Havcr1 (hepatitis A virus cellular receptor 1) - Rat Genome Database

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Gene: Havcr1 (hepatitis A virus cellular receptor 1) Rattus norvegicus
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Symbol: Havcr1
Name: hepatitis A virus cellular receptor 1
RGD ID: 708425
Description: Predicted to enable phosphatidylserine binding activity and virus receptor activity. Involved in several processes, including phagocytosis, engulfment; response to mycotoxin; and response to testosterone. Located in several cellular components, including apical plasma membrane; cell surface; and phagocytic vesicle. Biomarker of colitis; hypertension; kidney failure (multiple); and proteinuria (multiple). Human ortholog(s) of this gene implicated in atopic dermatitis. Orthologous to human HAVCR1 (hepatitis A virus cellular receptor 1); INTERACTS WITH (R)-lipoic acid; 1-naphthyl isothiocyanate; 11-deoxycorticosterone.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: HAVcr-1; hepatitis A virus cellular receptor 1 homolog; kidney injury molecule 1; KIM-1; Kim1; t cell immunoglobulin and mucin domain-containing protein 1; TIMD-1
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81031,619,914 - 31,652,955 (+)NCBIGRCr8
mRatBN7.21031,118,667 - 31,151,730 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1031,119,088 - 31,151,698 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1035,844,047 - 35,867,236 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0104,382,417 - 4,405,608 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01030,831,210 - 30,854,422 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01031,813,819 - 31,860,934 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1031,813,814 - 31,848,379 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01031,632,718 - 31,682,172 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41031,834,519 - 31,858,019 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11031,835,567 - 31,859,066 (+)NCBI
Celera1030,573,361 - 30,596,533 (+)NCBICelera
Cytogenetic Map10q21NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Original Reference(s)
Havcr1Ratacute kidney failure  ISOHAVCR1 (Homo sapiens)7245472associated with Pyelonephritis and protein:increased expression:urine:RGD 
Havcr1Ratacute kidney failure  IEP 7244370protein:increased expression:urineRGD 
Havcr1Ratacute kidney failure  ISOHavcr1 (Mus musculus)7245495protein:increased expression:urine:RGD 
Havcr1Ratacute kidney tubular necrosis  ISOHAVCR1 (Homo sapiens)7245970protein:increased expression:kidney tubule and urine:RGD 
Havcr1RatAlbuminuria  ISOHAVCR1 (Homo sapiens)7245982associated with Anemia more ...RGD 
Havcr1Ratasthma  ISOHAVCR1 (Homo sapiens)5128851 RGD 
Havcr1Ratatopic dermatitis  ISOHAVCR1 (Homo sapiens)5128852 RGD 
Havcr1Ratautosomal dominant polycystic kidney disease  ISOHavcr1 (Mus musculus)7245969protein:increased expression:kidney:RGD 
Havcr1RatCardio-Renal Syndrome susceptibilityISOHAVCR1 (Homo sapiens)7245477 RGD 
Havcr1RatCardio-Renal Syndrome  IEP 7245950protein:increased expression:kidney tubule:RGD 
Havcr1Ratchronic kidney disease  IEP 7245952 RGD 
Havcr1Ratcolitis  IEP 7245473mRNA:increased expression:kidney:RGD 
Havcr1RatContrast-Induced Nephropathy  IEP 7245471protein:increased expression:urine:RGD 
Havcr1RatDiabetic Nephropathies  IEP 7245497protein:increased expression:plasmaRGD 
Havcr1RatDiabetic Nephropathies disease_progressionISOHAVCR1 (Homo sapiens)7246890associated with Diabetes mellitus and Type 1RGD 
Havcr1RatDiabetic Nephropathies  ISOHAVCR1 (Homo sapiens)7245960associated with Diabetes Mellitus more ...RGD 
Havcr1Ratessential hypertension  ISOHAVCR1 (Homo sapiens)7245500protein:increased expression:urine:RGD 
Havcr1Rathepatocellular carcinoma disease_progressionISOHAVCR1 (Homo sapiens)153344586mRNA:increased expression:liver (human)RGD 
Havcr1Rathydronephrosis  ISOHAVCR1 (Homo sapiens)7245985protein:increased expression:urine:RGD 
Havcr1RatHyperoxaluria  IEP 7245498mRNA more ...RGD 
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Original Reference(s)
Havcr1RatIge Responsiveness, Atopic  ISOHAVCR1 (Homo sapiens)8554872ClinVar Annotator: match by term: IgE responsiveness and atopicClinVarPMID:14534576 and PMID:21339644
Havcr1Ratlymphoproliferative syndrome 1  ISOHAVCR1 (Homo sapiens)8554872ClinVar Annotator: match by term: Lymphoproliferative syndrome 1ClinVarPMID:16860760 more ...
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Original Reference(s)
Havcr1Ratacute kidney failure  ISOHAVCR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20118187 more ...
Havcr1RatChemical and Drug Induced Liver Injury  ISOHAVCR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:20623750
Havcr1RatDrug-Related Side Effects and Adverse Reactions  ISOHAVCR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:15805072 more ...
Havcr1Ratfocal segmental glomerulosclerosis  ISOHAVCR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19225054
Havcr1Ratkidney disease  ISOHAVCR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19349640 more ...
Havcr1RatNecrosis  ISOHAVCR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:24880025
Havcr1Ratproteinuria  ISOHAVCR1 (Homo sapiens)11554173CTD Direct Evidence: marker/mechanismCTDPMID:19225054

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Original Reference(s)
Havcr1Rat(R)-lipoic acid multiple interactionsISOHAVCR1 (Homo sapiens)6480464[Thioctic Acid binds to Gold] which results in increased expression of HAVCR1 proteinCTDPMID:28433809
Havcr1Rat(R)-lipoic acid multiple interactionsEXP 6480464Thioctic Acid inhibits the reaction [[colistinmethanesulfonic acid results in increased abundance of Colistin] which results in increased expression of HAVCR1 mRNA] and Thioctic Acid inhibits the reaction [[colistinmethanesulfonic acid results in increased abundance of Colistin] which results in increased expression of HAVCR1 protein]CTDPMID:33111558
Havcr1Rat(S)-naringenin multiple interactionsISOHavcr1 (Mus musculus)6480464naringenin inhibits the reaction [Carbon Tetrachloride results in increased expression of HAVCR1 protein]CTDPMID:23845967
Havcr1Rat(S)-nicotine increases expressionISOHavcr1 (Mus musculus)6480464Nicotine results in increased expression of HAVCR1 proteinCTDPMID:21511693
Havcr1Rat1-aminobenzotriazole multiple interactionsISOHavcr1 (Mus musculus)6480464[1-aminobenzotriazole co-treated with ochratoxin A] results in increased expression of HAVCR1 proteinCTDPMID:36227364
Havcr1Rat1-naphthyl isothiocyanate affects expressionEXP 64804641-Naphthylisothiocyanate affects the expression of HAVCR1 mRNACTDPMID:18289764
Havcr1Rat11-deoxycorticosterone multiple interactionsEXP 6480464[Desoxycorticosterone co-treated with Sodium Chloride and Dietary] results in increased expression of HAVCR1 mRNACTDPMID:21135038
Havcr1Rat17beta-estradiol decreases expressionISOHavcr1 (Mus musculus)6480464Estradiol results in decreased expression of HAVCR1 mRNACTDPMID:39298647
Havcr1Rat17beta-estradiol 3-benzoate decreases expressionEXP 6480464estradiol 3-benzoate results in decreased expression of HAVCR1 mRNACTDPMID:32741896
Havcr1Rat2,4,6-trinitrobenzenesulfonic acid increases expressionEXP 6480464Trinitrobenzenesulfonic Acid results in increased expression of HAVCR1 mRNACTDPMID:23307618
Havcr1Rat2,4,6-trinitrobenzenesulfonic acid increases secretionEXP 6480464Trinitrobenzenesulfonic Acid results in increased secretion of HAVCR1 proteinCTDPMID:23307618
Havcr1Rat3-chloropropane-1,2-diol increases expressionISOHavcr1 (Mus musculus)6480464alpha-Chlorohydrin analog results in increased expression of HAVCR1 mRNA and alpha-Chlorohydrin results in increased expression of HAVCR1 proteinCTDPMID:29860048 and PMID:33187795
Havcr1Rat3-chloropropane-1,2-diol multiple interactionsISOHavcr1 (Mus musculus)6480464alpha-Chlorohydrin promotes the reaction [glycidol results in increased expression of HAVCR1 protein] and glycidol promotes the reaction [alpha-Chlorohydrin results in increased expression of HAVCR1 protein]CTDPMID:33187795
Havcr1Rat3-methyladenine multiple interactionsISOHAVCR1 (Homo sapiens)64804643-methyladenine inhibits the reaction [alisol A 24-acetate results in increased expression of HAVCR1 protein] and 3-methyladenine inhibits the reaction [alisol B 23-acetate results in increased expression of HAVCR1 protein]CTDPMID:28408883
Havcr1Rat4,4'-diaminodiphenylmethane decreases expressionEXP 64804644 and 4'-diaminodiphenylmethane results in decreased expression of HAVCR1 mRNACTDPMID:18289764
Havcr1Rat4,4'-diaminodiphenylmethane decreases expressionISOHavcr1 (Mus musculus)64804644 and 4'-diaminodiphenylmethane results in decreased expression of HAVCR1 mRNACTDPMID:18648102
Havcr1Rat4,4'-sulfonyldiphenol decreases methylationISOHAVCR1 (Homo sapiens)6480464bisphenol S results in decreased methylation of HAVCR1 geneCTDPMID:31601247
Havcr1Rat4,4'-sulfonyldiphenol multiple interactionsEXP 6480464[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of HAVCR1 mRNACTDPMID:36041667
Havcr1Rat6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide multiple interactionsISOHavcr1 (Mus musculus)64804646-chloro-2 more ...CTDPMID:21593185 and PMID:37436358
Havcr1Rat7,9-dihydro-1H-purine-2,6,8(3H)-trione increases expressionEXP 6480464Uric Acid results in increased expression of HAVCR1 proteinCTDPMID:37815028

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Biological Process
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Cellular Component
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Object Symbol
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Original Reference(s)
Havcr1Ratapical plasma membrane  IDA 7245980 RGD 
Havcr1Ratbrush border located_inISOHavcr1 (Mus musculus)1624291 PMID:29402223RGDPMID:29402223
Havcr1Ratcell surface  IDA 2316593 RGD 
Havcr1Ratcell surface located_inISOHavcr1 (Mus musculus)1624291 PMID:18083575RGDPMID:18083575
Havcr1Ratcell surface is_active_inIBAMGI:2159680 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Havcr1Ratextracellular space  IDA 7244372 RGD 
Havcr1Ratextracellular space  IDA 2316588 RGD 
Havcr1Ratmembrane located_inIEAUniProtKB-KW:KW-04721600115GO_REF:0000043UniProtGO_REF:0000043
Havcr1Ratmotile cilium part_ofISOHAVCR1 (Homo sapiens)1624291 PMID:21536871RGDPMID:21536871
Havcr1Ratphagocytic vesicle  IDA 2316597 RGD 
Havcr1Ratplasma membrane located_inIEAUniProtKB-SubCell:SL-00391600115GO_REF:0000044UniProtGO_REF:0000044
Havcr1Ratplasma membrane located_inIEAUniProtKB-KW:KW-10031600115GO_REF:0000043UniProtGO_REF:0000043
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Molecular Function

  


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Reference Title
Reference Citation
1. Urinary NGAL and KIM-1: biomarkers for assessment of acute ischemic kidney injury following nephron sparing surgery. Abassi Z, etal., J Urol. 2013 Apr;189(4):1559-66. doi: 10.1016/j.juro.2012.10.029. Epub 2012 Oct 22.
2. Macrophage infiltration and renal damage are independent of matrix metalloproteinase 12 in the obstructed kidney. Abraham AP, etal., Nephrology (Carlton). 2012 May;17(4):322-9. doi: 10.1111/j.1440-1797.2012.01567.x.
3. Early urinary and plasma biomarkers for experimental diabetic nephropathy. Alter ML, etal., Clin Lab. 2012;58(7-8):659-71.
4. Fructose induces tubulointerstitial injury in the kidney of mice. Aoyama M, etal., Biochem Biophys Res Commun. 2012 Mar 9;419(2):244-9. doi: 10.1016/j.bbrc.2012.02.001. Epub 2012 Feb 8.
5. Urinary kidney injury molecule 1 and incidence of heart failure in elderly men. Carlsson AC, etal., Eur J Heart Fail. 2013 Apr;15(4):441-6. doi: 10.1093/eurjhf/hfs187. Epub 2012 Dec 7.
6. Hepatitis A virus cellular receptor 1/kidney injury molecule-1 is a susceptibility gene for clear cell renal cell carcinoma and hepatitis A virus cellular receptor/kidney injury molecule-1 ectodomain shedding a predictive biomarker of tumour progression. Cuadros T, etal., Eur J Cancer. 2013 May;49(8):2034-47. doi: 10.1016/j.ejca.2012.12.020. Epub 2013 Jan 23.
7. Chronic renovascular hypertension is associated with elevated levels of neutrophil gelatinase-associated lipocalin. Eirin A, etal., Nephrol Dial Transplant. 2012 Nov;27(11):4153-61. doi: 10.1093/ndt/gfs370. Epub 2012 Aug 23.
8. Changes of the tubular markers in type 2 diabetes mellitus with glomerular hyperfiltration. Fu WJ, etal., Diabetes Res Clin Pract. 2012 Jan;95(1):105-9. doi: 10.1016/j.diabres.2011.09.031. Epub 2011 Oct 20.
9. [Clinical study of kidney injury molecule-1 in the treatment of sepsis patients]. Gao LL, etal., Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. 2012 Nov;24(11):647-50.
10. Structural equation modeling highlights the potential of Kim-1 as a biomarker for chronic kidney disease. Gardiner L, etal., Am J Nephrol. 2012;35(2):152-63. doi: 10.1159/000335579. Epub 2012 Jan 20.
11. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
12. Association of atopy and eczema with polymorphisms in T-cell immunoglobulin domain and mucin domain-IL-2-inducible T-cell kinase gene cluster in chromosome 5 q 33. Graves PE, etal., J Allergy Clin Immunol. 2005 Sep;116(3):650-6.
13. Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury. Han WK, etal., Kidney Int. 2002 Jul;62(1):237-44.
14. Urinary macrophage migration inhibitory factor serves as a potential biomarker for acute kidney injury in patients with acute pyelonephritis. Hong MY, etal., Mediators Inflamm. 2012;2012:381358. doi: 10.1155/2012/381358. Epub 2012 Dec 23.
15. Early detection of renal injury using urinary vanin-1 in rats with experimental colitis. Hosohata K, etal., J Appl Toxicol. 2013 Jan 11. doi: 10.1002/jat.2849.
16. Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. Ichimura T, etal., J Biol Chem 1998 Feb 13;273(7):4135-42.
17. Kidney injury molecule-1 is a phosphatidylserine receptor that confers a phagocytic phenotype on epithelial cells. Ichimura T, etal., J Clin Invest. 2008 May;118(5):1657-68.
18. Kidney injury molecule-1 and osteopontin: new markers for prediction of early kidney transplant rejection. Jin ZK, etal., Mol Immunol. 2013 Jul;54(3-4):457-64. doi: 10.1016/j.molimm.2013.01.013. Epub 2013 Feb 27.
19. T Cell Ig- and mucin-domain-containing molecule-3 (TIM-3) and TIM-1 molecules are differentially expressed on human Th1 and Th2 cells and in cerebrospinal fluid-derived mononuclear cells in multiple sclerosis. Khademi M, etal., J Immunol. 2004 Jun 1;172(11):7169-76.
20. Kidney injury molecule-1 is up-regulated in renal epithelial cells in response to oxalate in vitro and in renal tissues in response to hyperoxaluria in vivo. Khandrika L, etal., PLoS One. 2012;7(9):e44174. doi: 10.1371/journal.pone.0044174. Epub 2012 Sep 12.
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PMID:15489334   PMID:16174863   PMID:16387092   PMID:16896183   PMID:17670906   PMID:17934191   PMID:18083575   PMID:19225054   PMID:19371616   PMID:19387469   PMID:20305092   PMID:20458318  
PMID:20566714   PMID:20660082   PMID:21536871   PMID:21905055   PMID:22898836   PMID:23360846   PMID:24158981   PMID:24816434   PMID:24904085   PMID:25087119   PMID:27050864   PMID:27231899  
PMID:27756197   PMID:28075469   PMID:29045706   PMID:29402223   PMID:30431687   PMID:30500779   PMID:31050655   PMID:31373312   PMID:33678127   PMID:36598304   PMID:36934678  



Havcr1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81031,619,914 - 31,652,955 (+)NCBIGRCr8
mRatBN7.21031,118,667 - 31,151,730 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1031,119,088 - 31,151,698 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1035,844,047 - 35,867,236 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0104,382,417 - 4,405,608 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01030,831,210 - 30,854,422 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01031,813,819 - 31,860,934 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1031,813,814 - 31,848,379 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01031,632,718 - 31,682,172 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41031,834,519 - 31,858,019 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11031,835,567 - 31,859,066 (+)NCBI
Celera1030,573,361 - 30,596,533 (+)NCBICelera
Cytogenetic Map10q21NCBI
HAVCR1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385157,029,413 - 157,069,407 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5157,026,742 - 157,069,396 (-)EnsemblGRCh38hg38GRCh38
GRCh375156,456,424 - 156,486,127 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365156,389,109 - 156,418,065 (-)NCBINCBI36Build 36hg18NCBI36
Build 345156,389,014 - 156,418,548NCBI
Celera5152,482,103 - 152,511,651 (-)NCBICelera
Cytogenetic Map5q33.3NCBI
HuRef5151,544,985 - 151,574,299 (-)NCBIHuRef
CHM1_15155,888,935 - 155,918,725 (-)NCBICHM1_1
T2T-CHM13v2.05157,548,433 - 157,588,641 (-)NCBIT2T-CHM13v2.0
Havcr1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391146,630,644 - 46,670,405 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1146,625,907 - 46,670,405 (+)EnsemblGRCm39 Ensembl
GRCm381146,739,822 - 46,779,578 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1146,735,080 - 46,779,578 (+)EnsemblGRCm38mm10GRCm38
MGSCv371146,553,725 - 46,593,080 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361146,594,600 - 46,622,036 (+)NCBIMGSCv36mm8
Celera1151,321,716 - 51,355,068 (+)NCBICelera
Cytogenetic Map11B1.1NCBI
cM Map1128.08NCBI
Havcr1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_00495540811,047,679 - 11,070,492 (-)NCBIChiLan1.0ChiLan1.0
HAVCR1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v24152,220,695 - 152,257,458 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan15150,360,242 - 150,397,005 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v05152,429,337 - 152,459,800 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.15158,413,054 - 158,442,481 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5158,413,073 - 158,442,481 (-)Ensemblpanpan1.1panPan2
HAVCR1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1453,012,223 - 53,066,611 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl453,046,970 - 53,128,952 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl453,012,234 - 53,033,393 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha452,939,224 - 52,956,256 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0453,479,175 - 53,503,280 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl453,456,833 - 53,570,712 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1453,309,862 - 53,326,891 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0453,416,885 - 53,433,922 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0453,933,785 - 53,950,850 (+)NCBIUU_Cfam_GSD_1.0
Havcr1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213107,580,999 - 107,601,858 (+)NCBIHiC_Itri_2
SpeTri2.0NW_0049365156,030,402 - 6,051,161 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HAVCR1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11666,162,318 - 66,208,868 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21671,949,487 - 71,963,277 (-)NCBISscrofa10.2Sscrofa10.2susScr3
HAVCR1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12359,422,769 - 59,454,183 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2359,423,334 - 59,453,531 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603418,176,581 - 18,208,543 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Havcr1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473332,284,793 - 32,310,980 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Havcr1
386 total Variants

Predicted Target Of
Summary Value
Count of predictions:510
Count of miRNA genes:262
Interacting mature miRNAs:316
Transcripts:ENSRNOT00000009573
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


1 to 10 of 49 rows
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
9589136Insul27Insulin level QTL 2710.460.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)101147401056474010Rat
631564Apr3Acute phase response QTL 33.9blood interleukin-6 amount (VT:0008595)plasma interleukin-6 level (CMO:0001927)101527595560275955Rat
1298069Bp168Blood pressure QTL 1685.5blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)102652195798003205Rat
631554Bp133Blood pressure QTL 1330.005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1074336463851208Rat
631557Bp136Blood pressure QTL 1360.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)103063205375632053Rat
61325Aia5Adjuvant induced arthritis QTL 50.01joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1023444813104060283Rat
1578761Stresp21Stress response QTL 213.3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)10637574651375746Rat
2293680Bss40Bone structure and strength QTL 405.660.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)10135225947Rat
2298544Neuinf9Neuroinflammation QTL 94.6nervous system integrity trait (VT:0010566)spinal cord complement component 1, q subcomponent, B chain mRNA level (CMO:0002126)10580199062146030Rat
10401803Kidm50Kidney mass QTL 50kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)1041834445418344Rat

1 to 10 of 49 rows
BQ203079  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21031,132,529 - 31,132,683 (+)MAPPERmRatBN7.2
Rnor_6.01031,827,689 - 31,827,842NCBIRnor6.0
Rnor_5.01031,648,824 - 31,648,977UniSTSRnor5.0
RGSC_v3.41031,838,850 - 31,839,003UniSTSRGSC3.4
Celera1030,577,354 - 30,577,507UniSTS
RH 3.4 Map10302.11UniSTS
Cytogenetic Map10q21UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 10 19 50 78 77 46 25 46 6 167 66 30 38 40 31



Ensembl Acc Id: ENSRNOT00000009573   ⟹   ENSRNOP00000009573
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1031,119,088 - 31,151,698 (+)Ensembl
Rnor_6.0 Ensembl1031,813,814 - 31,848,379 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000104970   ⟹   ENSRNOP00000076717
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1031,119,088 - 31,151,698 (+)Ensembl
RefSeq Acc Id: NM_173149   ⟹   NP_775172
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81031,629,778 - 31,652,951 (+)NCBI
mRatBN7.21031,128,531 - 31,151,700 (+)NCBI
Rnor_6.01031,823,688 - 31,846,859 (+)NCBI
Rnor_5.01031,632,718 - 31,682,172 (+)NCBI
RGSC_v3.41031,834,519 - 31,858,019 (+)RGD
Celera1030,573,361 - 30,596,533 (+)RGD
Sequence:
RefSeq Acc Id: XM_006246163   ⟹   XP_006246225
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81031,619,914 - 31,652,955 (+)NCBI
mRatBN7.21031,118,667 - 31,151,730 (+)NCBI
Rnor_6.01031,813,819 - 31,846,859 (+)NCBI
Rnor_5.01031,632,718 - 31,682,172 (+)NCBI
Sequence:
Protein RefSeqs NP_775172 (Get FASTA)   NCBI Sequence Viewer  
  XP_006246225 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC53546 (Get FASTA)   NCBI Sequence Viewer  
  AAH61820 (Get FASTA)   NCBI Sequence Viewer  
  EDM04183 (Get FASTA)   NCBI Sequence Viewer  
  EDM04185 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009573
GenBank Protein O54947 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_775172   ⟸   NM_173149
- Peptide Label: precursor
- UniProtKB: O54947 (UniProtKB/Swiss-Prot),   A0A8I5Y0B2 (UniProtKB/TrEMBL),   A6HDT0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006246225   ⟸   XM_006246163
- Peptide Label: isoform X1
- UniProtKB: G3V6W3 (UniProtKB/TrEMBL),   A6HDS9 (UniProtKB/TrEMBL),   A0A8I5Y0B2 (UniProtKB/TrEMBL),   A6HDT0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009573   ⟸   ENSRNOT00000009573
Ensembl Acc Id: ENSRNOP00000076717   ⟸   ENSRNOT00000104970
Ig-like   Ig-like V-type

Name Modeler Protein Id AA Range Protein Structure
AF-O54947-F1-model_v2 AlphaFold O54947 1-307 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13697130
Promoter ID:EPDNEW_R7655
Type:multiple initiation site
Name:Havcr1_1
Description:hepatitis A virus cellular receptor 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01031,814,221 - 31,814,281EPDNEW


1 to 28 of 28 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-25358 BioCyc
Ensembl Genes ENSRNOG00000007243 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000009573 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:5599247 IMAGE-MGC_LOAD
InterPro Ig-like_dom UniProtKB/Swiss-Prot
  Ig-like_dom_sf UniProtKB/Swiss-Prot
  Ig-like_fold UniProtKB/Swiss-Prot
  Ig_sub UniProtKB/Swiss-Prot
  Ig_V-set UniProtKB/Swiss-Prot
  TIM_domain-containing_protein UniProtKB/Swiss-Prot
KEGG Report rno:286934 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72269 IMAGE-MGC_LOAD
NCBI Gene 286934 ENTREZGENE
PANTHER HEPATITIS A VIRUS CELLULAR RECEPTOR 1 HOMOLOG UniProtKB/Swiss-Prot
  HEPATITIS A VIRUS CELLULAR RECEPTOR 1 HOMOLOG UniProtKB/Swiss-Prot
Pfam V-set UniProtKB/Swiss-Prot
PharmGKB HAVCR1 RGD
PhenoGen Havcr1 PhenoGen
PROSITE IG_LIKE UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000007243 RatGTEx
SMART SM00409 UniProtKB/Swiss-Prot
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot
UniProt A0A8I5Y0B2 ENTREZGENE, UniProtKB/TrEMBL
  A6HDS9 ENTREZGENE, UniProtKB/TrEMBL
  A6HDT0 ENTREZGENE, UniProtKB/TrEMBL
  G3V6W3 ENTREZGENE, UniProtKB/TrEMBL
  HAVR1_RAT UniProtKB/Swiss-Prot, ENTREZGENE
1 to 28 of 28 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Havcr1  hepatitis A virus cellular receptor 1  Havcr1  kidney injury molecule 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Havcr1  kidney injury molecule 1  Kim1    Symbol and Name updated 1299863 APPROVED

Note Type Note Reference
gene_expression expressed at a low level in normal kidney but increases dramatically in postischemic kidney 1299432