Defb22 (defensin beta 22) - Rat Genome Database

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Gene: Defb22 (defensin beta 22) Rattus norvegicus
Analyze
Symbol: Defb22
Name: defensin beta 22
RGD ID: 708352
Description: Predicted to be involved in antimicrobial humoral immune response mediated by antimicrobial peptide. Predicted to be located in cell surface and sperm glycocalyx. Orthologous to human DEFB126 (defensin beta 126); INTERACTS WITH allethrin; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: 2D6 glycoprotein; 2D6glycoprotein; beta-defensin 126; beta-defensin 22; E-3 epididymal fluid protein; LOC171412
RGD Orthologs
Human
Mouse
Bonobo
Dog
Pig
Green Monkey
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83161,417,380 - 161,421,659 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3161,417,377 - 161,421,659 (-)EnsemblGRCr8
mRatBN7.23140,957,093 - 140,961,373 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3140,957,090 - 140,961,373 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3144,862,391 - 144,866,652 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03153,446,236 - 153,450,497 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03151,186,206 - 151,190,465 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd3159,521,690 - 159,525,952 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive3166,489,051 - 166,493,330 (-)NCBILyon_Normotensive
Lyon_Hypertensive3158,348,916 - 158,353,195 (-)NCBILyon_Hypertensive
F344_StmMcwi3139,359,412 - 139,363,673 (-)NCBIF344_StmMcwi
Rnor_6.03147,961,818 - 147,966,097 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3147,961,818 - 147,966,097 (-)Ensemblrn6Rnor6.0
Rnor_5.03154,307,909 - 154,312,188 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43142,813,671 - 142,817,950 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3139,708,679 - 139,712,958 (-)NCBICelera
RGSC_v3.13142,719,243 - 142,723,523 (-)NCBI
Cytogenetic Map3q41NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Cloning and characterization of a novel sperm-associated isoantigen (E-3) with defensin- and lectin-like motifs expressed in rat epididymis. Rao J, etal., Biol Reprod 2003 Jan;68(1):290-301.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:16033865   PMID:18787081   PMID:19373462   PMID:21151152  


Genomics

Comparative Map Data
Defb22
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr83161,417,380 - 161,421,659 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl3161,417,377 - 161,421,659 (-)EnsemblGRCr8
mRatBN7.23140,957,093 - 140,961,373 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3140,957,090 - 140,961,373 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx3144,862,391 - 144,866,652 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.03153,446,236 - 153,450,497 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.03151,186,206 - 151,190,465 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Dahl_SR_JrHsd3159,521,690 - 159,525,952 (-)NCBIDahl_SR_JrHsd
Lyon_Normotensive3166,489,051 - 166,493,330 (-)NCBILyon_Normotensive
Lyon_Hypertensive3158,348,916 - 158,353,195 (-)NCBILyon_Hypertensive
F344_StmMcwi3139,359,412 - 139,363,673 (-)NCBIF344_StmMcwi
Rnor_6.03147,961,818 - 147,966,097 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3147,961,818 - 147,966,097 (-)Ensemblrn6Rnor6.0
Rnor_5.03154,307,909 - 154,312,188 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.43142,813,671 - 142,817,950 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera3139,708,679 - 139,712,958 (-)NCBICelera
RGSC_v3.13142,719,243 - 142,723,523 (-)NCBI
Cytogenetic Map3q41NCBI
DEFB126
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3820142,590 - 145,751 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl20142,590 - 145,751 (+)Ensemblhg38GRCh38
GRCh3720123,231 - 126,392 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362071,252 - 74,392 (+)NCBIBuild 36Build 36hg18NCBI36
Build 342071,251 - 74,392NCBI
Celera20218,098 - 221,236 (+)NCBICelera
Cytogenetic Map20p13NCBI
HuRef2076,402 - 79,598 (+)NCBIHuRef
CHM1_120123,217 - 126,409 (+)NCBICHM1_1
T2T-CHM13v2.020185,041 - 188,196 (+)NCBIT2T-CHM13v2.0
Defb22
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392152,327,586 - 152,332,058 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2152,327,583 - 152,332,058 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm382152,485,666 - 152,490,138 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2152,485,663 - 152,490,138 (-)Ensemblmm10GRCm38
MGSCv372152,311,402 - 152,315,874 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv362152,177,107 - 152,181,579 (-)NCBIMGSCv36mm8
Celera2158,301,129 - 158,305,581 (-)NCBICelera
Cytogenetic Map2H1NCBI
cM Map275.13NCBI
DEFB126
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2211,244,487 - 1,247,643 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1201,241,314 - 1,244,470 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v020367,017 - 370,168 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.120142,829 - 146,207 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl20142,829 - 146,213 (+)EnsemblpanPan2panpan1.1
DEFB126
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12420,725,762 - 20,730,314 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2420,725,762 - 20,730,314 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2420,371,940 - 20,376,492 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02421,412,645 - 21,417,197 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2421,412,645 - 21,417,197 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12420,688,851 - 20,693,403 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02420,794,008 - 20,798,560 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02421,224,602 - 21,229,154 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
LOC692190
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11735,043,632 - 35,044,109 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21740,019,519 - 40,019,996 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DEFB126
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Vero_WHO_p1.0NW_0236660787,444,418 - 7,447,041 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Defb126
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v15131,808,446 - 131,812,649 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Defb22
24 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:48
Count of miRNA genes:45
Interacting mature miRNAs:48
Transcripts:ENSRNOT00000009913
Prediction methods:Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2301411Bp320Blood pressure QTL 3200.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)3141555229186555229Rat
12879876Bw182Body weight QTL 1820.003body mass (VT:0001259)body weight (CMO:0000012)3141555229186555229Rat
1582233Insul10Insulin level QTL 105.40.0015blood insulin amount (VT:0001560)serum insulin level times blood glucose level (CMO:0002040)3133259579178259579Rat
12879872Cm97Cardiac mass QTL 970.001heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)3141555229186555229Rat
1578653Vnigr3Vascular neointimal growth QTL 33.1artery morphology trait (VT:0002191)artery neointimal hyperplastic lesion area (CMO:0001414)3151075912189428310Rat
12879873Cm96Cardiac mass QTL 960.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)3141555229186555229Rat
2302373Gluco39Glucose level QTL 395.01blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)3129154923182114333Rat
12879874Cm98Cardiac mass QTL 980.005heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)3141555229186555229Rat
12879875Kidm64Kidney mass QTL 640.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)3141555229186555229Rat
70216Cm14Cardiac mass QTL 142.1heart mass (VT:0007028)heart wet weight (CMO:0000069)351581665184004958Rat
2292591Esta4Estrogen-induced thymic atrophy QTL 4thymus mass (VT:0004954)thymus wet weight (CMO:0000855)367641776167835660Rat
1578754Stresp16Stress response QTL 1640.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)3133134628178134628Rat
1582213Insul6Insulin level QTL 63.70.0009blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
1300173Rf11Renal function QTL 113.38renal blood flow trait (VT:2000006)absolute change in renal blood flow rate (CMO:0001168)3141508991166376254Rat
9589106Insul23Insulin level QTL 2313.860.001blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)3152055202189428310Rat
10755461Coatc16Coat color QTL 16coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)3142898802187898802Rat
8662816Vetf4Vascular elastic tissue fragility QTL 44renal artery integrity trait (VT:0010642)number of ruptures of the internal elastic lamina of the renal arteries (CMO:0002563)379649560177741895Rat
1559282Emca5Estrogen-induced mammary cancer QTL 53.9mammary gland integrity trait (VT:0010552)percentage of study population developing mammary tumors during a period of time (CMO:0000948)3145335553189428310Rat
1354611Despr2Despair related QTL 23.030.0028locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)3117537367162537367Rat
2303620Vencon4Ventilatory control QTL 43.9respiration trait (VT:0001943)tidal volume (CMO:0000222)3125116475170116475Rat
1582256Insul9Insulin level QTL 94.40.0016blood insulin amount (VT:0001560)absolute change in serum insulin level (CMO:0002038)3155759447189428310Rat
1576306Schws3Schwannoma susceptibility QTL 30.001nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)3139299381184299381Rat
1300159Kidm4Kidney mass QTL 43.83kidney mass (VT:0002707)right kidney wet weight to body weight ratio (CMO:0001953)3141508991177728348Rat
5686842Rf59Renal function QTL 59urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)3122395989167395989Rat
631673Iddm13Insulin dependent diabetes mellitus QTL 131.30.663blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)3137114333182114333Rat
1582248Insul7Insulin level QTL 73.90.0041blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)3155759447189428310Rat
2301971Cm71Cardiac mass QTL 714.63heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)3131036586176036586Rat
2301970Bw81Body weight QTL 815.19body mass (VT:0001259)body weight (CMO:0000012)3131036586176036586Rat
1581546Pur13Proteinuria QTL 132.930.0335urine total protein amount (VT:0000032)urine protein excretion rate (CMO:0000759)398651826167012663Rat
1578666Vnigr1Vascular neointimal growth QTL 14.6artery morphology trait (VT:0002191)artery lumen area (CMO:0001409)3151075912189428310Rat
1578656Vnigr2Vascular neointimal growth QTL 24.2artery morphology trait (VT:0002191)lesioned artery residual lumen area (CMO:0001417)3151075912189428310Rat
12879871Am7Aortic mass QTL 70.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)3141555229186555229Rat
631541Bp81Blood pressure QTL 814arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)3144575244189428310Rat
2293087Iddm27Insulin dependent diabetes mellitus QTL 272.68blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)3160357340167835660Rat


Expression

RNA-SEQ Expression

ectoderm
nervous system
reproductive system
1 1 4

Sequence


Ensembl Acc Id: ENSRNOT00000009913   ⟹   ENSRNOP00000009913
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl3161,417,377 - 161,421,659 (-)Ensembl
mRatBN7.2 Ensembl3140,957,090 - 140,961,373 (-)Ensembl
Rnor_6.0 Ensembl3147,961,818 - 147,966,097 (-)Ensembl
RefSeq Acc Id: NM_134391   ⟹   NP_599218
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr83161,417,380 - 161,421,659 (-)NCBI
mRatBN7.23140,957,093 - 140,961,373 (-)NCBI
Dahl_SR_JrHsd3159,521,690 - 159,525,952 (-)NCBI
Lyon_Normotensive3166,489,051 - 166,493,330 (-)NCBI
Lyon_Hypertensive3158,348,916 - 158,353,195 (-)NCBI
F344_StmMcwi3139,359,412 - 139,363,673 (-)NCBI
Rnor_6.03147,961,818 - 147,966,097 (-)NCBI
Rnor_5.03154,307,909 - 154,312,188 (-)NCBI
RGSC_v3.43142,813,671 - 142,817,950 (-)RGD
Celera3139,708,679 - 139,712,958 (-)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_599218 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAK38836 (Get FASTA)   NCBI Sequence Viewer  
  AAT51892 (Get FASTA)   NCBI Sequence Viewer  
  CAC36191 (Get FASTA)   NCBI Sequence Viewer  
  EDL86066 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000009913
  ENSRNOP00000009913.3
RefSeq Acc Id: NP_599218   ⟸   NM_134391
- Peptide Label: precursor
- UniProtKB: Q99JD1 (UniProtKB/TrEMBL),   F7EMH3 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009913   ⟸   ENSRNOT00000009913
Protein Domains
Beta-defensin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q99JD1-F1-model_v2 AlphaFold Q99JD1 1-111 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:708352 AgrOrtholog
BioCyc Gene G2FUF-47267 BioCyc
Ensembl Genes ENSRNOG00000007525 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009913 ENTREZGENE
  ENSRNOT00000009913.7 UniProtKB/TrEMBL
InterPro Beta_defensin UniProtKB/TrEMBL
KEGG Report rno:171412 UniProtKB/TrEMBL
NCBI Gene 171412 ENTREZGENE
Pfam Defensin_beta_2 UniProtKB/TrEMBL
PhenoGen Defb22 PhenoGen
RatGTEx ENSRNOG00000007525 RatGTEx
UniProt F7EMH3 ENTREZGENE, UniProtKB/TrEMBL
  Q99JD1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-03-04 Defb22  defensin beta 22  LOC171412  E-3 epididymal fluid protein  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED