Lilrb2 (leukocyte immunoglobulin like receptor B2) - Rat Genome Database

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Gene: Lilrb2 (leukocyte immunoglobulin like receptor B2) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Lilrb2
Name: leukocyte immunoglobulin like receptor B2
RGD ID: 70895
Description: Predicted to enable inhibitory MHC class I receptor activity. Predicted to be involved in cytokine-mediated signaling pathway and immune response-regulating signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane. Orthologous to human LILRB1 (leukocyte immunoglobulin like receptor B1) and LILRB5 (leukocyte immunoglobulin like receptor B5); PARTICIPATES IN B cell receptor signaling pathway; INTERACTS WITH bisphenol A; dioxygen.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3; Lilrb3; neutrophil immunoglobulin-like receptor 1; neutrophil immunoglobulin-like receptor-1; NILR-1; Nilr1; paired Ig-like receptor B; paired-Ig-like receptor B; Pirb; type 1 one-pass transmembrane Ig-like receptor
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8174,242,200 - 74,250,051 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl174,242,200 - 74,250,047 (+)EnsemblGRCr8
mRatBN7.2165,326,832 - 65,334,683 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl165,326,832 - 65,334,679 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx170,779,082 - 70,786,933 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0179,197,951 - 79,205,798 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
Rnor_6.0163,734,135 - 63,741,986 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl163,734,135 - 63,741,982 (+)Ensemblrn6Rnor6.0
Rnor_5.0170,045,572 - 70,053,423 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4163,651,983 - 63,659,834 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera163,050,632 - 63,058,483 (+)NCBICelera
RGSC_v3.1163,794,981 - 63,802,831 (-)NCBI
Cytogenetic Map1q12NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
bisphenol A  (EXP)
dioxygen  (EXP)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component
plasma membrane  (IBA,IEA)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. NILR-1, a novel immunoglobulin-like receptor expressed by neutrophilic granulocytes, is encoded by a leukocyte receptor gene complex on rat chromosome 1. Berg SF, etal., Eur J Immunol 1999 Jun;29(6):2000-6.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Gene Data Set MGD Curation, June 12, 2002
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9842885   PMID:11169396   PMID:14971032   PMID:17056715   PMID:18802077   PMID:19124746   PMID:20008523   PMID:20448110   PMID:20702625   PMID:20714874   PMID:22562814   PMID:22580685  
PMID:22802125   PMID:24052308   PMID:24461182   PMID:26821234   PMID:27966582   PMID:28669876  


Genomics

Variants

.
Variants in Lilrb2
132 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1331732Srn4Serum renin concentration QTL 44.467renin activity (VT:0005581)plasma renin activity level (CMO:0000116)14345783787558729Rat
1357397Bw41Body weight QTL 414.190.0001body mass (VT:0001259)body weight (CMO:0000012)12940927974409279Rat
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1331792Rf29Renal function QTL 294.589urine potassium amount (VT:0010539)urine potassium level (CMO:0000128)14345783787558729Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
8552900Pigfal1Plasma insulin-like growth factor 1 level QTL 17.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
1354643Foco2Food consumption QTL 27.170.0001eating behavior trait (VT:0001431)food intake rate (CMO:0000427)14212296887122968Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
1331778Rf28Renal function QTL 284.66urine potassium amount (VT:0010539)urine potassium excretion rate (CMO:0000761)14345783787558729Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
1331785Rf27Renal function QTL 274.643urine sodium amount (VT:0006274)urine sodium level (CMO:0000129)13070837587558729Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
1300172Bp172Blood pressure QTL 1723.56arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)13456572679565726Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
9589820Insglur3Insulin/glucose ratio QTL 310.750.001blood insulin amount (VT:0001560)calculated plasma insulin level (CMO:0002170)14350995288509952Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
1354599Bw29Body weight QTL 293.460.001body mass (VT:0001259)body weight (CMO:0000012)14212296887122968Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat
8552948Pigfal11Plasma insulin-like growth factor 1 level QTL 114.7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)14350995288509952Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 11 56 143 86 85 54 92 54 6 327 180 11 117 69 87 31 10 10

Sequence


Ensembl Acc Id: ENSRNOT00000084439   ⟹   ENSRNOP00000075718
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl174,242,200 - 74,250,047 (+)Ensembl
mRatBN7.2 Ensembl165,326,832 - 65,334,679 (+)Ensembl
Rnor_6.0 Ensembl163,734,135 - 63,741,982 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000108341   ⟹   ENSRNOP00000079576
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl174,242,321 - 74,250,047 (+)Ensembl
mRatBN7.2 Ensembl165,326,953 - 65,334,679 (+)Ensembl
RefSeq Acc Id: NM_031713   ⟹   NP_113901
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8174,242,200 - 74,250,051 (+)NCBI
mRatBN7.2165,326,832 - 65,334,683 (+)NCBI
Rnor_6.0163,734,135 - 63,741,986 (+)NCBI
Rnor_5.0170,045,572 - 70,053,423 (+)NCBI
RGSC_v3.4163,651,983 - 63,659,834 (+)RGD
Celera163,050,632 - 63,058,483 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_113901 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAD29110 (Get FASTA)   NCBI Sequence Viewer  
  D3ZQX2 (Get FASTA)   NCBI Sequence Viewer  
  EDL84917 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000075718
  ENSRNOP00000075718.2
RefSeq Acc Id: NP_113901   ⟸   NM_031713
- UniProtKB: A2J8C0 (UniProtKB/Swiss-Prot),   A0A140TAJ6 (UniProtKB/TrEMBL),   D3ZQX2 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000075718   ⟸   ENSRNOT00000084439
Ensembl Acc Id: ENSRNOP00000079576   ⟸   ENSRNOT00000108341
Protein Domains
Ig-like C2-type   Immunoglobulin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-D3ZQX2-F1-model_v2 AlphaFold D3ZQX2 1-547 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70895 AgrOrtholog
BioCyc Gene G2FUF-61052 BioCyc
Ensembl Genes ENSRNOG00000054954 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000084439 ENTREZGENE
  ENSRNOT00000084439.2 UniProtKB/Swiss-Prot
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
InterPro Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig-like_Receptors_ImmuneReg UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
KEGG Report rno:65146 UniProtKB/Swiss-Prot
NCBI Gene 65146 ENTREZGENE
PANTHER LEUKOCYTE IMMUNOGLOBULIN-LIKE RECEPTOR SUBFAMILY A MEMBER 5 UniProtKB/Swiss-Prot
  MHC CLASS I NK CELL RECEPTOR UniProtKB/Swiss-Prot
Pfam Ig_2 UniProtKB/Swiss-Prot
PhenoGen Lilrb2 PhenoGen
RatGTEx ENSRNOG00000054954 RatGTEx
SMART SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt A0A140TAJ6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZNE1_RAT UniProtKB/TrEMBL
  A2J8C0 ENTREZGENE
  D3ZQX2 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary A2J8C0 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-05-24 Lilrb2  leukocyte immunoglobulin like receptor B2  Nilr1  neutrophil immunoglobulin-like receptor-1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2016-01-26 Nilr1  neutrophil immunoglobulin-like receptor-1  Pirb  paired Ig-like receptor B  Name and Symbol changed 629549 APPROVED
2015-09-21 Pirb  paired Ig-like receptor B  Lilrb3  leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3  Name and Symbol changed 629549 APPROVED
2008-03-17 Lilrb3  leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 3  Pirb  paired-Ig-like receptor B  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-07-09 Pirb  paired-Ig-like receptor B      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process member of regulatory Ig-like receptor family 70628
gene_protein 524 amino acids; 58.7 kDa 70628