Oas1b (2-5 oligoadenylate synthetase 1B) - Rat Genome Database

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Gene: Oas1b (2-5 oligoadenylate synthetase 1B) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Oas1b
Name: 2-5 oligoadenylate synthetase 1B
RGD ID: 708393
Description: Predicted to enable double-stranded RNA binding activity. Predicted to be involved in innate immune response; interleukin-27-mediated signaling pathway; and negative regulation of viral genome replication. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in cytosol; membrane; and nucleoplasm. Human ortholog(s) of this gene implicated in immunodeficiency 100. Orthologous to human OAS1 (2'-5'-oligoadenylate synthetase 1); PARTICIPATES IN hepatitis C pathway; influenza A pathway; measles pathway; INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: (2-5')oligo(A) synthase 1B; 2'5' oligoadenylate synthetase-2; 2'5'oligoadenylatesynthetase-2; 2-5A synthase 1B; 25 oligoadenylate synthetase-2; inactive 2'-5'-oligoadenylate synthase 1B; LOC246268; MGC108585
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81241,385,184 - 41,395,891 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1241,384,678 - 41,395,914 (-)EnsemblGRCr8
mRatBN7.21235,724,561 - 35,735,271 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1235,724,055 - 35,735,242 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1236,903,584 - 36,914,288 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01237,514,791 - 37,525,495 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01236,567,244 - 36,577,948 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01241,255,762 - 41,266,430 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1241,227,825 - 41,307,352 (-)Ensemblrn6Rnor6.0
Rnor_5.01243,117,220 - 43,127,888 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41236,858,902 - 36,869,570 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1237,387,484 - 37,398,152 (-)NCBICelera
RGSC_v3.11236,721,783 - 36,732,970 (-)NCBI
Cytogenetic Map12q16NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
3. GOA pipeline RGD automated data pipeline
4. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
5. Human T-cell leukemia virus type 1 Tax protein stimulates the interferon-responsive enhancer element via NF-kappaB activity. Shimizu T, etal., FEBS Lett 2003 Mar 27;539(1-3):73-7.
Additional References at PubMed
PMID:12477932  


Genomics

Variants

.
Variants in Oas1b
68 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:128
Count of miRNA genes:108
Interacting mature miRNAs:117
Transcripts:ENSRNOT00000001853
Prediction methods:Miranda
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631560Apr1Acute phase response QTL 16.1orosomucoid 1 amount (VT:0010541)plasma orosomucoid 1 level (CMO:0001467)122480502252308831Rat
70213Niddm27Non-insulin dependent diabetes mellitus QTL 273.72blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121120049452308831Rat
8552964Pigfal17Plasma insulin-like growth factor 1 level QTL 173.5blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
8693635Alc28Alcohol consumption QTL 282.70.439drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771850386405Rat
7411641Foco19Food consumption QTL 1927.70.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7411643Foco20Food consumption QTL 200.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)122598935552308831Rat
5684888Pia42Pristane induced arthritis QTL 42joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12348941648489416Rat
1300162Bp188Blood pressure QTL 1883.19arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)123776414551558799Rat
1641928Alcrsp5Alcohol response QTL 5response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)121847304152308831Rat
1549829Scl48Serum cholesterol level QTL 485blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)121526424852308831Rat
8552912Pigfal6Plasma insulin-like growth factor 1 level QTL 65blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049752308831Rat
10059594Kidm46Kidney mass QTL 463.790.025kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)121174352852308831Rat
8552918Pigfal7Plasma insulin-like growth factor 1 level QTL 7blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)121120049452308831Rat
70169Eae13Experimental allergic encephalomyelitis QTL 130.032nervous system integrity trait (VT:0010566)experimental autoimmune encephalomyelitis incidence/prevalence measurement (CMO:0001046)122977552242298555Rat
1600386Calcic2Intracellular calcium level QTL 20.001platelet physiology trait (VT:0005464)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
1300175Cm5Cardiac mass QTL 53.78heart mass (VT:0007028)heart left ventricle weight to body weight ratio (CMO:0000530)123370043251558799Rat
1556747Calcic1Intracellular calcium level QTL 13.6platelet calcium amount (VT:0010500)platelet intracellular calcium level (CMO:0000922)123370043246784661Rat
631829Alc6Alcohol consumption QTL 64.7consumption behavior trait (VT:0002069)ethanol drink intake rate (CMO:0001407)123424347543352593Rat
61404Bw120Body weight QTL 1205.1body mass (VT:0001259)body mass index (BMI) (CMO:0000105)121746497946784661Rat
1331786Kidm11Kidney mass QTL 113.571kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)121618743852308831Rat
8693658Alc33Alcohol consumption QTL 332.10.68drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)122871771849212240Rat
2293699Bss49Bone structure and strength QTL 495.610.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)121613502952308831Rat
1331761Bp218Blood pressure QTL 2182.973arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)121618743851213550Rat
1331763Wbc2White blood cell count QTL 23.162leukocyte quantity (VT:0000217)total white blood cell count (CMO:0000365)121120049452308831Rat
7411547Bw129Body weight QTL 1290.001body mass (VT:0001259)body weight gain (CMO:0000420)61120049452308831Rat
2303569Gluco44Glucose level QTL 442blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)121847304152308831Rat
1298081Cia25Collagen induced arthritis QTL 254.7joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)12274769447747694Rat
2303575Insul14Insulin level QTL 144blood insulin amount (VT:0001560)blood insulin level (CMO:0000349)12308718048087180Rat
7411588Foco6Food consumption QTL 60.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat
7243862Mcs30Mammary carcinoma susceptibility QTL 308.62mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)12563330650633306Rat
2300186Bmd59Bone mineral density QTL 597.10.0001lumbar vertebra mineral mass (VT:0010511)volumetric bone mineral density (CMO:0001553)121613502952308831Rat
7411597Foco10Food consumption QTL 100.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)121120049452308831Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
hemolymphoid system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
sensory system
visual system
7 1 18 51 67 138 95 11 50 36 32 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000001853   ⟹   ENSRNOP00000001853
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1235,724,055 - 35,733,534 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000048782   ⟹   ENSRNOP00000042591
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1241,384,678 - 41,395,914 (-)Ensembl
mRatBN7.2 Ensembl1235,724,055 - 35,735,242 (-)Ensembl
RefSeq Acc Id: NM_144752   ⟹   NP_653353
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81241,385,184 - 41,395,852 (-)NCBI
mRatBN7.21235,724,561 - 35,735,230 (-)NCBI
Rnor_6.01241,255,762 - 41,266,430 (-)NCBI
Rnor_5.01243,117,220 - 43,127,888 (-)NCBI
RGSC_v3.41236,858,902 - 36,869,570 (-)RGD
Celera1237,387,484 - 37,398,152 (-)RGD
Sequence:
RefSeq Acc Id: XM_039089068   ⟹   XP_038944996
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81241,385,184 - 41,395,781 (-)NCBI
mRatBN7.21235,724,561 - 35,735,161 (-)NCBI
RefSeq Acc Id: XM_039089069   ⟹   XP_038944997
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81241,385,184 - 41,393,675 (-)NCBI
mRatBN7.21235,724,561 - 35,732,725 (-)NCBI
RefSeq Acc Id: XR_005491597
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81241,388,173 - 41,395,891 (-)NCBI
mRatBN7.21235,727,551 - 35,735,271 (-)NCBI
Protein Sequences
Protein RefSeqs NP_653353 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944996 (Get FASTA)   NCBI Sequence Viewer  
  XP_038944997 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC19135 (Get FASTA)   NCBI Sequence Viewer  
  AAH91121 (Get FASTA)   NCBI Sequence Viewer  
  EDM13762 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000042591
  ENSRNOP00000042591.4
GenBank Protein Q5BKD0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_653353   ⟸   NM_144752
- UniProtKB: O70522 (UniProtKB/Swiss-Prot),   Q5BKD0 (UniProtKB/Swiss-Prot),   A0A8L2PZR9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038944996   ⟸   XM_039089068
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038944997   ⟸   XM_039089069
- Peptide Label: isoform X2
Ensembl Acc Id: ENSRNOP00000001853   ⟸   ENSRNOT00000001853
Ensembl Acc Id: ENSRNOP00000042591   ⟸   ENSRNOT00000048782

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q5BKD0-F1-model_v2 AlphaFold Q5BKD0 1-379 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13698662
Promoter ID:EPDNEW_R9187
Type:single initiation site
Name:Oas1b_1
Description:2-5 oligoadenylate synthetase 1B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_R9188  
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01241,266,439 - 41,266,499EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708393 AgrOrtholog
BioCyc Gene G2FUF-19193 BioCyc
Ensembl Genes ENSRNOG00000033220 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000048782 ENTREZGENE
  ENSRNOT00000048782.5 UniProtKB/Swiss-Prot
Gene3D-CATH 2'-5'-oligoadenylate synthetase 1, domain 2 UniProtKB/Swiss-Prot
  3.30.460.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7383389 IMAGE-MGC_LOAD
InterPro 2-5-oligoadenylate_synth_N UniProtKB/Swiss-Prot
  2-5-oligoAdlate_synth_1_dom2/C UniProtKB/Swiss-Prot
  NT_sf UniProtKB/Swiss-Prot
  Polymerase_NTP_transf_dom UniProtKB/Swiss-Prot
KEGG Report rno:246268 UniProtKB/Swiss-Prot
MGC_CLONE MGC:108585 IMAGE-MGC_LOAD
NCBI Gene 246268 ENTREZGENE
PANTHER INACTIVE 2'-5'-OLIGOADENYLATE SYNTHASE 1B UniProtKB/Swiss-Prot
  PTHR11258 UniProtKB/Swiss-Prot
Pfam NTP_transf_2 UniProtKB/Swiss-Prot
  OAS1_C UniProtKB/Swiss-Prot
PhenoGen Oas1b PhenoGen
PROSITE 25A_SYNTH_3 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000033220 RatGTEx
Superfamily-SCOP PAP/OAS1 substrate-binding domain UniProtKB/Swiss-Prot
  SSF81301 UniProtKB/Swiss-Prot
UniProt A0A8L2PZR9 ENTREZGENE
  A1DZF7_RAT UniProtKB/TrEMBL
  O70522 ENTREZGENE
  OAS1B_RAT UniProtKB/Swiss-Prot, ENTREZGENE
UniProt Secondary O70522 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-08 Oas1b  2-5 oligoadenylate synthetase 1B  LOC246268  25 oligoadenylate synthetase-2  Symbol and Name updated 1299863 APPROVED