Kcnip2 (potassium voltage-gated channel interacting protein 2) - Rat Genome Database

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Gene: Kcnip2 (potassium voltage-gated channel interacting protein 2) Rattus norvegicus
Analyze
Symbol: Kcnip2
Name: potassium voltage-gated channel interacting protein 2
RGD ID: 70887
Description: Enables calcium ion binding activity and potassium channel regulator activity. Involved in clustering of voltage-gated potassium channels and regulation of potassium ion transmembrane transport. Located in dendrite and plasma membrane. Part of voltage-gated potassium channel complex. Orthologous to human KCNIP2 (potassium voltage-gated channel interacting protein 2); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; INTERACTS WITH 3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione; 4,4'-sulfonyldiphenol; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A-type potassium channel modulatory protein 2; A-type potassium channel modulatory protein KCNIP2; Kchip2; Kv channel-interacting protein 2; Kv channel-interacting protein 2-like; LOC100911951; potassium channel auxiliary subunit KCHIP2; potassium channel modulatory protein 2; potassium channel-interacting protein 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Allele / Splice: Kcnip2_v1 ; Kcnip2_v2 ; Kcnip2_v3
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81254,590,172 - 254,614,437 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1254,590,175 - 254,613,898 (-)EnsemblGRCr8
mRatBN7.21244,641,147 - 244,664,939 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1244,641,150 - 244,664,874 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1252,782,586 - 252,806,733 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01259,480,725 - 259,504,561 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01252,132,599 - 252,156,275 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01265,549,610 - 265,573,393 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1265,549,593 - 265,573,409 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1262,892,545 - 262,916,361 (+)Ensemblrn6Rnor6.0
Rnor_5.01270,337,725 - 270,361,519 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41251,008,676 - 251,032,402 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1240,448,191 - 240,472,276 (-)NCBICelera
Cytogenetic Map1q54NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway   (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
alfentanil pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway   (ISO)
calcium/calcium-mediated signaling pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. C-terminal domain of Kv4.2 and associated KChIP2 interactions regulate functional expression and gating of Kv4.2. Han W, etal., J Biol Chem. 2006 Sep 15;281(37):27134-44. Epub 2006 Jul 4.
3. Contribution of KChIP2 to the developmental increase in transient outward current of rat cardiomyocytes. Kobayashi T, etal., J Mol Cell Cardiol. 2003 Sep;35(9):1073-82.
4. A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia. Kuo HC, etal., Cell 2001 Dec 14;107(6):801-13.
5. The diversity of calcium sensor proteins in the regulation of neuronal function. McCue HV, etal., Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a004085. doi: 10.1101/cshperspect.a004085. Epub 2010 Jul 28.
6. Gene Data Set MGD Curation, June 12, 2002
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
9. Molecular cloning and expression of the novel splice variants of K(+) channel-interacting protein 2. Ohya S, etal., Biochem Biophys Res Commun 2001 Mar 23;282(1):96-102.
10. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. KChIPs and Kv4 alpha subunits as integral components of A-type potassium channels in mammalian brain. Rhodes KJ, etal., J Neurosci. 2004 Sep 8;24(36):7903-15.
13. A fundamental role for KChIPs in determining the molecular properties and trafficking of Kv4.2 potassium channels. Shibata R, etal., J Biol Chem 2003 Sep 19;278(38):36445-54. Epub 2003 Jun 26.
14. Palmitoylation of KChIP splicing variants is required for efficient cell surface expression of Kv4.3 channels. Takimoto K, etal., J Biol Chem 2002 Jul 26;277(30):26904-11.
Additional References at PubMed
PMID:10676964   PMID:11287421   PMID:12477932   PMID:12928444   PMID:15060005   PMID:15358149   PMID:15454398   PMID:15489334   PMID:15736227   PMID:15946675   PMID:16385079   PMID:16484624  
PMID:16636498   PMID:17725325   PMID:17725712   PMID:18565539   PMID:18957440   PMID:19713751   PMID:20051248   PMID:20943905   PMID:21252158   PMID:21349352   PMID:21493962   PMID:24037673  
PMID:24486512   PMID:26742842   PMID:30760025   PMID:31362018  


Genomics

Comparative Map Data
Kcnip2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81254,590,172 - 254,614,437 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1254,590,175 - 254,613,898 (-)EnsemblGRCr8
mRatBN7.21244,641,147 - 244,664,939 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1244,641,150 - 244,664,874 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1252,782,586 - 252,806,733 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01259,480,725 - 259,504,561 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01252,132,599 - 252,156,275 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01265,549,610 - 265,573,393 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1265,549,593 - 265,573,409 (-)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl1262,892,545 - 262,916,361 (+)Ensemblrn6Rnor6.0
Rnor_5.01270,337,725 - 270,361,519 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41251,008,676 - 251,032,402 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1240,448,191 - 240,472,276 (-)NCBICelera
Cytogenetic Map1q54NCBI
KCNIP2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810101,825,974 - 101,843,800 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10101,825,969 - 101,843,965 (-)Ensemblhg38GRCh38
GRCh3710103,585,731 - 103,603,557 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3610103,575,721 - 103,593,667 (-)NCBIBuild 36Build 36hg18NCBI36
Build 3410103,575,721 - 103,593,667NCBI
Celera1097,324,471 - 97,342,415 (-)NCBICelera
Cytogenetic Map10q24.32NCBI
HuRef1097,216,464 - 97,234,410 (-)NCBIHuRef
CHM1_110103,869,314 - 103,887,271 (-)NCBICHM1_1
T2T-CHM13v2.010102,709,458 - 102,727,289 (-)NCBIT2T-CHM13v2.0
Kcnip2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391945,780,785 - 45,804,948 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1945,780,278 - 45,804,500 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm381945,792,346 - 45,816,422 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1945,791,839 - 45,816,061 (-)Ensemblmm10GRCm38
MGSCv371945,868,160 - 45,890,293 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361945,846,981 - 45,869,114 (-)NCBIMGSCv36mm8
Celera1946,555,638 - 46,577,688 (-)NCBICelera
Cytogenetic Map19C3NCBI
cM Map1938.75NCBI
Kcnip2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554858,467,207 - 8,470,950 (+)Ensembl
ChiLan1.0NW_0049554858,468,117 - 8,472,220 (+)NCBIChiLan1.0ChiLan1.0
KCNIP2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28113,712,657 - 113,730,573 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110113,717,971 - 113,735,894 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01098,428,619 - 98,446,581 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110101,899,898 - 101,918,691 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10101,899,898 - 101,918,691 (-)EnsemblpanPan2panpan1.1
KCNIP2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12814,409,526 - 14,425,641 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2814,409,526 - 14,425,641 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2814,578,242 - 14,596,662 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02814,877,733 - 14,896,184 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2814,859,845 - 14,896,560 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12814,424,193 - 14,442,591 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02814,463,755 - 14,482,179 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02814,596,080 - 14,614,481 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Kcnip2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440721332,337,576 - 32,371,125 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366003,940,813 - 3,961,803 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366003,940,806 - 3,974,455 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
KCNIP2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14112,857,062 - 112,876,439 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114112,857,058 - 112,876,469 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214122,709,372 - 122,726,785 (-)NCBISscrofa10.2Sscrofa10.2susScr3
KCNIP2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1994,854,024 - 94,873,655 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl994,855,403 - 94,873,312 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604855,930,976 - 55,951,582 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Kcnip2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248311,301,598 - 1,319,572 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248311,301,840 - 1,319,487 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Kcnip2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1245,267,753 - 45,290,482 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Kcnip2
139 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:1044
Count of miRNA genes:254
Interacting mature miRNAs:307
Transcripts:ENSRNOT00000024709, ENSRNOT00000024750, ENSRNOT00000044195, ENSRNOT00000048592, ENSRNOT00000055915, ENSRNOT00000068278
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
61327Eae7Experimental allergic encephalomyelitis QTL 75.6body mass (VT:0001259)change in body weight (CMO:0002045)1226175591270518180Rat
1578775Iddm21Insulin dependent diabetes mellitus QTL 214.13blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1245782829270518180Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1578763Kidm29Kidney mass QTL 293.30.0001kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1218829748263829748Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
631837Niddm35Non-insulin dependent diabetes mellitus QTL 350.01blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1248619887269633915Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631836Stl31Serum triglyceride level QTL 314.645e-06blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)1247133834270518180Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
1300108Rf8Renal function QTL 83.75renal blood flow trait (VT:2000006)absolute change in renal vascular resistance (CMO:0001900)1237995023269633915Rat
734767Niddm57Non-insulin dependent diabetes mellitus QTL 57body mass (VT:0001259)body weight (CMO:0000012)1233480549270108840Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631215Stl8Serum triglyceride level QTL 89.270.0001blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)1234540191270518180Rat
631843Bw116Body weight QTL 1164.10.016abdominal adipose amount (VT:1000220)abdominal fat pad weight (CMO:0000088)1233480549270108840Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
724538Kidm1Kidney mass QTL 13.2kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1223134011262090599Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
734769Niddm58Non-insulin dependent diabetes mellitus QTL 58body mass (VT:0001259)body weight (CMO:0000012)1225108840270108840Rat
724533Rf51Renal function QTL 515.30.0002kidney plasma flow trait (VT:0005524)renal plasma flow (CMO:0001914)1228180370266453608Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
70211Niddm24Non-insulin dependent diabetes mellitus QTL 243.79blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1224633915269633915Rat
724552Glom2Glomerulus QTL 23.30.0001kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)1232312773270518180Rat
2316896Gluco57Glucose level QTL 577.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1238398865255849249Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
61400Niddm1Non-insulin dependent diabetes mellitus QTL 111blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1228180243255849249Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
7387289Uae45Urinary albumin excretion QTL 452.860.0021urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1233204160270518180Rat
1581544Rf52Renal function QTL 520.05urine total protein amount (VT:0000032)urine protein excretion rate to body weight ratio (CMO:0001099)1241569529269633915Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
631536Lnnr2Liver neoplastic nodule remodeling QTL 22.90.0005liver integrity trait (VT:0010547)liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)1243953669270518180Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2302040Pia35Pristane induced arthritis QTL 353.80.001blood immunoglobulin amount (VT:0002460)serum immunoglobulin G1 level (CMO:0002115)1226175591270518180Rat
631669Iddm9Insulin dependent diabetes mellitus QTL 92.80.039blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1233349180270518180Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat
1598821Rf55Renal function QTL 556.3renal blood flow trait (VT:2000006)ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)1228174566270518180Rat

Markers in Region
RH128727  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21244,666,348 - 244,666,532 (-)MAPPERmRatBN7.2
mRatBN7.21244,666,348 - 244,666,532 (+)MAPPERmRatBN7.2
Rnor_6.01265,574,814 - 265,574,997NCBIRnor6.0
Rnor_6.01262,890,949 - 262,891,132NCBIRnor6.0
Rnor_5.01270,336,125 - 270,336,308UniSTSRnor5.0
Rnor_5.01273,005,112 - 273,005,295UniSTSRnor5.0
RGSC_v3.41251,033,877 - 251,034,060UniSTSRGSC3.4
Celera1240,473,751 - 240,473,934UniSTS
RH 3.4 Map11622.91UniSTS
Cytogenetic Map1q54UniSTS
AI059157  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21244,641,211 - 244,641,400 (-)MAPPERmRatBN7.2
mRatBN7.21244,641,211 - 244,641,400 (+)MAPPERmRatBN7.2
Rnor_6.01265,549,678 - 265,549,866NCBIRnor6.0
Rnor_6.01262,916,089 - 262,916,277NCBIRnor6.0
Rnor_5.01270,361,265 - 270,361,453UniSTSRnor5.0
Rnor_5.01272,979,975 - 272,980,163UniSTSRnor5.0
RGSC_v3.41251,008,741 - 251,008,929UniSTSRGSC3.4
Celera1240,448,256 - 240,448,444UniSTS
RH 3.4 Map11621.0UniSTS
Cytogenetic Map1q54UniSTS
Kcnip2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21244,642,822 - 244,644,181 (-)MAPPERmRatBN7.2
mRatBN7.21244,642,822 - 244,644,181 (+)MAPPERmRatBN7.2
Rnor_6.01265,551,289 - 265,552,647NCBIRnor6.0
Rnor_6.01262,913,308 - 262,914,666NCBIRnor6.0
Rnor_5.01272,981,586 - 272,982,944UniSTSRnor5.0
Rnor_5.01270,358,484 - 270,359,842UniSTSRnor5.0
Celera1240,449,867 - 240,451,225UniSTS
Cytogenetic Map1q54UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
21 1 52 140 61 53 29 78 29 12 258 164 11 115 44 71 24 16 16

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001033961 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_020094 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_020095 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760449 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_008760450 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589617 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017589618 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272076 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272080 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_063272081 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC093941 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF269283 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF269284 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF269285 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC085905 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CK226309 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  GU937871 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000024709   ⟹   ENSRNOP00000024709
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1254,590,175 - 254,613,898 (-)Ensembl
mRatBN7.2 Ensembl1244,641,150 - 244,664,874 (-)Ensembl
Rnor_6.0 Ensembl1262,892,607 - 262,916,339 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000024750   ⟹   ENSRNOP00000024750
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1254,590,175 - 254,613,898 (-)Ensembl
mRatBN7.2 Ensembl1244,641,150 - 244,664,874 (-)Ensembl
Rnor_6.0 Ensembl1262,892,607 - 262,916,339 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000044195   ⟹   ENSRNOP00000040277
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1265,550,924 - 265,573,117 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000048592   ⟹   ENSRNOP00000050779
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1254,591,423 - 254,600,945 (-)Ensembl
mRatBN7.2 Ensembl1244,642,398 - 244,651,921 (-)Ensembl
Rnor_6.0 Ensembl1265,550,864 - 265,560,386 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000055915   ⟹   ENSRNOP00000052766
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1265,550,924 - 265,573,117 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000068278   ⟹   ENSRNOP00000059337
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1262,892,545 - 262,916,361 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000086164   ⟹   ENSRNOP00000073300
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1254,590,175 - 254,610,242 (-)Ensembl
mRatBN7.2 Ensembl1244,641,150 - 244,661,191 (-)Ensembl
Rnor_6.0 Ensembl1265,549,593 - 265,573,409 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000090765   ⟹   ENSRNOP00000073871
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1262,905,570 - 262,915,031 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000128712   ⟹   ENSRNOP00000111656
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1254,590,175 - 254,613,898 (-)Ensembl
RefSeq Acc Id: NM_001033961   ⟹   NP_001029133
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,590,172 - 254,613,898 (-)NCBI
mRatBN7.21244,641,147 - 244,664,874 (-)NCBI
Rnor_6.01265,549,613 - 265,573,339 (-)NCBI
Rnor_5.01270,337,725 - 270,361,519 (+)NCBI
RGSC_v3.41251,008,676 - 251,032,402 (-)RGD
Celera1240,448,191 - 240,472,276 (-)RGD
Sequence:
RefSeq Acc Id: NM_020094   ⟹   NP_064479
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,590,172 - 254,613,898 (-)NCBI
mRatBN7.21244,641,147 - 244,664,874 (-)NCBI
Rnor_6.01265,549,613 - 265,573,339 (-)NCBI
Rnor_5.01270,337,725 - 270,361,519 (+)NCBI
RGSC_v3.41251,008,676 - 251,032,402 (-)RGD
Celera1240,448,191 - 240,472,276 (-)RGD
Sequence:
RefSeq Acc Id: NM_020095   ⟹   NP_064480
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,590,172 - 254,613,898 (-)NCBI
mRatBN7.21244,641,147 - 244,664,874 (-)NCBI
Rnor_6.01265,549,613 - 265,573,339 (-)NCBI
Rnor_5.01270,337,725 - 270,361,519 (+)NCBI
RGSC_v3.41251,008,676 - 251,032,402 (-)RGD
Celera1240,448,191 - 240,472,276 (-)RGD
Sequence:
RefSeq Acc Id: XM_008760450   ⟹   XP_008758672
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,590,172 - 254,601,064 (-)NCBI
mRatBN7.21244,641,961 - 244,652,025 (-)NCBI
Rnor_6.01265,549,610 - 265,560,490 (-)NCBI
Sequence:
RefSeq Acc Id: XM_063272069   ⟹   XP_063128139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,590,172 - 254,614,437 (-)NCBI
RefSeq Acc Id: XM_063272076   ⟹   XP_063128146
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,590,172 - 254,614,437 (-)NCBI
RefSeq Acc Id: XM_063272080   ⟹   XP_063128150
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,590,172 - 254,601,107 (-)NCBI
RefSeq Acc Id: XM_063272081   ⟹   XP_063128151
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81254,590,172 - 254,614,437 (-)NCBI
RefSeq Acc Id: NP_064479   ⟸   NM_020094
- Peptide Label: isoform a
- UniProtKB: Q9JI23 (UniProtKB/Swiss-Prot),   Q9JI22 (UniProtKB/Swiss-Prot),   Q9JI21 (UniProtKB/Swiss-Prot),   Q9JM60 (UniProtKB/Swiss-Prot),   Q9JM59 (UniProtKB/Swiss-Prot),   A6JHK0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_064480   ⟸   NM_020095
- Peptide Label: isoform b
- UniProtKB: A6JHJ9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001029133   ⟸   NM_001033961
- Peptide Label: isoform c
- UniProtKB: A6JHJ8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_008758672   ⟸   XM_008760450
- Peptide Label: isoform X5
- UniProtKB: D5LL09 (UniProtKB/TrEMBL),   A0A8L2UQY6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000052766   ⟸   ENSRNOT00000055915
Ensembl Acc Id: ENSRNOP00000073871   ⟸   ENSRNOT00000090765
Ensembl Acc Id: ENSRNOP00000073300   ⟸   ENSRNOT00000086164
Ensembl Acc Id: ENSRNOP00000024709   ⟸   ENSRNOT00000024709
Ensembl Acc Id: ENSRNOP00000024750   ⟸   ENSRNOT00000024750
Ensembl Acc Id: ENSRNOP00000040277   ⟸   ENSRNOT00000044195
Ensembl Acc Id: ENSRNOP00000050779   ⟸   ENSRNOT00000048592
Ensembl Acc Id: ENSRNOP00000059337   ⟸   ENSRNOT00000068278
RefSeq Acc Id: XP_063128151   ⟸   XM_063272081
- Peptide Label: isoform X4
RefSeq Acc Id: XP_063128146   ⟸   XM_063272076
- Peptide Label: isoform X2
RefSeq Acc Id: XP_063128139   ⟸   XM_063272069
- Peptide Label: isoform X1
- UniProtKB: A6JHK0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063128150   ⟸   XM_063272080
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000111656   ⟸   ENSRNOT00000128712
Protein Domains
EF-hand

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JM59-F1-model_v2 AlphaFold Q9JM59 1-270 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690953
Promoter ID:EPDNEW_R1478
Type:single initiation site
Name:Kcnip2_1
Description:potassium voltage-gated channel interacting protein 2
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01265,573,351 - 265,573,411EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70887 AgrOrtholog
BioCyc Gene G2FUF-55534 BioCyc
Ensembl Genes ENSRNOG00000018018 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
  ENSRNOG00000050450 Ensembl
Ensembl Transcript ENSRNOT00000024709 ENTREZGENE
  ENSRNOT00000024709.6 UniProtKB/Swiss-Prot
  ENSRNOT00000024750 ENTREZGENE
  ENSRNOT00000024750.5 UniProtKB/Swiss-Prot
  ENSRNOT00000048592 ENTREZGENE
  ENSRNOT00000128712 ENTREZGENE
Gene3D-CATH EF-hand UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7193750 IMAGE-MGC_LOAD
InterPro EF-hand-dom_pair UniProtKB/Swiss-Prot
  EF_Hand_1_Ca_BS UniProtKB/Swiss-Prot
  EF_hand_dom UniProtKB/Swiss-Prot
  Recoverin UniProtKB/Swiss-Prot
KEGG Report rno:56817 UniProtKB/Swiss-Prot
MGC_CLONE MGC:94740 IMAGE-MGC_LOAD
NCBI Gene 56817 ENTREZGENE
PANTHER KV CHANNEL-INTERACTING PROTEIN 2 UniProtKB/Swiss-Prot
  PTHR23055 UniProtKB/Swiss-Prot
Pfam EF-hand_7 UniProtKB/Swiss-Prot
  EF-hand_8 UniProtKB/Swiss-Prot
PharmGKB KCNIP2 RGD
PhenoGen Kcnip2 PhenoGen
PRINTS RECOVERIN UniProtKB/Swiss-Prot
PROSITE EF_HAND_1 UniProtKB/Swiss-Prot
  EF_HAND_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018018 RatGTEx
  ENSRNOG00000050450 RatGTEx
SMART EFh UniProtKB/Swiss-Prot
Superfamily-SCOP SSF47473 UniProtKB/Swiss-Prot
UniProt A0A8L2UQY6 ENTREZGENE, UniProtKB/TrEMBL
  A6JHJ8 ENTREZGENE, UniProtKB/TrEMBL
  A6JHJ9 ENTREZGENE, UniProtKB/TrEMBL
  A6JHK0 ENTREZGENE, UniProtKB/TrEMBL
  D5LL09 ENTREZGENE, UniProtKB/TrEMBL
  KCIP2_RAT UniProtKB/Swiss-Prot
  Q9JI21 ENTREZGENE
  Q9JI22 ENTREZGENE
  Q9JI23 ENTREZGENE
  Q9JM59 ENTREZGENE
  Q9JM60 ENTREZGENE
UniProt Secondary Q9JI21 UniProtKB/Swiss-Prot
  Q9JI22 UniProtKB/Swiss-Prot
  Q9JI23 UniProtKB/Swiss-Prot
  Q9JM60 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Kcnip2  potassium voltage-gated channel interacting protein 2  LOC100911951  Kv channel-interacting protein 2-like  Data merged from RGD:6489795 737654 PROVISIONAL
2016-02-11 Kcnip2  potassium voltage-gated channel interacting protein 2  Kcnip2  Kv channel-interacting protein 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-07-05 LOC100911951  Kv channel-interacting protein 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-05-10 Kcnip2  Kv channel-interacting protein 2  Kchip2  A-type potassium channel modulatory protein 2  Data merged from RGD:1591899 737654 APPROVED
2006-11-20 Kchip2  A-type potassium channel modulatory protein 2      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-07-09 Kcnip2  Kv channel-interacting protein 2      Symbol and Name updated to reflect Human and Mouse nomenclature 70877 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains the core conserved domain contains four EF hand motifs 625553
gene_expression expressed in the brain and heart 625553
gene_function essential component of the Kv channels in excitable cells 625553
gene_regulation palmitoylation controls plasma membrane localization along with plasma membrane localization of the associated K+ channels 625553
gene_transcript three isoforms exist with variable N-terminal peptides 625553