Tox4 (TOX high mobility group box family member 4)

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Gene: Tox4 (TOX high mobility group box family member 4) Rattus norvegicus

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Symbol:

Tox4

Name:

TOX high mobility group box family member 4

RGD ID:

708449

Description:

Predicted to enable chromatin DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in chromatin and chromosome, telomeric region. Predicted to be part of PTW/PP1 phosphatase complex. Predicted to be active in nucleus. Orthologous to human TOX4 (TOX high mobility group box family member 4); INTERACTS WITH (+)-schisandrin B; ammonium chloride; bisphenol A.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

epidermal Langerhans cell protein LCP1; LOC286990; MGC93073; RGD708449

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	27,462,735 - 27,476,320 (+)	NCBI		GRCr8
mRatBN7.2	15	24,989,246 - 25,002,833 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	24,988,853 - 25,002,833 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	27,761,942 - 27,775,492 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	28,716,039 - 28,729,621 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	26,968,978 - 26,982,572 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	28,696,378 - 28,709,960 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	28,695,912 - 28,709,957 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	32,506,578 - 32,520,161 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	27,729,485 - 27,743,620 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	27,745,184 - 27,759,317 (+)	NCBI
Celera	15	25,293,401 - 25,306,983 (+)	NCBI		Celera
Cytogenetic Map	15	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Brain-Lung-Thyroid Syndrome (ISO)

cone-rod dystrophy 13 (ISO)

purine nucleoside phosphorylase deficiency (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dimethylhydrazine (ISO)

2,3,7,8-tetrachlorodibenzodioxine (ISO)

3,3',4,4'-tetrachlorobiphenyl (ISO)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

arsenous acid (ISO)

benzo[a]pyrene (ISO)

benzo[b]fluoranthene (ISO)

beta-lapachone (ISO)

bisphenol A (EXP)

caffeine (ISO)

chlorpyrifos (ISO)

chrysene (ISO)

clofibrate (ISO)

copper(II) sulfate (ISO)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

Dibutyl phosphate (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

elemental selenium (ISO)

enzyme inhibitor (ISO)

epoxiconazole (ISO)

ethanol (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

gentamycin (EXP)

hydrogen peroxide (ISO)

inulin (ISO)

methyl methanesulfonate (ISO)

paracetamol (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenylmercury acetate (ISO)

rotenone (EXP)

SB 431542 (ISO)

selenium atom (ISO)

sodium arsenite (ISO)

testosterone enanthate (ISO)

tetrachloromethane (EXP,ISO)

tetraphene (ISO)

tributylstannane (EXP)

trichostatin A (ISO)

triphenyl phosphate (ISO)

valproic acid (ISO)

vitamin E (ISO)

zoledronic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

regulation of transcription by RNA polymerase II (IBA)

Cellular Component

chromatin (IEA,ISO)

chromosome, telomeric region (IEA,ISO)

nucleus (IBA,IEA)

PTW/PP1 phosphatase complex (IEA,ISO,ISS)

Molecular Function

chromatin DNA binding (IBA)

DNA binding (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
3.	GOA pipeline	RGD automated data pipeline
4.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
6.	Information Derived from GenBank Report	RGD, Sept. 2003
7.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:20516061	PMID:24270157

Genomics

Comparative Map Data

Tox4
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	15	27,462,735 - 27,476,320 (+)	NCBI		GRCr8
mRatBN7.2	15	24,989,246 - 25,002,833 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	15	24,988,853 - 25,002,833 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	15	27,761,942 - 27,775,492 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	15	28,716,039 - 28,729,621 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	15	26,968,978 - 26,982,572 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	15	28,696,378 - 28,709,960 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	15	28,695,912 - 28,709,957 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	15	32,506,578 - 32,520,161 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	15	27,729,485 - 27,743,620 (+)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	15	27,745,184 - 27,759,317 (+)	NCBI
Celera	15	25,293,401 - 25,306,983 (+)	NCBI		Celera
Cytogenetic Map	15	p14	NCBI

TOX4
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	14	21,477,195 - 21,499,170 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	14	21,476,597 - 21,499,175 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	14	21,945,354 - 21,967,314 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	14	21,015,175 - 21,037,159 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	14	21,015,245 - 21,036,880	NCBI
Celera	14	1,810,716 - 1,830,660 (+)	NCBI		Celera
Cytogenetic Map	14	q11.2	NCBI
HuRef	14	2,064,581 - 2,085,176 (+)	NCBI		HuRef
CHM1_1	14	21,946,806 - 21,968,784 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	14	15,674,564 - 15,696,534 (+)	NCBI		T2T-CHM13v2.0

Tox4
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	14	52,516,603 - 52,532,966 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	14	52,516,603 - 52,533,858 (+)	Ensembl		GRCm39 Ensembl
GRCm38	14	52,279,146 - 52,295,509 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	14	52,279,146 - 52,296,401 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	14	52,898,821 - 52,915,184 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	14	51,201,595 - 51,216,463 (+)	NCBI		MGSCv36	mm8
Celera	14	49,261,686 - 49,277,476 (+)	NCBI		Celera
Cytogenetic Map	14	C2	NCBI
cM Map	14	26.88	NCBI

Tox4
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955550	2,195,710 - 2,209,729 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955550	2,195,710 - 2,209,729 (+)	NCBI	ChiLan1.0	ChiLan1.0

TOX4
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	15	22,932,579 - 22,952,483 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	14	22,149,066 - 22,168,973 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	14	2,294,892 - 2,316,901 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	14	20,371,820 - 20,393,696 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	14	20,371,820 - 20,393,696 (+)	Ensembl	panpan1.1		panPan2

TOX4
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	15	18,512,270 - 18,528,293 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	15	18,512,327 - 18,528,516 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	15	18,996,794 - 19,012,736 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	15	18,771,256 - 18,787,208 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	15	18,771,289 - 18,788,953 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	15	18,453,331 - 18,469,249 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	15	18,509,388 - 18,525,329 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	15	18,638,257 - 18,654,205 (+)	NCBI		UU_Cfam_GSD_1.0

Tox4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024408640	32,718,872 - 32,737,761 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936880	627,576 - 646,006 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936880	628,316 - 646,006 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

TOX4
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	7	77,678,475 - 77,698,917 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	7	77,679,405 - 77,698,952 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	7	83,021,649 - 83,040,735 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

TOX4
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	29	21,946,311 - 21,966,197 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	29	21,945,901 - 21,965,740 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666059	24,462,325 - 24,484,109 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Tox4
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624825	7,493,953 - 7,511,846 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624825	7,493,911 - 7,511,852 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Tox4
38 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	265
Count of miRNA genes:	170
Interacting mature miRNAs:	194
Transcripts:	ENSRNOT00000017476
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1331729	Rf42	Renal function QTL 42	3.071		kidney blood vessel physiology trait (VT:0100012)	absolute change in renal blood flow rate (CMO:0001168)	15	17362897	73690657	Rat
1641887	Alcrsp14	Alcohol response QTL 14			response to alcohol trait (VT:0010489)	brain neurotensin receptor 1 density (CMO:0002068)	15	1	42356671	Rat
10755503	Bp391	Blood pressure QTL 391	2.37		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	15	20248600	37896129	Rat
1578646	Bmd18	Bone mineral density QTL 18	5.2		femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	15	22806240	98288169	Rat
9589149	Insul29	Insulin level QTL 29	9.06	0.001	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	15	1	34723002	Rat
1578647	Bmd17	Bone mineral density QTL 17	4		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	15	22806240	98288169	Rat
10401805	Kidm51	Kidney mass QTL 51			kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	15	306329	45306329	Rat
2317750	Glom26	Glomerulus QTL 26	4.3		urine protein amount (VT:0005160)	urine protein level (CMO:0000591)	15	12496141	65205939	Rat
2298549	Neuinf12	Neuroinflammation QTL 12	3.5		nervous system integrity trait (VT:0010566)	spinal cord beta-2 microglobulin mRNA level (CMO:0002125)	15	1	55302115	Rat
8552920	Pigfal8	Plasma insulin-like growth factor 1 level QTL 8	3		blood insulin-like growth factor amount (VT:0010479)	plasma insulin-like growth factor 1 level (CMO:0001299)	15	1	34723002	Rat
2293688	Bss29	Bone structure and strength QTL 29	5.31	0.0001	femur morphology trait (VT:0000559)	femur midshaft cortical cross-sectional area (CMO:0001663)	15	11111142	56111142	Rat
5685002	Bss103	Bone structure and strength QTL 103	2.8		tibia strength trait (VT:1000284)	tibia total energy absorbed before break (CMO:0001736)	15	14481165	28469888	Rat
8694361	Abfw6	Abdominal fat weight QTL 6	10.2	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	15	1	34723002	Rat
631273	Lecl2	Lens clarity QTL 2		0.001	lens clarity trait (VT:0001304)	age of onset/diagnosis of cataract (CMO:0001584)	15	10596089	55596089	Rat
2300167	Bmd63	Bone mineral density QTL 63	5.9	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
731170	Pur3	Proteinuria QTL 3	2.3	0.0005	urine protein amount (VT:0005160)	urine protein excretion rate (CMO:0000759)	15	1	41686771	Rat
738017	Hcas7	Hepatocarcinoma susceptibility QTL 7	2.91		liver integrity trait (VT:0010547)	liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)	15	2266368	46921453	Rat
10054130	Srcrt8	Stress Responsive Cort QTL 8	2.18	0.0085	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	15	22117933	67117933	Rat
2300173	Bmd62	Bone mineral density QTL 62	12.8	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	15	11111142	56111142	Rat
2324620	Coatc3	Coat color QTL 3			coat/hair pigmentation trait (VT:0010463)	pigmented coat/hair area to total coat/hair area ratio (CMO:0001810)	15	19856566	46187442	Rat
61424	Scl1	Serum cholesterol level QTL 1	7.7	0.001	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	15	16725528	80672115	Rat
1582251	Gluco24	Glucose level QTL 24	3.2	0.0008	blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	15	5530756	50530756	Rat
1354657	Despr13	Despair related QTL 13		0.0022	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	15	1	29912054	Rat
631550	Bw7	Body weight QTL 7	3.6		body mass (VT:0001259)	body weight (CMO:0000012)	15	19856566	34924750	Rat
1578660	Bss19	Bone structure and strength QTL 19	4.3		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	15	22806240	98288169	Rat

Markers in Region

AI236262

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	25,001,879 - 25,002,045 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	28,709,007 - 28,709,172	NCBI	Rnor6.0
Rnor_5.0	15	32,519,208 - 32,519,373	UniSTS	Rnor5.0
RGSC_v3.4	15	27,742,667 - 27,742,832	UniSTS	RGSC3.4
Celera	15	25,306,030 - 25,306,195	UniSTS
RH 3.4 Map	15	199.8	UniSTS
Cytogenetic Map	15	p14	UniSTS

RH140974

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	15	25,002,557 - 25,002,758 (+)	MAPPER	mRatBN7.2
Rnor_6.0	15	28,709,685 - 28,709,885	NCBI	Rnor6.0
Rnor_5.0	15	32,519,886 - 32,520,086	UniSTS	Rnor5.0
RGSC_v3.4	15	27,743,345 - 27,743,545	UniSTS	RGSC3.4
Celera	15	25,306,708 - 25,306,908	UniSTS
Cytogenetic Map	15	p14	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	11	49	113	91	90	59	25	59	6	218	97	93	45	60	31

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_173324	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC117101	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF267197	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC081696	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474040	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ210274	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ212245	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000015	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000017476 ⟹ ENSRNOP00000017476

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	24,988,853 - 25,002,833 (+)	Ensembl
Rnor_6.0 Ensembl	15	28,696,378 - 28,709,957 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000081830 ⟹ ENSRNOP00000073768

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	15	24,993,416 - 25,002,833 (+)	Ensembl
Rnor_6.0 Ensembl	15	28,695,912 - 28,709,128 (+)	Ensembl

RefSeq Acc Id:

NM_173324 ⟹ NP_775446

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	15	27,462,735 - 27,476,320 (+)	NCBI
mRatBN7.2	15	24,989,246 - 25,002,833 (+)	NCBI
Rnor_6.0	15	28,696,378 - 28,709,960 (+)	NCBI
Rnor_5.0	15	32,506,578 - 32,520,161 (+)	NCBI
RGSC_v3.4	15	27,729,485 - 27,743,620 (+)	RGD
Celera	15	25,293,401 - 25,306,983 (+)	RGD

Sequence:

show sequence

CGGTGGGAGCGATGCGGACGCGGAGTCGCTGAGACGCTGGTGGTGGTGTTGTGAAGATGGAGTT
TCCCGGAGGAAATGACAATTACCTGACGATCACTGGGCCCTCGCACCCTTTCCTGTCAGGGGCC
GAGACATTCCATACACCAAGCTTGGGCGATGAGGAATTTGAAATCCCACCTATCTCCTTGGACT
CTGATCCCTCACTGGCTGTTTCAGATGTGGTTGGCCACTTTGATGACCTGGCAGACCCCTCCTC
TTCCCAGGATGGCAGCTTCTCAGCTCAATACGGGGTCCAGACATTGGACATGCCTGTGGGCATG
ACCCATGGCCTGATGGAGCAGGGCGGGGGGCTCCTGAGTGGGGGCTTGACTATGGACCTGGACC
ATTCCATAGGAACTCAGTATAGTGCCAACCCACCTGTTACAATTGATGTACCGATGACAGACAT
GACATCTGGCTTAATGGGACACAGCCAGTTGACCACTATTGATCAGTCAGAACTGAGTTCTCAA
CTTGGTTTGAGTTTAGGAGGTGGCACCATCTTGCCACCCGCCCAGTCACCTGAGGATCGTCTTT
CAACTACTCCTTCACCTACCAATTCACTTCATGAGGATGGTGTTGATGATTTCCGGAGGCAACT
TCCTGCCCAGAAGACAGTGGTAGTGGAAACAGGGAAAAAGCAAAAGGCTCCCAAGAAGAGAAAA
AAGAAAGACCCTAATGAACCTCAAAAGCCAGTCTCTGCGTATGCACTGTTCTTCCGAGATACTC
AGGCAGCCATCAAGGGACAGAACCCAAATGCAACCTTTGGGGAGGTTTCCAAGATTGTGGCTTC
CATGTGGGACAGTCTTGGAGAAGAGCAAAAACAGGTGTACAAGCGGAAAACTGAAGCTGCCAAG
AAAGAGTATCTCAAGGCACTAGCTGCTTATAAAGACAACCAGGAGTGTCAGGCTACTGTGGAAA
CAGTGGAATTGGATCCTGTGCCACAGTCACAGACTCCTTCACCACCTCCTGTGACTACTGCTGA
CCCAGCATCTCCAGCACCAGCCTCAACGGAGTCCCCTGCTTTGTCCCCTTGCATTGTAGTTAAT
TCCACGCTTTCATCTTACGTGGCAAACCAGGCATCTTCTGGGCCTGGAGGTCAGCCCAATATCA
CCAAATTGATTATTACCAAACAAATGTTGCCTTCTTCTATTACCATGTCTCAAGGAGGAATGGT
TACTGTTATCCCAGCCACAGTGGTTACCTCCCGTGGGCTCCAGCTGGGCCAAACAAGTACAGCT
ACTATTCAGCCAAGCCAGCAGGCCCAGATTGTCACTCGGTCAGTGTTGCAGGCAGCAGCAGCTG
CCGCTGCTTCTATGCAACTGCCTCCACCCCGCCTGCAGCCTCCTCCATTGCAACAGATGCCTCA
GCCCCCAACTCAACAGCAAGTCACCATTCTCCAGCAACCTCCTCCCCTTCAGGCCATGCAGCAG
CCTCCACCTCAGAAAGTTAGAATCAACCTACAGCAGCAGCCGCCTCCTCTGCAGAGCAAGATCG
TGCCTCCACCCGCTCTGAAAATGCAGGCTACAGTGCTCCCTCCAACTGTAGAAAGCAGCCCTGA
GCAGCCTATGAACAGCAGCCCCGAGGCCCACACAGTAGAGGCAACCTCTCCTGAGACAATCTGT
GAAATGATTGCAGATGTAGTTCCTGAGGTGGAGTCCCCTTCCCAGATGGATGTTGAATTGGTGA
GTGGATCCCCTGTGACACTGTCCCCTCAGCCTCGATGTGTGAGGTCTGGTTGCGAGAACCCTCC
TGTTATCAGTAAGGACTGGGACAACGAATATTGCAGCAATGAGTGTGTGGTGAAGCACTGCAGG
GATGTATTCTTGGCCTGGGTGGCCTCTAGAAATCCAAACTCTGTGGTATTTGTGAAGTAGCCTT
CCTCTTCTCCAAGCCTTGAAGATTCATCTGCCGGACATGAGTCCCAAAGCCTGCTTTTGACACA
TAAGCTGGGCTTCTGGTAGTGCCTGACCTTTACCAATAGTCCTTCATGCCTCCACCTCCCTTTT
CTTTCTTCAGCAGAGGCCAGACTATGTCGCAGAGCCAGCAAATTTACTGTAATTTAGAATTGCT
TTTTACTCAACTGTAAACAAAATTACCAGCTTATCACAAGCACAGGGAAGGGTGATGGGAGCAG
ATCATAGGGGTTATTAGAAGAAATGTCAGTAAAATTGTCAGAAGACTTGACTAAATGTTATTGG
GAGAGTGCTTAGCTTTGTTCTAGGAGGAAACAGCACTGAGATAATAAAGGCTTAGGATTACAGC
TCAGTGGTAAAGTGCATTGGGTTTAAATCCCAAATGAAGGAGAAATGAAAATACTGATTTAAAA
TAAAATGTGTAATAACCTACTATTATTAATATACACAGTGATTCAAGGATGAAGGCTTATAGAC
CTGGAGTTATGGCTTAGCACTACAAAGCTCTGAGTTCAGACCCCAGGCAGGAAGATCAGGAGCT
CAAGGTCATCCAAAACATGGTGGCCCATGCCTTTAATCCTAGTACTTTGGAGGTGGCTATAGGA
AGATTTTTGAGTTAAAGGCCAATCTGAACTTACATAGTAGACTTTGTCTCAAAAAACAGACTGG
GTGTGGTGGCGCTCTCCTCTACTCCTAGAACCTGGGAGGCCAGTGGCAGGCTGGATCTCTGAGT
TTGAAGTTAGCCAGGGTTACCTAGTGAGGTCCTATCTTTGCCCTCCCTGCCCTCCCTGCCCTCC
CTGCCCTTGACAGAAACAAATTCTGCTTCTGTCTCAGTCTTAGCACATTGAACTAGAGGGGAAA
GATATCATCCAGAACTCTCTCTCTATAAGTATTTCTTTACCTGACTTGGTTACCAGTTTTGCAT
GTAAGAAGCAGAACTCTATAACCCTAATAAGAGGTTTACAAAGTAAAGAATCTGTGTTTGATGA
AAAAAAAAAAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_775446	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAH81696	(Get FASTA)	NCBI Sequence Viewer
	AAK00807	(Get FASTA)	NCBI Sequence Viewer
	EDL88477	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000017476.5
	ENSRNOP00000073768.2
GenBank Protein	Q99PM1	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_775446 ⟸ NM_173324

- UniProtKB:

Q99PM1 (UniProtKB/Swiss-Prot), Q66HT2 (UniProtKB/TrEMBL), A6KEH2 (UniProtKB/TrEMBL), F7EPW2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MEFPGGNDNYLTITGPSHPFLSGAETFHTPSLGDEEFEIPPISLDSDPSLAVSDVVGHFDDLAD
PSSSQDGSFSAQYGVQTLDMPVGMTHGLMEQGGGLLSGGLTMDLDHSIGTQYSANPPVTIDVPM
TDMTSGLMGHSQLTTIDQSELSSQLGLSLGGGTILPPAQSPEDRLSTTPSPTNSLHEDGVDDFR
RQLPAQKTVVVETGKKQKAPKKRKKKDPNEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKI
VASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYKDNQECQATVETVELDPVPQSQTPSPPPVT
TADPASPAPASTESPALSPCIVVNSTLSSYVANQASSGPGGQPNITKLIITKQMLPSSITMSQG
GMVTVIPATVVTSRGLQLGQTSTATIQPSQQAQIVTRSVLQAAAAAAASMQLPPPRLQPPPLQQ
MPQPPTQQQVTILQQPPPLQAMQQPPPQKVRINLQQQPPPLQSKIVPPPALKMQATVLPPTVES
SPEQPMNSSPEAHTVEATSPETICEMIADVVPEVESPSQMDVELVSGSPVTLSPQPRCVRSGCE
NPPVISKDWDNEYCSNECVVKHCRDVFLAWVASRNPNSVVFVK

hide sequence

Ensembl Acc Id:

ENSRNOP00000017476 ⟸ ENSRNOT00000017476

Ensembl Acc Id:

ENSRNOP00000073768 ⟸ ENSRNOT00000081830

Protein Domains

HMG box

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q99PM1-F1-model_v2	AlphaFold	Q99PM1	1-619	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13699639

Promoter ID:

EPDNEW_R10163

Type:

initiation region

Name:

Tox4_1

Description:

TOX high mobility group box family member 4

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	15	28,696,370 - 28,696,430	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:708449	AgrOrtholog
BioCyc Gene	G2FUF-13975	BioCyc
Ensembl Genes	ENSRNOG00000012844	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000017476.8	UniProtKB/TrEMBL
	ENSRNOT00000081830.2	UniProtKB/TrEMBL
Gene3D-CATH	1.10.30.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
IMAGE_CLONE	IMAGE:7112549	IMAGE-MGC_LOAD
InterPro	HMG_box_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	HMG_box_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	TOX_HMG-box_domain	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:286990	UniProtKB/TrEMBL
MGC_CLONE	MGC:93073	IMAGE-MGC_LOAD
NCBI Gene	286990	ENTREZGENE
PANTHER	AGAP000281-PA	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	PTHR45781:SF2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	HMG_box	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Tox4	PhenoGen
PRINTS	HIGHMOBLTY12	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE	HMG_BOX_2	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000012844	RatGTEx
SMART	HMG	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP	SSF47095	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A0G2K6D4_RAT	UniProtKB/TrEMBL
	A6KEH2	ENTREZGENE, UniProtKB/TrEMBL
	F7EPW2	ENTREZGENE, UniProtKB/TrEMBL
	Q66HT2	ENTREZGENE
	Q99PM1	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	Q66HT2	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2008-02-25	Tox4	TOX high mobility group box family member 4	RGD708449	epidermal Langerhans cell protein LCP1	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2006-03-30	RGD708449	epidermal Langerhans cell protein LCP1	LOC286990		Symbol updated	1299863	APPROVED
2005-09-30	LOC286990				Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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