Slc15a4 (solute carrier family 15 member 4)

Gene: Slc15a4 (solute carrier family 15 member 4) Rattus norvegicus

Analyze

Symbol:

Slc15a4

Name:

solute carrier family 15 member 4

RGD ID:

708469

Description:

Enables L-histidine transmembrane transporter activity. Involved in histidine transport. Predicted to be located in early endosome membrane and endolysosome membrane. Predicted to be active in membrane. Orthologous to human SLC15A4 (solute carrier family 15 member 4); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,6-dinitrotoluene; ammonium chloride.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

LOC246280; MGC105315; peptide transporter 4; peptide/histidine transporter; peptide/histidine transporter 1; rPHT1; solute carrier family 15 (oligopeptide transporter), member 4; solute carrier family 15, member 4

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SLC15A4 (solute carrier family 15 member 4)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Mus musculus (house mouse):	Slc15a4 (solute carrier family 15, member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Slc15a4 (solute carrier family 15 member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SLC15A4 (solute carrier family 15 member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SLC15A4 (solute carrier family 15 member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Slc15a4 (solute carrier family 15 member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SLC15A4 (solute carrier family 15 member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SLC15A4 (solute carrier family 15 member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Slc15a4 (solute carrier family 15 member 4)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Homo sapiens (human):	SLC15A4 (solute carrier family 15 member 4)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Slc15a4 (solute carrier family 15, member 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	slc15a4 (solute carrier family 15 member 4)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	PTR2	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB)
Xenopus tropicalis (tropical clawed frog):	mrpl46	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	slc15a4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	34,684,583 - 34,718,429 (+)	NCBI		GRCr8
mRatBN7.2	12	29,048,634 - 29,082,480 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	29,063,015 - 29,082,480 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	30,198,626 - 30,218,177 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	30,810,079 - 30,829,630 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	29,869,246 - 29,888,797 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	32,753,824 - 32,773,277 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	32,753,824 - 32,773,277 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	34,660,965 - 34,680,418 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	30,111,863 - 30,131,134 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	29,975,250 - 29,994,522 (+)	NCBI
Celera	12	30,749,254 - 30,768,706 (+)	NCBI		Celera
Cytogenetic Map	12	q14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

systemic lupus erythematosus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

17alpha-ethynylestradiol (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,6-dinitrotoluene (EXP)

2-methylcholine (ISO)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

bromobenzene (EXP)

cadmium atom (ISO)

carbon nanotube (ISO)

carnosine (EXP)

chlorpyrifos (ISO)

cobalt dichloride (EXP)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

dexamethasone (EXP,ISO)

dextran sulfate (ISO)

dichlorine (EXP)

dimethylarsinic acid (ISO)

epoxiconazole (ISO)

fipronil (EXP)

fonofos (ISO)

FR900359 (ISO)

gentamycin (EXP)

inulin (ISO)

menadione (ISO)

ozone (EXP)

paracetamol (EXP,ISO)

parathion (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

resveratrol (ISO)

sodium arsenite (ISO)

terbufos (ISO)

testosterone (EXP)

titanium dioxide (ISO)

trichloroethene (EXP)

triptonide (ISO)

tungsten (ISO)

valproic acid (ISO)

vinclozolin (EXP)

vincristine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

dipeptide import across plasma membrane (IBA,IEA,ISO,ISS)

histidine transport (IBA,IMP)

innate immune response (IEA)

L-histidine transmembrane export from vacuole (IEA,ISO)

mast cell homeostasis (IEA,ISO,ISS)

peptide transport (IEA)

peptidoglycan transport (IEA,ISO,ISS)

positive regulation of innate immune response (ISO,ISS)

positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway (IEA,ISO,ISS)

positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway (IEA,ISO,ISS)

positive regulation of toll-like receptor 7 signaling pathway (IEA,ISO,ISS)

positive regulation of toll-like receptor 8 signaling pathway (IEA,ISO,ISS)

positive regulation of toll-like receptor 9 signaling pathway (IEA,ISO,ISS)

protein transport (IEA)

proton transmembrane transport (IEA)

regulation of isotype switching to IgG isotypes (IEA,ISO,ISS)

regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway (ISO,ISS)

Cellular Component

early endosome membrane (IEA,ISO)

endolysosome membrane (IEA,ISO,ISS)

endosome membrane (ISO)

lysosomal membrane (ISO,ISS)

membrane (IBA)

Molecular Function

dipeptide transmembrane transporter activity (IBA,IEA,ISO,ISS)

L-histidine transmembrane transporter activity (IBA,IEA,IMP,ISO,ISS)

peptide:proton symporter activity (IEA,ISO,ISS)

peptidoglycan transmembrane transporter activity (IEA,ISO,ISS)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
5.	Cloning and functional expression of a brain peptide/histidine transporter.	Yamashita T, etal., J Biol Chem 1997 Apr 11;272(15):10205-11.

Additional References at PubMed

PMID:12477932	PMID:19913073	PMID:24548120

Genomics

Comparative Map Data

Slc15a4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	34,684,583 - 34,718,429 (+)	NCBI		GRCr8
mRatBN7.2	12	29,048,634 - 29,082,480 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	29,063,015 - 29,082,480 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	30,198,626 - 30,218,177 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	30,810,079 - 30,829,630 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	29,869,246 - 29,888,797 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	32,753,824 - 32,773,277 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	32,753,824 - 32,773,277 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	34,660,965 - 34,680,418 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	30,111,863 - 30,131,134 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	29,975,250 - 29,994,522 (+)	NCBI
Celera	12	30,749,254 - 30,768,706 (+)	NCBI		Celera
Cytogenetic Map	12	q14	NCBI

SLC15A4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	128,793,194 - 128,823,958 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	128,793,194 - 128,823,958 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	129,277,739 - 129,308,503 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	127,843,713 - 127,874,494 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	127,802,644 - 127,833,421	NCBI
Celera	12	128,891,861 - 128,922,740 (-)	NCBI		Celera
Cytogenetic Map	12	q24.33	NCBI
HuRef	12	126,263,573 - 126,285,425 (-)	NCBI		HuRef
CHM1_1	12	129,098,609 - 129,129,417 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	128,825,188 - 128,855,979 (-)	NCBI		T2T-CHM13v2.0

Slc15a4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	127,668,795 - 127,710,356 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	127,672,728 - 127,709,961 (-)	Ensembl		GRCm39 Ensembl
GRCm38	5	127,594,545 - 127,633,292 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	127,595,664 - 127,632,897 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	128,076,036 - 128,097,762 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	127,884,869 - 127,906,595 (-)	NCBI		MGSCv36	mm8
Celera	5	124,625,149 - 124,646,865 (-)	NCBI		Celera
Cytogenetic Map	5	G1.2	NCBI
cM Map	5	66.0	NCBI

Slc15a4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955482	2,327,137 - 2,343,980 (+)	NCBI	ChiLan1.0	ChiLan1.0

SLC15A4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	136,865,833 - 136,896,753 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	136,862,353 - 136,893,242 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	126,418,071 - 126,448,917 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	130,639,525 - 130,669,822 (-)	NCBI	panpan1.1	PanPan1.1	panPan2

SLC15A4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	2,803,798 - 2,832,057 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	2,802,724 - 2,831,530 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	3,006,941 - 3,035,199 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	3,056,487 - 3,084,750 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	3,056,499 - 3,084,223 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	2,988,152 - 3,015,703 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	3,086,221 - 3,113,814 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	2,996,157 - 3,024,420 (+)	NCBI		UU_Cfam_GSD_1.0

Slc15a4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	124,227,513 - 124,239,308 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936660	481,772 - 493,567 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SLC15A4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	26,122,386 - 26,154,781 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	26,122,362 - 26,154,414 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	27,770,845 - 27,803,186 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SLC15A4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	124,170,785 - 124,204,358 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	124,169,732 - 124,204,200 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	121,090,609 - 121,123,572 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Slc15a4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	26,252,492 - 26,275,173 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	26,252,788 - 26,275,273 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Slc15a4
307 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	615
Count of miRNA genes:	279
Interacting mature miRNAs:	350
Transcripts:	ENSRNOT00000001277
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1581516	Cm56	Cardiac mass QTL 56	4.2	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	1	29333307	Rat
1598855	Bp294	Blood pressure QTL 294	3.5		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	1	34851688	Rat
7411660	Foco28	Food consumption QTL 28	10.9	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
9590086	Insglur6	Insulin/glucose ratio QTL 6	18.97	0.001	blood insulin amount (VT:0001560)	calculated plasma insulin level (CMO:0002170)	12	1	42110980	Rat
8694179	Bw150	Body weight QTL 150	2.9	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
7411586	Foco5	Food consumption QTL 5	5.4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
7411595	Foco9	Food consumption QTL 9	4	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	1	42110980	Rat
7411545	Bw128	Body weight QTL 128	5.2	0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	12	1	42110980	Rat
9590147	Scort7	Serum corticosterone level QTL 7	13.61	0.001	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	12	1	42110980	Rat
2303575	Insul14	Insulin level QTL 14	4		blood insulin amount (VT:0001560)	blood insulin level (CMO:0000349)	12	1	42450532	Rat
737979	Pia22	Pristane induced arthritis QTL 22	53.1		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	1	44465750	Rat
634351	Apr5	Acute phase response QTL 5	6.7		blood interleukin-6 amount (VT:0008595)	plasma interleukin-6 level (CMO:0001927)	12	1	44503507	Rat
2302042	Pia38	Pristane induced arthritis QTL 38	3.5	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	1	44503507	Rat
634350	Apr4	Acute phase response QTL 4	6		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	1172005	46172005	Rat
8552918	Pigfal7	Plasma insulin-like growth factor 1 level QTL 7			blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
7411547	Bw129	Body weight QTL 129		0.001	body mass (VT:0001259)	body weight gain (CMO:0000420)	6	5564495	46669029	Rat
7411597	Foco10	Food consumption QTL 10		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
7411641	Foco19	Food consumption QTL 19	27.7	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
8552964	Pigfal17	Plasma insulin-like growth factor 1 level QTL 17	3.5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564495	46669029	Rat
7411588	Foco6	Food consumption QTL 6		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	5564495	46669029	Rat
8552912	Pigfal6	Plasma insulin-like growth factor 1 level QTL 6	5		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	12	5564498	46669029	Rat
10059594	Kidm46	Kidney mass QTL 46	3.79	0.025	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	12	6107579	46669029	Rat
1302792	Scl21	Serum cholesterol level QTL 21	3.8	0.0011	blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	12	7196730	46669029	Rat
1300157	Rf21	Renal function QTL 21	4.4		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	12	9318216	32103380	Rat
1549829	Scl48	Serum cholesterol level QTL 48	5		blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	12	9603277	46669029	Rat
2293699	Bss49	Bone structure and strength QTL 49	5.61	0.0001	lumbar vertebra size trait (VT:0010518)	lumbar vertebra trabecular cross-sectional area (CMO:0001692)	12	10474137	46669029	Rat
2300186	Bmd59	Bone mineral density QTL 59	7.1	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	12	10474137	46669029	Rat
1331761	Bp218	Blood pressure QTL 218	2.973		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	12	11073825	45055165	Rat
61404	Bw120	Body weight QTL 120	5.1		body mass (VT:0001259)	body mass index (BMI) (CMO:0000105)	12	12351619	46669029	Rat
1641928	Alcrsp5	Alcohol response QTL 5			response to alcohol trait (VT:0010489)	duration of loss of righting reflex (CMO:0002289)	12	12812385	46669029	Rat
2303569	Gluco44	Glucose level QTL 44	2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	12812385	46669029	Rat
1549902	Bp269	Blood pressure QTL 269			arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	13182736	46669029	Rat
1549912	Bp268	Blood pressure QTL 268			arterial blood pressure trait (VT:2000000)	diastolic blood pressure (CMO:0000005)	10	13182736	46669029	Rat
2302060	Pia37	Pristane induced arthritis QTL 37	6.1	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	12	13198157	46669029	Rat
61416	Pia4	Pristane induced arthritis QTL 4	8.4		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	12	13635523	30827399	Rat
61421	Cia12	Collagen induced arthritis QTL 12	4.6		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	13635523	35682913	Rat
631543	Bp83	Blood pressure QTL 83	5.8		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	12	15550826	38478808	Rat
2293684	Bmd26	Bone mineral density QTL 26	4.4	0.0002	femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	12	15872653	32974238	Rat
631560	Apr1	Acute phase response QTL 1	6.1		orosomucoid 1 amount (VT:0010541)	plasma orosomucoid 1 level (CMO:0001467)	12	19144362	46669029	Rat
737822	Alc10	Alcohol consumption QTL 10	2.2		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	12	19610870	40218516	Rat
5684888	Pia42	Pristane induced arthritis QTL 42			joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	19610870	42828880	Rat
61324	Eae5	Experimental allergic encephalomyelitis QTL 5	14		nervous system integrity trait (VT:0010566)	percentage of study population developing relapsing-remitting experimental autoimmune encephalomyelitis during a period of time (CMO:0001402)	12	19610870	46669029	Rat
1298081	Cia25	Collagen induced arthritis QTL 25	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	12	19610889	35682913	Rat
70213	Niddm27	Non-insulin dependent diabetes mellitus QTL 27	3.72		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	12	19835789	38193007	Rat
7411643	Foco20	Food consumption QTL 20		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	12	20328819	46669029	Rat
70169	Eae13	Experimental allergic encephalomyelitis QTL 13		0.032	nervous system integrity trait (VT:0010566)	experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)	12	24139202	36638073	Rat
1331763	Wbc2	White blood cell count QTL 2	3.162		leukocyte quantity (VT:0000217)	total white blood cell count (CMO:0000365)	12	24234777	31894213	Rat
1556747	Calcic1	Intracellular calcium level QTL 1		3.6	platelet calcium amount (VT:0010500)	platelet intracellular calcium level (CMO:0000922)	12	28064433	40130419	Rat
1300175	Cm5	Cardiac mass QTL 5	3.78		heart mass (VT:0007028)	heart left ventricle weight to body weight ratio (CMO:0000530)	12	28064433	45899022	Rat
1600386	Calcic2	Intracellular calcium level QTL 2		0.001	platelet physiology trait (VT:0005464)	platelet intracellular calcium level (CMO:0000922)	12	28064433	46669029	Rat
1331787	Rf41	Renal function QTL 41	2.998		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	12	28064557	40218380	Rat
631829	Alc6	Alcohol consumption QTL 6	4.7		consumption behavior trait (VT:0002069)	ethanol drink intake rate (CMO:0001407)	12	28607526	37691617	Rat

Markers in Region

AA987064

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	29,082,258 - 29,082,421 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	32,773,056 - 32,773,218	NCBI	Rnor6.0
Rnor_5.0	12	34,680,197 - 34,680,359	UniSTS	Rnor5.0
RGSC_v3.4	12	30,130,913 - 30,131,075	UniSTS	RGSC3.4
Celera	12	30,768,485 - 30,768,647	UniSTS
Cytogenetic Map	12	q14	UniSTS

RH141739

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	12	29,082,152 - 29,082,335 (+)	MAPPER	mRatBN7.2
Rnor_6.0	12	32,772,950 - 32,773,132	NCBI	Rnor6.0
Rnor_5.0	12	34,680,091 - 34,680,273	UniSTS	Rnor5.0
RGSC_v3.4	12	30,130,807 - 30,130,989	UniSTS	RGSC3.4
Celera	12	30,768,379 - 30,768,561	UniSTS
RH 3.4 Map	12	480.3	UniSTS
Cytogenetic Map	12	q14	UniSTS

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium	2	10	19	10	19	10			74	30	41	11
Low	1	33	38	31		31	8	11		5			8
Below cutoff

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_144758	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089070	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089071	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039089072	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005491598	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB000280	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC087709	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473973	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000012	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000001277 ⟹ ENSRNOP00000001277

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	12	29,063,015 - 29,082,480 (+)	Ensembl
Rnor_6.0 Ensembl	12	32,753,824 - 32,773,277 (+)	Ensembl

RefSeq Acc Id:

NM_144758 ⟹ NP_653359

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	34,698,975 - 34,718,428 (+)	NCBI
mRatBN7.2	12	29,063,027 - 29,082,480 (+)	NCBI
Rnor_6.0	12	32,753,824 - 32,773,277 (+)	NCBI
Rnor_5.0	12	34,660,965 - 34,680,418 (+)	NCBI
RGSC_v3.4	12	30,111,863 - 30,131,134 (+)	RGD
Celera	12	30,749,254 - 30,768,706 (+)	RGD

Sequence:

show sequence

ACCGGGTCCTTAGGGAACCAGCCATGGAGGGCGAGCGGGCGCCGCTGTTAGGTTCGCGGCGTGC
GGCGGCAGCAGCTGGGGTGTTTGCGGGGCGTCGTGCGGCGTGCGGGGCGGTACTGTTGGCCGAA
CTGCTGGAGCGCGCGGCCTTCTACGGCGTCACGGCCAACCTAGTGTTATTCTTGAATGGCGCGC
CGTTCAACTGGGAGGGCGCGCAGGCCAGCCAGGCACTGCTGCTCTTCATGGGCCTCACCTACCT
GGGATCCCCGTTCGGGGGATGGCTCGCTGACGCGCGACTCGGCCGGGCGCGCGCCATCCTGCTC
AGCCTGGCGCTCTACCTGCTGGGCATGCTGGCCTTCCCGCTGCTGGCCGCGCCCCGCTCGCGCT
CTTTTCTCTGCGGGGATCCGCACCCGGAGCTGGTGCGCAACTGCTCGGCTCCCTTCCCTAACGG
AACGGCGGTCTGTCCCGATGCTGCCGCGCGCCGCTGTGCTCCCGCCACCTTCGCGGGTCTAGTG
CTCGTGGGACTCGGTGTGGCCACGGTCAAGGCCAACATCACACCCTTTGGAGCGGATCAGGTCA
AAGATCGAGGTCCAGAGGCCACTCGGAGATTTTTCAATTGGTTTTACTGGAGCATTAATTTGGG
AGCAATCCTGTCATTAGGAGGTATTGCCTATATTCAGCAGAATGTGAGCTTTCTCACAGGCTAC
CTGATTCCTACAGTCTGCGTGGCCATTGCTTTCCTGGTCTTCCTCTGTGGCCAGAGTGTCTTCA
TCACCAAGCCTCCTGATGGCAGTGCCTTCACTGACATGTTCAGGATTCTGACCTACAGCTGCTG
CTCCCAGAGAGGAGGGCAGCGGAGAAGTGGTGAAGGCCTTGGAGTCTTTCAGCAATCTTCTAAA
CACAGTCTGTTTGATTCATGTAAGATGTCGCGTGGAGGGCCGTTCACAGAGGACAAAGTGGAAG
ACGTGAAAGCCCTGGTCAAGATTGTGCCCGTGTTCTTGGCTCTGATTCCTTACTGGACAGTGTA
TTTCCAAATGCAGACCACATATGTTTTACAGAGTCTTCATTTGAAGATTCCAGAAATCTCAAGT
ATCACCACCACCCATCACACGCTGCCTGCAGCTTGGCTCACCATGTTTGATGCGGTGCTCATCC
TCCTGCTCATCCCACTGAAGGACAAGCTAGTGGACCCGGTGCTGAGGAGACACGGCCTGCTCCC
ATCCTCCCTGAAGAGGATTGCCGTGGGGATGTTCTTCGTCACATGCTCTGCCTTTGCTGCAGGA
ATCCTGGAGAGTAAAAGGCTGGACCTGGTGAAGGAGAAGACCATCAACCAGACCATTGGTGGTG
TGGTCTACCATGCTGCTGACCTGCCCATCTGGTGGCAGATCCCACAGTATGTGCTCATTGGCAT
CAGTGAGATATTTGCAAGTATAGCAGGTCTGGAGTTTGCGTACTCGGCTGCCCCCAAGTCCATG
CAGAGTGCCATCATGGGACTCTTCTTCTTCTTCTCTGGCATTGGGTCCTTCGTGGGCTCAGGAC
TGCTGGCCCTGGTGTCTCTCAAGGCCATCGGGTGGATGAGCAGTCATACAGACTTTGGGAACAT
CAACAGCTGCCACCTGCATTACTACTTCTTCCTGCTGGCCGCCATCCAGGGAGCTACGCTGCTG
CTCTTCCTCATTGTGTCTGTGAAGTACGACCGCCAGCGAGCCAGGACAGATGGGGGGACAGCCA
GCACGAGGACCTGATGCAGCCAGCCAGCATGCTCACAGGTTCTGCAGACTATAAGGCCTCAGGG
CTTGCTAACTACCAGGGCACTGCCAGCAAGCAGGTTGAGGCTAGATGGTTGGTGTCCCAACTTC
TGAACTTGCATGTTGTCTGGACTGGCTTCTCCCTCCCTGTGCCCAGATGATGGTGGTGAGTGCC
TTACTGTGGCCCGTCTCATGTGCACTGGGCCTACCAGGAGATGAGAATGTGGCTTCTCTCACTG
AAGGTCTCTGCCCGTTCTGAGCCAGCCATGCTTTCTCTTTTAGAATCCTGAGCAGCCCCTGTCC
TGCTGCTGGGCATCCTTATTCCTTACAAACACTGTTACTTTCATAGCATCTCCTGTAAGATTAG
CAAGCATTTCCATCAAGCGGTAGGAGGATTCTCTTCAGAGATCAAAGTGTGGTTGATGGCGAGA
GAGCCCCATGAGCTGTTTCTGCTCCATTGATGGTCTCTTGTCACAGATCTTGCTGATGCCAAGG
CCTTTGTGGGTCAGTAGTGTAGACTCATCTGCTCAAAAAGTAGTTTTGTTGGCTAAGGTGAAGA
AGTGTTTCTTATTACACTAGGCTGGCCTCACTAGGCTGACCTCAAACTTGGTGCTGCCTCCTGT
CTGCTTCTCAAGTGCTAAGATCTCAGATGTCCATCACCATGGTCAGCAGGACTTAGGTCATGAA
CTACTGATCTGCTTTAAGCACATGCATCAGTGGTGAGTGAGGACACCATGTTCTCACTGAGACC
AGACAGCAGCTGGCAGGAGATTGGCATTTACACCTGGCAGATCTTTTCTGAGAACTTGACTTTG
TGTAGCAGTAAGATTGGAGGCAGGTGGTGAGTGGGGAAAACACGGGAGCTGTTGGGCTGGTCGC
CCACCTTTGTATTGTTACTGACATATCTGGGGTTCTGAGTGTGTCAACTAAACCATTTTATGTG
TTGCTGTGTCTTGTATAATTTGATAAAAGCTTCTCAGACATG

hide sequence

RefSeq Acc Id:

XM_039089070 ⟹ XP_038944998

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	34,703,258 - 34,718,429 (+)	NCBI
mRatBN7.2	12	29,067,312 - 29,081,698 (+)	NCBI

RefSeq Acc Id:

XM_039089071 ⟹ XP_038944999

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	34,700,585 - 34,718,429 (+)	NCBI
mRatBN7.2	12	29,064,647 - 29,081,698 (+)	NCBI

RefSeq Acc Id:

XM_039089072 ⟹ XP_038945000

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	34,684,583 - 34,718,429 (+)	NCBI
mRatBN7.2	12	29,048,634 - 29,081,698 (+)	NCBI

RefSeq Acc Id:

XR_005491598

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	12	34,698,949 - 34,710,715 (+)	NCBI
mRatBN7.2	12	29,063,001 - 29,081,380 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_653359	(Get FASTA)	NCBI Sequence Viewer
	XP_038944998	(Get FASTA)	NCBI Sequence Viewer
	XP_038944999	(Get FASTA)	NCBI Sequence Viewer
	XP_038945000	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH87709	(Get FASTA)	NCBI Sequence Viewer
	BAA20489	(Get FASTA)	NCBI Sequence Viewer
	EDM13532	(Get FASTA)	NCBI Sequence Viewer
	EDM13533	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000001277
	ENSRNOP00000001277.2
	ENSRNOP00055018697
	ENSRNOP00060001605
	ENSRNOP00065001566
GenBank Protein	O09014	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_653359 ⟸ NM_144758

- UniProtKB:

Q5M931 (UniProtKB/Swiss-Prot), O09014 (UniProtKB/Swiss-Prot), A0A0G2JSH0 (UniProtKB/TrEMBL), A6J0U3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEGERAPLLGSRRAAAAAGVFAGRRAACGAVLLAELLERAAFYGVTANLVLFLNGAPFNWEGAQ
ASQALLLFMGLTYLGSPFGGWLADARLGRARAILLSLALYLLGMLAFPLLAAPRSRSFLCGDPH
PELVRNCSAPFPNGTAVCPDAAARRCAPATFAGLVLVGLGVATVKANITPFGADQVKDRGPEAT
RRFFNWFYWSINLGAILSLGGIAYIQQNVSFLTGYLIPTVCVAIAFLVFLCGQSVFITKPPDGS
AFTDMFRILTYSCCSQRGGQRRSGEGLGVFQQSSKHSLFDSCKMSRGGPFTEDKVEDVKALVKI
VPVFLALIPYWTVYFQMQTTYVLQSLHLKIPEISSITTTHHTLPAAWLTMFDAVLILLLIPLKD
KLVDPVLRRHGLLPSSLKRIAVGMFFVTCSAFAAGILESKRLDLVKEKTINQTIGGVVYHAADL
PIWWQIPQYVLIGISEIFASIAGLEFAYSAAPKSMQSAIMGLFFFFSGIGSFVGSGLLALVSLK
AIGWMSSHTDFGNINSCHLHYYFFLLAAIQGATLLLFLIVSVKYDRQRARTDGGTASTRT

hide sequence

RefSeq Acc Id:

ENSRNOP00000001277 ⟸ ENSRNOT00000001277

RefSeq Acc Id:	XP_038945000 ⟸ XM_039089072
- Peptide Label:	isoform X3
- UniProtKB:	A6J0U4 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_038944999 ⟸ XM_039089071
- Peptide Label:	isoform X2

RefSeq Acc Id:	XP_038944998 ⟸ XM_039089070
- Peptide Label:	isoform X1

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-O09014-F1-model_v2	AlphaFold	O09014	1-572	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13698598

Promoter ID:

EPDNEW_R9122

Type:

multiple initiation site

Name:

Slc15a4_1

Description:

solute carrier family 15 member 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	12	32,753,835 - 32,753,895	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:708469	AgrOrtholog
BioCyc Gene	G2FUF-19446	BioCyc
Ensembl Genes	ENSRNOG00000000962	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00055013455	UniProtKB/Swiss-Prot
	ENSRNOG00060001642	UniProtKB/Swiss-Prot
	ENSRNOG00065001668	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000001277	ENTREZGENE
	ENSRNOT00000001277.4	UniProtKB/TrEMBL
	ENSRNOT00055023054	UniProtKB/Swiss-Prot
	ENSRNOT00060002481	UniProtKB/Swiss-Prot
	ENSRNOT00065002236	UniProtKB/Swiss-Prot
Gene3D-CATH	1.20.1250.20	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7315369	IMAGE-MGC_LOAD
InterPro	MFS_trans_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	POT_fam	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTR2_symporter_CS	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:246280	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:105315	IMAGE-MGC_LOAD
NCBI Gene	246280	ENTREZGENE
PANTHER	PTHR11654	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SOLUTE CARRIER FAMILY 15 MEMBER 4	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	PTR2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Slc15a4	PhenoGen
PROSITE	PTR2_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000000962	RatGTEx
	ENSRNOG00055013455	RatGTEx
	ENSRNOG00060001642	RatGTEx
	ENSRNOG00065001668	RatGTEx
Superfamily-SCOP	SSF103473	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2JSH0	ENTREZGENE, UniProtKB/TrEMBL
	A6J0U3	ENTREZGENE, UniProtKB/TrEMBL
	A6J0U4	ENTREZGENE, UniProtKB/TrEMBL
	O09014	ENTREZGENE
	Q5M931	ENTREZGENE
	S15A4_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	Q5M931	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-02-25	Slc15a4	solute carrier family 15 member 4	Slc15a4	solute carrier family 15 (oligopeptide transporter), member 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-08-02	Slc15a4	solute carrier family 15 (oligopeptide transporter), member 4	Slc15a4	solute carrier family 15, member 4	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	Slc15a4	solute carrier family 15, member 4		peptide/histidine transporter	Name updated	1299863	APPROVED
2004-09-10	Slc15a4	peptide/histidine transporter	LOC246280		Symbol and Name updated	1299863	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in hippocampus, choroid plexus, cerebellum, and pontine nucleus	1299463
gene_regulation	transport inhibited by dipeptides and tripeptides but not by free amino acids	1299463

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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