Cyp4f1 (cytochrome P450, family 4, subfamily f, polypeptide 1) - Rat Genome Database

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Gene: Cyp4f1 (cytochrome P450, family 4, subfamily f, polypeptide 1) Rattus norvegicus
Analyze
Symbol: Cyp4f1
Name: cytochrome P450, family 4, subfamily f, polypeptide 1
RGD ID: 70926
Description: Enables arachidonate binding activity; heme binding activity; and monooxygenase activity. Involved in leukotriene B4 catabolic process; omega-hydroxylase P450 pathway; and response to toxic substance. Predicted to be located in endoplasmic reticulum membrane. Biomarker of hypertension. Human ortholog(s) of this gene implicated in colorectal adenocarcinoma. Orthologous to several human genes including CYP4F2 (cytochrome P450 family 4 subfamily F member 2); PARTICIPATES IN cytochrome P450 monooxygenase mediated pathway of arachidonic acid metabolism; arachidonic acid metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-Tetrachlorodibenzofuran; ammonium chloride.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Cyp4f14; Cyp4f2; CYPIVF1; cytochrome P450 4F1; cytochrome P450, family 4, subfamily F, polypeptide 2; cytochrome P450, subfamily IVF, polypeptide 14 (leukotriene B4 omega hydroxylase); cytochrome P450-A3; leukotriene-B4 20-monooxygenase; MGC93476; P450-A3
RGD Orthologs
Human
Mouse
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8712,661,357 - 12,672,952 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl712,661,359 - 12,672,612 (-)EnsemblGRCr8
mRatBN7.2712,010,850 - 12,022,497 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl712,010,852 - 12,022,046 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx714,812,767 - 14,823,988 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0716,690,173 - 16,701,390 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0714,561,760 - 14,572,976 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0715,179,472 - 15,191,113 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl715,179,467 - 15,190,796 (-)Ensemblrn6Rnor6.0
Rnor_5.0715,338,346 - 15,349,540 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4713,589,662 - 13,600,856 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera710,104,934 - 10,116,152 (-)NCBICelera
RGSC_v3.1713,589,661 - 13,600,856 (-)NCBI
Cytogenetic Map7q11NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17beta-estradiol  (EXP,ISO)
1H-pyrazole  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (ISO)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
4,4'-sulfonyldiphenol  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (EXP)
avobenzone  (ISO)
Azoxymethane  (ISO)
azoxystrobin  (EXP)
barium sulfate  (EXP)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
buspirone  (EXP)
chlorpyrifos  (EXP)
choline  (ISO)
ciprofibrate  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
deoxynivalenol  (ISO)
dextran sulfate  (ISO)
dibenzofurans  (ISO)
Dibutyl phosphate  (ISO)
doxorubicin  (EXP)
epoxiconazole  (ISO)
ethanol  (ISO)
fipronil  (ISO)
folic acid  (ISO)
formaldehyde  (ISO)
genistein  (EXP,ISO)
glafenine  (EXP)
glyphosate  (EXP)
hexadecanoic acid  (ISO)
imidacloprid  (EXP)
indometacin  (EXP)
inulin  (ISO)
irinotecan  (EXP)
ketoconazole  (ISO)
L-methionine  (ISO)
lithocholic acid  (ISO)
methoxychlor  (EXP)
methylisothiazolinone  (ISO)
N,N-diethyl-m-toluamide  (ISO)
N-nitrosodiethylamine  (ISO)
nefazodone  (EXP)
nickel atom  (ISO)
nimesulide  (EXP)
nitrofen  (EXP)
obeticholic acid  (ISO)
okadaic acid  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phlorizin  (ISO)
pirinixic acid  (EXP,ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
propiconazole  (ISO)
rotenone  (EXP)
senecionine  (ISO)
Senkirkine  (ISO)
silicon dioxide  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dodecyl sulfate  (ISO)
streptozocin  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thiabendazole  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichloroethene  (EXP)
triphenyl phosphate  (ISO)
Triptolide  (ISO)
zinc atom  (EXP)
zinc(0)  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Identification of a new P450 subfamily, CYP4F1, expressed in rat hepatic tumors. Chen L and Hardwick JP, Arch Biochem Biophys 1993 Jan;300(1):18-23.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Identification of differentially expressed genes in aflatoxin B1-treated cultured primary rat hepatocytes and Fischer 344 rats. Harris AJ, etal., Carcinogenesis. 1998 Aug;19(8):1451-8.
4. Localization of rat cytochrome P450 in various tissues and comparison of arachidonic acid metabolism by rat P450 with that by human P450 orthologs. Imaoka S, etal., Drug Metab Pharmacokinet. 2005 Dec;20(6):478-84.
5. Renal localization, expression, and developmental regulation of P450 4F cytochromes in three substrains of spontaneously hypertensive rats. Kalsotra A, etal., Biochem Biophys Res Commun. 2005 Dec 9;338(1):423-31. Epub 2005 Aug 25.
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Purification and characterization of recombinant rat hepatic CYP4F1. Kikuta Y, etal., Arch Biochem Biophys. 1999 Sep 15;369(2):193-6.
8. Covalent attachment of the heme prosthetic group in the CYP4F cytochrome P450 family. LeBrun LA, etal., Biochemistry. 2002 May 7;41(18):5931-7.
9. Gene Data Set MGD Curation, June 12, 2002
10. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
11. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
12. GOA pipeline RGD automated data pipeline
13. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
14. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
15. CYP4Fs Expression in Rat Brain Correlates with Changes in LTB(4) Levels after Traumatic Brain Injury. Wang Y, etal., J Neurotrauma. 2008 Oct 11.
16. Catalytic activity and isoform-specific inhibition of rat cytochrome p450 4F enzymes. Xu F, etal., J Pharmacol Exp Ther. 2004 Mar;308(3):887-95. Epub 2003 Nov 21.
Additional References at PubMed
PMID:12477932   PMID:18262487   PMID:25866300  


Genomics

Comparative Map Data
Cyp4f1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8712,661,357 - 12,672,952 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl712,661,359 - 12,672,612 (-)EnsemblGRCr8
mRatBN7.2712,010,850 - 12,022,497 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl712,010,852 - 12,022,046 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx714,812,767 - 14,823,988 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0716,690,173 - 16,701,390 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0714,561,760 - 14,572,976 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0715,179,472 - 15,191,113 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl715,179,467 - 15,190,796 (-)Ensemblrn6Rnor6.0
Rnor_5.0715,338,346 - 15,349,540 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4713,589,662 - 13,600,856 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera710,104,934 - 10,116,152 (-)NCBICelera
RGSC_v3.1713,589,661 - 13,600,856 (-)NCBI
Cytogenetic Map7q11NCBI
CYP4F12
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381915,673,087 - 15,697,174 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1915,673,018 - 15,698,817 (+)Ensemblhg38GRCh38
GRCh371915,783,897 - 15,807,984 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361915,644,886 - 15,668,984 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341915,644,917 - 15,668,984NCBI
Celera1915,680,803 - 15,704,255 (+)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1915,352,410 - 15,376,054 (+)NCBIHuRef
CHM1_11915,783,320 - 15,806,476 (+)NCBICHM1_1
T2T-CHM13v2.01915,798,486 - 15,822,059 (+)NCBIT2T-CHM13v2.0
Cyp4f14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391733,122,331 - 33,136,353 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1733,124,044 - 33,136,316 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381732,903,357 - 32,917,376 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1732,905,070 - 32,917,342 (-)Ensemblmm10GRCm38
MGSCv371733,042,015 - 33,054,023 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361732,643,488 - 32,655,496 (-)NCBIMGSCv36mm8
Celera1733,817,222 - 33,829,231 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI

Variants

.
Variants in Cyp4f1
97 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:140
Count of miRNA genes:110
Interacting mature miRNAs:121
Transcripts:ENSRNOT00000006533
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61410Bw19Body weight QTL 196.20.001body mass (VT:0001259)body weight (CMO:0000012)7166965846669658Rat
1300176Hrtrt10Heart rate QTL 103.19heart pumping trait (VT:2000009)heart rate (CMO:0000002)7123748937Rat
9590102Sffal5Serum free fatty acids level QTL 58.620.001blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)7721609752216097Rat
1578652Bmd15Bone mineral density QTL 155.2femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)71051708662346019Rat
1643004Pain2Pain QTL 21mechanical nociception trait (VT:0002734)self mutilation severity score (CMO:0002145)71011291699900612Rat
2290372Gluco33Glucose level QTL 332.71blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)7131777942Rat
1300149Cm6Cardiac mass QTL 64.09heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)71104117804Rat
631503Bp102Blood pressure QTL 1021.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)7170952746709527Rat
634336Anxrr17Anxiety related response QTL 173.66locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)71509236116977875Rat
9590142Scort5Serum corticosterone level QTL 524.40.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)7132612984Rat
1582260Bw72Body weight QTL 723.20.0043body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582261Bw69Body weight QTL 693.20.0048body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
1582262Bw75Body weight QTL 7530.0038body mass (VT:0001259)body weight (CMO:0000012)7139960528Rat
2298547Neuinf5Neuroinflammation QTL 53.7nervous system integrity trait (VT:0010566)spinal cord Cd74 protein level (CMO:0002131)71011291660150541Rat
10059592Kidm45Kidney mass QTL 453.950.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)7946087754460877Rat
2298550Neuinf6Neuroinflammation QTL 63.3nervous system integrity trait (VT:0010566)spinal cord RT1-B protein level (CMO:0002132)7129716167Rat
1300138Hrtrt9Heart rate QTL 94.72heart pumping trait (VT:2000009)heart rate (CMO:0000002)71049882055498820Rat
724560Plsm3Polydactyly-luxate syndrome (PLS) morphotypes QTL 30.0003tibia length (VT:0004357)tibia length (CMO:0000450)7134650782Rat
7411566Bw136Body weight QTL 13610.40.001body mass (VT:0001259)body weight gain (CMO:0000420)7132612984Rat

Markers in Region
D7Rat217  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8712,665,700 - 12,665,941 (+)Marker Load Pipeline
mRatBN7.2712,015,193 - 12,015,434 (+)MAPPERmRatBN7.2
Rnor_6.0715,183,870 - 15,184,110NCBIRnor6.0
Rnor_5.0715,342,690 - 15,342,930UniSTSRnor5.0
RGSC_v3.4713,594,005 - 13,594,246RGDRGSC3.4
RGSC_v3.4713,594,006 - 13,594,246UniSTSRGSC3.4
Celera710,109,278 - 10,109,534UniSTS
RGSC_v3.1713,594,005 - 13,594,246RGD
SHRSP x BN Map74.58UniSTS
SHRSP x BN Map74.58RGD
Cytogenetic Map7q11UniSTS
D7Uia4  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21068,731,803 - 68,732,645 (+)MAPPERmRatBN7.2
mRatBN7.2712,015,443 - 12,015,645 (+)MAPPERmRatBN7.2
Rnor_6.0715,184,120 - 15,184,321NCBIRnor6.0
Rnor_6.01071,155,773 - 71,156,614NCBIRnor6.0
Rnor_5.01070,774,281 - 70,775,122UniSTSRnor5.0
Rnor_5.0715,342,940 - 15,343,141UniSTSRnor5.0
RGSC_v3.4713,594,256 - 13,594,457UniSTSRGSC3.4
RGSC_v3.4713,594,255 - 13,594,457RGDRGSC3.4
RGSC_v3.41072,076,880 - 72,077,721UniSTSRGSC3.4
Celera1067,664,758 - 67,665,599UniSTS
Celera710,109,544 - 10,109,753UniSTS
RGSC_v3.1713,594,255 - 13,594,457RGD
Cytogenetic Map7q11UniSTS
D7Wox50  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2712,023,533 - 12,023,731 (+)MAPPERmRatBN7.2
Rnor_6.0715,192,208 - 15,192,405NCBIRnor6.0
Rnor_5.0715,351,028 - 15,351,225UniSTSRnor5.0
RGSC_v3.4713,602,344 - 13,602,541UniSTSRGSC3.4
Cytogenetic Map7q11UniSTS
D7Wox54  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2712,022,879 - 12,023,453 (+)MAPPERmRatBN7.2
Rnor_6.0715,191,554 - 15,192,127NCBIRnor6.0
Rnor_5.0715,350,374 - 15,350,947UniSTSRnor5.0
RGSC_v3.4713,601,690 - 13,602,263UniSTSRGSC3.4
Cytogenetic Map7q11UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 8 50 105 88 84 59 23 59 4 252 92 87 78 74 25 6 6

Sequence


Ensembl Acc Id: ENSRNOT00000006533   ⟹   ENSRNOP00000006533
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl712,661,359 - 12,672,553 (-)Ensembl
mRatBN7.2 Ensembl712,010,852 - 12,022,046 (-)Ensembl
Rnor_6.0 Ensembl715,179,467 - 15,190,796 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090844   ⟹   ENSRNOP00000072675
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl712,661,703 - 12,672,553 (-)Ensembl
mRatBN7.2 Ensembl712,011,196 - 12,022,046 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000142584   ⟹   ENSRNOP00000098703
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl712,661,359 - 12,672,612 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000155976   ⟹   ENSRNOP00000103573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl712,661,359 - 12,672,553 (-)Ensembl
RefSeq Acc Id: NM_019623   ⟹   NP_062569
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,661,357 - 12,672,553 (-)NCBI
mRatBN7.2712,010,850 - 12,022,046 (-)NCBI
Rnor_6.0715,179,526 - 15,190,720 (-)NCBI
Rnor_5.0715,338,346 - 15,349,540 (-)NCBI
RGSC_v3.4713,589,662 - 13,600,856 (-)RGD
Celera710,104,934 - 10,116,152 (-)RGD
Sequence:
RefSeq Acc Id: XM_008765180   ⟹   XP_008763402
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,661,357 - 12,672,952 (-)NCBI
mRatBN7.2712,010,859 - 12,022,497 (-)NCBI
Rnor_6.0715,179,472 - 15,191,113 (-)NCBI
Sequence:
RefSeq Acc Id: XM_008765181   ⟹   XP_008763403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,661,357 - 12,672,869 (-)NCBI
mRatBN7.2712,011,238 - 12,022,356 (-)NCBI
Rnor_6.0715,179,472 - 15,191,032 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039079791   ⟹   XP_038935719
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,661,357 - 12,672,627 (-)NCBI
mRatBN7.2712,011,238 - 12,022,121 (-)NCBI
RefSeq Acc Id: XM_039079792   ⟹   XP_038935720
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,661,357 - 12,672,863 (-)NCBI
mRatBN7.2712,010,859 - 12,022,357 (-)NCBI
RefSeq Acc Id: XM_063264165   ⟹   XP_063120235
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,661,357 - 12,672,727 (-)NCBI
RefSeq Acc Id: XM_063264166   ⟹   XP_063120236
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8712,661,357 - 12,672,947 (-)NCBI
RefSeq Acc Id: NP_062569   ⟸   NM_019623
- UniProtKB: P33274 (UniProtKB/Swiss-Prot),   A6K970 (UniProtKB/TrEMBL),   F7F3E1 (UniProtKB/TrEMBL),   Q66HK8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763402   ⟸   XM_008765180
- Peptide Label: isoform X1
- UniProtKB: P33274 (UniProtKB/Swiss-Prot),   A6K970 (UniProtKB/TrEMBL),   F7F3E1 (UniProtKB/TrEMBL),   Q66HK8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008763403   ⟸   XM_008765181
- Peptide Label: isoform X1
- UniProtKB: P33274 (UniProtKB/Swiss-Prot),   A6K970 (UniProtKB/TrEMBL),   F7F3E1 (UniProtKB/TrEMBL),   Q66HK8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006533   ⟸   ENSRNOT00000006533
RefSeq Acc Id: XP_038935720   ⟸   XM_039079792
- Peptide Label: isoform X1
- UniProtKB: P33274 (UniProtKB/Swiss-Prot),   A6K970 (UniProtKB/TrEMBL),   F7F3E1 (UniProtKB/TrEMBL),   Q66HK8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038935719   ⟸   XM_039079791
- Peptide Label: isoform X1
- UniProtKB: P33274 (UniProtKB/Swiss-Prot),   A6K970 (UniProtKB/TrEMBL),   F7F3E1 (UniProtKB/TrEMBL),   Q66HK8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000072675   ⟸   ENSRNOT00000090844
RefSeq Acc Id: XP_063120236   ⟸   XM_063264166
- Peptide Label: isoform X1
- UniProtKB: P33274 (UniProtKB/Swiss-Prot),   A6K970 (UniProtKB/TrEMBL),   F7F3E1 (UniProtKB/TrEMBL),   Q66HK8 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063120235   ⟸   XM_063264165
- Peptide Label: isoform X1
- UniProtKB: P33274 (UniProtKB/Swiss-Prot),   A6K970 (UniProtKB/TrEMBL),   F7F3E1 (UniProtKB/TrEMBL),   Q66HK8 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000098703   ⟸   ENSRNOT00000142584
Ensembl Acc Id: ENSRNOP00000103573   ⟸   ENSRNOT00000155976

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P33274-F1-model_v2 AlphaFold P33274 1-524 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695075
Promoter ID:EPDNEW_R5599
Type:initiation region
Name:Cyp4f1_1
Description:cytochrome P450, family 4, subfamily f, polypeptide 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0715,190,796 - 15,190,856EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70926 AgrOrtholog
BioCyc Gene G2FUF-34799 BioCyc
Ensembl Genes ENSRNOG00000004786 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000006533 ENTREZGENE
Gene3D-CATH 1.10.630.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7109036 IMAGE-MGC_LOAD
InterPro Cyt_P450 UniProtKB/Swiss-Prot
  Cyt_P450_CS UniProtKB/Swiss-Prot
  Cyt_P450_E_grp-I UniProtKB/Swiss-Prot
  Cyt_P450_sf UniProtKB/Swiss-Prot
  Cytochrome_P450_Monoox UniProtKB/Swiss-Prot
MGC_CLONE MGC:93476 IMAGE-MGC_LOAD
NCBI Gene Cyp4f1 ENTREZGENE
PANTHER CYTOCHROME P450 FAMILY 4 UniProtKB/Swiss-Prot
  LEUKOTRIENE-B4 OMEGA-HYDROXYLASE 3 UniProtKB/Swiss-Prot
Pfam p450 UniProtKB/Swiss-Prot
PhenoGen Cyp4f1 PhenoGen
PRINTS EP450I UniProtKB/Swiss-Prot
  P450 UniProtKB/Swiss-Prot
PROSITE CYTOCHROME_P450 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000004786 RatGTEx
Superfamily-SCOP SSF48264 UniProtKB/Swiss-Prot
UniProt A0A0G2K3K4_RAT UniProtKB/TrEMBL
  A0ABK0LBQ5_RAT UniProtKB/TrEMBL
  A0ABK0LQV5_RAT UniProtKB/TrEMBL
  A6K970 ENTREZGENE, UniProtKB/TrEMBL
  CP4F1_RAT UniProtKB/Swiss-Prot
  F7F3E1 ENTREZGENE, UniProtKB/TrEMBL
  P33274 ENTREZGENE
  Q66HK8 ENTREZGENE
  Q9ESF5_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2007-07-06 Cyp4f1  cytochrome P450, family 4, subfamily f, polypeptide 1  Cyp4f2  cytochrome P450, family 4, subfamily F, polypeptide 2  Name updated 1299863 APPROVED
2004-09-10 Cyp4f2  cytochrome P450, family 4, subfamily F, polypeptide 2  Cyp4f14  cytochrome P450, subfamily IVF, polypeptide 14 (leukotriene B4 omega hydroxylase)  Symbol and Name updated 1299863 APPROVED
2002-07-09 Cyp4f14  cytochrome P450, subfamily IVF, polypeptide 14 (leukotriene B4 omega hydroxylase)      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in hepatic tumors; expression levels are higher than those detected in parental liver tissue 70707
gene_regulation Cyp4 genes differentially regulated during hepatic carcinogenesis 70707