Impg2 (interphotoreceptor matrix proteoglycan 2) - Rat Genome Database

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Gene: Impg2 (interphotoreceptor matrix proteoglycan 2) Rattus norvegicus
Analyze
Symbol: Impg2 (Ensembl: Senp7)
Name: interphotoreceptor matrix proteoglycan 2 (Ensembl:SUMO specific peptidase 7)
RGD ID: 708358
Description: Predicted to enable heparin binding activity and hyaluronic acid binding activity. Predicted to be involved in visual perception. Predicted to act upstream of or within extracellular matrix organization; intracellular protein localization; and retina morphogenesis in camera-type eye. Predicted to be located in interphotoreceptor matrix. Predicted to be part of receptor complex. Human ortholog(s) of this gene implicated in retinitis pigmentosa 56 and vitelliform macular dystrophy. Orthologous to human IMPG2 (interphotoreceptor matrix proteoglycan 2); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; bisphenol A; flavonoids.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: Pg10.2; sialoprotein associated with cones and rods proteoglycan; spacrcan
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81157,787,914 - 57,887,450 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1157,787,914 - 58,033,766 (-)EnsemblGRCr8
mRatBN7.21144,318,836 - 44,418,382 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1144,318,836 - 44,418,382 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1153,102,588 - 53,195,399 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01145,764,196 - 45,857,013 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01144,888,351 - 44,981,173 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01146,615,091 - 46,693,565 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1146,615,200 - 46,693,565 (-)Ensemblrn6Rnor6.0
Rnor_5.01149,797,496 - 49,875,529 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41145,267,158 - 45,385,026 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1144,082,608 - 44,170,046 (-)NCBICelera
RGSC_v3.11145,324,746 - 45,442,615 (-)NCBI
Cytogenetic Map11q12NCBI
JBrowse:




Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
3. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
4. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
5. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
6. Sequence analysis of PG10.2, a gene expressed in the pineal gland and the outer nuclear layer of the retina. Wang X, etal., Brain Res Mol Brain Res 1996 Sep 5;41(1-2):269-78.
Additional References at PubMed
PMID:15044457   PMID:23382219  


Genomics

Comparative Map Data
Impg2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81157,787,914 - 57,887,450 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1157,787,914 - 58,033,766 (-)EnsemblGRCr8
mRatBN7.21144,318,836 - 44,418,382 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1144,318,836 - 44,418,382 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1153,102,588 - 53,195,399 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01145,764,196 - 45,857,013 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01144,888,351 - 44,981,173 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01146,615,091 - 46,693,565 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1146,615,200 - 46,693,565 (-)Ensemblrn6Rnor6.0
Rnor_5.01149,797,496 - 49,875,529 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41145,267,158 - 45,385,026 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1144,082,608 - 44,170,046 (-)NCBICelera
RGSC_v3.11145,324,746 - 45,442,615 (-)NCBI
Cytogenetic Map11q12NCBI
IMPG2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383101,222,546 - 101,320,575 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3101,222,546 - 101,320,575 (-)Ensemblhg38GRCh38
GRCh373100,941,390 - 101,039,419 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363102,427,978 - 102,522,109 (-)NCBIBuild 36Build 36hg18NCBI36
Build 343102,427,977 - 102,522,109NCBI
Celera399,336,927 - 99,431,029 (-)NCBICelera
Cytogenetic Map3q12.3NCBI
HuRef398,310,078 - 98,408,005 (-)NCBIHuRef
CHM1_13100,904,435 - 101,002,378 (-)NCBICHM1_1
T2T-CHM13v2.03103,928,482 - 104,026,449 (-)NCBIT2T-CHM13v2.0
Impg2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391656,019,447 - 56,094,119 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1656,024,676 - 56,094,119 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm381656,203,839 - 56,273,753 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1656,204,313 - 56,273,756 (+)Ensemblmm10GRCm38
MGSCv371656,204,426 - 56,273,866 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv361656,129,264 - 56,198,704 (+)NCBIMGSCv36mm8
Celera1656,513,770 - 56,586,681 (+)NCBICelera
Cytogenetic Map16C1.1NCBI
cM Map1633.91NCBI
Impg2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554272,826,457 - 2,919,282 (-)Ensembl
ChiLan1.0NW_0049554272,825,940 - 2,919,282 (-)NCBIChiLan1.0ChiLan1.0
IMPG2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2299,175,172 - 99,265,863 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1399,179,956 - 99,270,644 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0398,325,379 - 98,418,344 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.13105,005,029 - 105,098,122 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3105,005,553 - 105,097,902 (-)EnsemblpanPan2panpan1.1
IMPG2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1337,706,069 - 7,785,817 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl337,709,683 - 7,785,309 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha337,857,507 - 7,940,480 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.0337,842,019 - 7,924,899 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl337,848,570 - 7,924,188 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1337,730,507 - 7,813,125 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0337,776,490 - 7,858,926 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0338,116,576 - 8,198,496 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Impg2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405602149,085,104 - 149,174,028 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366301,982,783 - 2,071,953 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366301,982,860 - 2,069,472 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IMPG2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13157,675,265 - 157,759,266 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.113157,672,973 - 157,763,817 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213167,156,425 - 167,213,189 (+)NCBISscrofa10.2Sscrofa10.2susScr3
IMPG2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12279,560,987 - 79,664,906 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2279,561,498 - 79,660,472 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604186,901,526 - 86,998,968 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Impg2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462478915,060,525 - 15,175,617 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462478915,056,692 - 15,184,385 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Impg2
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1440,319,401 - 40,383,182 (+)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Impg2
306 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:45
Count of miRNA genes:42
Interacting mature miRNAs:43
Transcripts:ENSRNOT00000044900
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1300147Bp187Blood pressure QTL 1873.67arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)112252474682951192Rat
724554Iddm17Insulin dependent diabetes mellitus QTL 170.001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)114644316891443168Rat
1598841Memor7Memory QTL 7exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)113330600878306008Rat
1598811Bp291Blood pressure QTL 2911.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113330600878306008Rat
8694376Bw156Body weight QTL 1562.250.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
10755497Bp388Blood pressure QTL 3882.76arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)113294306789836615Rat
1300130Rf20Renal function QTL 204.44kidney glomerulus integrity trait (VT:0010546)kidney glomerulus diameter (CMO:0001166)113191546976915469Rat
10058952Gmadr6Adrenal mass QTL 62.290.0072adrenal gland mass (VT:0010420)both adrenal glands wet weight to body weight ratio (CMO:0002411)113642841681428416Rat
1600394Edcs1Endometrial carcinoma susceptibility QTL12.90.04uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)111282315257823152Rat
1300135Rf19Renal function QTL 193.38blood creatinine amount (VT:0005328)creatinine clearance (CMO:0000765)115441539196071021Rat
1558659Tescar1Testicular tumor resistance QTL 13.9testis integrity trait (VT:0010572)percentage of study population developing testis tumors during a period of time (CMO:0001261)113461876079618760Rat
2312566Glom20Glomerulus QTL 203.60.001kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)115775483796071021Rat
724563Uae10Urinary albumin excretion QTL 106urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)112019354996351019Rat
9589032Epfw10Epididymal fat weight QTL 109.290.001epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)113674945981749459Rat
9590313Scort20Serum corticosterone level QTL 206.510.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)113674945981749459Rat
8694424Bw162Body weight QTL 1623.80.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)113674945981749459Rat
1300110Stl7Serum triglyceride level QTL 74.64blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)115107102196071021Rat
631510Spl2Serum phospholipid level QTL 24.1blood phospholipid amount (VT:0006084)serum phospholipid level (CMO:0001171)112755668572556685Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
10 8 48 150 66 65 34 75 34 6 265 149 8 130 64 89 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000044900   ⟹   ENSRNOP00000046981
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1144,318,836 - 44,418,382 (-)Ensembl
Rnor_6.0 Ensembl1146,615,200 - 46,693,565 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000094394   ⟹   ENSRNOP00000092307
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1144,318,836 - 44,418,382 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000103062   ⟹   ENSRNOP00000083635
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1144,321,439 - 44,418,382 (-)Ensembl
RefSeq Acc Id: NM_139088   ⟹   NP_620788
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81157,787,914 - 57,887,450 (-)NCBI
mRatBN7.21144,318,836 - 44,418,382 (-)NCBI
Rnor_6.01146,615,200 - 46,693,565 (-)NCBI
Rnor_5.01149,797,496 - 49,875,529 (-)NCBI
RGSC_v3.41145,267,158 - 45,385,026 (-)RGD
Celera1144,082,608 - 44,170,046 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_620788 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAC52891 (Get FASTA)   NCBI Sequence Viewer  
  EDM11049 (Get FASTA)   NCBI Sequence Viewer  
  EDM11050 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000046981
GenBank Protein P70628 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_620788   ⟸   NM_139088
- Peptide Label: precursor
- UniProtKB: P70628 (UniProtKB/Swiss-Prot),   A6IQP7 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000046981   ⟸   ENSRNOT00000044900
Ensembl Acc Id: ENSRNOP00000083635   ⟸   ENSRNOT00000103062
Ensembl Acc Id: ENSRNOP00000092307   ⟸   ENSRNOT00000094394
Protein Domains
EGF-like   SEA   Ubiquitin-like protease family profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70628-F1-model_v2 AlphaFold P70628 1-1241 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708358 AgrOrtholog
BioCyc Gene G2FUF-21520 BioCyc
Ensembl Genes ENSRNOG00000001616 Ensembl, ENTREZGENE
  ENSRNOG00000001622 Ensembl
Ensembl Transcript ENSRNOT00000044900 ENTREZGENE
Gene3D-CATH 3.30.70.960 UniProtKB/Swiss-Prot
  Laminin UniProtKB/Swiss-Prot
InterPro EGF-like_dom UniProtKB/Swiss-Prot
  IMPG UniProtKB/Swiss-Prot
  SEA_dom UniProtKB/Swiss-Prot
  SEA_dom_sf UniProtKB/Swiss-Prot
NCBI Gene 245919 ENTREZGENE
PANTHER PTHR12199 UniProtKB/Swiss-Prot
  PTHR12199:SF4 UniProtKB/Swiss-Prot
Pfam SEA UniProtKB/Swiss-Prot
PhenoGen Impg2 PhenoGen
PROSITE EGF_2 UniProtKB/Swiss-Prot
  EGF_3 UniProtKB/Swiss-Prot
  SEA UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000001616 RatGTEx
  ENSRNOG00000001622 RatGTEx
SMART SEA UniProtKB/Swiss-Prot
Superfamily-SCOP SSF82671 UniProtKB/Swiss-Prot
UniProt A0A8I5ZQB4_RAT UniProtKB/TrEMBL
  A0A8I5ZZQ5_RAT UniProtKB/TrEMBL
  A0A8I6GJN4_RAT UniProtKB/TrEMBL
  A0A8L2ULP5_RAT UniProtKB/TrEMBL
  A0ABK0KWC1_RAT UniProtKB/TrEMBL
  A0ABK0M2V5_RAT UniProtKB/TrEMBL
  A6IQP6_RAT UniProtKB/TrEMBL
  A6IQP7 ENTREZGENE, UniProtKB/TrEMBL
  F1LNC8_RAT UniProtKB/TrEMBL
  IMPG2_RAT UniProtKB/Swiss-Prot, ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2005-07-08 Impg2  interphotoreceptor matrix proteoglycan 2  Pg10.2  PG10.2 protein  Symbol and Name updated 1299863 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed only in the pineal gland and the retina outer nuclear layer 1299390