Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | type 2 diabetes mellitus | | ISO | CNKSR2 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:30718926 | |
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Imported Disease Annotations - CTDTerm | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | type 2 diabetes mellitus | | ISO | CNKSR2 (Homo sapiens) | 11554173 | CTD Direct Evidence: marker/mechanism | CTD | PMID:30718926 | |
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# | Reference Title | Reference Citation |
1. | Synaptic localization of membrane-associated guanylate kinase-interacting protein mediated by the pleckstrin homology domain. | Iida J, etal., Eur J Neurosci 2002 May;15(9):1493-8. |
2. | The CNK2 scaffold interacts with vilse and modulates Rac cycling during spine morphogenesis in hippocampal neurons. | Lim J, etal., Curr Biol. 2014 Mar 31;24(7):786-92. doi: 10.1016/j.cub.2014.02.036. Epub 2014 Mar 20. |
3. | Densin-180, a synaptic protein, links to PSD-95 through its direct interaction with MAGUIN-1. | Ohtakara K, etal., Genes Cells. 2002 Nov;7(11):1149-60. |
4. | ClinVar Automated Import and Annotation Pipeline | RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations |
5. | Data Import for Chemical-Gene Interactions | RGD automated import pipeline for gene-chemical interactions |
6. | MAGUIN, a novel neuronal membrane-associated guanylate kinase-interacting protein. | Yao I, etal., J Biol Chem 1999 Apr 23;274(17):11889-96. |
7. | Disease-associated synaptic scaffold protein CNK2 modulates PSD size and influences localisation of the regulatory kinase TNIK. | Zieger HL, etal., Sci Rep. 2020 Mar 31;10(1):5709. doi: 10.1038/s41598-020-62207-4. |
PMID:14597674 | PMID:17114649 | PMID:19056867 | PMID:22871113 | PMID:29476059 | PMID:30053369 |
Cnksr2 (Rattus norvegicus - Norway rat) |
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CNKSR2 (Homo sapiens - human) |
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Cnksr2 (Mus musculus - house mouse) |
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Cnksr2 (Chinchilla lanigera - long-tailed chinchilla) |
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CNKSR2 (Pan paniscus - bonobo/pygmy chimpanzee) |
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CNKSR2 (Canis lupus familiaris - dog) |
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Cnksr2 (Ictidomys tridecemlineatus - thirteen-lined ground squirrel) |
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CNKSR2 (Sus scrofa - pig) |
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CNKSR2 (Chlorocebus sabaeus - green monkey) |
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Cnksr2 (Heterocephalus glaber - naked mole-rat) |
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Variants in Cnksr2
699 total Variants |
The detailed report is available here: | Full Report | CSV | TAB | Printer | ||||
miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/). For more information about miRGate, see PMID:25858286 or access the full paper here. |
The following QTLs overlap with this region. | Full Report | CSV | TAB | Printer | Gviewer |
RH140438 |
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CNKSR2_4601 |
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RH15676 |
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UniSTS:224320 |
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alimentary part of gastrointestinal system | circulatory system | endocrine system | exocrine system | hemolymphoid system | hepatobiliary system | integumental system | musculoskeletal system | nervous system | renal system | reproductive system | respiratory system | appendage | |
High | |||||||||||||
Medium | 56 | 1 | |||||||||||
Low | 10 | 16 | 6 | 2 | 6 | 8 | 8 | 18 | 17 | 35 | 11 | 8 | |
Below cutoff | 3 | 33 | 12 | 6 | 15 | 6 | 3 | 17 | 5 |
RefSeq Transcripts | NM_001113366 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
NM_021686 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_008773224 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_017602144 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_039100001 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
XM_063280272 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
GenBank Nucleotide | AF102853 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
AF102854 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
CH473966 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles | |
JAXUCZ010000021 | (Get FASTA) | NCBI Sequence Viewer | Search GEO for Microarray Profiles |
RefSeq Acc Id: | ENSRNOT00000009802 ⟹ ENSRNOP00000009802 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000080512 ⟹ ENSRNOP00000071915 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | ENSRNOT00000095688 ⟹ ENSRNOP00000084300 | ||||||||
Type: | CODING | ||||||||
Position: |
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RefSeq Acc Id: | NM_001113366 ⟹ NP_001106837 | ||||||||||||||||||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | NM_021686 ⟹ NP_067718 | ||||||||||||||||||||||||||||
RefSeq Status: | VALIDATED | ||||||||||||||||||||||||||||
Type: | CODING | ||||||||||||||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_008773224 ⟹ XP_008771446 | ||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_017602144 ⟹ XP_017457633 | ||||||||||||||||
Type: | CODING | ||||||||||||||||
Position: |
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Sequence: |
RefSeq Acc Id: | XM_039100001 ⟹ XP_038955929 | ||||||||||||
Type: | CODING | ||||||||||||
Position: |
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RefSeq Acc Id: | XM_063280272 ⟹ XP_063136342 | ||||||||
Type: | CODING | ||||||||
Position: |
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Protein RefSeqs | NP_001106837 | (Get FASTA) | NCBI Sequence Viewer |
NP_067718 | (Get FASTA) | NCBI Sequence Viewer | |
XP_008771446 | (Get FASTA) | NCBI Sequence Viewer | |
XP_017457633 | (Get FASTA) | NCBI Sequence Viewer | |
XP_038955929 | (Get FASTA) | NCBI Sequence Viewer | |
XP_063136342 | (Get FASTA) | NCBI Sequence Viewer | |
GenBank Protein | AAD04567 | (Get FASTA) | NCBI Sequence Viewer |
AAD04568 | (Get FASTA) | NCBI Sequence Viewer | |
EDL96122 | (Get FASTA) | NCBI Sequence Viewer | |
EDL96123 | (Get FASTA) | NCBI Sequence Viewer | |
EDL96124 | (Get FASTA) | NCBI Sequence Viewer | |
Ensembl Protein | ENSRNOP00000009802 | ||
ENSRNOP00000009802.3 | |||
ENSRNOP00000071915 | |||
ENSRNOP00000071915.1 | |||
ENSRNOP00000084300 | |||
ENSRNOP00000084300.1 | |||
GenBank Protein | Q9Z1T4 | (Get FASTA) | NCBI Sequence Viewer |
RefSeq Acc Id: | NP_067718 ⟸ NM_021686 |
- Peptide Label: | isoform 2 |
- UniProtKB: | A6IPP1 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | NP_001106837 ⟸ NM_001113366 |
- Peptide Label: | isoform 1 |
- UniProtKB: | Q9R093 (UniProtKB/Swiss-Prot), Q9Z1T4 (UniProtKB/Swiss-Prot), A6IPN9 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | XP_008771446 ⟸ XM_008773224 |
- Peptide Label: | isoform X1 |
- Sequence: |
RefSeq Acc Id: | XP_017457633 ⟸ XM_017602144 |
- Peptide Label: | isoform X2 |
- UniProtKB: | A0A8I6A0Z8 (UniProtKB/TrEMBL), A6IPP0 (UniProtKB/TrEMBL) |
- Sequence: |
RefSeq Acc Id: | ENSRNOP00000071915 ⟸ ENSRNOT00000080512 |
RefSeq Acc Id: | ENSRNOP00000009802 ⟸ ENSRNOT00000009802 |
RefSeq Acc Id: | XP_038955929 ⟸ XM_039100001 |
- Peptide Label: | isoform X3 |
RefSeq Acc Id: | ENSRNOP00000084300 ⟸ ENSRNOT00000095688 |
RefSeq Acc Id: | XP_063136342 ⟸ XM_063280272 |
- Peptide Label: | isoform X4 |
Name | Modeler | Protein Id | AA Range | Protein Structure |
AF-Q9Z1T4-F1-model_v2 | AlphaFold | Q9Z1T4 | 1-1032 | view protein structure |
eQTL | View at Phenogen | |
WGCNA | View at Phenogen | |
Tissue/Strain Expression | View at Phenogen |
RGD ID: | 13701813 | ||||||||
Promoter ID: | EPDNEW_R12337 | ||||||||
Type: | single initiation site | ||||||||
Name: | Cnksr2_1 | ||||||||
Description: | connector enhancer of kinase suppressor of Ras 2 | ||||||||
SO ACC ID: | SO:0000170 | ||||||||
Source: | EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/) | ||||||||
Experiment Methods: | Single-end sequencing. | ||||||||
Position: |
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Database | Acc Id | Source(s) |
AGR Gene | RGD:708454 | AgrOrtholog |
BioCyc Gene | G2FUF-2472 | BioCyc |
Ensembl Genes | ENSRNOG00000007014 | Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
Ensembl Transcript | ENSRNOT00000009802 | ENTREZGENE |
ENSRNOT00000009802.6 | UniProtKB/Swiss-Prot | |
ENSRNOT00000080512 | ENTREZGENE | |
ENSRNOT00000080512.2 | UniProtKB/Swiss-Prot | |
ENSRNOT00000095688.1 | UniProtKB/TrEMBL | |
Gene3D-CATH | 1.10.150.50 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
2.30.29.30 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
2.30.42.10 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
InterPro | CNK1-3_SAM | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
CNK2/3_dom | UniProtKB/TrEMBL, UniProtKB/Swiss-Prot | |
CRIC_domain | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PDZ | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PDZ_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PH-like_dom_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PH_domain | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SAM | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SAM/pointed_sf | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
KEGG Report | rno:59322 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
NCBI Gene | 59322 | ENTREZGENE |
PANTHER | CONNECTOR ENCHANCER OF KINASE SUPPRESSOR OF RAS | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
CONNECTOR ENHANCER OF KINASE SUPPRESSOR OF RAS 2 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Pfam | CRIC_ras_sig | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
DUF1170 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PDZ | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PF00169 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SAM_1 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PhenoGen | Cnksr2 | PhenoGen |
PROSITE | CRIC | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
PDZ | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
PH_DOMAIN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SAM_DOMAIN | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
RatGTEx | ENSRNOG00000007014 | RatGTEx |
SMART | PDZ | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
SAM | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SM00233 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
Superfamily-SCOP | PH domain-like | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL |
SSF47769 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
SSF50156 | UniProtKB/Swiss-Prot, UniProtKB/TrEMBL | |
UniProt | A0A8I6A0Z8 | ENTREZGENE, UniProtKB/TrEMBL |
A6IPN9 | ENTREZGENE, UniProtKB/TrEMBL | |
A6IPP0 | ENTREZGENE, UniProtKB/TrEMBL | |
A6IPP1 | ENTREZGENE, UniProtKB/TrEMBL | |
CNKR2_RAT | UniProtKB/Swiss-Prot | |
Q9R093 | ENTREZGENE | |
Q9Z1T4 | ENTREZGENE | |
UniProt Secondary | Q9R093 | UniProtKB/Swiss-Prot |
Date | Current Symbol | Current Name | Previous Symbol | Previous Name | Description | Reference | Status |
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2006-03-30 | Cnksr2 | connector enhancer of kinase suppressor of Ras 2 | membrane-associated guanylate kinase-interacting protein | Name updated | 1299863 | APPROVED | |
2004-09-10 | Cnksr2 | membrane-associated guanylate kinase-interacting protein | LOC59322 | Symbol and Name updated | 1299863 | APPROVED |