Cst12 (cystatin 12) - Rat Genome Database

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Gene: Cst12 (cystatin 12) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Cst12
Name: cystatin 12
RGD ID: 708514
Description: Predicted to enable cysteine-type endopeptidase inhibitor activity. Predicted to be located in extracellular region; INTERACTS WITH amitriptyline; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cystatin TE-1; cystatin-12; LOC266776
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83156,688,155 - 156,692,052 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3156,688,049 - 156,692,052 (+)EnsemblGRCr8
mRatBN7.23136,235,052 - 136,238,912 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3136,235,041 - 136,238,909 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3140,186,879 - 140,190,741 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03148,771,029 - 148,774,891 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03146,460,678 - 146,464,538 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03143,119,697 - 143,123,557 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3143,119,687 - 143,123,582 (+)Ensemblrn6Rnor6.0
Rnor_5.03149,528,537 - 149,532,397 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43137,548,053 - 137,551,913 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3135,076,458 - 135,080,318 (+)NCBICelera
RGSC_v3.13137,453,628 - 137,457,483 (+)NCBI
Cytogenetic Map3q41NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification and characterization of testis- and epididymis-specific genes: cystatin SC and cystatin TE-1. Li Y, etal., Biol Reprod 2002 Dec;67(6):1872-80.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions

Genomics

Variants

.
Variants in Cst12
11 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:35
Count of miRNA genes:34
Interacting mature miRNAs:35
Transcripts:ENSRNOT00000006608
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3141508991166376254Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
8694437Bw167Body weight QTL 16722.460.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)3112250810157250810Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
724532Cm17Cardiac mass QTL 172heart mass (VT:0007028)calculated heart weight (CMO:0000073)3116188400161188400Rat


Expression

RNA-SEQ Expression

appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
mesenchyme
mesoderm
nervous system
reproductive system
respiratory system
5 2 11 13 14 5 6 5 19 9 10 47 9

Sequence


Ensembl Acc Id: ENSRNOT00000006608   ⟹   ENSRNOP00000006608
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3156,688,049 - 156,692,052 (+)Ensembl
mRatBN7.2 Ensembl3136,235,041 - 136,238,909 (+)Ensembl
Rnor_6.0 Ensembl3143,119,687 - 143,123,582 (+)Ensembl
RefSeq Acc Id: NM_153734   ⟹   NP_714956
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83156,688,192 - 156,692,052 (+)NCBI
mRatBN7.23136,235,052 - 136,238,912 (+)NCBI
Rnor_6.03143,119,697 - 143,123,557 (+)NCBI
Rnor_5.03149,528,537 - 149,532,397 (+)NCBI
RGSC_v3.43137,548,053 - 137,551,913 (+)RGD
Celera3135,076,458 - 135,080,318 (+)RGD
Sequence:
RefSeq Acc Id: XM_063283176   ⟹   XP_063139246
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83156,688,155 - 156,691,090 (+)NCBI
Protein Sequences
Protein RefSeqs NP_714956 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139246 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAL30842 (Get FASTA)   NCBI Sequence Viewer  
  EDL95087 (Get FASTA)   NCBI Sequence Viewer  
  EDL95088 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000006608
GenBank Protein Q8VII2 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_714956   ⟸   NM_153734
- UniProtKB: Q8VII2 (UniProtKB/Swiss-Prot),   A6K7D1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000006608   ⟸   ENSRNOT00000006608
RefSeq Acc Id: XP_063139246   ⟸   XM_063283176
- Peptide Label: isoform X1
Protein Domains
Cystatin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VII2-F1-model_v2 AlphaFold Q8VII2 1-128 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692501
Promoter ID:EPDNEW_R3025
Type:initiation region
Name:Cst12_1
Description:cystatin 12
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03143,119,693 - 143,119,753EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708514 AgrOrtholog
BioCyc Gene G2FUF-47491 BioCyc
Ensembl Genes ENSRNOG00000004946 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000006608 ENTREZGENE
Gene3D-CATH 3.10.450.10 UniProtKB/Swiss-Prot
InterPro Cystatin_dom UniProtKB/Swiss-Prot
  Cystatin_sf UniProtKB/Swiss-Prot
  Cystatin_spermatogenesis UniProtKB/Swiss-Prot
KEGG Report rno:266776 UniProtKB/Swiss-Prot
NCBI Gene 266776 ENTREZGENE
PANTHER CYSTATIN-12 UniProtKB/Swiss-Prot
  CYSTATIN-12-RELATED UniProtKB/Swiss-Prot
Pfam Cystatin UniProtKB/Swiss-Prot
PhenoGen Cst12 PhenoGen
RatGTEx ENSRNOG00000004946 RatGTEx
Superfamily-SCOP SSF54403 UniProtKB/Swiss-Prot
UniProt A6K7D1 ENTREZGENE, UniProtKB/TrEMBL
  CST12_RAT UniProtKB/Swiss-Prot
  G3V6M1_RAT UniProtKB/TrEMBL
  Q8VII2 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-25 Cst12  cystatin 12  LOC266776  cystatin TE-1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-09-30 LOC266776        Symbol and Name status set to provisional 70820 PROVISIONAL

RGD Curation Notes
Note Type Note Reference