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Gene: Hgfac (HGF activator) Rattus norvegicus

Analyze

Symbol:

Hgfac

Name:

HGF activator

RGD ID:

70909

Description:

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in blood coagulation and zymogen activation. Predicted to be located in cytoplasm. Predicted to be active in extracellular space and rough endoplasmic reticulum. Orthologous to human HGFAC (HGF activator); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 6-propyl-2-thiouracil.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

hepatocyte growth factor activator; MGC109000

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	HGFAC (HGF activator)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Hgfac (hepatocyte growth factor activator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Hgfac (HGF activator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	HGFAC (HGF activator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	HGFAC (HGF activator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Hgfac (HGF activator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	HGFAC (HGF activator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	HGFAC (HGF activator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Hgfac (HGF activator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Hgfac (HGF activator)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RXRG (retinoid X receptor gamma)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Hgfac (hepatocyte growth factor activator)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	HGFAC (HGF activator)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	hgfac	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	79,932,219 - 79,938,773 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	79,932,222 - 79,939,029 (-)	Ensembl				GRCr8
mRatBN7.2	14	75,707,588 - 75,714,182 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	75,707,591 - 75,714,278 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	80,160,640 - 80,167,194 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	81,401,267 - 81,407,821 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	77,846,489 - 77,853,043 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	80,966,902 - 80,973,525 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	80,966,903 - 80,973,456 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	81,655,780 - 81,662,442 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	81,348,282 - 81,354,836 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	74,633,495 - 74,640,049 (-)	NCBI		Celera
RGSC_v3.1	14	81,351,701 - 81,351,935 (-)	NCBI
Cytogenetic Map	14	q21	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Crohn's disease (ISO)

hepatocellular carcinoma (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

17beta-estradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2,4-dinitrotoluene (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

amiodarone (ISO)

amitrole (EXP)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cadmium atom (ISO)

cadmium dichloride (ISO)

carbon nanotube (ISO)

chlordecone (ISO)

chlorpyrifos (ISO)

clofibrate (ISO)

cobalt dichloride (EXP)

cyclosporin A (ISO)

dichloroacetic acid (ISO)

genistein (ISO)

hydrogen peroxide (ISO)

irinotecan (EXP)

leflunomide (EXP)

methimazole (EXP)

mono(2-ethylhexyl) phthalate (ISO)

N-nitrosodiethylamine (ISO)

N-nitrosodimethylamine (EXP)

nitrofen (EXP)

okadaic acid (ISO)

paraquat (EXP)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

pirinixic acid (ISO)

pregnenolone 16alpha-carbonitrile (ISO)

propiconazole (ISO)

sodium dichromate (EXP)

sulfadimethoxine (EXP)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP,ISO)

thioacetamide (EXP)

triadimefon (ISO)

triptonide (ISO)

urethane (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

blood coagulation (IBA)

proteolysis (IEA)

zymogen activation (IBA)

Cellular Component

cytoplasm (IEA,ISO)

extracellular region (IEA)

extracellular space (IBA)

rough endoplasmic reticulum (IBA,IEA,ISO)

Molecular Function

hydrolase activity (IEA)

peptidase activity (IEA)

protein binding (ISO)

serine-type endopeptidase activity (IBA,IEA)

serine-type peptidase activity (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Exogenously Administered HGF Activator Augments Liver Regeneration through the Production of Biologically Active HGF.	Kaibori M, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):475-81.
3.	Gene Data Set	MGD Curation, June 12, 2002
4.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
5.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
9.	Changes in gene expression during progression of ovarian carcinoma.	Tapper J, etal., Cancer Genet Cytogenet 2001 Jul 1;128(1):1-6.

Additional References at PubMed

PMID:12477932	PMID:12923239

Genomics

Comparative Map Data

Hgfac
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	14	79,932,219 - 79,938,773 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	14	79,932,222 - 79,939,029 (-)	Ensembl				GRCr8
mRatBN7.2	14	75,707,588 - 75,714,182 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	14	75,707,591 - 75,714,278 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	14	80,160,640 - 80,167,194 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	14	81,401,267 - 81,407,821 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	14	77,846,489 - 77,853,043 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	14	80,966,902 - 80,973,525 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	14	80,966,903 - 80,973,456 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	14	81,655,780 - 81,662,442 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	14	81,348,282 - 81,354,836 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	14	74,633,495 - 74,640,049 (-)	NCBI		Celera
RGSC_v3.1	14	81,351,701 - 81,351,935 (-)	NCBI
Cytogenetic Map	14	q21	NCBI

HGFAC
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	4	3,441,005 - 3,449,486 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	4	3,441,924 - 3,449,493 (+)	Ensembl			hg38	GRCh38
GRCh37	4	3,443,695 - 3,451,213 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	4	3,413,524 - 3,421,011 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	4	3,480,694 - 3,488,182	NCBI
Celera	4	3,354,522 - 3,362,009 (+)	NCBI		Celera
Cytogenetic Map	4	p16.3	NCBI
HuRef	4	3,380,866 - 3,388,353 (+)	NCBI		HuRef
CHM1_1	4	3,441,294 - 3,448,781 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	4	3,440,789 - 3,449,270 (+)	NCBI		T2T-CHM13v2.0

Hgfac
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	35,198,853 - 35,205,805 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	35,198,853 - 35,205,805 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	5	35,041,509 - 35,048,461 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	35,041,509 - 35,048,461 (+)	Ensembl			mm10	GRCm38
MGSCv37	5	35,384,202 - 35,391,085 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	5	35,358,455 - 35,365,270 (+)	NCBI		MGSCv36	mm8
Celera	5	32,516,343 - 32,523,227 (+)	NCBI		Celera
Cytogenetic Map	5	B2	NCBI
cM Map	5	17.99	NCBI

Hgfac
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955514	2,155,384 - 2,165,957 (+)	Ensembl
ChiLan1.0	NW_004955514	2,155,924 - 2,161,302 (+)	NCBI	ChiLan1.0	ChiLan1.0

HGFAC
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	3	3,785,510 - 3,793,038 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	4	3,719,251 - 3,726,711 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	4	3,590,908 - 3,599,781 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	4	3,575,819 - 3,583,436 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	4	3,575,819 - 3,583,436 (+)	Ensembl			panPan2	panpan1.1

HGFAC
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	3	60,906,839 - 60,916,879 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	3	60,906,844 - 60,915,280 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	3	63,557,017 - 63,565,265 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	3	61,382,412 - 61,390,658 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	3	61,382,412 - 61,390,658 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	3	60,874,179 - 60,882,422 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	3	61,080,281 - 61,088,528 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	3	61,436,631 - 61,444,882 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Hgfac
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405285	66,587,535 - 66,597,492 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936477	20,291,852 - 20,298,764 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936477	20,291,791 - 20,298,764 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HGFAC
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	8	2,077,176 - 2,084,507 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	8	2,077,164 - 2,084,506 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	8	1,757,622 - 1,764,975 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HGFAC
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	27	45,283,213 - 45,290,922 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	27	45,283,206 - 45,290,644 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666051	1,638,295 - 1,645,982 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hgfac
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624755	24,483,431 - 24,488,450 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624755	24,483,358 - 24,488,505 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Hgfac
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	11	70,036,719 - 70,043,367 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Hgfac
17 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	56
Count of miRNA genes:	52
Interacting mature miRNAs:	56
Transcripts:	ENSRNOT00000013257
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2313089	Bss81	Bone structure and strength QTL 81	3.4	0.0001	body length (VT:0001256)	body length, nose to rump (CMO:0000079)	14	38023710	83023710	Rat
9590294	Uminl4	Urine mineral level QTL 4	5.66	0.001	urine mineral amount (VT:0015086)	urine electrolyte level (CMO:0000593)	14	59848686	104848686	Rat
1582236	Gluco22	Glucose level QTL 22	3.3	0.0164	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	77640071	96755654	Rat
2300197	Scl59	Serum cholesterol level QTL 59			blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	14	77914838	104348525	Rat
70214	Niddm28	Non-insulin dependent diabetes mellitus QTL 28	4.06		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	39009444	84009444	Rat
70153	Bp59	Blood pressure QTL 59	3.2		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	14	72970210	87582095	Rat
70187	Pancm5	Pancreatic morphology QTL 5	16.7		pancreas mass (VT:0010144)	pancreas weight to body weight ratio (CMO:0000630)	14	30674469	85041098	Rat
631523	Pia13	Pristane induced arthritis QTL 13	3.3		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	14	33424686	102238540	Rat
1582259	Gluco23	Glucose level QTL 23	3.1	0.0008	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	74255551	109089856	Rat
1582197	Gluco27	Glucose level QTL 27	3.4	0.0006	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	14	77640071	96755654	Rat
2313100	Bss82	Bone structure and strength QTL 82	3	0.0001	tibia size trait (VT:0100001)	tibia midshaft cross-sectional area (CMO:0001717)	14	38023710	83023710	Rat
634328	Hc5	Hypercalciuria QTL 5	2.3		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	14	62398852	107398852	Rat
1582250	Gluco26	Glucose level QTL 26	3.3	0.0009	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	77640071	100078267	Rat
2317879	Alcrsp27	Alcohol response QTL 27	3.3	0.63	response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	14	60854936	105854936	Rat
1641900	Alcrsp11	Alcohol response QTL 11			alcohol metabolism trait (VT:0015089)	blood ethanol level (CMO:0000535)	14	74255551	109089856	Rat
631839	Niddm37	Non-insulin dependent diabetes mellitus QTL 37	3.37		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	11334716	100078267	Rat
1582255	Gluco29	Glucose level QTL 29	3.1	0.0025	blood glucose amount (VT:0000188)	absolute change in blood glucose level area under curve (CMO:0002034)	14	77640071	96755654	Rat
9589034	Epfw11	Epididymal fat weight QTL 11	6	0.001	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	14	59848686	104848686	Rat
1582209	Gluco20	Glucose level QTL 20	3.8	0.0005	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	14	77640071	96755654	Rat
2313048	Bss84	Bone structure and strength QTL 84	3.1	0.0001	tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	14	38023710	83023710	Rat
1300136	Rf22	Renal function QTL 22	3.9		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	14	42616258	99224555	Rat
1549834	Scl45	Serum cholesterol level QTL 45	5.8		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	14	65920283	99224555	Rat
738037	Hcas6	Hepatocarcinoma susceptibility QTL 6	2.93		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	14	39411170	87582095	Rat
2313084	Bss83	Bone structure and strength QTL 83	2.9	0.0001	tibia size trait (VT:0100001)	tibia midshaft endosteal cross-sectional area (CMO:0001716)	14	38023710	83023710	Rat

Markers in Region

MARC_16871-16872:1015445619:1

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	14	79,933,295 - 79,933,925 (+)	Marker Load Pipeline
mRatBN7.2	14	75,708,664 - 75,709,293 (+)	MAPPER	mRatBN7.2
Rnor_6.0	14	80,967,979 - 80,968,607	NCBI	Rnor6.0
Rnor_5.0	14	81,656,862 - 81,657,490	UniSTS	Rnor5.0
RGSC_v3.4	14	81,349,359 - 81,349,987	UniSTS	RGSC3.4
Celera	14	74,634,572 - 74,635,200	UniSTS
Cytogenetic Map	14	q21	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	9	41	115	91	90	59	51	59	6	278	114	5	95	81	90	31	4	4

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053320	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008770352	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB013092	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC114393	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC089871	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473963	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000014	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000013257 ⟹ ENSRNOP00000013257

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	14	79,932,222 - 79,939,029 (-)	Ensembl
mRatBN7.2 Ensembl	14	75,707,591 - 75,714,278 (-)	Ensembl
Rnor_6.0 Ensembl	14	80,966,903 - 80,973,456 (-)	Ensembl

RefSeq Acc Id:

NM_053320 ⟹ NP_445772

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	14	79,932,219 - 79,938,773 (-)	NCBI
mRatBN7.2	14	75,707,588 - 75,714,142 (-)	NCBI
Rnor_6.0	14	80,966,902 - 80,973,456 (-)	NCBI
Rnor_5.0	14	81,655,780 - 81,662,442 (-)	NCBI
RGSC_v3.4	14	81,348,282 - 81,354,836 (-)	RGD
Celera	14	74,633,495 - 74,640,049 (-)	RGD

Sequence:

show sequence

CAGGAGGAGCCATGCGGCAACGGGCCTGGCTCCCTAGTGTCTCTTCCAGGCCATGTCCCTTCCT
GCTGCTCCTGCTACTGCTGGTGGTGCCTCGGGTGGCCCAGCCCCAGGCTGGCAGGAACCACACA
GAGCCCCCAGGACCTAATGTTACAGCCACCCGCATGACTCCCATGATCCCTGCGACCTCTGGCA
ACTTCAGCACCTCAATAGGAAGTGATCCAGAGGGAGAGGCAGAGACCGAGGGACCCCAAAGTGA
GAGGTATCTCCTTTCCTCCAGCAGCAGCCCTCTCGGGGGCCAAGTGCTCACCGAGTCCGGACAG
CCGTGCAGGTTCCCTTTCCGCTATGGTGGCCGCATGCTGCACTCCTGTTCCTCTGAGGGAAGTG
CCTACAGGAAGTGGTGTGCTACGACACACAACTACGACAGAGACCGGGCCTGGGGCTACTGTGC
AGAGGCCACCCTGCCTGTGGAAGGCCCAGCTGTCCTTGATCCTTGTGCCTCTGGGCCCTGCCTC
AATGGAGGCACATGTTCCAGTACCCAGGACCATGTGTCCTACCACTGTGCTTGCCCGCTGGCCT
TCACAGGCAAGGACTGTGGCACAGAGAAGTGCTTTGATGAAACACGCTACGAGTATTTTGAGGT
GGGCGACCACTGGGCCCGTGTGAGCGAGGGACATGTGGAGCAGTGCAGCTGTATCGAGGGGCAG
GCCCGGTGTGAAGACACCCACCACACAGCTTGCCTGAGCAGCCCATGTCTGAATGGAGGAACCT
GCCACCTGATTGTGGGCACAGGGACCAGCATCTGCGCCTGCCCGTTGGGTTATGCTGGGCGGTT
CTGCAACATTGTTCCCACTGAGCGCTGCTTCCTGGGCAATGGAACAGAGTACCGCGGTGTGGCC
AGCACCTCTGCCTCGGGCCTGAGCTGCCTGGCCTGGAATTCCGACCTGCTCTACCAGGAGCTCC
ATGTAGACTCAGTGGGTGCTGCTGCCCTGCTTGGCCTGGGCCCTCATGCTTACTGCCGGAACCC
AGACAAGGACGAGAGGCCTTGGTGCTATGTGGTGAAGGACAGCGCGCTGTCATGGGAGTATTGT
CGCCTGGCAGCTTGTGAATCCTTGGCCAGAGTCCATTCCCGAATCCCGGAGGTCCTAGCGACCC
TGCCTGAGTCGACCTCAACTGCACGTCCGACCTGTGGCAAGAGGCACAAGAAGAGGACATTCTT
GAGGCCACGCATCATTGGTGGCTCATCGTCTTTGCCCGGCTCACACCCCTGGCTGGCCGCCATC
TACATTGGGAACGGCTTCTGTGCTGGGAGCCTCGTCCACACCTGCTGGGTAGTGTCTGCAGCCC
ACTGCTTCTCCAGCAGCCCCCCCAGGGACAGCATCACAGTGGTACTGGGTCAGCACTTCTTCAA
CCGCACGACGGATGTGACACAGACCTTTGCCATTGAGAAGTACGTGCCCTACACCCTCTACTCG
GTGTTCAACCCCAACGACCATGACCTTGTCTTGATCCGGCTGAAGAAGAAGGGGGAGCGCTGTG
CTGTCCGCTCCCAGTTCGTTCAGCCCATCTGCCTCCCTGAGGCAGGCAGCTCTTTCCCTACAGG
ACACAAGTGTCAGATTGCAGGCTGGGGTCACATGGACGAGAATGTGAGTGGATATTCCAACTCC
CTGCTGGAGGCACTGGTCCCCCTGGTTGCTGACCACAAGTGCAGCAGCCCTGAGGTGTATGGTG
CCGACATCAGCCCCAACATGCTCTGTGCTGGATACTTTGACTGCAAGTCTGATGCCTGCCAGGG
GGACTCGGGTGGGCCCTTGGTCTGTGAGAAGAATGGTGTGGCTTACCTGTATGGCATCATCAGC
TGGGGTGATGGCTGTGGGAGGCTCAACAAGCCAGGAGTCTACACCCGTGTGTCCAATTATGTGG
ACTGGATCAACGACCGCATTCGGCCACCCAAGCGACCTGCAGCTGCCTCCTGAACCATGGTCTC
CAAGGAGAGGATGCTCACAATTCCCTTTCTACTACCAATAATAAAAGTGTTGCCTAGAAAAAAA
AAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_445772	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH89871	(Get FASTA)	NCBI Sequence Viewer
	BAA25981	(Get FASTA)	NCBI Sequence Viewer
	EDM00074	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000013257
	ENSRNOP00000013257.5

RefSeq Acc Id:	NP_445772 ⟸ NM_053320
- Peptide Label:	precursor
- UniProtKB:	Q5EBA7 (UniProtKB/TrEMBL), F7ELL4 (UniProtKB/TrEMBL)
- Sequence:	show sequence MRQRAWLPSVSSRPCPFLLLLLLLVVPRVAQPQAGRNHTEPPGPNVTATRMTPMIPATSGNFST SIGSDPEGEAETEGPQSERYLLSSSSSPLGGQVLTESGQPCRFPFRYGGRMLHSCSSEGSAYRK WCATTHNYDRDRAWGYCAEATLPVEGPAVLDPCASGPCLNGGTCSSTQDHVSYHCACPLAFTGK DCGTEKCFDETRYEYFEVGDHWARVSEGHVEQCSCIEGQARCEDTHHTACLSSPCLNGGTCHLI VGTGTSICACPLGYAGRFCNIVPTERCFLGNGTEYRGVASTSASGLSCLAWNSDLLYQELHVDS VGAAALLGLGPHAYCRNPDKDERPWCYVVKDSALSWEYCRLAACESLARVHSRIPEVLATLPES TSTARPTCGKRHKKRTFLRPRIIGGSSSLPGSHPWLAAIYIGNGFCAGSLVHTCWVVSAAHCFS SSPPRDSITVVLGQHFFNRTTDVTQTFAIEKYVPYTLYSVFNPNDHDLVLIRLKKKGERCAVRS QFVQPICLPEAGSSFPTGHKCQIAGWGHMDENVSGYSNSLLEALVPLVADHKCSSPEVYGADIS PNMLCAGYFDCKSDACQGDSGGPLVCEKNGVAYLYGIISWGDGCGRLNKPGVYTRVSNYVDWIN DRIRPPKRPAAAS hide sequence

Ensembl Acc Id:

ENSRNOP00000013257 ⟸ ENSRNOT00000013257

Protein Domains

EGF-like Fibronectin type-I Fibronectin type-II Kringle Peptidase S1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5EBA7-F1-model_v2	AlphaFold	Q5EBA7	1-653	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699392

Promoter ID:

EPDNEW_R9917

Type:

initiation region

Name:

Hgfac_1

Description:

HGF activator

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	14	80,973,472 - 80,973,532	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:70909	AgrOrtholog
BioCyc Gene	G2FUF-15312	BioCyc
Ensembl Genes	ENSRNOG00000009572	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000013257	ENTREZGENE
	ENSRNOT00000013257.8	UniProtKB/TrEMBL
Gene3D-CATH	2.10.10.10	UniProtKB/TrEMBL
	2.40.10.10	UniProtKB/TrEMBL
	2.40.20.10	UniProtKB/TrEMBL
	Laminin	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7324508	IMAGE-MGC_LOAD
InterPro	Coagulation_fac_XIIa/HGFA	UniProtKB/TrEMBL
	EG-like_dom	UniProtKB/TrEMBL
	Fibronectin_type1	UniProtKB/TrEMBL
	FN_type2_col-bd	UniProtKB/TrEMBL
	FN_type2_sf	UniProtKB/TrEMBL
	Kringle	UniProtKB/TrEMBL
	Kringle-like	UniProtKB/TrEMBL
	Kringle_CS	UniProtKB/TrEMBL
	Kringle_sf	UniProtKB/TrEMBL
	Pept_cys/ser_Trypsin-like	UniProtKB/TrEMBL
	Peptidase_S1/S6_AS	UniProtKB/TrEMBL
	Peptidase_S1_PA_chymotrypsin	UniProtKB/TrEMBL
	Peptidase_S1_S6	UniProtKB/TrEMBL
	Peptidase_S1A	UniProtKB/TrEMBL
	Serine_Proteases_S1	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
KEGG Report	rno:58947	UniProtKB/TrEMBL
MGC_CLONE	MGC:109000	IMAGE-MGC_LOAD
NCBI Gene	58947	ENTREZGENE
PANTHER	HEPATOCYTE GROWTH FACTOR ACTIVATOR	UniProtKB/TrEMBL
	TRYPSIN-RELATED	UniProtKB/TrEMBL
Pfam	EGF	UniProtKB/TrEMBL
	fn1	UniProtKB/TrEMBL
	fn2	UniProtKB/TrEMBL
	Kringle	UniProtKB/TrEMBL
	Trypsin	UniProtKB/TrEMBL
PhenoGen	Hgfac	PhenoGen
PIRSF	Factor_XII_HGFA	UniProtKB/TrEMBL
PRINTS	CHYMOTRYPSIN	UniProtKB/TrEMBL
	FNTYPEII	UniProtKB/TrEMBL
	KRINGLE	UniProtKB/TrEMBL
PROSITE	EGF_1	UniProtKB/TrEMBL
	EGF_2	UniProtKB/TrEMBL
	EGF_3	UniProtKB/TrEMBL
	FN1_1	UniProtKB/TrEMBL
	FN1_2	UniProtKB/TrEMBL
	FN2_1	UniProtKB/TrEMBL
	FN2_2	UniProtKB/TrEMBL
	KRINGLE_1	UniProtKB/TrEMBL
	KRINGLE_2	UniProtKB/TrEMBL
	TRYPSIN_DOM	UniProtKB/TrEMBL
	TRYPSIN_HIS	UniProtKB/TrEMBL
	TRYPSIN_SER	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000009572	RatGTEx
SMART	EGF	UniProtKB/TrEMBL
	FN1	UniProtKB/TrEMBL
	FN2	UniProtKB/TrEMBL
	SM00130	UniProtKB/TrEMBL
	Tryp_SPc	UniProtKB/TrEMBL
Superfamily-SCOP	EGF/Laminin	UniProtKB/TrEMBL
	FnI-like domain	UniProtKB/TrEMBL
	Kringle-like	UniProtKB/TrEMBL
	Pept_Ser_Cys	UniProtKB/TrEMBL
UniProt	F7ELL4	ENTREZGENE, UniProtKB/TrEMBL
	Q5EBA7	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-01-15	Hgfac	HGF activator	Hgfac	hepatocyte growth factor activator	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-07-09	Hgfac	hepatocyte growth factor activator			Symbol and Name updated to reflect Human and Mouse nomenclature	70877	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_function	cleaves hepatocyte growth factor precursor (pro Hgf) to form mature Hgf	70251

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD