Crot (carnitine O-octanoyltransferase) - Rat Genome Database

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Gene: Crot (carnitine O-octanoyltransferase) Rattus norvegicus
Analyze
Symbol: Crot
Name: carnitine O-octanoyltransferase
RGD ID: 70908
Description: Enables carnitine O-octanoyltransferase activity. Involved in response to xenobiotic stimulus. Located in peroxisome. Orthologous to human CROT (carnitine O-octanoyltransferase); PARTICIPATES IN adrenoleukodystrophy pathway; carnitine-acylcarnitine translocase deficiency; fatty acid beta degradation pathway; INTERACTS WITH (+)-schisandrin B; (R)-noradrenaline; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: COT; peroxisomal carnitine O-octanoyltransferase
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8426,031,729 - 26,088,057 (+)NCBIGRCr8
mRatBN7.2425,068,270 - 25,133,111 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl425,080,587 - 25,133,109 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx430,097,079 - 30,131,595 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0426,023,348 - 26,057,839 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0424,409,862 - 24,444,651 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0422,079,837 - 22,116,265 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl422,081,604 - 22,116,265 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0422,018,106 - 22,053,087 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4422,023,913 - 22,067,029 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1422,023,912 - 22,067,029 (-)NCBI
Celera420,575,938 - 20,626,257 (+)NCBICelera
Cytogenetic Map4q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(-)-epigallocatechin 3-gallate  (ISO)
(R)-noradrenaline  (EXP)
1,1-dichloroethene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-dinitrotoluene  (EXP)
2-hydroxypropanoic acid  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
3H-1,2-dithiole-3-thione  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
9-cis-retinoic acid  (EXP)
aflatoxin B1  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
atrazine  (ISO)
benzo[a]pyrene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (EXP)
bezafibrate  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bromuconazole  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (EXP,ISO)
cannabidiol  (ISO)
CGP 52608  (ISO)
chlorpyrifos  (ISO)
cisplatin  (ISO)
clofibrate  (EXP,ISO)
clofibric acid  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
corn oil  (EXP,ISO)
cyclosporin A  (ISO)
DDT  (EXP)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (ISO)
dibenz[a,h]anthracene  (ISO)
Dibutyl phosphate  (ISO)
dichloroacetic acid  (ISO)
dorsomorphin  (ISO)
endosulfan  (EXP)
entinostat  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
ethyl methanesulfonate  (ISO)
fenofibrate  (EXP)
fentin chloride  (EXP)
flutamide  (EXP)
formaldehyde  (ISO)
furan  (EXP)
gentamycin  (EXP)
glafenine  (EXP)
glycidyl methacrylate  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
indometacin  (EXP)
ivermectin  (ISO)
lipopolysaccharide  (ISO)
lithocholic acid  (ISO)
maneb  (ISO)
metformin  (EXP)
methapyrilene  (EXP)
methyl methanesulfonate  (ISO)
methylmercury chloride  (ISO)
Muraglitazar  (EXP)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
niclosamide  (ISO)
nimesulide  (EXP)
O-octanoylcarnitine  (ISO)
p-toluidine  (EXP)
paracetamol  (ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenformin  (EXP)
phenobarbital  (EXP,ISO)
phenylmercury acetate  (ISO)
pirinixic acid  (EXP,ISO)
potassium chromate  (ISO)
potassium dichromate  (ISO)
pregnenolone 16alpha-carbonitrile  (EXP,ISO)
propiconazole  (ISO)
rac-lactic acid  (ISO)
resveratrol  (EXP,ISO)
ritonavir  (EXP)
rotenone  (EXP,ISO)
S-(1,2-dichlorovinyl)-L-cysteine  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP,ISO)
streptozocin  (EXP)
Tesaglitazar  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
thioacetamide  (EXP)
titanium dioxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (EXP,ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP)
valproic acid  (EXP,ISO)
vinclozolin  (EXP)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Cloning, sequencing, and regulation of rat liver carnitine octanoyltransferase: transcriptional stimulation of the enzyme during peroxisome proliferation. Chatterjee B, etal., Biochemistry 1988 Dec 13;27(25):9000-6.
2. Molecular cloning and sequence analysis of the rat liver carnitine octanoyltransferase cDNA, its natural gene and the gene promoter. Choi SJ, etal., Biochim Biophys Acta 1995 Nov 7;1264(2):215-22.
3. Molecular cloning and expression of human carnitine octanoyltransferase: evidence for its role in the peroxisomal beta-oxidation of branched-chain fatty acids. Ferdinandusse S, etal., Biochem Biophys Res Commun. 1999 Sep 16;263(1):213-8.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
6. KEGG: Kyoto Encyclopedia of Genes and Genomes KEGG
7. Gene expression profile of cardiomyocytes in hypertrophic heart induced by continuous norepinephrine infusion in the rats. Li P, etal., Cell Mol Life Sci. 2003 Oct;60(10):2200-9.
8. Gene Data Set MGD Curation, June 12, 2002
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Purification and properties of carnitine octanoyltransferase and carnitine palmitoyltransferase from rat liver. Miyazawa S, etal., J Biochem. 1983 Aug;94(2):529-42.
11. Inhibition by etomoxir of rat liver carnitine octanoyltransferase is produced through the co-ordinate interaction with two histidine residues. Morillas M, etal., Biochem J. 2000 Oct 15;351 Pt 2:495-502.
12. Structural model of a malonyl-CoA-binding site of carnitine octanoyltransferase and carnitine palmitoyltransferase I: mutational analysis of a malonyl-CoA affinity domain. Morillas M, etal., J Biol Chem 2002 Mar 29;277(13):11473-80.
13. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
14. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
15. GOA pipeline RGD automated data pipeline
16. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
18. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.
Additional References at PubMed
PMID:6436243   PMID:11553629   PMID:15155769   PMID:15492013   PMID:18614015   PMID:20178365   PMID:21619872  


Genomics

Comparative Map Data
Crot
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8426,031,729 - 26,088,057 (+)NCBIGRCr8
mRatBN7.2425,068,270 - 25,133,111 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl425,080,587 - 25,133,109 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx430,097,079 - 30,131,595 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0426,023,348 - 26,057,839 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0424,409,862 - 24,444,651 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0422,079,837 - 22,116,265 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl422,081,604 - 22,116,265 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0422,018,106 - 22,053,087 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4422,023,913 - 22,067,029 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1422,023,912 - 22,067,029 (-)NCBI
Celera420,575,938 - 20,626,257 (+)NCBICelera
Cytogenetic Map4q12NCBI
CROT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38787,345,664 - 87,399,794 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl787,345,664 - 87,399,794 (+)EnsemblGRCh38hg38GRCh38
GRCh37786,974,980 - 87,029,110 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36786,812,947 - 86,867,045 (+)NCBINCBI36Build 36hg18NCBI36
Build 34786,619,661 - 86,673,760NCBI
Celera781,679,821 - 81,733,990 (+)NCBICelera
Cytogenetic Map7q21.12NCBI
HuRef781,585,930 - 81,640,108 (+)NCBIHuRef
CHM1_1786,905,052 - 86,959,218 (+)NCBICHM1_1
T2T-CHM13v2.0788,595,278 - 88,649,555 (+)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2786,306,455 - 86,360,622 (+)NCBI
Crot
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3959,016,033 - 9,047,926 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl59,016,033 - 9,047,324 (-)EnsemblGRCm39 Ensembl
GRCm3858,966,033 - 8,997,146 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl58,966,033 - 8,997,324 (-)EnsemblGRCm38mm10GRCm38
MGSCv3758,966,048 - 8,997,146 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3658,972,054 - 9,003,152 (-)NCBIMGSCv36mm8
Celera58,885,457 - 8,916,553 (-)NCBICelera
Cytogenetic Map5A1NCBI
cM Map53.5NCBI
Crot
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955607378,439 - 413,394 (-)EnsemblChiLan1.0
ChiLan1.0NW_004955607379,121 - 413,394 (-)NCBIChiLan1.0ChiLan1.0
CROT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26105,224,533 - 105,278,705 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17153,489,171 - 153,543,350 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0779,339,498 - 79,393,676 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1792,989,868 - 93,043,832 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl792,989,868 - 93,043,832 (+)Ensemblpanpan1.1panPan2
CROT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11413,475,130 - 13,532,536 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1413,475,235 - 13,532,536 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1413,046,798 - 13,104,279 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01413,240,042 - 13,298,355 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1413,240,015 - 13,299,882 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11413,443,706 - 13,500,941 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01413,169,264 - 13,227,485 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01413,452,909 - 13,510,196 (+)NCBIUU_Cfam_GSD_1.0
Crot
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511826,538,694 - 26,575,933 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049367631,424,935 - 1,462,679 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049367631,425,394 - 1,462,638 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CROT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl993,258,619 - 93,308,151 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1993,263,606 - 93,308,150 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29102,743,699 - 102,788,243 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CROT
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12161,531,263 - 61,584,448 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2161,531,060 - 61,584,447 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604242,477,754 - 42,533,686 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crot
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473934,696,511 - 34,730,419 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462473934,696,516 - 34,738,143 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Crot
114 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:109
Count of miRNA genes:84
Interacting mature miRNAs:103
Transcripts:ENSRNOT00000067462
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829457114705Rat
2303585Bw86Body weight QTL 864body mass (VT:0001259)body weight (CMO:0000012)41467806559678065Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4131934116Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4127716890Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4131934116Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41008408955084089Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4133250345Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4133250345Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41008408955084089Rat
70222Eae2Experimental allergic encephalomyelitis QTL 24.3nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)42133334339505420Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521917856647776Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41008408955084089Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4130372989Rat
634323Hc2Hypercalciuria QTL 22.15urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)421079645210796Rat
2313401Anxrr27Anxiety related response QTL 27aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)41793350862933508Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4127716890Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4994088544463908Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)42271068534430484Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41008408955084089Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4131934116Rat
61412Pia2Pristane induced arthritis QTL 23.9joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)42133334362278020Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41008408955084089Rat
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4127716890Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4139505420Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4129494328Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4521460278882945Rat
7387227Uae40Urinary albumin excretion QTL 402.90.0052urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)41794699962946999Rat
1358201Gluco12Glucose level QTL121.6adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake (CMO:0000870)4521839229593287Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4132584199Rat
1358203Stl19Serum triglyceride level QTL 192.80.002blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4521829465958103Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41008408955084089Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4131934116Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
1354665Stl10Serum triglyceride level QTL 103.57blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)42133334344463908Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41002490139524530Rat

Markers in Region
RH142432  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2425,132,724 - 25,132,963 (+)MAPPERmRatBN7.2
Rnor_6.0422,115,881 - 22,116,119NCBIRnor6.0
Rnor_5.0422,052,703 - 22,052,941UniSTSRnor5.0
RGSC_v3.4422,024,059 - 22,024,297UniSTSRGSC3.4
Celera420,625,873 - 20,626,111UniSTS
Cytogenetic Map4q12UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31

Sequence


Ensembl Acc Id: ENSRNOT00000067462   ⟹   ENSRNOP00000063856
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl425,098,110 - 25,133,105 (+)Ensembl
Rnor_6.0 Ensembl422,081,604 - 22,116,265 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000090968   ⟹   ENSRNOP00000071087
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl425,107,632 - 25,133,109 (+)Ensembl
Rnor_6.0 Ensembl422,084,954 - 22,111,749 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000091799   ⟹   ENSRNOP00000073847
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl425,080,587 - 25,133,109 (+)Ensembl
Rnor_6.0 Ensembl422,082,194 - 22,116,241 (+)Ensembl
RefSeq Acc Id: NM_031987   ⟹   NP_114193
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,053,124 - 26,088,057 (+)NCBI
mRatBN7.2425,098,174 - 25,133,109 (+)NCBI
Rnor_6.0422,081,604 - 22,116,265 (+)NCBI
Rnor_5.0422,018,106 - 22,053,087 (+)NCBI
RGSC_v3.4422,023,913 - 22,067,029 (-)RGD
Celera420,575,938 - 20,626,257 (+)RGD
Sequence:
RefSeq Acc Id: XM_006236004   ⟹   XP_006236066
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,049,329 - 26,088,057 (+)NCBI
mRatBN7.2425,098,279 - 25,133,111 (+)NCBI
Rnor_6.0422,081,673 - 22,116,264 (+)NCBI
Rnor_5.0422,018,106 - 22,053,087 (+)NCBI
Sequence:
RefSeq Acc Id: XM_006236005   ⟹   XP_006236067
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,049,329 - 26,088,057 (+)NCBI
mRatBN7.2425,097,399 - 25,133,111 (+)NCBI
Rnor_6.0422,079,837 - 22,116,264 (+)NCBI
Rnor_5.0422,018,106 - 22,053,087 (+)NCBI
Sequence:
RefSeq Acc Id: XM_039108454   ⟹   XP_038964382
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,031,729 - 26,088,057 (+)NCBI
mRatBN7.2425,079,428 - 25,133,111 (+)NCBI
RefSeq Acc Id: XM_039108458   ⟹   XP_038964386
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8426,031,729 - 26,088,057 (+)NCBI
mRatBN7.2425,079,428 - 25,133,111 (+)NCBI
RefSeq Acc Id: NP_114193   ⟸   NM_031987
- UniProtKB: P48033 (UniProtKB/Swiss-Prot),   P11466 (UniProtKB/Swiss-Prot),   Q6GMN6 (UniProtKB/TrEMBL),   A6K232 (UniProtKB/TrEMBL),   F7F5D0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236067   ⟸   XM_006236005
- Peptide Label: isoform X2
- UniProtKB: P48033 (UniProtKB/Swiss-Prot),   P11466 (UniProtKB/Swiss-Prot),   Q6GMN6 (UniProtKB/TrEMBL),   A6K232 (UniProtKB/TrEMBL),   F7F5D0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236066   ⟸   XM_006236004
- Peptide Label: isoform X1
- UniProtKB: P48033 (UniProtKB/Swiss-Prot),   P11466 (UniProtKB/Swiss-Prot)
- Sequence:
Ensembl Acc Id: ENSRNOP00000063856   ⟸   ENSRNOT00000067462
Ensembl Acc Id: ENSRNOP00000071087   ⟸   ENSRNOT00000090968
Ensembl Acc Id: ENSRNOP00000073847   ⟸   ENSRNOT00000091799
RefSeq Acc Id: XP_038964382   ⟸   XM_039108454
- Peptide Label: isoform X2
- UniProtKB: A6K232 (UniProtKB/TrEMBL),   F7F5D0 (UniProtKB/TrEMBL),   Q6GMN6 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038964386   ⟸   XM_039108458
- Peptide Label: isoform X2
- UniProtKB: P48033 (UniProtKB/Swiss-Prot),   P11466 (UniProtKB/Swiss-Prot),   Q6GMN6 (UniProtKB/TrEMBL),   A6K232 (UniProtKB/TrEMBL),   F7F5D0 (UniProtKB/TrEMBL)
Protein Domains
Choline/carnitine acyltransferase

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P11466-F1-model_v2 AlphaFold P11466 1-612 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692826
Promoter ID:EPDNEW_R3351
Type:initiation region
Name:Crot_1
Description:carnitine O-octanoyltransferase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0422,081,564 - 22,081,624EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70908 AgrOrtholog
BioCyc Gene G2FUF-45833 BioCyc
Ensembl Genes ENSRNOG00000006779 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000067462.3 UniProtKB/TrEMBL
  ENSRNOT00000090968.2 UniProtKB/TrEMBL
  ENSRNOT00000091799.2 UniProtKB/TrEMBL
Gene3D-CATH 1.10.275.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.559.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.30.559.70 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7098081 IMAGE-MGC_LOAD
InterPro Carn_acyl_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Carn_acyl_trans_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CAT-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cho/carn_acyl_trans UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Cho/carn_acyl_trans_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:83842 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGC_CLONE MGC:91606 IMAGE-MGC_LOAD
NCBI Gene 83842 ENTREZGENE
PANTHER PEROXISOMAL CARNITINE O-OCTANOYLTRANSFERASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR22589 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Carn_acyltransf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Crot PhenoGen
PROSITE ACYLTRANSF_C_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ACYLTRANSF_C_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000006779 RatGTEx
Superfamily-SCOP CoA-dependent acyltransferases UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2JZK8_RAT UniProtKB/TrEMBL
  A0A0G2K6K3_RAT UniProtKB/TrEMBL
  A6K232 ENTREZGENE, UniProtKB/TrEMBL
  F7F5D0 ENTREZGENE, UniProtKB/TrEMBL
  OCTC_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  P48033 ENTREZGENE
  Q6GMN6 ENTREZGENE
UniProt Secondary P48033 UniProtKB/Swiss-Prot
  Q6GMN6 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-07-09 Crot  carnitine O-octanoyltransferase      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_regulation activity is inhibited by malonyl-CoA 727629