Ceacam4 (CEA cell adhesion molecule 4) - Rat Genome Database

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Gene: Ceacam4 (CEA cell adhesion molecule 4) Rattus norvegicus
Analyze
Symbol: Ceacam4
Name: CEA cell adhesion molecule 4
RGD ID: 708435
Description: Predicted to be involved in phagocytosis. Orthologous to human CEACAM4 (CEA cell adhesion molecule 4); INTERACTS WITH 1-naphthyl isothiocyanate; 17alpha-ethynylestradiol; 2,3,4,7,8-Pentachlorodibenzofuran.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: C-CAM4 protein; carcinoembryonic antigen-related cell adhesion molecule 1-like; carcinoembryonic antigen-related cell adhesion molecule 10; carcinoembryonic antigen-related cell adhesion molecule 4; CEA-related cell adhesion molecule 10; Ceacam10; LOC103689942; LOC287009
RGD Orthologs
Human
Mouse
Bonobo
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8189,504,555 - 89,510,831 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl189,504,555 - 89,510,831 (+)EnsemblGRCr8
mRatBN7.2180,376,667 - 80,382,943 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl180,376,648 - 80,382,915 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx185,769,090 - 85,775,366 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0194,320,073 - 94,326,349 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0187,524,853 - 87,531,129 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0181,643,809 - 81,650,085 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,643,816 - 81,650,094 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl183,003,841 - 83,010,171 (+)Ensemblrn6Rnor6.0
Rnor_5.0184,261,150 - 84,267,459 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0182,900,924 - 82,907,200 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4180,070,252 - 80,076,528 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera174,825,727 - 74,832,054 (+)NCBICelera
RGSC_v3.1180,148,362 - 80,154,639 (+)NCBI
Cytogenetic Map1q21NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
phagocytosis  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Identification of a new isoform of cell-cell adhesion molecule 105 (C-CAM), C-CAM4: a secretory protein with only one Ig domain. Earley K, etal., Biochem J 1996 May 1;315 ( Pt 3):799-806.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15901639   PMID:25567962  


Genomics

Comparative Map Data
Ceacam4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8189,504,555 - 89,510,831 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl189,504,555 - 89,510,831 (+)EnsemblGRCr8
mRatBN7.2180,376,667 - 80,382,943 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl180,376,648 - 80,382,915 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx185,769,090 - 85,775,366 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0194,320,073 - 94,326,349 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0187,524,853 - 87,531,129 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0181,643,809 - 81,650,085 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl181,643,816 - 81,650,094 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl183,003,841 - 83,010,171 (+)Ensemblrn6Rnor6.0
Rnor_5.0184,261,150 - 84,267,459 (+)NCBIRnor_5.0Rnor_5.0rn5
Rnor_5.0182,900,924 - 82,907,200 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4180,070,252 - 80,076,528 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera174,825,727 - 74,832,054 (+)NCBICelera
RGSC_v3.1180,148,362 - 80,154,639 (+)NCBI
Cytogenetic Map1q21NCBI
CEACAM4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381941,613,436 - 41,627,074 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1941,619,015 - 41,627,074 (-)Ensemblhg38GRCh38
GRCh371942,125,388 - 42,133,442 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361946,817,184 - 46,825,282 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341946,817,183 - 46,825,268NCBI
Celera1938,925,178 - 38,933,270 (-)NCBICelera
Cytogenetic Map19q13.2NCBI
HuRef1938,557,191 - 38,565,284 (-)NCBIHuRef
CHM1_11942,124,506 - 42,132,609 (-)NCBICHM1_1
T2T-CHM13v2.01944,435,204 - 44,448,818 (-)NCBIT2T-CHM13v2.0
Ceacam10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39724,476,592 - 24,484,081 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl724,476,631 - 24,484,082 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38724,777,167 - 24,784,656 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl724,777,206 - 24,784,657 (+)Ensemblmm10GRCm38
MGSCv37725,562,223 - 25,569,675 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36724,485,964 - 24,493,416 (+)NCBIMGSCv36mm8
Celera719,391,701 - 19,399,153 (+)NCBICelera
Cytogenetic Map7A3NCBI
cM Map712.78NCBI
CEACAM4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22047,729,564 - 47,737,604 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11949,598,456 - 49,606,494 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01938,512,661 - 38,520,693 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11947,018,593 - 47,026,596 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1947,018,593 - 47,026,596 (-)EnsemblpanPan2panpan1.1

Variants

.
Variants in Ceacam4
54 total Variants

QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578649Bmd8Bone mineral density QTL 84.9femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)151940904101229020Rat
1582234Gluco18Glucose level QTL 183.40.0003blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)187889942132889942Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
1358359Sradr1Stress Responsive Adrenal Weight QTL 14.74adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)139728272132889942Rat
4889929Bss87Bone structure and strength QTL 876.7tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)14630261591302615Rat
2313062Bmd73Bone mineral density QTL 733.90.0001tibia mineral mass (VT:1000283)compact volumetric bone mineral density (CMO:0001730)14630261591302615Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2313065Bss67Bone structure and strength QTL 673.10.0001tibia area (VT:1000281)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
1331800Scl25Serum cholesterol level QTL 253.013blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)187785026142582336Rat
7421628Bp361Blood pressure QTL 3610.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)183019780128019780Rat
631495Bp96Blood pressure QTL 964.52arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)166404680111404680Rat
2313069Bss68Bone structure and strength QTL 682.90.0001tibia size trait (VT:0100001)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
2313075Bss66Bone structure and strength QTL 663.40.0001tibia length (VT:0004357)tibia length (CMO:0000450)14630261591302615Rat
631512Scl6Serum cholesterol level QTL 69.6blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)18126986099645535Rat
2298545Neuinf8Neuroinflammation QTL 84.6nervous system integrity trait (VT:0010566)spinal cord beta-2 microglobulin mRNA level (CMO:0002125)166009857160501508Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
2313077Bss69Bone structure and strength QTL 693.50.0001tibia strength trait (VT:1000284)bone polar moment of inertia (CMO:0001558)14630261591302615Rat
1302788Scl19Serum cholesterol QTL 194.60.001blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)166400974132889942Rat
1549903Bp267Blood pressure QTL 267arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)184107164115183752Rat
2313402Anxrr24Anxiety related response QTL 24aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)151511344153680016Rat
61342Bp27Blood pressure QTL 273.40.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16540563796805205Rat
4889962Bss94Bone structure and strength QTL 943.8tibia area (VT:1000281)tibia-fibula cortical bone endosteal cross-sectional area (CMO:0001722)15190920691302615Rat
1358192Ept13Estrogen-induced pituitary tumorigenesis QTL 133.4pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)186622262131622262Rat
6903308Scl36Serum cholesterol QTL 3620.0125blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)158769992103769992Rat
2300164Bmd44Bone mineral density QTL 445.40.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)166077886111077886Rat
2313092Bmd72Bone mineral density QTL 722.50.0001tibia mineral mass (VT:1000283)total volumetric bone mineral density (CMO:0001728)14630261591302615Rat
2313097Bss70Bone structure and strength QTL 703.50.0001tibia strength trait (VT:1000284)tibia total energy absorbed before break (CMO:0001736)14630261591302615Rat
10054135Gmadr2Adrenal mass QTL 21.970.0129adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)186993904131993904Rat
152025249Scl82Serum cholesterol level QTL 824.77blood cholesterol amount (VT:0000180)152891222109116986Rat
7411712Strs4Sensitivity to stroke QTL 48.7cerebrum integrity trait (VT:0010549)percentage of study population developing cerebrovascular lesions during a period of time (CMO:0000932)187558587132558587Rat
4889919Bss86Bone structure and strength QTL 864.1tibia area (VT:1000281)tibia midshaft total cross-sectional area (CMO:0001715)14630261591302615Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
19 1 27 108 80 81 47 84 47 12 258 141 11 77 51 73 34 8 8

Sequence


Ensembl Acc Id: ENSRNOT00000027214   ⟹   ENSRNOP00000027213
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl181,643,816 - 81,650,094 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000057384   ⟹   ENSRNOP00000054195
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl189,504,566 - 89,507,976 (+)Ensembl
mRatBN7.2 Ensembl180,376,648 - 80,382,915 (+)Ensembl
Rnor_6.0 Ensembl183,003,841 - 83,010,171 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000170891   ⟹   ENSRNOP00000111193
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl189,504,555 - 89,510,831 (+)Ensembl
RefSeq Acc Id: NM_173339   ⟹   NP_775461
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8189,504,555 - 89,510,831 (+)NCBI
mRatBN7.2180,376,667 - 80,382,943 (+)NCBI
Rnor_6.0181,643,809 - 81,650,085 (+)NCBI
Rnor_5.0182,900,924 - 82,907,200 (+)NCBI
RGSC_v3.4180,070,252 - 80,076,528 (+)RGD
Celera174,825,727 - 74,832,054 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_775461 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52590 (Get FASTA)   NCBI Sequence Viewer  
  AAC52591 (Get FASTA)   NCBI Sequence Viewer  
  EDM08074 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000054195.4
  ENSRNOP00000111193
  ENSRNOP00000111193.1
RefSeq Acc Id: NP_775461   ⟸   NM_173339
- Peptide Label: precursor
- UniProtKB: Q64724 (UniProtKB/TrEMBL),   Q78E86 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000027213   ⟸   ENSRNOT00000027214
Ensembl Acc Id: ENSRNOP00000054195   ⟸   ENSRNOT00000057384
Ensembl Acc Id: ENSRNOP00000111193   ⟸   ENSRNOT00000170891
Protein Domains
Immunoglobulin V-set

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q64724-F1-model_v2 AlphaFold Q64724 1-142 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708435 AgrOrtholog
BioCyc Gene G2FUF-60420 BioCyc
Ensembl Genes ENSRNOG00000046222 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000050105 Ensembl
Ensembl Transcript ENSRNOT00000057384.6 UniProtKB/TrEMBL
  ENSRNOT00000170891 ENTREZGENE
  ENSRNOT00000170891.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/TrEMBL
InterPro CEA_cell_adhesion UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/TrEMBL
  Ig_V-set UniProtKB/TrEMBL
KEGG Report rno:287009 UniProtKB/TrEMBL
NCBI Gene 287009 ENTREZGENE
PANTHER CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 1 UniProtKB/TrEMBL
  CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19 UniProtKB/TrEMBL
Pfam V-set UniProtKB/TrEMBL
PhenoGen Ceacam4 PhenoGen
RatGTEx ENSRNOG00000046222 RatGTEx
  ENSRNOG00000050105 RatGTEx
Superfamily-SCOP SSF48726 UniProtKB/TrEMBL
UniProt A0ABK0M2D8_RAT UniProtKB/TrEMBL
  F7FL34_RAT UniProtKB/TrEMBL
  Q64724 ENTREZGENE, UniProtKB/TrEMBL
  Q78E86 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Ceacam4  CEA cell adhesion molecule 4  LOC103689942  carcinoembryonic antigen-related cell adhesion molecule 1-like  Data merged from RGD:9361803 737654 PROVISIONAL
2019-09-03 Ceacam4  CEA cell adhesion molecule 4  Ceacam4  carcinoembryonic antigen-related cell adhesion molecule 4  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-30 Ceacam4  carcinoembryonic antigen-related cell adhesion molecule 4  Ceacam10  carcinoembryonic antigen-related cell adhesion molecule 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2014-08-25 LOC103689942  carcinoembryonic antigen-related cell adhesion molecule 1-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2008-09-09 Ceacam10  carcinoembryonic antigen-related cell adhesion molecule 10  Ceacam10  CEA-related cell adhesion molecule 10  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Ceacam10  CEA-related cell adhesion molecule 10  LOC287009  C-CAM4 protein  Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization a secreted protein 1299441
gene_expression expressed in placenta, spleen, lung and large intestine 1299441
gene_process may play a role in regulating the function of other C-CAM family proteins 1299441