Itih4 (inter-alpha-trypsin inhibitor heavy chain 4)

Gene: Itih4 (inter-alpha-trypsin inhibitor heavy chain 4) Rattus norvegicus

Analyze

Symbol:

Itih4

Name:

inter-alpha-trypsin inhibitor heavy chain 4

RGD ID:

70881

Description:

Predicted to be involved in acute-phase response and response to cytokine. Located in extracellular space. Biomarker of amyotrophic lateral sclerosis and obesity. Human ortholog(s) of this gene implicated in intermediate coronary syndrome and myocardial infarction. Orthologous to human ITIH4 (inter-alpha-trypsin inhibitor heavy chain 4); INTERACTS WITH 1,3-dinitrobenzene; 17beta-estradiol; 2,4-dinitrotoluene.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

inter alpha-trypsin inhibitor, heavy chain 4; inter-alpha-inhibitor H4 heavy chain; inter-alpha-trypsin inhibitor heavy chain family, member 4; inter-alpha-trypsin inhibitor heavy chain H4

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	6,086,985 - 6,102,162 (+)	NCBI		GRCr8
mRatBN7.2	16	6,080,539 - 6,095,710 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	6,080,539 - 6,095,708 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	6,091,889 - 6,107,055 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	7,237,346 - 7,252,512 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	6,099,223 - 6,114,442 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	6,970,367 - 6,985,538 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	6,970,342 - 6,985,579 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	6,896,782 - 6,912,274 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	6,319,608 - 6,334,782 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	6,319,608 - 6,334,777 (+)	NCBI
Celera	16	9,093,866 - 9,109,046 (-)	NCBI		Celera
Cytogenetic Map	16	p16	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

amyotrophic lateral sclerosis (IEP,ISO)

Bacteremia (ISO)

Chronic Hepatitis B (ISO)

Colonic Neoplasms (IEP,ISO)

congenital disorder of glycosylation In (ISO)

familial adenomatous polyposis (ISO)

genetic disease (ISO)

hepatocellular carcinoma (ISO)

Hypercholesterolemia (ISO)

intermediate coronary syndrome (ISO)

Invasive Pulmonary Aspergillosis (IEP)

liver cirrhosis (ISO)

myocardial infarction (ISO)

obesity (IEP)

pulmonary tuberculosis (ISO)

Spinal Cord Injuries (IEP)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(1->4)-beta-D-glucan (ISO)

1,2-dimethylhydrazine (ISO)

1,3-dinitrobenzene (EXP)

1-naphthyl isothiocyanate (ISO)

17alpha-ethynylestradiol (ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

2,4-dinitrotoluene (EXP)

2,6-dinitrotoluene (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

3,3',4,4'-tetrachlorobiphenyl (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

3H-1,2-dithiole-3-thione (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-methoxy-2-\{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl\}-1H-benzimidazole (EXP)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (ISO)

aflatoxin B1 (ISO)

aluminium oxide (ISO)

amiodarone (EXP)

benzbromarone (EXP)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bromobenzene (EXP)

cadmium atom (ISO)

cadmium dichloride (EXP)

carbon nanotube (ISO)

cisplatin (ISO)

clofibrate (EXP,ISO)

cobalt dichloride (EXP)

copper atom (ISO)

copper(0) (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dextran sulfate (ISO)

dichloroacetic acid (ISO)

diclofenac (ISO)

diethyl maleate (ISO)

diethylstilbestrol (EXP)

fulvestrant (ISO)

fumonisin B1 (ISO)

furan (EXP)

gentamycin (EXP)

indometacin (ISO)

inulin (ISO)

isoprenaline (ISO)

L-ethionine (EXP)

lead diacetate (ISO)

lead(0) (ISO)

lipopolysaccharide (ISO)

mercury atom (ISO)

mercury(0) (ISO)

methapyrilene (EXP)

methotrexate (EXP)

methylmercury chloride (ISO)

nickel atom (ISO)

nitrofen (EXP)

olanzapine (ISO)

omeprazole (EXP)

ozone (ISO)

p-toluidine (EXP)

paracetamol (EXP,ISO)

paraquat (EXP)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

pirinixic acid (EXP,ISO)

pregnenolone 16alpha-carbonitrile (ISO)

silicon dioxide (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

sodium fluoride (ISO)

testosterone undecanoate (ISO)

tetrachloromethane (EXP,ISO)

tetraphene (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

Triptolide (EXP)

triptonide (ISO)

valproic acid (EXP,ISO)

vinclozolin (EXP)

zidovudine (ISO)

zinc atom (ISO)

zinc(0) (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

acute-phase response (ISO)

biological_process (ND)

response to cytokine (ISO)

Cellular Component

cytoplasm (ISO)

extracellular space (IDA)

plasma membrane (ISO)

Molecular Function

calcium ion binding (ISO)

hyaluronic acid binding (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Profiling of gender-specific rat plasma proteins associated with susceptibility or resistance to diet-induced obesity.	Choi JW, etal., J Proteomics. 2012 Feb 2;75(4):1386-400. doi: 10.1016/j.jprot.2011.11.012. Epub 2011 Nov 20.
2.	Proteomic demonstration of the recurrent presence of inter-alpha-inhibitor H4 heavy-chain during aspergillosis induced in an animal model.	Desoubeaux G, etal., Int J Med Microbiol. 2014 May;304(3-4):327-38. doi: 10.1016/j.ijmm.2013.11.015. Epub 2013 Dec 1.
3.	Hypercholesterolemia associated with splice-junction variation of inter-alpha-trypsin inhibitor heavy chain 4 (ITIH4) gene.	Fujita Y, etal., J Hum Genet. 2004;49(1):24-8. Epub 2003 Dec 6.
4.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
6.	The concentrations of EGFR, LRG1, ITIH4, and F5 in serum correlate with the number of colonic adenomas in ApcPirc/+ rats.	Ivancic MM, etal., Cancer Prev Res (Phila). 2014 Nov;7(11):1160-9. doi: 10.1158/1940-6207.CAPR-14-0056. Epub 2014 Sep 8.
7.	Biomarkers for severity of spinal cord injury in the cerebrospinal fluid of rats.	Lubieniecka JM, etal., PLoS One. 2011 Apr 29;6(4):e19247. doi: 10.1371/journal.pone.0019247.
8.	ITIH4, as an inflammation biomarker, mainly increases in bacterial bloodstream infection.	Ma Y, etal., Cytokine. 2020 Dec 18;138:155377. doi: 10.1016/j.cyto.2020.155377.
9.	Gene Data Set	MGD Curation, June 12, 2002
10.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
11.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
12.	Inter-alpha-trypsin inhibitor heavy chain H4 as a diagnostic and prognostic indicator in patients with hepatitis B virus-associated hepatocellular carcinoma.	Noh CK, etal., Clin Biochem. 2014 Sep;47(13-14):1257-61. doi: 10.1016/j.clinbiochem.2014.05.002. Epub 2014 May 14.
13.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
14.	ITIH4 serum concentration increases during acute-phase processes in human patients and is up-regulated by interleukin-6 in hepatocarcinoma HepG2 cells.	Pineiro M, etal., Biochem Biophys Res Commun. 1999 Sep 16;263(1):224-9.
15.	GOA pipeline	RGD automated data pipeline
16.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
17.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
18.	Comprehensive gene review and curation	RGD comprehensive gene curation
19.	The H4P heavy chain of inter-alpha-inhibitor family largely differs in the structure and synthesis of its prolin-rich region from rat to human.	Soury E, etal., Biochem Biophys Res Commun 1998 Feb 13;243(2):522-30.
20.	ITIH4 and Gpx3 are potential biomarkers for amyotrophic lateral sclerosis.	Tanaka H, etal., J Neurol. 2013 Jul;260(7):1782-97. doi: 10.1007/s00415-013-6877-3. Epub 2013 Feb 23.
21.	Identification of potential urine proteins and microRNA biomarkers for the diagnosis of pulmonary tuberculosis patients.	Wang J, etal., Emerg Microbes Infect. 2018 Apr 11;7(1):63. doi: 10.1038/s41426-018-0066-5.

Additional References at PubMed

PMID:10712621	PMID:11803570	PMID:12477932	PMID:19056867	PMID:19263524	PMID:22516433	PMID:23376485	PMID:23533145

Genomics

Comparative Map Data

Itih4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	6,086,985 - 6,102,162 (+)	NCBI		GRCr8
mRatBN7.2	16	6,080,539 - 6,095,710 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	6,080,539 - 6,095,708 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	16	6,091,889 - 6,107,055 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	7,237,346 - 7,252,512 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	6,099,223 - 6,114,442 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	6,970,367 - 6,985,538 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	6,970,342 - 6,985,579 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	16	6,896,782 - 6,912,274 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	16	6,319,608 - 6,334,782 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	16	6,319,608 - 6,334,777 (+)	NCBI
Celera	16	9,093,866 - 9,109,046 (-)	NCBI		Celera
Cytogenetic Map	16	p16	NCBI

ITIH4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	3	52,812,962 - 52,830,672 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	3	52,812,962 - 52,830,688 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	3	52,846,978 - 52,864,688 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	3	52,822,046 - 52,839,734 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	3	52,822,045 - 52,839,734	NCBI
Celera	3	52,825,723 - 52,843,435 (-)	NCBI		Celera
Cytogenetic Map	3	p21.1	NCBI
HuRef	3	52,908,665 - 52,926,377 (-)	NCBI		HuRef
CHM1_1	3	52,799,205 - 52,816,916 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	3	52,845,872 - 52,863,582 (-)	NCBI		T2T-CHM13v2.0

Itih4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	30,608,433 - 30,623,943 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	30,608,433 - 30,624,310 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	30,886,476 - 30,901,986 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	30,886,476 - 30,902,353 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	31,699,678 - 31,715,169 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	29,715,522 - 29,730,858 (+)	NCBI		MGSCv36	mm8
Celera	14	27,143,865 - 27,159,266 (+)	NCBI		Celera
Cytogenetic Map	14	B	NCBI
cM Map	14	19.09	NCBI

Itih4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955430	2,770,373 - 2,789,131 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955430	2,772,064 - 2,787,912 (-)	NCBI	ChiLan1.0	ChiLan1.0

ITIH4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	2	52,807,762 - 52,827,998 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	3	52,807,876 - 52,832,769 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	3	52,754,664 - 52,774,867 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	3	53,980,529 - 54,000,560 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	3	53,980,668 - 53,998,038 (-)	Ensembl	panpan1.1		panPan2

ITIH4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Dog10K_Boxer_Tasha	20	36,984,232 - 36,999,685 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	20	37,352,995 - 37,368,452 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	20	37,352,366 - 37,401,740 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UNSW_CanFamBas_1.0	20	37,125,001 - 37,140,491 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	20	37,402,544 - 37,418,024 (+)	NCBI		UU_Cfam_GSD_1.0

Itih4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	170,434,701 - 170,450,834 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936473	3,573,384 - 3,589,345 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936473	3,573,282 - 3,589,345 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ITIH4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	13	34,928,439 - 34,948,229 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	13	34,928,455 - 34,948,250 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	13	38,197,507 - 38,209,005 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

ITIH4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	22	14,194,979 - 14,216,180 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	22	14,195,701 - 14,213,603 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666041	152,684,251 - 152,702,173 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Itih4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624822	4,397,744 - 4,411,406 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624822	4,397,704 - 4,411,562 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Itih4
43 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	72
Count of miRNA genes:	33
Interacting mature miRNAs:	36
Transcripts:	ENSRNOT00000048344, ENSRNOT00000061294
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1357403	Slep4	Serum leptin concentration QTL 4	3.91		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	1	9639137	Rat
1600369	Hcas8	Hepatocarcinoma susceptibility QTL 8			liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	16	1	22477621	Rat
631830	Alc7	Alcohol consumption QTL 7	2.9		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	1	26727669	Rat
634355	Rends4	Renal damage susceptibility QTL 4		0.05	kidney blood vessel morphology trait (VT:0000530)	organ lesion measurement (CMO:0000677)	16	1	26727669	Rat
1582235	Insul8	Insulin level QTL 8	3.3	0.0063	blood insulin amount (VT:0001560)	calculated serum insulin level (CMO:0000359)	16	1	26727669	Rat
9590151	Scort8	Serum corticosterone level QTL 8	8.45	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	16	1	30836262	Rat
2302380	Slep6	Serum leptin concentration QTL 6	3.36		blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	1	32139025	Rat
2307172	Activ4	Activity QTL 4	3.71	0.00023	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	1	33418960	Rat
1354584	Despr6	Despair related QTL 6	3.1	0.0067	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	39533930	Rat
2303566	Bw90	Body weight QTL 90	2		body mass (VT:0001259)	body weight (CMO:0000012)	16	1	39533930	Rat
631561	Hcuc2	Hepatic copper content QTL 2	2.8		liver copper amount (VT:0003065)	liver total copper weight (CMO:0001507)	16	1	39533949	Rat
6903319	Bw114	Body weight QTL 114	2.7	0.0037	body mass (VT:0001259)	body weight (CMO:0000012)	16	1	43534949	Rat
7411664	Foco30	Food consumption QTL 30	11	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	1	44588133	Rat
1354625	Despr7	Despair related QTL 7	3.16	0.016	locomotor behavior trait (VT:0001392)	amount of time spent in voluntary immobility (CMO:0001043)	16	1	44977551	Rat
1600378	Arunc4	Aerobic running capacity QTL 4		0.03	exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	16	380245	80345693	Rat
2293343	Glom16	Glomerulus QTL 16	7.4		kidney glomerulus integrity trait (VT:0010546)	kidney sclerotic glomeruli count to total glomeruli count ratio (CMO:0001269)	16	832236	46053497	Rat
2312660	Bw95	Body weight QTL 95		0.05	inguinal fat pad mass (VT:0010424)	inguinal fat pad weight to body weight ratio (CMO:0001253)	16	832236	59492508	Rat
2312663	Slep9	Serum leptin concentration QTL 9		0.001	blood leptin amount (VT:0005667)	serum leptin level (CMO:0000780)	16	832236	59492508	Rat
2312666	Insul16	Insulin level QTL 16		0.01	blood insulin amount (VT:0001560)	serum insulin level (CMO:0000358)	16	832236	59492508	Rat
2312669	Stl23	Serum triglyceride level QTL 23		0.01	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	16	832236	59492508	Rat
2301406	Kidm39	Kidney mass QTL 39		0.002	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	16	2851709	15884239	Rat
1300133	Rf24	Renal function QTL 24	3.64		blood creatinine amount (VT:0005328)	creatinine clearance (CMO:0000765)	16	3380150	21361552	Rat
2306902	Bp339	Blood pressure QTL 339		0.01	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	3380150	43025077	Rat
737825	Alc13	Alcohol consumption QTL 13	4.5		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	4227609	16039848	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	16	4227609	43025077	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	4227609	43025077	Rat
70183	BpQTLcluster13	Blood pressure QTL cluster 13	3.654		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	16	4227609	43025077	Rat
737819	Hcas4	Hepatocarcinoma susceptibility QTL 4	4.43		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	16	4227609	46975965	Rat
61405	Niddm6	Non-insulin dependent diabetes mellitus QTL 6	3.66	0.001	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	16	4227609	48972724	Rat
61338	Bp23	Blood pressure QTL 23	4.3		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	16	4227609	49227609	Rat
737826	Alc11	Alcohol consumption QTL 11	3.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	16	4227609	60252231	Rat
61372	Bp40	Blood pressure QTL 40	2.2		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	16	4227730	17696785	Rat

Markers in Region

RH128651

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	6,095,503 - 6,095,686 (+)	MAPPER	mRatBN7.2
Rnor_6.0	16	6,985,332 - 6,985,514	NCBI	Rnor6.0
Rnor_5.0	16	6,912,068 - 6,912,250	UniSTS	Rnor5.0
RGSC_v3.4	16	6,334,576 - 6,334,758	UniSTS	RGSC3.4
Celera	16	9,093,890 - 9,094,072	UniSTS
RH 3.4 Map	16	45.0	UniSTS
Cytogenetic Map	16	p16	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High			21	21		21
Medium			16	14		14					2	2
Low		11	20	6	18	6	8	8	60	25	27	9	8
Below cutoff	3	32			1			2	14	10	10

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_019369	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC121615	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC089806	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474046	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210456	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210475	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ218879	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219223	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ219717	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	Y11283	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000048344 ⟹ ENSRNOP00000048673

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	6,080,539 - 6,095,708 (+)	Ensembl
Rnor_6.0 Ensembl	16	6,970,382 - 6,985,388 (+)	Ensembl

RefSeq Acc Id:

ENSRNOT00000061294 ⟹ ENSRNOP00000058007

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	16	6,080,539 - 6,095,708 (+)	Ensembl
Rnor_6.0 Ensembl	16	6,970,342 - 6,985,579 (+)	Ensembl

RefSeq Acc Id:

NM_019369 ⟹ NP_062242

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	6,086,985 - 6,102,162 (+)	NCBI
mRatBN7.2	16	6,080,539 - 6,095,710 (+)	NCBI
Rnor_6.0	16	6,970,367 - 6,985,538 (+)	NCBI
Rnor_5.0	16	6,896,782 - 6,912,274 (+)	NCBI
RGSC_v3.4	16	6,319,608 - 6,334,782 (+)	RGD
Celera	16	9,093,866 - 9,109,046 (-)	RGD

Sequence:

show sequence

GGCAACTGGAGACAAATGAAGAGCCCTGCCCCTGCCCACATGTGGAACATTGTACTGGTCTTGC
TCTCGCTGTTGGCTGTGCTTCCGATCACTACTACTGAGAAGAATGGCATCGATATCTACAGTCT
CACAGTGGACTCCCGGGTCTCTTCCCGATTTGCTCATACTGTTGTTACCAGCCGGGTGGTCAAC
AGAGCCGATACTGTTCAAGAAGCGACCTTCCAAGTAGAGCTACCCAGGAAAGCCTTCATCACCA
ACTTCTCCATGATCATTGATGGTGTGACCTACCCAGGGGTTGTCAAAGAGAAGGCTGAAGCCCA
GAAGCAATACACTGCTGCTGTGGGCCGGGGAGAGAGCGCTGGCCTTGTCAAGACCACTGGGAGA
AAGACAGAGCAGTTTGAAGTGTCAGTCAACGTGGCCCCTGGTTCCAAGACTACCTTCGAACTCA
TATACCAAGAGCTGCTCCAAAGACGGCTGGGAATGTATGAGCTACTCCTCAAAGTGAGGCCTGA
GCAGCTGGTCAAGCACCTTCAGATGGACATCTACATCTTTGAGCCTCAGGGTATCAGCACCCTG
GAGACAGAGAGTACTTTCATGACCCAGGAGTTGGCAAATGCCCTTACCACTTCACAGAACAAGA
CCAAGGCACATATCCAGTTCAAGCCGACACTCTCCCAGCAACGGAAGTCTCAGAATGAGCAGGA
CACGGTGCTAGATGGGGATTTCACCGTTCGCTATGATGTGGACCGGTCTTCCACTGGCGGTACC
ATTCAGATTGAGAACGGCTACTTTGTGCACCACTTTGCCCCAGAGGACCTTCCTACAATGGCCA
AGAATGTGCTCTTTGTCATTGATAAAAGCGGATCTATGGCAGGCAAGAAAATCCAACAGACCCG
AGAAGCCCTAATCAAGATCTTGAAAGACCTCAGCACCCAAGACCAGTTCAATATCATTGTGTTC
AGTGGGGAAGCAAACCAGTGGGAGCAGTTGCTGGTGCAAGCAACAGAAGAGAACTTGAACAGGG
CGGTTGACTATGCTTCCAAGATCCCGGCTCAGGGAGGGACCAACATCAATAAAGCAGTGCTATC
GGCTGTGGAACTGCTGGATAAAAGCAACCAGGCTGAGCTACTGCCCTCCAAGAGCGTTTCCCTC
ATCATCCTGCTCACGGATGGCGAGCCCACTGTGGGGGAGACCAATCCCAAGATTATCCAGAAGA
ACACACAGGAAGCCATCAATGGGCGGTATAGCCTCTTCTGCCTGGGGTTTGGCTTTGATGTGAA
CTATCCTTTCCTGGAGAAGCTGGCCCTGGACAACGGAGGCCTGGCCCGGCGCATCTACGAGGAC
TCAGACTCTGCTCTGCAGCTTCAGGACTTCTACCAGGAAGTGGCCAATCCGCTGCTGTCATCAG
TGACCTTTGAATATCCCAGCAATGCTGTGGAGGACGTCACGCGGTACAACTTCCAACACCACTT
TAAGGGCTCAGAGATGGTGGTGGCTGGGAAGCTCCGGGACCAGGGCCCTGATGTCCTCTTAGCC
AAAGTCAGTGGGCAGATGCACCTGCAGAACATCACTTTCCAAACGGAGGCCAGCATAGCCCAAC
AAGAGAAAGAGTTCCAGGGTCCTAAGTACATCTTTCATAACTTTATGGAGAGACTCTGGGCGTT
GCTGACCATACAGCAACAGCTGGAGCAGAGGATTTCAGCCTCAGGAGCTGAGTTAGAGGCCCTC
GAGGCCCAAGTTCTGAACTTGTCACTCAAGTACAATTTTGTCACTCCTCTCACGCACATGGTGG
TCACCAAACCTGAAGATCAAGAACAATTCCAAGTTGCTGAGAAGCCTACGGAAGTCGATGGTGG
AGTGTGGAGTATCCTCTCAGCAGTTCAACGGCATTTCAAGACTCCTACCACAGGATCTAAACTG
CTGACATCCAGGCTGAGAGGAAATAGGTTCCAGACATTGTCCAGACTCGGGGATGGTCTCGTTG
GATCTAGACAATACATGCCTCCTCCTGGACTTCCTGGACCTCCTGGACTTCCTGGACCTCCTGG
GCCTCCCGGACATCCTCATTTTGCTTCTAGCATTGACTACGGCAGGCAGCCTTCCTTGGGAAGG
GTGCTAGACCTGCCATCCTTATCCTCACAAGATCCAGCCGGCCCAAGTCTAGCCATGTTACCGA
AAGTGGTGGAACAAGAAGGCACCACACCAGAGGAATCCCCAAACCCAGACCACCCCCGGGCTCC
TACCATCATCCTGCCGCTTCCGGGATCTGGTGTGGACCAGCTCTGTGTGGATATCTTACATTCT
GAGAAGCCCATGAAGCTGTTTGTAGACATCAATCAGGGGCTGGAGGTGGTTGGCAAGTATGAGA
AGAATATCGGGTTCTCATGGATCGAAGTGACCATCCTGAAGCCTCACCTGCAGGTCCATGCAAC
GCCTGAACGACTGGTGGTGACAAGGGGCCGAAAAAACTCTGAATACAAGTGGAAGAAGACACTG
TTCTCTGTGTTACCTGGCTTAAAGATGACCATGGATAAGACGGGACTGCTACAGCTCAGTGGCC
CAGACAAAGTCACCATCAGCCTCTTGTCTCTGGATGACCCTCAGAGAGGACTCATGCTGCTTTT
GAATGACACTCATCACTTCTCCAACGACATTACAGGGGAGCTTGGTCAGTTTTACCAGGATATC
ATCTGGGATGATACAAAACAGACAGTCAGAGTTCTAGGAATCGACTACCCGGCTACCAGAGAGC
TCAAGTTGAGTTATCAAGACGGGTTCCCGGGAACAGAGATTTCCTGCTGGACGGTGAAGATATA
GAACTGACAGGAGCATTGTTTGCTACCTGCCATGTTGTCCTCGTATGCAGGCGGATGACACTGT
GTGCCAACAGGGCCGCCTGTGAGGCCTAGACCTTGATGGGGAAGAGGATGCTCTCTTGTTACAA
ATAAAGAAGGGTGATGTGAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_062242	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH89806	(Get FASTA)	NCBI Sequence Viewer
	CAA72155	(Get FASTA)	NCBI Sequence Viewer
	EDL88978	(Get FASTA)	NCBI Sequence Viewer
	EDL88979	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000048673.5
	ENSRNOP00000058007
	ENSRNOP00000058007.2

RefSeq Acc Id:	NP_062242 ⟸ NM_019369
- Peptide Label:	precursor
- UniProtKB:	Q5EBC0 (UniProtKB/TrEMBL), F7EYF5 (UniProtKB/TrEMBL), D3ZFC6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MKSPAPAHMWNIVLVLLSLLAVLPITTTEKNGIDIYSLTVDSRVSSRFAHTVVTSRVVNRADTV QEATFQVELPRKAFITNFSMIIDGVTYPGVVKEKAEAQKQYTAAVGRGESAGLVKTTGRKTEQF EVSVNVAPGSKTTFELIYQELLQRRLGMYELLLKVRPEQLVKHLQMDIYIFEPQGISTLETEST FMTQELANALTTSQNKTKAHIQFKPTLSQQRKSQNEQDTVLDGDFTVRYDVDRSSTGGTIQIEN GYFVHHFAPEDLPTMAKNVLFVIDKSGSMAGKKIQQTREALIKILKDLSTQDQFNIIVFSGEAN QWEQLLVQATEENLNRAVDYASKIPAQGGTNINKAVLSAVELLDKSNQAELLPSKSVSLIILLT DGEPTVGETNPKIIQKNTQEAINGRYSLFCLGFGFDVNYPFLEKLALDNGGLARRIYEDSDSAL QLQDFYQEVANPLLSSVTFEYPSNAVEDVTRYNFQHHFKGSEMVVAGKLRDQGPDVLLAKVSGQ MHLQNITFQTEASIAQQEKEFQGPKYIFHNFMERLWALLTIQQQLEQRISASGAELEALEAQVL NLSLKYNFVTPLTHMVVTKPEDQEQFQVAEKPTEVDGGVWSILSAVQRHFKTPTTGSKLLTSRL RGNRFQTLSRLGDGLVGSRQYMPPPGLPGPPGLPGPPGPPGHPHFASSIDYGRQPSLGRVLDLP SLSSQDPAGPSLAMLPKVVEQEGTTPEESPNPDHPRAPTIILPLPGSGVDQLCVDILHSEKPMK LFVDINQGLEVVGKYEKNIGFSWIEVTILKPHLQVHATPERLVVTRGRKNSEYKWKKTLFSVLP GLKMTMDKTGLLQLSGPDKVTISLLSLDDPQRGLMLLLNDTHHFSNDITGELGQFYQDIIWDDT KQTVRVLGIDYPATRELKLSYQDGFPGTEISCWTVKI hide sequence

RefSeq Acc Id:

ENSRNOP00000058007 ⟸ ENSRNOT00000061294

RefSeq Acc Id:

ENSRNOP00000048673 ⟸ ENSRNOT00000048344

Protein Domains

VIT VWFA

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q5EBC0-F1-model_v2	AlphaFold	Q5EBC0	1-933	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699915

Promoter ID:

EPDNEW_R10439

Type:

multiple initiation site

Name:

Itih4_1

Description:

inter-alpha-trypsin inhibitor heavy chain family, member 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	16	6,970,355 - 6,970,415	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:70881	AgrOrtholog
BioCyc Gene	G2FUF-12176	BioCyc
Ensembl Genes	ENSRNOG00000017381	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000048344.5	UniProtKB/TrEMBL
	ENSRNOT00000061294	ENTREZGENE
	ENSRNOT00000061294.5	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.410	UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7326076	IMAGE-MGC_LOAD
InterPro	VIT	UniProtKB/TrEMBL
	VWF_A	UniProtKB/TrEMBL
	vWFA_dom_sf	UniProtKB/TrEMBL
KEGG Report	rno:54404	UniProtKB/TrEMBL
MGC_CLONE	MGC:108706	IMAGE-MGC_LOAD
NCBI Gene	54404	ENTREZGENE
PANTHER	INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN FAMILY MEMBER	UniProtKB/TrEMBL
	INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H4	UniProtKB/TrEMBL
Pfam	VIT	UniProtKB/TrEMBL
	VWA	UniProtKB/TrEMBL
PhenoGen	Itih4	PhenoGen
PROSITE	VIT	UniProtKB/TrEMBL
	VWFA	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000017381	RatGTEx
SMART	VIT	UniProtKB/TrEMBL
	VWA	UniProtKB/TrEMBL
Superfamily-SCOP	SSF53300	UniProtKB/TrEMBL
UniProt	A6KG22_RAT	UniProtKB/TrEMBL
	D3ZFC6	ENTREZGENE, UniProtKB/TrEMBL
	F7EYF5	ENTREZGENE, UniProtKB/TrEMBL
	O35802_RAT	UniProtKB/TrEMBL
	Q5EBC0	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-04-10	Itih4	inter-alpha-trypsin inhibitor heavy chain 4	Itih4	inter-alpha-trypsin inhibitor heavy chain family, member 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2012-01-17	Itih4	inter-alpha-trypsin inhibitor heavy chain family, member 4	Itih4	inter alpha-trypsin inhibitor, heavy chain 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-07-09	Itih4	inter alpha-trypsin inhibitor, heavy chain 4			Symbol and Name updated to reflect Human and Mouse nomenclature	70877	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_domains	collagen-like pattern with 6 repeats of a Gly-X-Pro motifs	633094
gene_domains	only member of inter-alpha-inhibitor family to have a Pro-rich region (PRR) in its C-terminal	633094
gene_regulation	mRNA up-regulated by an acute, systemic inflammation in the liver	633094

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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