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Gene: Hsd17b12 (hydroxysteroid (17-beta) dehydrogenase 12) Rattus norvegicus

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Symbol:

Hsd17b12

Name:

hydroxysteroid (17-beta) dehydrogenase 12

RGD ID:

708367

Description:

Predicted to enable several functions, including fibronectin binding activity; heparin binding activity; and very-long-chain 3-oxoacyl-CoA reductase activity. Predicted to be involved in fatty acid elongation, saturated fatty acid. Predicted to act upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Predicted to be located in extracellular matrix. Predicted to be part of fatty acid elongase complex. Predicted to be active in endoplasmic reticulum. Orthologous to human HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12); PARTICIPATES IN steroid hormone biosynthetic pathway; unsaturated fatty acid biosynthetic pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

17-beta-HSD 12; 17-beta-hydroxysteroid dehydrogenase 12; 3-ketoacyl-CoA reductase; estradiol 17-beta-dehydrogenase 12; KAR; LOC84013; smooth muscle-specific 17 beta-hydroxysteroid dehydrogenase type 3; very-long-chain 3-oxoacyl-CoA reductase

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Mus musculus (house mouse):	Hsd17b12 (hydroxysteroid (17-beta) dehydrogenase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Hsd17b12 (hydroxysteroid 17-beta dehydrogenase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Hsd17b12 (hydroxysteroid 17-beta dehydrogenase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Hsd17b12 (hydroxysteroid 17-beta dehydrogenase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Hsd17b12 (hydroxysteroid 17-beta dehydrogenase 12)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	PCDHB16 (protocadherin beta 16)	HGNC	OMA
Alliance orthologs ³
Mus musculus (house mouse):	Hsd17b12 (hydroxysteroid (17-beta) dehydrogenase 12)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	HSD17B12 (hydroxysteroid 17-beta dehydrogenase 12)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	hsd17b12b (hydroxysteroid (17-beta) dehydrogenase 12b)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	hsd17b12a (hydroxysteroid (17-beta) dehydrogenase 12a)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Saccharomyces cerevisiae (baker's yeast):	IFA38	Alliance	DIOPT (Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	stdh-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	stdh-2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	stdh-3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	stdh-4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	let-767	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	let-767	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Drosophila melanogaster (fruit fly):	spidey	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	spidey	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	hsd17b12	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	100,445,393 - 100,568,898 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	100,445,400 - 100,568,938 (-)	Ensembl				GRCr8
mRatBN7.2	3	79,990,048 - 80,113,556 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	79,990,056 - 80,113,617 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	83,463,561 - 83,587,647 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	92,062,651 - 92,186,743 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	89,908,167 - 90,032,005 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	82,924,699 - 83,048,465 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	82,924,687 - 83,048,435 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	89,626,176 - 89,749,541 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	78,436,634 - 78,559,707 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	79,190,922 - 79,314,232 (-)	NCBI		Celera
RGSC_v3.1	3	78,333,061 - 78,456,135 (-)	NCBI
Cytogenetic Map	3	q31	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (EXP,ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (EXP)

2,6-dimethoxyphenol (ISO)

2,6-dinitrotoluene (EXP)

3H-1,2-dithiole-3-thione (EXP)

4,4'-sulfonyldiphenol (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

ammonium chloride (EXP)

androst-4-ene-3,17-dione (ISO)

androst-5-ene-3beta,17beta-diol (ISO)

androstane-3,17-diol (ISO)

androsterone (ISO)

aristolochic acid A (EXP,ISO)

Aroclor 1254 (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenous acid (ISO)

benzatropine (ISO)

benzo[a]pyrene (EXP)

benzo[a]pyrene diol epoxide I (ISO)

bexarotene (EXP)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP,ISO)

bisphenol AF (ISO)

Bisphenol B (ISO)

bisphenol F (ISO)

bucladesine (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcitriol (EXP)

calcium atom (EXP)

calcium(0) (EXP)

carbon nanotube (ISO)

CGP 52608 (ISO)

cisplatin (EXP)

clofibrate (ISO)

clozapine (ISO)

cobalt dichloride (ISO)

cyclosporin A (ISO)

dehydroepiandrosterone (ISO)

dexamethasone (EXP)

diarsenic trioxide (ISO)

dorsomorphin (ISO)

doxorubicin (ISO)

epoxiconazole (ISO)

estrone (ISO)

ethyl methanesulfonate (ISO)

fenthion (ISO)

fipronil (EXP)

formaldehyde (ISO)

furfural (ISO)

genistein (ISO)

gentamycin (EXP)

indometacin (EXP)

inulin (ISO)

isoniazide (ISO)

isotretinoin (ISO)

ivermectin (ISO)

leflunomide (EXP)

methyl methanesulfonate (ISO)

NADP zwitterion (ISO)

NADP(+) (ISO)

nimesulide (EXP)

ozone (ISO)

paracetamol (ISO)

paraquat (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

phenobarbital (ISO)

pirinixic acid (EXP,ISO)

resveratrol (ISO)

rotenone (EXP,ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sodium chloride (ISO)

Tesaglitazar (EXP)

testosterone (ISO)

thapsigargin (EXP)

titanium dioxide (ISO)

tolcapone (EXP)

triptonide (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

androgen biosynthetic process (IEA)

biological_process (ND)

estrogen biosynthetic process (IEA)

extracellular matrix organization (ISO)

fatty acid biosynthetic process (IEA)

fatty acid elongation, saturated fatty acid (IEA,ISO)

lipid metabolic process (IEA)

positive regulation of cell-substrate adhesion (ISO)

steroid biosynthetic process (IEA)

Cellular Component

endoplasmic reticulum (IBA)

endoplasmic reticulum membrane (IEA)

extracellular matrix (IEA,ISO)

fatty acid elongase complex (IEA,ISO)

Molecular Function

collagen binding (IEA,ISO)

estradiol 17-beta-dehydrogenase [NAD(P)+] activity (IEA)

fibronectin binding (IEA,ISO)

heparin binding (IEA,ISO)

oxidoreductase activity (IBA,IEA)

protein binding (ISO)

testosterone dehydrogenase (NADP+) activity (IEA)

very-long-chain 3-oxoacyl-CoA reductase activity (IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

steroid hormone biosynthetic pathway (IEA)

unsaturated fatty acid biosynthetic pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2.	KEGG: Kyoto Encyclopedia of Genes and Genomes	KEGG
3.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
4.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
5.	GOA pipeline	RGD automated data pipeline
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Comprehensive gene review and curation	RGD comprehensive gene curation
8.	Information Derived from GenBank Report	RGD, Sept. 2003
9.	Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.	Strausberg RL, etal., Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. Epub 2002 Dec 11.

Additional References at PubMed

PMID:12482854	PMID:15489334	PMID:18757743	PMID:23106098

Genomics

Comparative Map Data

Hsd17b12
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	3	100,445,393 - 100,568,898 (-)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	3	100,445,400 - 100,568,938 (-)	Ensembl				GRCr8
mRatBN7.2	3	79,990,048 - 80,113,556 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	3	79,990,056 - 80,113,617 (-)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	3	83,463,561 - 83,587,647 (-)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	3	92,062,651 - 92,186,743 (-)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	3	89,908,167 - 90,032,005 (-)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	3	82,924,699 - 83,048,465 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	3	82,924,687 - 83,048,435 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	3	89,626,176 - 89,749,541 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	3	78,436,634 - 78,559,707 (-)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	3	79,190,922 - 79,314,232 (-)	NCBI		Celera
RGSC_v3.1	3	78,333,061 - 78,456,135 (-)	NCBI
Cytogenetic Map	3	q31	NCBI

HSD17B12
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	43,556,721 - 43,856,615 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	43,680,509 - 43,857,741 (+)	Ensembl			hg38	GRCh38
GRCh37	11	43,702,288 - 43,878,165 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	43,658,719 - 43,834,745 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	11	43,658,880 - 43,834,744	NCBI
Celera	11	43,848,404 - 44,024,379 (+)	NCBI		Celera
Cytogenetic Map	11	p11.2	NCBI
HuRef	11	43,412,072 - 43,587,812 (+)	NCBI		HuRef
CHM1_1	11	43,701,792 - 43,877,827 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	11	43,731,842 - 44,012,332 (+)	NCBI		T2T-CHM13v2.0

Hsd17b12
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	2	93,863,042 - 93,988,254 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	2	93,863,034 - 93,988,309 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	2	94,032,697 - 94,157,909 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	2	94,032,689 - 94,157,964 (-)	Ensembl			mm10	GRCm38
MGSCv37	2	93,872,854 - 93,998,066 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	2	93,833,536 - 93,958,748 (-)	NCBI		MGSCv36	mm8
Celera	2	95,429,240 - 95,554,423 (-)	NCBI		Celera
Cytogenetic Map	2	E1	NCBI
cM Map	2	51.62	NCBI

Hsd17b12
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955422	3,717,666 - 3,864,801 (-)	Ensembl
ChiLan1.0	NW_004955422	3,721,452 - 3,864,801 (-)	NCBI	ChiLan1.0	ChiLan1.0

HSD17B12
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	45,895,986 - 46,071,909 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	45,901,905 - 46,077,829 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	43,641,323 - 43,817,214 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	44,137,597 - 44,312,986 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	44,137,597 - 44,312,986 (+)	Ensembl			panPan2	panpan1.1

HSD17B12
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	25,907,366 - 26,061,643 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	25,908,555 - 26,061,616 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	25,594,145 - 25,748,413 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	26,529,683 - 26,683,219 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	26,529,049 - 26,683,212 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	26,039,150 - 26,192,361 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	25,684,733 - 25,839,066 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	26,296,764 - 26,451,042 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Hsd17b12
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	22,688,930 - 22,837,837 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936562	4,802,282 - 4,949,468 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936562	4,802,282 - 4,949,500 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

HSD17B12
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	18,456,019 - 18,611,782 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	2	18,461,487 - 18,611,761 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	20,061,561 - 20,211,999 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

HSD17B12
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	21,530,292 - 21,702,552 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	21,528,391 - 21,702,455 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666038	118,767,304 - 118,938,354 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Hsd17b12
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624767	4,160,053 - 4,316,370 (-)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624767	4,163,452 - 4,315,827 (-)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Hsd17b12
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	5	68,190,715 - 68,314,559 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Hsd17b12
498 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	646
Count of miRNA genes:	233
Interacting mature miRNAs:	290
Transcripts:	ENSRNOT00000012806, ENSRNOT00000047571
Prediction methods:	Microtar, Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300178	Hrtrt4	Heart rate QTL 4	3.74		heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	51490129	111359995	Rat
61377	Edpm3	Estrogen-dependent pituitary mass QTL 3	7.05	0.038	pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	73592611	110333156	Rat
1358293	Bw38	Body weight QTL 38	6	0.0000031	body mass (VT:0001259)	body weight (CMO:0000012)	3	74364268	119364268	Rat
2301414	Kidm37	Kidney mass QTL 37		0.001	kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	3	96509147	141509147	Rat
1582238	Bw68	Body weight QTL 68	3.2	0.0064	body mass (VT:0001259)	body weight (CMO:0000012)	3	73592512	136118980	Rat
1582239	Epfw1	Epididymal fat weight QTL 1	4.5	0.0006	epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	3	73592512	136118980	Rat
70216	Cm14	Cardiac mass QTL 14	2.1		heart mass (VT:0007028)	heart wet weight (CMO:0000069)	3	51581665	184004958	Rat
2292591	Esta4	Estrogen-induced thymic atrophy QTL 4			thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	3	67641776	167835660	Rat
1358362	Srcrt2	Stress Responsive Cort QTL 2	2.78		blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	3	58601291	153936591	Rat
737818	Hcar12	Hepatocarcinoma resistance QTL 12	2.6		liver integrity trait (VT:0010547)	volume of individual liver tumorous lesion (CMO:0001078)	3	49872657	138829559	Rat
1582218	Bw74	Body weight QTL 74	3.9	0.0021	body mass (VT:0001259)	body weight (CMO:0000012)	3	73592512	136118980	Rat
1582221	Kidm30	Kidney mass QTL 30	3.5	0.0008	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	3	85062224	136118980	Rat
1582210	Bw71	Body weight QTL 71	3.3	0.0012	body mass (VT:0001259)	body weight (CMO:0000012)	3	85062224	136118980	Rat
1300111	Rf12	Renal function QTL 12	3.78		renal blood flow trait (VT:2000006)	absolute change in renal blood flow rate (CMO:0001168)	3	81425008	141509147	Rat
724523	Tsu1	Thymus enlargement suppressive QTL 1	3.84		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	3	70845569	136091483	Rat
1600376	Arunc5	Aerobic running capacity QTL 5		0.21	exercise endurance trait (VT:0002332)	longest distance run on treadmill (CMO:0001406)	3	93829559	138829559	Rat
8662816	Vetf4	Vascular elastic tissue fragility QTL 4	4		renal artery integrity trait (VT:0010642)	number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)	3	79649560	177741895	Rat
2292613	Ept16	Estrogen-induced pituitary tumorigenesis QTL 16	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	67641995	130815812	Rat
1581503	Cm58	Cardiac mass QTL 58	2.7	0.05	heart left ventricle mass (VT:0007031)	heart left ventricle weight to body weight ratio (CMO:0000530)	3	96509147	141509147	Rat
738019	Anxrr10	Anxiety related response QTL 10	3.9		exploratory behavior trait (VT:0010471)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	3	58925062	103925062	Rat
631841	Niddm39	Non-insulin dependent diabetes mellitus QTL 39	3.36		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	3	70311536	115311536	Rat
631200	Cm25	Cardiac mass QTL 25	4.8	0.0001	heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	3	81541464	126563126	Rat
12879848	Bw181	Body weght QTL 181		0.015	body mass (VT:0001259)	body weight (CMO:0000012)	3	90755164	141509147	Rat
1358905	Hrtrt17	Heart rate QTL 17	5.9	0.000014	heart pumping trait (VT:2000009)	heart rate (CMO:0000002)	3	36721849	110333156	Rat
1358885	Bp251	Blood pressure QTL 251	3.8		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	1	141509147	Rat
1354597	Kidm13	Kidney mass QTL 13	2.9		kidney mass (VT:0002707)	right kidney wet weight (CMO:0000082)	3	42158111	124558371	Rat
1581546	Pur13	Proteinuria QTL 13	2.93	0.0335	urine total protein amount (VT:0000032)	urine protein excretion rate (CMO:0000759)	3	98651826	167012663	Rat
1354604	Bw36	Body weight QTL 36	2.9		body mass (VT:0001259)	body weight (CMO:0000012)	3	42158111	124558371	Rat
1358888	Bp264	Blood pressure QTL 264	4.43		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	3	5675975	141509147	Rat
1358186	Ept2	Estrogen-induced pituitary tumorigenesis QTL 2	8.3		pituitary gland mass (VT:0010496)	pituitary gland wet weight (CMO:0000853)	3	67641995	130815812	Rat

Markers in Region

RH134631

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	79,990,143 - 79,990,352 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	82,924,789 - 82,924,997	NCBI	Rnor6.0
Rnor_5.0	3	89,626,266 - 89,626,474	UniSTS	Rnor5.0
RGSC_v3.4	3	78,436,722 - 78,436,930	UniSTS	RGSC3.4
Celera	3	79,191,010 - 79,191,218	UniSTS
RH 3.4 Map	3	691.6	UniSTS
Cytogenetic Map	3	q31	UniSTS

RH138068

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	3	80,097,295 - 80,097,426 (+)	MAPPER	mRatBN7.2
Rnor_6.0	3	83,032,055 - 83,032,185	NCBI	Rnor6.0
Rnor_5.0	3	89,733,310 - 89,733,440	UniSTS	Rnor5.0
RGSC_v3.4	3	78,543,281 - 78,543,411	UniSTS	RGSC3.4
Celera	3	79,298,084 - 79,298,214	UniSTS
RH 3.4 Map	3	694.9	UniSTS
Cytogenetic Map	3	q31	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	165	91	90	59	92	59	6	356	192	11	144	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_032066	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006234599	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC140988	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC061543	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473949	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ213557	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FQ214777	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U81186	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000012806 ⟹ ENSRNOP00000012806

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	100,445,400 - 100,568,938 (-)	Ensembl
mRatBN7.2 Ensembl	3	79,990,056 - 80,113,617 (-)	Ensembl
Rnor_6.0 Ensembl	3	82,924,687 - 83,048,435 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000047571 ⟹ ENSRNOP00000041197

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	100,445,400 - 100,568,938 (-)	Ensembl
mRatBN7.2 Ensembl	3	79,990,058 - 80,113,549 (-)	Ensembl
Rnor_6.0 Ensembl	3	82,924,701 - 83,048,289 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000111181 ⟹ ENSRNOP00000082994

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	3	100,451,171 - 100,568,938 (-)	Ensembl
mRatBN7.2 Ensembl	3	79,996,765 - 80,113,563 (-)	Ensembl

RefSeq Acc Id:

NM_032066 ⟹ NP_114455

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	3	100,445,393 - 100,568,898 (-)	NCBI
mRatBN7.2	3	79,990,048 - 80,113,556 (-)	NCBI
Rnor_6.0	3	82,924,701 - 83,048,289 (-)	NCBI
Rnor_5.0	3	89,626,176 - 89,749,541 (-)	NCBI
RGSC_v3.4	3	78,436,634 - 78,559,707 (-)	RGD
Celera	3	79,190,922 - 79,314,232 (-)	RGD

Sequence:

show sequence

TGGCGAGTTATGGAGCGCGCTCTCCCGGCGGCCGGCTTCCTATACTGGGTGGGCGCGAGCACCA
TTGCTTACCTGACCCTGCGAGCCTCGTACTCGCTCTTCAGGGCCTTCCAGGTGTGGTGCGTGGG
CAACCAGGCCTTTGTCGGCCCGCGGCTCGGAGAATGGGCAGTTGTTACAGGTGGCACTGATGGA
ATTGGAAAATCATATGCAGAAGAGTTAGCAAAGCGTGGAATGAAGATTGTCTTGATAAGCAGAT
CCCAGGATAAACTGAAGGAAGTTTCCAACAACATCAAAGAAAAATTCAACGTTGAAACAAGGAC
CATTGCTGTCGACTTTTCATTGGATGATATTTATGATAAAATTAAGACAGGCCTGTCTGGTCTT
GAAATTGGCGTTTTAGTGAACAACGTGGGCATGTCATACGAGTATCCAGAATACTTTTTGGAAA
TTCCTGACTTGGACAACACCATCAAGAAACTGATAAATATTAATGTGCTTTCCATTTGCAAGGT
GACACGCTTGGTGCTGCCTGGCATGGTAGAGAGATCTAAAGGGGTGATTCTCAACATCTCCTCT
GCCAGTGGCATGCTCCCGGTTCCACTGTTGACAGTCTACTCTGCAACCAAGGCCTTTGTAGATT
TCTTCTCTCAGTGCCTCCATGAGGAGTATAAGAGCAAGGGCATCTTTGTGCAGAGTGTCCTGCC
ATTCTTTGTATCTACAAAACTGGCAAAAATACGGAAGCCGACTTTGGATAAGCCCTCTGCAGAG
ACATTTGTGAAGTCTGCAATTAAAACAGTAGGTCTGCAGACCCGAACCACTGGGATATGTGATC
CACGCCATCATGGGCTCAATAAACTCAATCTTGCCCCGTTGGATTTATTTTAAAACGATCATGG
GTTTCAACAAGTCTTTGCGGAATCGCTATCTGAAGAAAACCAAGAAGAACTAAGTTCTGCTGGG
TCATCGAGCTCCTTGGCCAGACGCTTGACCTGTGCTTGCATACTGGGCCCCTGCCTGTCCCCAG
AGTCTCTACTGTCATCTCAGTAATTACTAACATGGCATAGCTGGCGGAAAGCAAATTCCTTTTA
GAGGTTCCTAACATATATTCTGGATACAACCAGGAGTAATTTGAAGTTTAATATAAATGTTCTT
GGCAAATGTATGTATACCACTTTGACAGAAAGGAACAGATCCCAGAATGACAGACGTAGCACCC
ATCCGGCCCAGAATGCCAATGATTACCTAATATTTGGTCTGGAACCTACTATAAAGTGTAATAG
CTAGCTACTTTTTTATTTTTAACATTAAAGGGAATGGGGCTTAGTTGATTTTTTTTTTATGGGC
AGATACAATGCAGTTTACATTGATTTCTGTAAGGTTTTCTAAAGGTATGTTCCAGCTTATGTGT
TTCTATGGAACTGGTCTTCTTAAAAGTAGCTAAGAAAGACATAAAGAGAATTGAAACACGGAGT
TCTTTCTAACACAGAAGTCCACAAAATGTTATTCTTGGAACACACATTATGTCTGCTCTGTTCC
ATGTATGTAAATACTGAATGCTATATAGTGTGACTGAAATGTAAAGGTAAGTGGGCCCAAGTGT
ACATCAAGACCAGCAACATCCTGTGGTACTGTGGGATCCAGAAGAGCAGCCTGCCTGGATATCC
AGTGTTGGTCATGTCTGTACTGCACCCATACTATTTGCCTAGGATGACAGACTCCTTCTGTGGT
AGTGAGGGGTCATGGAAACATGTTCTTTTTAAGTTGGTGTCTCATTTGAATTCATATATCCACT
TTTAATAAAAGATGATGTAACCGCAAAAAAAAAAAAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_114455	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAD00504	(Get FASTA)	NCBI Sequence Viewer
	AAH61543	(Get FASTA)	NCBI Sequence Viewer
	EDL79605	(Get FASTA)	NCBI Sequence Viewer
	EDL79606	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000012806
	ENSRNOP00000012806.4
GenBank Protein	Q6P7R8	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_114455 ⟸ NM_032066

- UniProtKB:

Q6P7R8 (UniProtKB/Swiss-Prot), Q9Z1B9 (UniProtKB/Swiss-Prot), A6HNK4 (UniProtKB/TrEMBL), D3ZPU3 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MERALPAAGFLYWVGASTIAYLTLRASYSLFRAFQVWCVGNQAFVGPRLGEWAVVTGGTDGIGK
SYAEELAKRGMKIVLISRSQDKLKEVSNNIKEKFNVETRTIAVDFSLDDIYDKIKTGLSGLEIG
VLVNNVGMSYEYPEYFLEIPDLDNTIKKLININVLSICKVTRLVLPGMVERSKGVILNISSASG
MLPVPLLTVYSATKAFVDFFSQCLHEEYKSKGIFVQSVLPFFVSTKLAKIRKPTLDKPSAETFV
KSAIKTVGLQTRTTGICDPRHHGLNKLNLAPLDLF

hide sequence

Ensembl Acc Id:

ENSRNOP00000041197 ⟸ ENSRNOT00000047571

Ensembl Acc Id:

ENSRNOP00000012806 ⟸ ENSRNOT00000012806

Ensembl Acc Id:

ENSRNOP00000082994 ⟸ ENSRNOT00000111181

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q6P7R8-F1-model_v2	AlphaFold	Q6P7R8	1-312	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13692236

Promoter ID:

EPDNEW_R2761

Type:

multiple initiation site

Name:

Hsd17b12_1

Description:

hydroxysteroid (17-beta) dehydrogenase 12

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	3	83,048,324 - 83,048,384	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:708367	AgrOrtholog
BioCyc Gene	G2FUF-48658	BioCyc
BioCyc Pathway	PWY-5080 [very long chain fatty acid biosynthesis I]	BioCyc
	PWY-6598 [sciadonate biosynthesis]	BioCyc
	PWY-7036 [very long chain fatty acid biosynthesis II]	BioCyc
	PWY-7049 [icosapentaenoate biosynthesis II (6-desaturase, mammals)]	BioCyc
	PWY-7592 [arachidonate biosynthesis III (6-desaturase, mammals)]	BioCyc
	PWY-7606 [docosahexaenoate biosynthesis III (6-desaturase, mammals)]	BioCyc
	PWY-7619 [juniperonate biosynthesis]	BioCyc
	PWY-7726 [(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)]	BioCyc
	PWY-8041 [ultra-long-chain fatty acid biosynthesis]	BioCyc
BioCyc Pathway Image	PWY-5080	BioCyc
	PWY-6598	BioCyc
	PWY-7036	BioCyc
	PWY-7049	BioCyc
	PWY-7592	BioCyc
	PWY-7606	BioCyc
	PWY-7619	BioCyc
	PWY-7726	BioCyc
	PWY-8041	BioCyc
Ensembl Genes	ENSRNOG00000009630	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000012806	ENTREZGENE
	ENSRNOT00000012806.8	UniProtKB/Swiss-Prot
Gene3D-CATH	NAD(P)-binding Rossmann-like Domain	UniProtKB/Swiss-Prot
IMAGE_CLONE	IMAGE:6888949	IMAGE-MGC_LOAD
InterPro	NAD(P)-bd_dom_sf	UniProtKB/Swiss-Prot
	Sc_DH/Rdtase_CS	UniProtKB/Swiss-Prot
	SDR_fam	UniProtKB/Swiss-Prot
	VLCFA-Steroid_DH	UniProtKB/Swiss-Prot
KEGG Report	rno:84013	UniProtKB/Swiss-Prot
MGC_CLONE	MGC:72757	IMAGE-MGC_LOAD
NCBI Gene	84013	ENTREZGENE
PANTHER	RH59310P	UniProtKB/Swiss-Prot
	VERY-LONG-CHAIN 3-OXOACYL-COA REDUCTASE	UniProtKB/Swiss-Prot
Pfam	adh_short	UniProtKB/Swiss-Prot
PhenoGen	Hsd17b12	PhenoGen
PIRSF	11-beta-HSD1	UniProtKB/Swiss-Prot
PRINTS	GDHRDH	UniProtKB/Swiss-Prot
	SDRFAMILY	UniProtKB/Swiss-Prot
PROSITE	ADH_SHORT	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000009630	RatGTEx
Superfamily-SCOP	SSF51735	UniProtKB/Swiss-Prot
UniProt	A0A8I5ZVN1_RAT	UniProtKB/TrEMBL
	A6HNK4	ENTREZGENE, UniProtKB/TrEMBL
	A6HNK5_RAT	UniProtKB/TrEMBL
	D3ZPU3	ENTREZGENE, UniProtKB/TrEMBL
	DHB12_RAT	UniProtKB/Swiss-Prot, ENTREZGENE
	Q9Z1B9	ENTREZGENE
UniProt Secondary	Q9Z1B9	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2006-03-30	Hsd17b12	hydroxysteroid (17-beta) dehydrogenase 12		smooth muscle-specific 17 beta-hydroxysteroid dehydrogenase type 3	Name updated	1299863	APPROVED
2004-09-10	Hsd17b12	smooth muscle-specific 17 beta-hydroxysteroid dehydrogenase type 3	LOC84013		Symbol and Name updated	1299863	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Annotations - KEGG (archival)

BioCyc Pathways

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Imported Annotations - KEGG (archival)

BioCyc Pathways