Gene-Chemical Interaction Annotations Click to see Annotation Detail View
Object Symbol | Species | Term | Qualifier | Evidence | With | Reference | Notes | Source | Original Reference(s) | Pcyt1b | Rat | 2,3,7,8-tetrachlorodibenzodioxine | increases expression | ISO | Pcyt1b (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin results in increased expression of PCYT1B mRNA | CTD | PMID:19933214 | Pcyt1b | Rat | 2,3,7,8-tetrachlorodibenzodioxine | decreases expression | EXP | | 6480464 | Tetrachlorodibenzodioxin results in decreased expression of PCYT1B mRNA | CTD | PMID:33387578 | Pcyt1b | Rat | 2,3,7,8-tetrachlorodibenzodioxine | affects expression | ISO | Pcyt1b (Mus musculus) | 6480464 | Tetrachlorodibenzodioxin affects the expression of PCYT1B mRNA | CTD | PMID:21570461 | Pcyt1b | Rat | 2-butoxyethanol | increases expression | ISO | Pcyt1b (Mus musculus) | 6480464 | n-butoxyethanol results in increased expression of PCYT1B mRNA | CTD | PMID:19812364 | Pcyt1b | Rat | 4,4'-sulfonyldiphenol | decreases expression | ISO | Pcyt1b (Mus musculus) | 6480464 | bisphenol S results in decreased expression of PCYT1B mRNA | CTD | PMID:39298647 | Pcyt1b | Rat | 4,4'-sulfonyldiphenol | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of more ... | CTD | PMID:36041667 | Pcyt1b | Rat | acrylamide | decreases expression | ISO | PCYT1B (Homo sapiens) | 6480464 | Acrylamide results in decreased expression of PCYT1B mRNA | CTD | PMID:32763439 | Pcyt1b | Rat | all-trans-retinoic acid | decreases expression | ISO | PCYT1B (Homo sapiens) | 6480464 | Tretinoin results in decreased expression of PCYT1B mRNA | CTD | PMID:21934132 | Pcyt1b | Rat | ammonium chloride | affects expression | EXP | | 6480464 | Ammonium Chloride affects the expression of PCYT1B mRNA | CTD | PMID:16483693 | Pcyt1b | Rat | amphetamine | decreases expression | EXP | | 6480464 | Amphetamine results in decreased expression of PCYT1B mRNA | CTD | PMID:30779732 | Pcyt1b | Rat | benzo[a]pyrene | affects methylation | ISO | PCYT1B (Homo sapiens) | 6480464 | Benzo(a)pyrene affects the methylation of PCYT1B 3' UTR; Benzo(a)pyrene affects the methylation of PCYT1B promoter | CTD | PMID:27901495 | Pcyt1b | Rat | benzo[a]pyrene | increases methylation | ISO | PCYT1B (Homo sapiens) | 6480464 | Benzo(a)pyrene results in increased methylation of PCYT1B exon | CTD | PMID:27901495 | Pcyt1b | Rat | bis(2-ethylhexyl) phthalate | decreases expression | ISO | Pcyt1b (Mus musculus) | 6480464 | Diethylhexyl Phthalate results in decreased expression of PCYT1B mRNA | CTD | PMID:34319233 | Pcyt1b | Rat | bisphenol A | decreases expression | EXP | | 6480464 | bisphenol A results in decreased expression of PCYT1B mRNA | CTD | PMID:25181051 | Pcyt1b | Rat | bisphenol A | decreases expression | ISO | Pcyt1b (Mus musculus) | 6480464 | bisphenol A results in decreased expression of PCYT1B mRNA | CTD | PMID:32156529 | Pcyt1b | Rat | bisphenol A | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of more ... | CTD | PMID:36041667 | Pcyt1b | Rat | bisphenol A | affects expression | ISO | Pcyt1b (Mus musculus) | 6480464 | bisphenol A affects the expression of PCYT1B mRNA | CTD | PMID:39742910 | Pcyt1b | Rat | bisphenol F | increases expression | ISO | Pcyt1b (Mus musculus) | 6480464 | bisphenol F results in increased expression of PCYT1B mRNA | CTD | PMID:30951980 | Pcyt1b | Rat | bisphenol F | decreases expression | ISO | Pcyt1b (Mus musculus) | 6480464 | bisphenol F results in decreased expression of PCYT1B mRNA | CTD | PMID:38685157 | Pcyt1b | Rat | bisphenol F | multiple interactions | EXP | | 6480464 | [bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of more ... | CTD | PMID:36041667 | Pcyt1b | Rat | caffeine | increases phosphorylation | ISO | PCYT1B (Homo sapiens) | 6480464 | Caffeine results in increased phosphorylation of PCYT1B protein | CTD | PMID:35688186 | Pcyt1b | Rat | CGP 52608 | multiple interactions | ISO | PCYT1B (Homo sapiens) | 6480464 | CGP 52608 promotes the reaction [RORA protein binds to PCYT1B gene] | CTD | PMID:28238834 | Pcyt1b | Rat | chlorpyrifos | increases expression | ISO | Pcyt1b (Mus musculus) | 6480464 | Chlorpyrifos results in increased expression of PCYT1B mRNA | CTD | PMID:32715474 | Pcyt1b | Rat | cyclosporin A | decreases expression | ISO | PCYT1B (Homo sapiens) | 6480464 | Cyclosporine results in decreased expression of PCYT1B mRNA | CTD | PMID:25562108 | Pcyt1b | Rat | Dibutyl phosphate | affects expression | ISO | PCYT1B (Homo sapiens) | 6480464 | di-n-butylphosphoric acid affects the expression of PCYT1B mRNA | CTD | PMID:37042841 | Pcyt1b | Rat | dorsomorphin | multiple interactions | ISO | PCYT1B (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Pcyt1b | Rat | doxorubicin | decreases expression | ISO | PCYT1B (Homo sapiens) | 6480464 | Doxorubicin results in decreased expression of PCYT1B mRNA | CTD | PMID:29803840 | Pcyt1b | Rat | endosulfan | decreases expression | EXP | | 6480464 | Endosulfan results in decreased expression of PCYT1B mRNA | CTD | PMID:29391264 | Pcyt1b | Rat | fenamidone | decreases expression | ISO | Pcyt1b (Mus musculus) | 6480464 | fenamidone results in decreased expression of PCYT1B mRNA | CTD | PMID:27029645 | Pcyt1b | Rat | genistein | decreases expression | ISO | Pcyt1b (Mus musculus) | 6480464 | Genistein results in decreased expression of PCYT1B mRNA | CTD | PMID:32186404 | Pcyt1b | Rat | gentamycin | decreases expression | EXP | | 6480464 | Gentamicins results in decreased expression of PCYT1B mRNA | CTD | PMID:22061828|PMID:33387578 | Pcyt1b | Rat | lead diacetate | multiple interactions | ISO | Pcyt1b (Mus musculus) | 6480464 | [lead acetate results in increased abundance of Lead] which results in increased methylation of PCYT1B more ... | CTD | PMID:33445541 | Pcyt1b | Rat | lead(0) | multiple interactions | ISO | Pcyt1b (Mus musculus) | 6480464 | [lead acetate results in increased abundance of Lead] which results in increased methylation of PCYT1B more ... | CTD | PMID:33445541 | Pcyt1b | Rat | lipopolysaccharide | multiple interactions | ISO | PCYT1B (Homo sapiens) | 6480464 | [S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in increased expression of PCYT1B mRNA | CTD | PMID:35811015 | Pcyt1b | Rat | lithocholic acid | increases expression | ISO | Pcyt1b (Mus musculus) | 6480464 | Lithocholic Acid results in increased expression of PCYT1B mRNA | CTD | PMID:21480330|PMID:23034213 | Pcyt1b | Rat | lithocholic acid | multiple interactions | ISO | Pcyt1b (Mus musculus) | 6480464 | SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of PCYT1B mRNA] | CTD | PMID:23034213 | Pcyt1b | Rat | methotrexate | affects expression | ISO | Pcyt1b (Mus musculus) | 6480464 | Methotrexate affects the expression of PCYT1B mRNA | CTD | PMID:18502557 | Pcyt1b | Rat | methylmercury chloride | increases expression | ISO | PCYT1B (Homo sapiens) | 6480464 | methylmercuric chloride results in increased expression of PCYT1B mRNA | CTD | PMID:28001369 | Pcyt1b | Rat | paracetamol | decreases expression | EXP | | 6480464 | Acetaminophen results in decreased expression of PCYT1B mRNA | CTD | PMID:33387578 | Pcyt1b | Rat | phenylmercury acetate | decreases expression | ISO | PCYT1B (Homo sapiens) | 6480464 | Phenylmercuric Acetate results in decreased expression of PCYT1B mRNA | CTD | PMID:26272509 | Pcyt1b | Rat | phenylmercury acetate | multiple interactions | ISO | PCYT1B (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Pcyt1b | Rat | pirinixic acid | multiple interactions | ISO | Pcyt1b (Mus musculus) | 6480464 | [pirinixic acid binds to and results in increased activity of PPARA protein] which results in more ... | CTD | PMID:19710929 | Pcyt1b | Rat | potassium dichromate | decreases expression | ISO | Pcyt1b (Mus musculus) | 6480464 | Potassium Dichromate results in decreased expression of PCYT1B mRNA | CTD | PMID:23608068 | Pcyt1b | Rat | S-(1,2-dichlorovinyl)-L-cysteine | increases expression | ISO | PCYT1B (Homo sapiens) | 6480464 | S-(1,2-dichlorovinyl)cysteine results in increased expression of PCYT1B mRNA | CTD | PMID:35811015 | Pcyt1b | Rat | S-(1,2-dichlorovinyl)-L-cysteine | multiple interactions | ISO | PCYT1B (Homo sapiens) | 6480464 | [S-(1,2-dichlorovinyl)cysteine co-treated with Lipopolysaccharides] results in increased expression of PCYT1B mRNA | CTD | PMID:35811015 | Pcyt1b | Rat | SB 431542 | multiple interactions | ISO | PCYT1B (Homo sapiens) | 6480464 | [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased more ... | CTD | PMID:27188386 | Pcyt1b | Rat | sodium arsenite | decreases methylation | ISO | PCYT1B (Homo sapiens) | 6480464 | sodium arsenite results in decreased methylation of PCYT1B gene | CTD | PMID:24570342 | Pcyt1b | Rat | sodium arsenite | increases expression | ISO | Pcyt1b (Mus musculus) | 6480464 | sodium arsenite results in increased expression of PCYT1B mRNA | CTD | PMID:37682722|PMID:39515575 | Pcyt1b | Rat | sodium arsenite | multiple interactions | ISO | PCYT1B (Homo sapiens) | 6480464 | sodium arsenite promotes the reaction [PCYT1B protein binds to CAPRIN1 protein] | CTD | PMID:33939924 | Pcyt1b | Rat | sodium arsenite | increases expression | ISO | PCYT1B (Homo sapiens) | 6480464 | sodium arsenite results in increased expression of PCYT1B mRNA | CTD | PMID:24570342 | Pcyt1b | Rat | sunitinib | decreases expression | ISO | PCYT1B (Homo sapiens) | 6480464 | Sunitinib results in decreased expression of PCYT1B mRNA | CTD | PMID:31533062 | Pcyt1b | Rat | trichostatin A | increases expression | ISO | PCYT1B (Homo sapiens) | 6480464 | trichostatin A results in increased expression of PCYT1B mRNA | CTD | PMID:24935251 | Pcyt1b | Rat | triphenyl phosphate | affects expression | ISO | PCYT1B (Homo sapiens) | 6480464 | triphenyl phosphate affects the expression of PCYT1B mRNA | CTD | PMID:37042841 | Pcyt1b | Rat | troglitazone | increases expression | ISO | Pcyt1b (Mus musculus) | 6480464 | troglitazone results in increased expression of PCYT1B mRNA | CTD | PMID:28973697 | Pcyt1b | Rat | urethane | decreases expression | ISO | PCYT1B (Homo sapiens) | 6480464 | Urethane results in decreased expression of PCYT1B mRNA | CTD | PMID:28818685 | Pcyt1b | Rat | valproic acid | increases expression | ISO | PCYT1B (Homo sapiens) | 6480464 | Valproic Acid results in increased expression of PCYT1B mRNA | CTD | PMID:23179753|PMID:24383497|PMID:26272509 | Pcyt1b | Rat | valproic acid | multiple interactions | ISO | PCYT1B (Homo sapiens) | 6480464 | [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased more ... | CTD | PMID:27188386 | Pcyt1b | Rat | vinclozolin | affects expression | EXP | | 6480464 | vinclozolin affects the expression of PCYT1B mRNA | CTD | PMID:19015723 | Pcyt1b | Rat | vorinostat | multiple interactions | ISO | PCYT1B (Homo sapiens) | 6480464 | [NOG protein co-treated with Vorinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression more ... | CTD | PMID:27188386 | | 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