   ENSRNOT00000024280
Ensembl Acc Id: ENSRNOP00000074012   ⟸   ENSRNOT00000091265
RefSeq Acc Id: XP_038961854   ⟸   XM_039105926
- Peptide Label: isoform X4
- UniProtKB: A0A8I6AMI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038961852   ⟸   XM_039105924
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000097565   ⟸   ENSRNOT00000117598
Ensembl Acc Id: ENSRNOP00000087400   ⟸   ENSRNOT00000095998
Ensembl Acc Id: ENSRNOP00000090177   ⟸   ENSRNOT00000112973
RefSeq Acc Id: NP_001402081   ⟸   NM_001415152
- Peptide Label: isoform 1
- UniProtKB: A0A0G2K707 (UniProtKB/TrEMBL),   A0A8I6AMI5 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063140712   ⟸   XM_063284642
- Peptide Label: isoform X1
- UniProtKB: A0A8I6A444 (UniProtKB/TrEMBL),   A6HNF2 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000111485   ⟸   ENSRNOT00000142538
Protein Domains
DAGKc

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O08560-F1-model_v2 AlphaFold O08560 1-929 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692222
Promoter ID:EPDNEW_R2745
Type:multiple initiation site
Name:Dgkz_1
Description:diacylglycerol kinase zeta
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0380,873,894 - 80,873,954EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70929 AgrOrtholog
BioCyc Gene G2FUF-48716 BioCyc
Ensembl Genes ENSRNOG00000017737 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024280 ENTREZGENE
  ENSRNOT00000024280.5 UniProtKB/Swiss-Prot
  ENSRNOT00000091265 ENTREZGENE
  ENSRNOT00000095998 ENTREZGENE
  ENSRNOT00000117598 ENTREZGENE
Gene3D-CATH 1.25.40.20 UniProtKB/Swiss-Prot
  2.60.200.40 UniProtKB/Swiss-Prot
  Probable inorganic polyphosphate/atp-NAD kinase, domain 1 UniProtKB/Swiss-Prot
InterPro Ankyrin_rpt UniProtKB/Swiss-Prot
  Ankyrin_rpt-contain_sf UniProtKB/Swiss-Prot
  ATP-NAD_kinase_N UniProtKB/Swiss-Prot
  C1_DGKzeta_rpt1 UniProtKB/Swiss-Prot
  C1_DGKzeta_rpt2 UniProtKB/Swiss-Prot
  DGK UniProtKB/Swiss-Prot
  DGKI-like_dom UniProtKB/Swiss-Prot
  Diacylglycerol_kin_accessory UniProtKB/Swiss-Prot
  Diacylglycerol_kinase_cat_dom UniProtKB/Swiss-Prot
  NAD/diacylglycerol_kinase_sf UniProtKB/Swiss-Prot
  PE/DAG-bd UniProtKB/Swiss-Prot
KEGG Report rno:81821 UniProtKB/Swiss-Prot
NCBI Gene 81821 ENTREZGENE
PANTHER DIACYLGLYCEROL KINASE ZETA UniProtKB/Swiss-Prot
  PTHR11255 UniProtKB/Swiss-Prot
Pfam Ank_2 UniProtKB/Swiss-Prot
  C1_1 UniProtKB/Swiss-Prot
  DAGK_acc UniProtKB/Swiss-Prot
  DAGK_cat UniProtKB/Swiss-Prot
  DGKI UniProtKB/Swiss-Prot
PhenoGen Dgkz PhenoGen
PROSITE ANK_REP_REGION UniProtKB/Swiss-Prot
  ANK_REPEAT UniProtKB/Swiss-Prot
  DAGK UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000017737 RatGTEx
SMART ANK UniProtKB/Swiss-Prot
  DAGKa UniProtKB/Swiss-Prot
  DAGKc UniProtKB/Swiss-Prot
  SM00109 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF111331 UniProtKB/Swiss-Prot
  SSF48403 UniProtKB/Swiss-Prot
UniProt A0A0G2K707 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6A444 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AMI5 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6GM44 ENTREZGENE, UniProtKB/TrEMBL
  A0ABK0M0P4_RAT UniProtKB/TrEMBL
  A6HNF1 ENTREZGENE, UniProtKB/TrEMBL
  A6HNF2 ENTREZGENE, UniProtKB/TrEMBL
  A6HNF3_RAT UniProtKB/TrEMBL
  DGKZ_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Dgkz  diacylglycerol kinase zeta      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference