Card9 (caspase recruitment domain family, member 9)

Gene: Card9 (caspase recruitment domain family, member 9) Rattus norvegicus

Analyze

Symbol:

Card9

Name:

caspase recruitment domain family, member 9

RGD ID:

708370

Description:

Predicted to enable CARD domain binding activity; protein homodimerization activity; and protein self-association. Involved in response to aldosterone. Predicted to be located in nucleoplasm. Predicted to be part of CBM complex. Predicted to be active in cytoplasm. Biomarker of retinal degeneration. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human CARD9 (caspase recruitment domain family member 9); PARTICIPATES IN NOD-like receptor signaling pathway; tuberculosis pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; acetamide.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

caspase recruitment domain protein 9; caspase recruitment domain-containing protein 9; LOC64171; rCARD9

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	29,569,907 - 29,578,402 (-)	NCBI		GRCr8
mRatBN7.2	3	9,171,814 - 9,180,310 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	9,171,815 - 9,180,237 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	12,225,191 - 12,233,701 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	20,808,421 - 20,816,931 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	19,063,758 - 19,072,269 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	3,798,346 - 3,806,841 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	3,798,347 - 3,806,713 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	9,159,493 - 9,169,133 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	4,524,781 - 4,533,412 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	4,524,781 - 4,533,412 (-)	NCBI
Celera	3	3,991,729 - 4,000,095 (-)	NCBI		Celera
Cytogenetic Map	3	p13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

6-propyl-2-thiouracil (EXP)

acetamide (EXP)

acrylamide (EXP)

all-trans-retinoic acid (ISO)

amiodarone (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arsenous acid (ISO)

atrazine (EXP,ISO)

bisphenol A (EXP)

bortezomib (ISO)

caffeine (ISO)

copper(II) sulfate (ISO)

corn oil (ISO)

Cuprizon (EXP)

cyclosporin A (ISO)

diarsenic trioxide (ISO)

diazinon (ISO)

dieldrin (EXP)

furan (EXP)

iron dichloride (ISO)

Licochalcone B (ISO)

manganese(II) chloride (EXP)

methimazole (EXP)

nickel dichloride (EXP)

ozone (EXP)

p-menthan-3-ol (ISO)

paracetamol (ISO)

propanal (ISO)

prothioconazole (ISO)

silicon dioxide (EXP,ISO)

sodium arsenite (ISO)

sodium dichromate (ISO)

Soman (EXP)

thapsigargin (ISO)

trichloroethene (EXP)

triptonide (ISO)

tunicamycin (ISO)

urethane (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antifungal innate immune response (ISO,ISS)

defense response to Gram-positive bacterium (ISO)

defense response to virus (ISO)

host-mediated regulation of intestinal microbiota composition (ISO,ISS)

immunoglobulin mediated immune response (ISO,ISS)

JNK cascade (ISO)

neutrophil mediated immunity (ISO,ISS)

positive regulation of canonical NF-kappaB signal transduction (IBA,IEA,ISO)

positive regulation of chemokine production (ISO)

positive regulation of cytokine production (ISO,ISS)

positive regulation of cytokine production involved in inflammatory response (ISO,ISS)

positive regulation of ERK1 and ERK2 cascade (ISO,ISS)

positive regulation of granulocyte macrophage colony-stimulating factor production (ISO,ISS)

positive regulation of innate immune response (ISO)

positive regulation of interleukin-17 production (ISO,ISS)

positive regulation of interleukin-6 production (ISO,ISS)

positive regulation of JNK cascade (ISO)

positive regulation of macrophage cytokine production (ISO)

positive regulation of stress-activated MAPK cascade (ISO,ISS)

positive regulation of T-helper 17 type immune response (ISO)

positive regulation of tumor necrosis factor production (ISO)

protein folding (IBA)

protein homooligomerization (ISO,ISS)

protein import into mitochondrial matrix (IBA)

protein stabilization (IBA)

regulation of apoptotic process (IEA)

regulation of interleukin-2 production (ISO)

regulation of interleukin-6 production (ISO)

regulation of tumor necrosis factor production (ISO)

response to aldosterone (IEP)

response to exogenous dsRNA (ISO)

response to fungus (ISO)

response to muramyl dipeptide (ISO)

response to peptidoglycan (ISO)

response to xenobiotic stimulus (ISO)

stress-activated MAPK cascade (ISO)

Cellular Component

CBM complex (ISO)

cytoplasm (IBA,IEA,ISO)

mitochondrion (IBA)

protein-containing complex (ISO)

Molecular Function

CARD domain binding (IBA,IEA,ISO)

identical protein binding (ISO)

metal ion binding (IEA)

protein binding (ISO)

protein homodimerization activity (ISO)

protein-folding chaperone binding (IBA)

signaling adaptor activity (ISO)

zinc ion binding (IEA)

Molecular Pathway Annotations Click to see Annotation Detail View

NOD-like receptor signaling pathway (IEA)

tuberculosis pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	CARD9 is a novel caspase recruitment domain-containing protein that interacts with BCL10/CLAP and activates NF-kappa B.	Bertin J, etal., J Biol Chem 2000 Dec 29;275(52):41082-6.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
4.	Gene expression changes in the retina after systemic administration of aldosterone.	Ono A, etal., Jpn J Ophthalmol. 2018 Jul;62(4):499-507. doi: 10.1007/s10384-018-0595-4. Epub 2018 Apr 30.
5.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
6.	GOA pipeline	RGD automated data pipeline
7.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
8.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions

Additional References at PubMed

PMID:16862125	PMID:17187069	PMID:22267217	PMID:27957800	PMID:31212066	PMID:32248306	PMID:32790017

Genomics

Comparative Map Data

Card9
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	29,569,907 - 29,578,402 (-)	NCBI		GRCr8
mRatBN7.2	3	9,171,814 - 9,180,310 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	9,171,815 - 9,180,237 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	3	12,225,191 - 12,233,701 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	20,808,421 - 20,816,931 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	19,063,758 - 19,072,269 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	3,798,346 - 3,806,841 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	3,798,347 - 3,806,713 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	3	9,159,493 - 9,169,133 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	3	4,524,781 - 4,533,412 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	3	4,524,781 - 4,533,412 (-)	NCBI
Celera	3	3,991,729 - 4,000,095 (-)	NCBI		Celera
Cytogenetic Map	3	p13	NCBI

CARD9
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	9	136,363,956 - 136,373,669 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	9	136,363,956 - 136,373,681 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	9	139,258,408 - 139,268,121 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	9	138,378,229 - 138,387,939 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	9	136,534,245 - 136,543,945	NCBI
Celera	9	109,773,344 - 109,783,069 (-)	NCBI		Celera
Cytogenetic Map	9	q34.3	NCBI
HuRef	9	108,717,764 - 108,727,489 (-)	NCBI		HuRef
CHM1_1	9	139,406,604 - 139,416,329 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	9	148,593,287 - 148,603,003 (-)	NCBI		T2T-CHM13v2.0

Card9
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	26,242,199 - 26,250,957 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	26,242,188 - 26,250,930 (-)	Ensembl		GRCm39 Ensembl
GRCm38	2	26,352,187 - 26,360,945 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	26,352,176 - 26,360,918 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	2	26,207,832 - 26,215,067 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	2	26,174,196 - 26,181,556 (-)	NCBI		MGSCv36	mm8
Celera	2	26,070,008 - 26,077,188 (-)	NCBI		Celera
Cytogenetic Map	2	A3	NCBI
cM Map	2	18.87	NCBI

Card9
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955513	4,350,147 - 4,359,345 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955513	4,350,873 - 4,359,345 (+)	NCBI	ChiLan1.0	ChiLan1.0

CARD9
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	11	3,012,876 - 3,022,629 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	9	3,015,211 - 3,024,658 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	9	107,432,709 - 107,446,271 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	9	136,416,279 - 136,426,048 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	9	136,416,279 - 136,424,756 (-)	Ensembl	panpan1.1		panPan2

CARD9
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	49,110,913 - 49,120,758 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	9	49,113,923 - 49,120,591 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	48,361,817 - 48,371,360 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	49,987,891 - 49,997,435 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	49,990,618 - 49,997,434 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	48,768,457 - 48,777,984 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	49,062,612 - 49,072,157 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	49,110,140 - 49,119,684 (+)	NCBI		UU_Cfam_GSD_1.0

Card9
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	201,937,046 - 201,946,896 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936669	1,429,594 - 1,438,005 (+)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936669	1,428,208 - 1,438,012 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

CARD9
(Sus scrofa - pig)

No map positions available.

CARD9
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	12	1,829,913 - 1,841,489 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	12	1,832,989 - 1,837,914 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666058	3,374,636 - 3,386,427 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Card9
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624760	1,533,390 - 1,540,162 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624760	1,533,247 - 1,542,529 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Card9
21 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	50
Count of miRNA genes:	43
Interacting mature miRNAs:	50
Transcripts:	ENSRNOT00000025456
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
70202	Alc19	Alcohol consumption QTL 19	2.5		drinking behavior trait (VT:0001422)	ethanol intake volume to total fluid intake volume ratio (CMO:0001591)	3	1	27494778	Rat
631679	Cm10	Cardiac mass QTL 10	7.34	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	1	31158234	Rat
631831	Alc8	Alcohol consumption QTL 8	2.7		consumption behavior trait (VT:0002069)	calculated ethanol drink intake rate (CMO:0001615)	3	1	33230976	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	diastolic blood pressure (CMO:0000005)	3	1	33278763	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	systolic blood pressure (CMO:0000004)	3	1	33278763	Rat
61468	Bp15	Blood pressure QTL 15	4.4		blood pressure trait (VT:0000183)	pulse pressure (CMO:0000292)	3	1	33278763	Rat
631545	Bp85	Blood pressure QTL 85	3.1		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	33278763	Rat
4889966	Bss95	Bone structure and strength QTL 95	4.4		tibia area (VT:1000281)	tibia-fibula cross-sectional area (CMO:0001718)	3	1	36847613	Rat
2312664	Scl62	Serum cholesterol level QTL 62		0.05	blood cholesterol amount (VT:0000180)	serum total cholesterol level (CMO:0000363)	3	1	38710544	Rat
631568	Bp92	Blood pressure QTL 92	2.2	0.005	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	3	1	39874793	Rat
2290452	Scl56	Serum cholesterol level QTL 56	2.26		blood cholesterol amount (VT:0000180)	plasma total cholesterol level (CMO:0000585)	3	1	91609953	Rat
1358185	Ept6	Estrogen-induced pituitary tumorigenesis QTL 6	6.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	6537645	10778823	Rat
2292615	Ept17	Estrogen-induced pituitary tumorigenesis QTL 17	6.7		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	6537645	10778823	Rat
1298526	Arunc3	Aerobic running capacity QTL 3	2.2		exercise endurance trait (VT:0002332)	maximum distance run on treadmill (CMO:0001406)	3	8227194	33703538	Rat
10401810	Kidm53	Kidney mass QTL 53			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	8227194	47233430	Rat
70203	Gcr2	Gastric cancer resistance QTL 2	2.6		stomach morphology trait (VT:0000470)	stomach tumor susceptibility score (CMO:0002043)	3	8658162	27494778	Rat
1358357	Srcrtb1	Stress Responsive Cort Basal QTL 1	6.36	0.002	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	8658162	27494778	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium					3						2	1
Low	3	41	57	41	16	41	8	11	74	35	39	10	8
Below cutoff		2

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_022303	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_008761626	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017592019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063284517	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005501978	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC129824	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF311288	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH474001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSRNOT00000091484 ⟹ ENSRNOP00000074450

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	9,171,815 - 9,180,237 (-)	Ensembl
Rnor_6.0 Ensembl	3	3,798,347 - 3,806,713 (-)	Ensembl

RefSeq Acc Id:

ENSRNOT00000095848 ⟹ ENSRNOP00000086525

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	3	9,171,815 - 9,180,237 (-)	Ensembl

RefSeq Acc Id:

NM_022303 ⟹ NP_071639

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	29,569,907 - 29,578,402 (-)	NCBI
mRatBN7.2	3	9,171,814 - 9,180,310 (-)	NCBI
Rnor_6.0	3	3,798,346 - 3,806,713 (-)	NCBI
Rnor_5.0	3	9,159,493 - 9,169,133 (-)	NCBI
RGSC_v3.4	3	4,524,781 - 4,533,412 (-)	RGD
Celera	3	3,991,729 - 4,000,095 (-)	RGD

Sequence:

show sequence

CCACGCGTCCGAGCATCTCCACACTCCCAGAGGCTCGCTCCTGGAGTGCCCATAGCCCAGGCAG
CATCCAGCTGGCAGGTGGCTCCCACAGGACCCTGAGCCTACAGAGGACATGTCAGACTATGAAA
ATGACGACGAGTGCTGGAGTGCCCTGGAGAGCTTCCGGGTGAAGCTAATCTCTGTCATTGACCC
CTCACGAATCACACCCTATCTGCGCCAGTGCAAAGTCCTGAACCCCGATGATGAGGAGCAGGTG
CTCAGTGACCCCAACCTGGTCATCCGCAAGCGGAAAGTGGGTGTGCTCCTGGACATCCTGCAGC
GGACAGGCCACAAGGGCTACGTGGCCTTTCTTGAGAGTCTGGAACTCTACTACCCTCAGTTATA
CAGGAAAGTCACTGGCAAGGAGCCAGCGCGTGTCTTCTCCATGATCATCGACGCATCAGGGGAG
TCGGGCCTGACGCAGCTGCTGATGACAGAGGTCATGAAGCTGCAGAAGAAGGTTCAGGACCTGA
CGGCCCTTCTGAGCTCCAAGGATGACTTCATCAAGGAGCTGAGGGTAAAGGACAGCCTCCTGCG
CAAGCACCAGGAGCGGGTGCAGCGGCTCAAGGAGGAGTGTGAGCTGAGCAGTGCCGAGCTGAAG
CGCTGCAAGGATGAGAACTACGACCTGGCCATGCGCCTGGCTCACCTGAGTGAAGAGAAGGGAG
CAGCACTCATGCGGAACCGTGACCTGCAGCTTGAGGTGGACCAGCTCAGGCACAGCCTCATGAA
GGCAGAGGATGACTGCAAGGTGGAGCGCAAACACACACTGAAGCTCCGGCACGCCATGGAGCAG
CGGCCTAGCCAGGAGCTGCTGTGGGACCTGCAGCAGGAGAGGGACTTGTTGCAGGCCCGGGTGC
AGGAGCTGGAGGTCTCCGTGCAGGAGGGTAAGCTACACAGGAATAGCCCATACATCCAGGTGCT
GGAGGAGGACTGGCGTCAGGCACTGCAGGAACACCAGGAGCAGGCCAGCACCATCTTCTCCCTA
CGAAAGGACCTCCGCCAGGCTGAGGCCCTCCGGACCCGGTGCATGGAGGAAAAGGAGATGTTCG
AGCTGCAGTGCCTGGCCTTGCGCAAGGATGCCAAGATGTACAAGGACCGGATCGAGGCTATCCT
GCAGCAGATGGAGGAAGTCTCCATTGAGCGGGACCAGGCTATGACCTCAAGGGAAGAGCTGCAT
GCACAGTGTGCCCAAAGCTTTCAGGACAAAGATAAGCTGCGAAAGCAGGTTCGAGAACTGGATG
AGAAGGCCGACGAGTTGCAGCTGCAGCTGTTCCAGACCGAGAGCCGATTACTGGCCGCTGAGGG
CAGACTCAAGCAGCAGCAATTGGACATGCTCATCCTGAGCTCTGACTTGGAAGACAGTTCCCCC
AGGAACTCCCAGGAGCTTTCACTGCCTCAGGACCTGGAGGAGGATGCCCAGCTCTCAGACAAAG
GTGTCCTGGCAGACAGGGAGAGCCCAGAGCAGCCCTTCGTGGTTCTGAACAAGAAGCATCTTTC
GCAGACCCATGACACGGTGCCCAGCAGCAGCGAGCCCCCGGAGAAGGAGCGGCGGCGCCTCAAG
GAGAGCTTCGAGAACTACCGCAGGAAGCGGGCGCTCCGCAAGATGCAGAACAGCTGGCGACAGG
GAGAAGGGGATCACGGGAATACGACAGGCAGCGACAACACCGACACCGAGGGCTCCTAGAGGAC
CACGCCGAGGCTGAGCGTCTGTGTAATTGTGAAGGGATGCTGCGGGTTTTTTTACTGTACGCTA
CACATACGTTGTACAAGTATTAGAAAAAAATGCAGCCTAATAAAATGACCTCTGAGCTGAAAAA
AAAAAAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_063284517 ⟹ XP_063140587

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	29,570,220 - 29,577,088 (-)	NCBI

RefSeq Acc Id:

XR_005501978

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	29,572,100 - 29,578,346 (-)	NCBI
mRatBN7.2	3	9,174,006 - 9,180,255 (-)	NCBI

Protein Sequences


Protein RefSeqs	NP_071639	(Get FASTA)	NCBI Sequence Viewer
	XP_063140587	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAG28791	(Get FASTA)	NCBI Sequence Viewer
	EDL93509	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000025386.5
	ENSRNOP00000074450
	ENSRNOP00000074450.1
	ENSRNOP00000086525.1
GenBank Protein	Q9EPY0	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_071639 ⟸ NM_022303

- UniProtKB:

F1LQK8 (UniProtKB/Swiss-Prot), Q9EPY0 (UniProtKB/Swiss-Prot), A6JTD8 (UniProtKB/TrEMBL), A0A8I6A3T6 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSDYENDDECWSALESFRVKLISVIDPSRITPYLRQCKVLNPDDEEQVLSDPNLVIRKRKVGVL
LDILQRTGHKGYVAFLESLELYYPQLYRKVTGKEPARVFSMIIDASGESGLTQLLMTEVMKLQK
KVQDLTALLSSKDDFIKELRVKDSLLRKHQERVQRLKEECELSSAELKRCKDENYDLAMRLAHL
SEEKGAALMRNRDLQLEVDQLRHSLMKAEDDCKVERKHTLKLRHAMEQRPSQELLWDLQQERDL
LQARVQELEVSVQEGKLHRNSPYIQVLEEDWRQALQEHQEQASTIFSLRKDLRQAEALRTRCME
EKEMFELQCLALRKDAKMYKDRIEAILQQMEEVSIERDQAMTSREELHAQCAQSFQDKDKLRKQ
VRELDEKADELQLQLFQTESRLLAAEGRLKQQQLDMLILSSDLEDSSPRNSQELSLPQDLEEDA
QLSDKGVLADRESPEQPFVVLNKKHLSQTHDTVPSSSEPPEKERRRLKESFENYRRKRALRKMQ
NSWRQGEGDHGNTTGSDNTDTEGS

hide sequence

RefSeq Acc Id:

ENSRNOP00000074450 ⟸ ENSRNOT00000091484

RefSeq Acc Id:

ENSRNOP00000086525 ⟸ ENSRNOT00000095848

RefSeq Acc Id:	XP_063140587 ⟸ XM_063284517
- Peptide Label:	isoform X1

Protein Domains

CARD DNL-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9EPY0-F1-model_v2	AlphaFold	Q9EPY0	1-536	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13691902

Promoter ID:

EPDNEW_R2427

Type:

initiation region

Name:

Card9_1

Description:

caspase recruitment domain family, member 9

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	3,806,703 - 3,806,763	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:708370	AgrOrtholog
BioCyc Gene	G2FUF-50386	BioCyc
Ensembl Genes	ENSRNOG00000018791	ENTREZGENE, UniProtKB/TrEMBL
	ENSRNOG00000051470	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Transcript	ENSRNOT00000025386.7	UniProtKB/TrEMBL
	ENSRNOT00000091484	ENTREZGENE
	ENSRNOT00000091484.2	UniProtKB/Swiss-Prot
	ENSRNOT00000095848.1	UniProtKB/TrEMBL
Gene3D-CATH	1.10.533.10	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	CARD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CARD_CARD9	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DEATH-like_dom_sf	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Mt_import_TIM15	UniProtKB/TrEMBL
	Znf_DNL-typ	UniProtKB/TrEMBL
KEGG Report	rno:64171	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	64171	ENTREZGENE
PANTHER	CASPASE RECRUITMENT DOMAIN FAMILY	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	CASPASE RECRUITMENT DOMAIN-CONTAINING PROTEIN 9	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	DNL-TYPE ZINC FINGER PROTEIN	UniProtKB/TrEMBL
	UNCHARACTERIZED	UniProtKB/TrEMBL
Pfam	CARD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	zf-DNL	UniProtKB/TrEMBL
PhenoGen	Card9	PhenoGen
PROSITE	CARD	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ZF_DNL	UniProtKB/TrEMBL
RatGTEx	ENSRNOG00000018791	RatGTEx
	ENSRNOG00000051470	RatGTEx
Superfamily-SCOP	SSF47986	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt	A0A8I6A3T6	ENTREZGENE, UniProtKB/TrEMBL
	A6JTD8	ENTREZGENE, UniProtKB/TrEMBL
	CARD9_RAT	UniProtKB/Swiss-Prot
	D3ZWJ1_RAT	UniProtKB/TrEMBL
	F1LQK8	ENTREZGENE
	Q9EPY0	ENTREZGENE
UniProt Secondary	F1LQK8	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2005-07-08	Card9	caspase recruitment domain family, member 9	LOC64171	caspase recruitment domain protein 9	Symbol and Name updated	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)