Tmem176b (transmembrane protein 176B) - Rat Genome Database

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Gene: Tmem176b (transmembrane protein 176B) Rattus norvegicus
Analyze
Symbol: Tmem176b
Name: transmembrane protein 176B
RGD ID: 708403
Description: Predicted to be involved in negative regulation of dendritic cell differentiation. Predicted to be located in nuclear membrane. Orthologous to human TMEM176B (transmembrane protein 176B); INTERACTS WITH (+)-schisandrin B; 17alpha-ethynylestradiol; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Lr8; MGC72697; tolerance-related and induced transcript protein; TORID
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8479,097,808 - 79,105,263 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl479,097,808 - 79,105,263 (-)EnsemblGRCr8
mRatBN7.2477,766,928 - 77,774,740 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl477,766,928 - 77,774,384 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx482,974,338 - 82,981,748 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0478,749,810 - 78,757,220 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0477,190,100 - 77,197,510 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0478,450,724 - 78,458,600 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl478,450,724 - 78,458,179 (-)Ensemblrn6Rnor6.0
Rnor_5.04143,138,367 - 143,146,237 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4476,911,922 - 76,918,859 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera472,703,996 - 72,711,451 (-)NCBICelera
RGSC_v3.1477,188,051 - 77,194,989 (-)NCBI
Cytogenetic Map4q24NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (EXP)
(1->4)-beta-D-glucan  (ISO)
1,2-dimethylhydrazine  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
17beta-estradiol 3-benzoate  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-hydroxyphenyl retinamide  (ISO)
aflatoxin B1  (ISO)
all-trans-retinoic acid  (EXP)
ammonium chloride  (EXP)
amphotericin B  (ISO)
antirheumatic drug  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (EXP)
bisphenol F  (EXP)
Butylbenzyl phthalate  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
carbon nanotube  (ISO)
chlorpyrifos  (ISO)
clofibrate  (ISO)
cobalt dichloride  (EXP)
copper atom  (ISO)
copper(0)  (ISO)
Cuprizon  (EXP)
cyclosporin A  (ISO)
cyproconazole  (ISO)
diazinon  (ISO)
dibutyl phthalate  (EXP,ISO)
dioxygen  (EXP)
diuron  (EXP)
doxorubicin  (ISO)
epoxiconazole  (ISO)
ethanol  (ISO)
flutamide  (EXP)
folic acid  (ISO)
FR900359  (ISO)
fumonisin B1  (ISO)
furan  (EXP)
genistein  (ISO)
L-ascorbic acid  (EXP)
levofloxacin  (EXP)
lidocaine  (EXP)
lipopolysaccharide  (ISO)
methidathion  (ISO)
methotrexate  (ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
nickel atom  (ISO)
nitrates  (ISO)
okadaic acid  (ISO)
oxaliplatin  (EXP)
paracetamol  (EXP,ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (EXP)
pirinixic acid  (ISO)
propiconazole  (ISO)
rotenone  (EXP)
senecionine  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sunitinib  (ISO)
tamoxifen  (ISO)
testosterone  (EXP)
tetrachloroethene  (ISO)
tetrachloromethane  (EXP,ISO)
tetradecane  (EXP)
thioacetamide  (EXP)
titanium dioxide  (ISO)
topotecan  (EXP)
triphenyl phosphate  (ISO)
triptonide  (ISO)
ursodeoxycholic acid  (EXP)
valproic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Isolation of a gene product expressed by a subpopulation of human lung fibroblasts by differential display. Lurton J, etal., Am J Respir Cell Mol Biol 1999 Feb;20(2):327-31.
3. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
4. GOA pipeline RGD automated data pipeline
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:12477932   PMID:16095493   PMID:20501748   PMID:22871113  


Genomics

Comparative Map Data
Tmem176b
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8479,097,808 - 79,105,263 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl479,097,808 - 79,105,263 (-)EnsemblGRCr8
mRatBN7.2477,766,928 - 77,774,740 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl477,766,928 - 77,774,384 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx482,974,338 - 82,981,748 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0478,749,810 - 78,757,220 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0477,190,100 - 77,197,510 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0478,450,724 - 78,458,600 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl478,450,724 - 78,458,179 (-)Ensemblrn6Rnor6.0
Rnor_5.04143,138,367 - 143,146,237 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4476,911,922 - 76,918,859 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera472,703,996 - 72,711,451 (-)NCBICelera
RGSC_v3.1477,188,051 - 77,194,989 (-)NCBI
Cytogenetic Map4q24NCBI
TMEM176B
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387150,791,301 - 150,801,360 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7150,790,382 - 150,803,404 (-)Ensemblhg38GRCh38
GRCh377150,488,389 - 150,498,448 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367150,119,308 - 150,129,381 (-)NCBIBuild 36Build 36hg18NCBI36
Celera7145,045,399 - 145,055,476 (-)NCBICelera
Cytogenetic Map7q36.1NCBI
HuRef7144,300,451 - 144,310,528 (-)NCBIHuRef
CHM1_17150,496,593 - 150,506,660 (-)NCBICHM1_1
T2T-CHM13v2.07151,964,072 - 151,974,120 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27149,817,661 - 149,827,738 (-)NCBI
Tmem176b
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39648,810,745 - 48,818,363 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl648,810,752 - 48,818,430 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38648,833,811 - 48,845,948 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl648,833,818 - 48,841,496 (-)Ensemblmm10GRCm38
MGSCv37648,783,810 - 48,791,373 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36648,763,415 - 48,770,566 (-)NCBIMGSCv36mm8
Celera649,343,557 - 49,351,127 (-)NCBICelera
Cytogenetic Map6B2.3NCBI
cM Map623.75NCBI
Tmem176b
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554915,197,583 - 5,209,030 (-)Ensembl
ChiLan1.0NW_0049554915,201,832 - 5,209,117 (-)NCBIChiLan1.0ChiLan1.0
TMEM176B
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26187,206,714 - 187,216,754 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1739,216,831 - 39,227,018 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v07142,373,598 - 142,383,646 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17154,525,878 - 154,535,943 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7154,525,878 - 154,535,862 (-)EnsemblpanPan2panpan1.1
TMEM176B
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11614,918,491 - 14,926,673 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1614,919,126 - 14,926,583 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1615,527,179 - 15,534,932 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01616,634,409 - 16,642,163 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1616,630,357 - 16,642,097 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11615,013,397 - 15,021,153 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01615,594,923 - 15,602,668 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01615,645,460 - 15,653,204 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Tmem176b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244051186,636,564 - 6,643,832 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365276,258,856 - 6,264,323 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365276,258,858 - 6,269,604 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TMEM176B
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl186,342,611 - 6,348,867 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1186,334,420 - 6,348,887 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2186,650,879 - 6,657,215 (+)NCBISscrofa10.2Sscrofa10.2susScr3
TMEM176B
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.121118,982,623 - 119,015,521 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl21118,982,603 - 118,992,860 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366607214,954,556 - 14,963,877 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tmem176b
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248005,756,109 - 5,842,180 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248005,756,262 - 5,847,755 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Tmem176b
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1692,151,874 - 92,159,696 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Tmem176b
107 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:58
Count of miRNA genes:44
Interacting mature miRNAs:50
Transcripts:ENSRNOT00000011327
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)439431983123203361Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)459753119104753119Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44140057786400577Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44442502489425024Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)427730518170099664Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)458817672103817672Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)426234499134199155Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)474233320119233320Rat
61336Bp21Blood pressure QTL 214.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45808014680212111Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)471647492116647492Rat
6909128Pancm4Pancreatic morphology QTL 411.35pancreas mass (VT:0010144)pancreas wet weight (CMO:0000626)427862204126119996Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44140060386400603Rat
61476Aia3Adjuvant induced arthritis QTL 33.9joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)475939858140508796Rat
8655906Rf60Renal function QTL 603.8blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)43044896182336920Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)465060960127749483Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)445429897149763204Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)451085655113588029Rat
2317588Eae27Experimental allergic encephalomyelitis QTL 27nervous system integrity trait (VT:0010566)percentage of study population developing experimental autoimmune encephalomyelitis during a period of time (CMO:0001047)469036742114036742Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)440490442117737312Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)457613339151163960Rat
4889969Bss96Bone structure and strength QTL 964.9tibia size trait (VT:0100001)tibia cortical bone volume (CMO:0001725)457613242102613242Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
4889972Bss97Bone structure and strength QTL 975.6tibia size trait (VT:0100001)tibia total bone volume (CMO:0001724)457613242102613242Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
5685012Bmd87Bone mineral density QTL 875.1tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)43511329080113290Rat
5685009Bmd86Bone mineral density QTL 863.7tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)457613242102613242Rat
634311Sach7Saccharin preference QTL 7taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)45807987582597589Rat
2306547Iddm38Insulin dependent diabetes mellitus QTL 38blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)468353567113353567Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)460916264184426481Rat
2306545Iddm39Insulin dependent diabetes mellitus QTL 39blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478687630123687630Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)474169813134199155Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)459836842104836842Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)43726957782269577Rat
61406Scwia1Streptococcal cell wall induced arthritis QTL 12.3joint integrity trait (VT:0010548)experimental arthritis severity measurement (CMO:0001459)475939858140508796Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)445429897149763204Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)46104105794638356Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264174095838Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)445429709157555683Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463245026129846354Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)464209744109209744Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)460916264184426481Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)44140057786400577Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)457664252127749483Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45807987592690793Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)465495851159259805Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)464084079109084079Rat
61434Cia3Collagen induced arthritis QTL 34.8joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)463224393108224393Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46390045888813920Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)433538597116185060Rat
631671Iddm11Insulin dependent diabetes mellitus QTL 113.60.0012blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)45960331980216952Rat

Markers in Region
RH133167  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2477,767,002 - 77,767,203 (+)MAPPERmRatBN7.2
Rnor_6.0478,450,799 - 78,450,999NCBIRnor6.0
Rnor_5.04143,138,442 - 143,138,642UniSTSRnor5.0
RGSC_v3.4476,911,981 - 76,912,181UniSTSRGSC3.4
Celera472,704,071 - 72,704,271UniSTS
RH 3.4 Map4499.71UniSTS
Cytogenetic Map4q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 163 91 90 59 92 59 6 356 192 11 142 81 92 31 15 15

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001270589 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270590 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270591 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270592 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270593 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001270594 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_134390 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017592424 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC127409 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF370882 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC059116 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH474011 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM070640 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FM086181 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FN804490 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ209634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ212987 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219149 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219532 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219576 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ219583 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ220000 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ226357 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ227177 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ233370 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FQ235102 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JAXUCZ010000004 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Ensembl Acc Id: ENSRNOT00000011327   ⟹   ENSRNOP00000011327
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl479,097,808 - 79,105,263 (-)Ensembl
mRatBN7.2 Ensembl477,766,928 - 77,774,384 (-)Ensembl
Rnor_6.0 Ensembl478,450,724 - 78,458,179 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000078473   ⟹   ENSRNOP00000074935
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl477,766,928 - 77,769,931 (-)Ensembl
Rnor_6.0 Ensembl478,450,724 - 78,458,179 (-)Ensembl
RefSeq Acc Id: NM_001270589   ⟹   NP_001257518
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8479,097,808 - 79,105,263 (-)NCBI
mRatBN7.2477,766,928 - 77,774,384 (-)NCBI
Rnor_6.0478,450,724 - 78,458,179 (-)NCBI
Rnor_5.04143,138,367 - 143,146,237 (-)NCBI
Celera472,703,996 - 72,711,451 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270590   ⟹   NP_001257519
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8479,097,808 - 79,105,263 (-)NCBI
mRatBN7.2477,766,928 - 77,774,384 (-)NCBI
Rnor_6.0478,450,724 - 78,458,179 (-)NCBI
Rnor_5.04143,138,367 - 143,146,237 (-)NCBI
Celera472,703,996 - 72,711,451 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270591   ⟹   NP_001257520
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8479,097,808 - 79,105,263 (-)NCBI
mRatBN7.2477,766,928 - 77,774,384 (-)NCBI
Rnor_6.0478,450,724 - 78,458,179 (-)NCBI
Rnor_5.04143,138,367 - 143,146,237 (-)NCBI
Celera472,703,996 - 72,711,451 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270592   ⟹   NP_001257521
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8479,097,808 - 79,105,263 (-)NCBI
mRatBN7.2477,766,928 - 77,774,384 (-)NCBI
Rnor_6.0478,450,724 - 78,458,179 (-)NCBI
Rnor_5.04143,138,367 - 143,146,237 (-)NCBI
Celera472,703,996 - 72,711,451 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270593   ⟹   NP_001257522
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8479,097,808 - 79,105,263 (-)NCBI
mRatBN7.2477,766,928 - 77,774,384 (-)NCBI
Rnor_6.0478,450,724 - 78,458,179 (-)NCBI
Rnor_5.04143,138,367 - 143,146,237 (-)NCBI
Celera472,703,996 - 72,711,451 (-)NCBI
Sequence:
RefSeq Acc Id: NM_001270594   ⟹   NP_001257523
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8479,097,808 - 79,105,263 (-)NCBI
mRatBN7.2477,766,928 - 77,774,384 (-)NCBI
Rnor_6.0478,450,724 - 78,458,179 (-)NCBI
Rnor_5.04143,138,367 - 143,146,237 (-)NCBI
Celera472,703,996 - 72,711,451 (-)NCBI
Sequence:
RefSeq Acc Id: NM_134390   ⟹   NP_599217
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8479,097,808 - 79,105,263 (-)NCBI
mRatBN7.2477,766,928 - 77,774,384 (-)NCBI
Rnor_6.0478,450,724 - 78,458,179 (-)NCBI
Rnor_5.04143,138,367 - 143,146,237 (-)NCBI
RGSC_v3.4476,911,922 - 76,918,859 (-)RGD
Celera472,703,996 - 72,711,451 (-)NCBI
Sequence:
RefSeq Acc Id: NP_599217   ⟸   NM_134390
- UniProtKB: Q925D4 (UniProtKB/Swiss-Prot),   A6K0I5 (UniProtKB/TrEMBL),   A6K0I4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257523   ⟸   NM_001270594
- UniProtKB: Q925D4 (UniProtKB/Swiss-Prot),   A6K0I5 (UniProtKB/TrEMBL),   A6K0I4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257522   ⟸   NM_001270593
- UniProtKB: Q925D4 (UniProtKB/Swiss-Prot),   A6K0I5 (UniProtKB/TrEMBL),   A6K0I4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257521   ⟸   NM_001270592
- UniProtKB: Q925D4 (UniProtKB/Swiss-Prot),   A6K0I5 (UniProtKB/TrEMBL),   A6K0I4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257520   ⟸   NM_001270591
- UniProtKB: Q925D4 (UniProtKB/Swiss-Prot),   A6K0I5 (UniProtKB/TrEMBL),   A6K0I4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257519   ⟸   NM_001270590
- UniProtKB: Q925D4 (UniProtKB/Swiss-Prot),   A6K0I5 (UniProtKB/TrEMBL),   A6K0I4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001257518   ⟸   NM_001270589
- UniProtKB: Q925D4 (UniProtKB/Swiss-Prot),   A6K0I5 (UniProtKB/TrEMBL),   A6K0I4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000074935   ⟸   ENSRNOT00000078473
Ensembl Acc Id: ENSRNOP00000011327   ⟸   ENSRNOT00000011327

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q925D4-F1-model_v2 AlphaFold Q925D4 1-263 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13693033
Promoter ID:EPDNEW_R3556
Type:multiple initiation site
Name:Tmem176b_1
Description:transmembrane protein 176B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0478,458,179 - 78,458,239EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708403 AgrOrtholog
BioCyc Gene G2FUF-44938 BioCyc
Ensembl Genes ENSRNOG00000008465 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000011327 ENTREZGENE
  ENSRNOT00000011327.7 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:6920949 IMAGE-MGC_LOAD
InterPro CD20-like UniProtKB/Swiss-Prot
  TMEM176A/TMEM176B UniProtKB/Swiss-Prot
KEGG Report rno:171411 UniProtKB/Swiss-Prot
MGC_CLONE MGC:72697 IMAGE-MGC_LOAD
NCBI Gene 171411 ENTREZGENE
PANTHER PTHR15756 UniProtKB/Swiss-Prot
  TRANSMEMBRANE PROTEIN 176B UniProtKB/Swiss-Prot
Pfam CD20 UniProtKB/Swiss-Prot
PhenoGen Tmem176b PhenoGen
RatGTEx ENSRNOG00000008465 RatGTEx
UniProt A6K0I4 ENTREZGENE, UniProtKB/TrEMBL
  A6K0I5 ENTREZGENE, UniProtKB/TrEMBL
  Q925D4 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-06 Tmem176b  transmembrane protein 176B  Lr8  LR8 protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2005-07-08 Lr8  LR8 protein  Torid  TORID  Symbol and Name updated 1299863 APPROVED