Svs3a (seminal vesicle secretory protein 3A) - Rat Genome Database

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Gene: Svs3a (seminal vesicle secretory protein 3A) Rattus norvegicus
Analyze
No known orthologs.
Symbol: Svs3a
Name: seminal vesicle secretory protein 3A
RGD ID: 708390
Description: Predicted to be involved in sperm capacitation. Predicted to be located in extracellular region. Predicted to be active in acrosomal vesicle and extracellular space. Orthologous to human SEMG1 (semenogelin 1) and SEMG2 (semenogelin 2); INTERACTS WITH 17beta-estradiol; bisphenol A; indole-3-methanol.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: androgen-responsive protein pSv-1; LOC100909545; LOC103690143; LOC192239; seminal vesicle secretion 3; seminal vesicle secretion 3 alpha; seminal vesicle secretory protein 2-like; Svs3
RGD Orthologs
Alliance Orthologs
More Info homologs ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83173,377,977 - 173,383,302 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3173,381,085 - 173,383,301 (+)EnsemblGRCr8
mRatBN7.23152,961,706 - 152,963,922 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3152,961,706 - 152,963,922 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3156,771,532 - 156,773,748 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03165,270,469 - 165,272,685 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03163,015,720 - 163,017,936 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.03159,082,547 - 159,084,618 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3160,679,301 - 160,680,323 (+)Ensemblrn6Rnor6.0
Rnor_6.0 Ensembl3160,648,449 - 160,649,471 (-)NCBIrn6Rnor6.0
Rnor_5.03166,862,837 - 166,865,053 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43155,230,827 - 155,233,043 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3151,606,569 - 151,608,785 (+)NCBICelera
RGSC_v3.13155,136,914 - 155,139,079 (+)NCBI
Cytogenetic Map3q42NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Nucleotide sequences of cDNA clones, pSv-1 and pSv-2, hybridizing to androgen-stimulated mRNAs in rat seminal vesicles. Izawa M Endocrinol Jpn 1991 Dec;38(6):577-81.
3. GOA pipeline RGD automated data pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15582586  


Genomics

miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:125
Count of miRNA genes:100
Interacting mature miRNAs:108
Transcripts:ENSRNOT00000018481
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
1300113Bp176Blood pressure QTL 1763.9arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3166376089177728348Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
1298068Bp167Blood pressure QTL 1670.004arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161492708189428310Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
8552791Vie2Viral induced encephalitis QTL 24.1brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)3166376089189428310Rat
61335Bp20Blood pressure QTL 203arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3161799493176036425Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1331726Bp208Blood pressure QTL 2083.129arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3161799270187311134Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1598854Memor10Memory QTL 102exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)3166376089189428310Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat

Markers in Region
BF417389  
Rat AssemblyChrPosition (strand)SourceJBrowse
Rnor_5.03166,864,726 - 166,864,893NCBIRnor5.0
Rnor_5.03165,323,882 - 165,324,049NCBIRnor5.0
Rnor_5.03165,290,144 - 165,290,313NCBIRnor5.0
Rnor_5.03166,830,990 - 166,831,159NCBIRnor5.0
RGSC_v3.43155,232,717 - 155,232,883UniSTSRGSC3.4
RGSC_v3.43155,198,980 - 155,199,148UniSTSRGSC3.4
Celera3151,608,459 - 151,608,625UniSTS
Celera3151,574,741 - 151,574,909UniSTS
RH 3.4 Map31421.2UniSTS
Cytogenetic Map3q42UniSTS


Expression

RNA-SEQ Expression

endoderm
mesenchyme
renal system
reproductive system
respiratory system
1 6 6 27 1

Sequence


Ensembl Acc Id: ENSRNOT00000090188   ⟹   ENSRNOP00000071990
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl3160,679,301 - 160,680,323 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000097242   ⟹   ENSRNOP00000078205
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3173,381,085 - 173,383,301 (+)Ensembl
mRatBN7.2 Ensembl3152,961,706 - 152,963,922 (+)Ensembl
RefSeq Acc Id: NM_001007605   ⟹   NP_001007606
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83173,381,085 - 173,383,301 (+)NCBI
mRatBN7.23152,961,706 - 152,963,922 (+)NCBI
Rnor_6.03159,082,547 - 159,084,618 (-)NCBI
Rnor_5.03166,862,837 - 166,865,053 (+)NCBI
RGSC_v3.43155,230,827 - 155,233,043 (+)RGD
Celera3151,606,569 - 151,608,785 (+)RGD
Sequence:
RefSeq Acc Id: XM_063283057   ⟹   XP_063139127
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83173,377,977 - 173,383,302 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001007606 (Get FASTA)   NCBI Sequence Viewer  
  XP_063139127 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL96537 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000078205
  ENSRNOP00000078205.1
RefSeq Acc Id: NP_001007606   ⟸   NM_001007605
- Peptide Label: precursor
- UniProtKB: Q7TQ59 (UniProtKB/TrEMBL),   A0A8I5ZJQ1 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000071990   ⟸   ENSRNOT00000090188
Ensembl Acc Id: ENSRNOP00000078205   ⟸   ENSRNOT00000097242
RefSeq Acc Id: XP_063139127   ⟸   XM_063283057
- Peptide Label: isoform X1

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q7TQ59-F1-model_v2 AlphaFold Q7TQ59 1-264 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13692630
Promoter ID:EPDNEW_R3153
Type:single initiation site
Name:Svs3b_1
Description:seminal vesicle secretory protein 3B
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.03159,084,619 - 159,084,679EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708390 AgrOrtholog
BioCyc Gene G2FUF-46872 BioCyc
Ensembl Genes ENSRNOG00000049613 Ensembl
  ENSRNOG00000059369 Ensembl
  ENSRNOG00000062737 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000097242 ENTREZGENE
  ENSRNOT00000097242.2 UniProtKB/TrEMBL
InterPro Semenogelin UniProtKB/TrEMBL
KEGG Report rno:192239 UniProtKB/TrEMBL
NCBI Gene 192239 ENTREZGENE
PANTHER SEMENOGELIN/SEMINAL VESICLE SECRETORY PROTEIN UniProtKB/TrEMBL
  SEMINAL VESICLE SECRETORY PROTEIN 3A-RELATED UniProtKB/TrEMBL
Pfam Semenogelin UniProtKB/TrEMBL
PhenoGen Svs3a PhenoGen
RatGTEx ENSRNOG00000049613 RatGTEx
  ENSRNOG00000059369 RatGTEx
  ENSRNOG00000062737 RatGTEx
UniProt A0A8I5ZJQ1 ENTREZGENE, UniProtKB/TrEMBL
  Q7TQ59 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Svs3a  seminal vesicle secretory protein 3A  LOC103690143  seminal vesicle secretory protein 2-like  Data merged from RGD:9438702 737654 PROVISIONAL
2015-07-29 LOC103690143  seminal vesicle secretory protein 2-like  LOC100909545  seminal vesicle secretory protein 2-like  Data merged from RGD:6502934 737654 PROVISIONAL
2014-08-25 LOC103690143  seminal vesicle secretory protein 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2012-07-05 LOC100909545  seminal vesicle secretory protein 2-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2011-02-23 Svs3a  seminal vesicle secretory protein 3A  Svs3  seminal vesicle secretion 3  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Svs3  seminal vesicle secretion 3  LOC192239  androgen-responsive protein pSv-1  Symbol and Name updated 1299863 APPROVED