Crhr2 (corticotropin releasing hormone receptor 2) - Rat Genome Database

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Gene: Crhr2 (corticotropin releasing hormone receptor 2) Rattus norvegicus
Analyze
Symbol: Crhr2
Name: corticotropin releasing hormone receptor 2
RGD ID: 70547
Description: Enables corticotropin-releasing hormone receptor activity and peptide hormone binding activity. Involved in several processes, including negative regulation of secretion; regulation of intracellular signal transduction; and regulation of macromolecule biosynthetic process. Located in several cellular components, including axon; cell body fiber; and perikaryon. Used to study colitis; ischemia; and muscular atrophy. Biomarker of colitis; depressive disorder; functional colonic disease; and irritable bowel syndrome. Human ortholog(s) of this gene implicated in asthma. Orthologous to human CRHR2 (corticotropin releasing hormone receptor 2); PARTICIPATES IN protein kinase A (PKA) signaling pathway; corticotropin-releasing hormone signaling pathway; G protein mediated signaling pathway via Galphas family; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium acetate.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: corticotrophin releasing hormone receptor 2; corticotropin-releasing factor receptor 2; corticotropin-releasing factor receptor subtype 2; corticotropin-releasing hormone receptor 2; CRF-R 2; CRF-R-2; CRF-R2; CRF2; Crf2r; CRFR-2; CRH-R 2; CRH-R-2; CRH-R2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Candidate Gene For: Alc18 Alc21 Alc22 Bw126
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8485,553,163 - 85,596,203 (-)NCBIGRCr8
mRatBN7.2484,222,897 - 84,265,924 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl484,224,002 - 84,265,904 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx489,447,028 - 89,474,226 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0485,222,449 - 85,249,647 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0483,634,840 - 83,661,994 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0485,286,371 - 85,329,374 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl485,286,372 - 85,329,362 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04149,943,615 - 149,986,646 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4483,839,822 - 83,867,017 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1484,085,174 - 84,112,370 (+)NCBI
Celera479,091,140 - 79,118,337 (-)NCBICelera
Cytogenetic Map4q24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin filament organization  (IMP)
adenylate cyclase-modulating G protein-coupled receptor signaling pathway  (IBA)
catecholamine biosynthetic process  (IMP)
cell surface receptor signaling pathway  (IEA)
cellular response to corticotropin-releasing hormone stimulus  (IEA)
cellular response to glucocorticoid stimulus  (IEP)
cerebellum development  (IEP)
epithelial cell differentiation  (IMP)
G protein-coupled receptor signaling pathway  (IEA,ISO)
gastric motility  (IMP)
hormone-mediated signaling pathway  (IEA)
hypothalamus development  (IEP)
long-term synaptic potentiation  (IBA,IMP)
negative regulation of angiogenesis  (ISO)
negative regulation of calcium ion import  (IMP)
negative regulation of defecation  (IMP)
negative regulation of epinephrine secretion  (IMP)
negative regulation of feeding behavior  (IDA)
negative regulation of follicle-stimulating hormone secretion  (IMP)
negative regulation of gene expression  (IMP)
negative regulation of insulin secretion involved in cellular response to glucose stimulus  (IMP)
negative regulation of luteinizing hormone secretion  (IMP)
negative regulation of norepinephrine secretion  (IMP)
phospholipase C-activating G protein-coupled receptor signaling pathway  (IMP)
positive regulation of blood pressure  (IMP)
positive regulation of cAMP/PKA signal transduction  (IDA,IMP)
positive regulation of DNA biosynthetic process  (IMP)
positive regulation of gene expression  (IMP)
positive regulation of heart rate  (IMP)
positive regulation of interleukin-6 production  (IMP)
positive regulation of NF-kappaB transcription factor activity  (IMP)
positive regulation of serotonin secretion  (IMP)
positive regulation of stress-activated MAPK cascade  (IMP)
regulation of ERK1 and ERK2 cascade  (IMP)
skeletal muscle tissue growth  (IDA)

Cellular Component
axon  (IDA)
axon terminus  (IBA,IDA)
cell body fiber  (IDA)
dendrite  (IBA,IDA)
membrane  (IEA)
neuronal cell body  (IDA)
perikaryon  (IDA)
plasma membrane  (IBA,IEA,ISO)
varicosity  (IDA)

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Alterations in the central CRF system of two different rat models of comorbid depression and functional gastrointestinal disorders. Bravo JA, etal., Int J Neuropsychopharmacol. 2011 Jun;14(5):666-83. Epub 2010 Sep 22.
2. Antalarmin blockade of corticotropin releasing hormone-induced hypertension in rats. Briscoe RJ, etal., Brain Res. 2000 Oct 27;881(2):204-7.
3. [cDNA cloning and analysis of tissue-specific gene expression of rat urocortin II]. Chae JI, etal., Mol Biol (Mosk). 2009 Jan-Feb;43(1):91-6.
4. Urocortin 1 modulates immunosignaling in a rat model of colitis via corticotropin-releasing factor receptor 2. Chang J, etal., Am J Physiol Gastrointest Liver Physiol. 2011 May;300(5):G884-94. Epub 2011 Feb 17.
5. Urocortin 2 expression in the rat gastrointestinal tract under basal conditions and in chemical colitis. Chang J, etal., Peptides. 2007 Jul;28(7):1453-60. Epub 2007 May 21.
6. Des-acyl ghrelin acts by CRF type 2 receptors to disrupt fasted stomach motility in conscious rats. Chen CY, etal., Gastroenterology. 2005 Jul;129(1):8-25.
7. Abnormal adaptations to stress and impaired cardiovascular function in mice lacking corticotropin-releasing hormone receptor-2. Coste SC, etal., Nat Genet 2000 Apr;24(4):403-9.
8. Neuroanatomical evidence for reciprocal regulation of the corticotrophin-releasing factor and oxytocin systems in the hypothalamus and the bed nucleus of the stria terminalis of the rat: Implications for balancing stress and affect. Dabrowska J, etal., Psychoneuroendocrinology. 2011 Oct;36(9):1312-26. Epub 2011 Apr 9.
9. Corticotropin-releasing factor (CRF) and the urocortins differentially regulate catecholamine secretion in human and rat adrenals, in a CRF receptor type-specific manner. Dermitzaki E, etal., Endocrinology. 2007 Apr;148(4):1524-38. Epub 2006 Dec 28.
10. Maternal deprivation alters epithelial secretory cell lineages in rat duodenum: role of CRF-related peptides. Estienne M, etal., Gut. 2010 Jun;59(6):744-51.
11. Gestational hypoxia alone or combined with restraint sensitizes the hypothalamic-pituitary-adrenal axis and induces anxiety-like behavior in adult male rat offspring. Fan JM, etal., Neuroscience. 2009 Apr 10;159(4):1363-73. Epub 2009 Feb 12.
12. Activation of the nociceptin/orphanin FQ system is unable to reverse CRF2 receptor mediated anorexia in the rat. Fedeli A, etal., Peptides. 2006 Dec;27(12):3284-91. Epub 2006 Oct 16.
13. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
14. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
15. The dynamic developmental localization of the full-length corticotropin-releasing factor receptor type 2 in rat cerebellum. Gounko NV, etal., Eur J Neurosci. 2006 Jun;23(12):3217-24.
16. Activation of corticotropin-releasing factor receptor 2 mediates the colonic motor coping response to acute stress in rodents. Gourcerol G, etal., Gastroenterology. 2011 May;140(5):1586-96.e6. Epub 2011 Jan 26.
17. Cocaine withdrawal enhances long-term potentiation in rat hippocampus via changing the activity of corticotropin-releasing factor receptor subtype 2. Guan X, etal., Neuroscience. 2009 Jul 7;161(3):665-70. Epub 2009 Apr 17.
18. The molecular mechanisms underlying the regulation of the biological activity of corticotropin-releasing hormone receptors: implications for physiology and pathophysiology. Hillhouse EW and Grammatopoulos DK, Endocr Rev. 2006 May;27(3):260-86. Epub 2006 Feb 16.
19. Treatment with a corticotrophin releasing factor 2 receptor agonist modulates skeletal muscle mass and force production in aged and chronically ill animals. Hinkle RT, etal., BMC Musculoskelet Disord. 2011 Jan 14;12:15.
20. Urocortin induces interleukin-6 release from rat cardiomyocytes through p38 MAP kinase, ERK and NF-kappaB activation. Huang M, etal., J Mol Endocrinol. 2009 May;42(5):397-405. Epub 2009 Feb 11.
21. Glucocorticoids differentially regulate the expression of CRFR1 and CRFR2alpha in MIN6 insulinoma cells and rodent islets. Huising MO, etal., Endocrinology. 2011 Jan;152(1):138-50. Epub 2010 Nov 24.
22. [Analgesic effect of corticotropin releasing factor (CRF) on somatic pain sensitivity: participation of glucocorticoid and CRF-2 receptors]. Iarushkina NI, etal., Ross Fiziol Zh Im I M Sechenova. 2008 Oct;94(10):1118-25.
23. Effects of urocortin II on neonatal rat cardiac myocytes and non-myocytes. Ikeda K, etal., Peptides. 2005 Dec;26(12):2473-81. Epub 2005 Jul 7.
24. Corticotropin-releasing hormone receptor-1 and 2 activity produces divergent resistance against stress-induced pulmonary Streptococcus pneumoniae infection. Kim BJ, etal., J Neuroimmunol. 2011 Jul 18.
25. Over-expression of neuropeptide urocortin and its receptors in human allergic nasal mucosa. Kim TH, etal., Laryngoscope. 2007 Sep;117(9):1513-8.
26. Corticotrophin-releasing factor alters the timing of puberty in the female rat. Kinsey-Jones JS, etal., J Neuroendocrinol. 2010 Feb;22(2):102-9. Epub 2009 Dec 4.
27. Deletion of crhr2 reveals an anxiolytic role for corticotropin-releasing hormone receptor-2. Kishimoto T, etal., Nat Genet 2000 Apr;24(4):415-9.
28. Urocortin 3 regulates glucose-stimulated insulin secretion and energy homeostasis. Li C, etal., Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):4206-11. Epub 2007 Feb 27.
29. Excitatory responses of cardiovascular activities to urocortin3 administration into the PVN of the rat. Li X, etal., Auton Neurosci. 2010 Apr 19;154(1-2):108-11. Epub 2010 Jan 8.
30. Cloning and characterization of a functionally distinct corticotropin-releasing factor receptor subtype from rat brain. Lovenberg TW, etal., Proc Natl Acad Sci U S A 1995 Jan 31;92(3):836-40.
31. Dopamine-dependent responses to cocaine depend on corticotropin-releasing factor receptor subtypes. Lu L, etal., J Neurochem 2003 Mar;84(6):1378-86.
32. Topographical distribution of corticotropin-releasing factor type 2 receptor-like immunoreactivity in the rat dorsal raphe nucleus: co-localization with tryptophan hydroxylase. Lukkes JL, etal., Neuroscience. 2011 Jun 2;183:47-63. Epub 2011 Mar 29.
33. The use of H-2 mutants as models for the study of T cell activation. McKenzie IF, etal., Immunol Rev 1977;35:179-230.
34. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
35. Activation of corticotropin-releasing factor receptor-2 causes bronchorelaxation and inhibits pulmonary inflammation in mice. Moffatt JD, etal., FASEB J. 2006 Sep;20(11):1877-9. Epub 2006 Jul 19.
36. Urocortin stimulates tyrosine hydroxylase activity via the cAMP/protein kinase a pathway in rat Pheochromocytoma PC12 cells. Nanmoku T, etal., Neurosci Lett. 2005 Jul 1-8;382(1-2):124-7. Epub 2005 Mar 25.
37. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
38. Novel action of pituitary urocortin 2 in the regulation of expression and secretion of gonadotropins. Nemoto T, etal., J Endocrinol. 2009 Apr;201(1):105-14. Epub 2009 Feb 4.
39. Urocortin, a member of the corticotropin-releasing factor family, in normal and diseased heart. Nishikimi T, etal., Am J Physiol Heart Circ Physiol. 2000 Dec;279(6):H3031-9.
40. Alterations in colonic corticotropin-releasing factor receptors in the maternally separated rat model of irritable bowel syndrome: differential effects of acute psychological and physical stressors. O'Malley D, etal., Peptides. 2010 Apr;31(4):662-70. Epub 2010 Jan 21.
41. Urocortin, but not urocortin II, protects cultured hippocampal neurons from oxidative and excitotoxic cell death via corticotropin-releasing hormone receptor type I. Pedersen WA, etal., J Neurosci 2002 Jan 15;22(2):404-12.
42. Cocaine withdrawal enhances long-term potentiation induced by corticotropin-releasing factor at central amygdala glutamatergic synapses via CRF, NMDA receptors and PKA. Pollandt S, etal., Eur J Neurosci. 2006 Sep;24(6):1733-43.
43. Association of corticotropin-releasing hormone receptor-2 genetic variants with acute bronchodilator response in asthma. Poon AH, etal., Pharmacogenet Genomics. 2008 May;18(5):373-82.
44. Leptin regulates appetite-related neuropeptides in the hypothalamus of developing rats without affecting food intake. Proulx K, etal., Endocrinology 2002 Dec;143(12):4683-92.
45. GOA pipeline RGD automated data pipeline
46. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
47. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
48. Chronic amphetamine treatment enhances corticotropin-releasing factor-induced serotonin release in the amygdala. Scholl JL, etal., Eur J Pharmacol. 2010 Oct 10;644(1-3):80-7. Epub 2010 Jul 23.
49. The pseudo signal peptide of the corticotropin-releasing factor receptor type 2a decreases receptor expression and prevents Gi-mediated inhibition of adenylyl cyclase activity. Schulz K, etal., J Biol Chem. 2010 Oct 22;285(43):32878-87. Epub 2010 Aug 3.
50. Urocortin 2 protects against retinal degeneration following bilateral common carotid artery occlusion in the rat. Szabadfi K, etal., Neurosci Lett. 2009 May 8;455(1):42-5. Epub 2009 Mar 11.
51. Activation of corticotropin-releasing factor 2 receptor inhibits Purkinje neuron P-type calcium currents via G(o)alpha-dependent PKC epsilon pathway. Tao J, etal., Cell Signal. 2009 Sep;21(9):1436-43. Epub 2009 May 9.
52. Alterations in central neuropeptide expression, release, and receptor binding in rats bred for high anxiety: critical role of vasopressin. Wigger A, etal., Neuropsychopharmacology 2004 Jan;29(1):1-14.
53. Alcohol-preferring rats show decreased corticotropin-releasing hormone-2 receptor expression and differences in HPA activation compared to alcohol-nonpreferring rats. Yong W, etal., Alcohol Clin Exp Res. 2014 May;38(5):1275-83. doi: 10.1111/acer.12379. Epub 2014 Mar 10.
Additional References at PubMed
PMID:8612563   PMID:9423932   PMID:11416224   PMID:12032352   PMID:12639937   PMID:12746300   PMID:12855401   PMID:12911751   PMID:12959937   PMID:14675144   PMID:15174080   PMID:15178552  
PMID:15201629   PMID:15228587   PMID:15388651   PMID:15514029   PMID:15652653   PMID:15659593   PMID:15664670   PMID:16337313   PMID:16403469   PMID:16413121   PMID:16423352   PMID:16513211  
PMID:16614059   PMID:16741581   PMID:16769145   PMID:16867181   PMID:17019404   PMID:17218420   PMID:17437087   PMID:17512918   PMID:17551262   PMID:17578887   PMID:17680889   PMID:17944898  
PMID:17945210   PMID:18400885   PMID:18534257   PMID:18585412   PMID:18702701   PMID:19120136   PMID:19246489   PMID:19358876   PMID:19707872   PMID:19797401   PMID:19819946   PMID:19952342  
PMID:20072117   PMID:20130533   PMID:21376756   PMID:21627635   PMID:21854167   PMID:21964377   PMID:22227020   PMID:22245585   PMID:22249942   PMID:23183626   PMID:23205497   PMID:23312492  
PMID:23645119   PMID:23962778   PMID:24035863   PMID:24856473   PMID:24859650   PMID:25146701   PMID:25205625   PMID:25275258   PMID:25665407   PMID:25701320   PMID:25712670   PMID:26333123  
PMID:26454419   PMID:26503565   PMID:26662216   PMID:26696011   PMID:27035969   PMID:27538655   PMID:27637621   PMID:27779480   PMID:28612996   PMID:28811708   PMID:29183827   PMID:29857328  
PMID:30898126   PMID:31130301   PMID:31666410   PMID:32215915   PMID:34213722   PMID:34331656   PMID:36089237  


Genomics

Comparative Map Data
Crhr2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8485,553,163 - 85,596,203 (-)NCBIGRCr8
mRatBN7.2484,222,897 - 84,265,924 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl484,224,002 - 84,265,904 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx489,447,028 - 89,474,226 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0485,222,449 - 85,249,647 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0483,634,840 - 83,661,994 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0485,286,371 - 85,329,374 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl485,286,372 - 85,329,362 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.04149,943,615 - 149,986,646 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4483,839,822 - 83,867,017 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1484,085,174 - 84,112,370 (+)NCBI
Celera479,091,140 - 79,118,337 (-)NCBICelera
Cytogenetic Map4q24NCBI
CRHR2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38730,651,942 - 30,700,103 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl730,651,942 - 30,700,129 (-)EnsemblGRCh38hg38GRCh38
GRCh37730,691,558 - 30,739,719 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36730,659,388 - 30,688,665 (-)NCBINCBI36Build 36hg18NCBI36
Build 34730,465,439 - 30,495,136NCBI
Celera730,682,041 - 30,711,309 (-)NCBICelera
Cytogenetic Map7p14.3NCBI
HuRef730,573,396 - 30,621,616 (-)NCBIHuRef
CHM1_1730,691,838 - 30,739,995 (-)NCBICHM1_1
T2T-CHM13v2.0730,789,546 - 30,837,766 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2730,741,211 - 30,789,281 (-)NCBI
Crhr2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39655,067,033 - 55,110,001 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl655,067,034 - 55,110,001 (-)EnsemblGRCm39 Ensembl
GRCm38655,090,048 - 55,133,016 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl655,090,049 - 55,133,016 (-)EnsemblGRCm38mm10GRCm38
MGSCv37655,040,042 - 55,082,966 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36655,019,665 - 55,062,550 (-)NCBIMGSCv36mm8
Celera655,625,289 - 55,668,208 (-)NCBICelera
Cytogenetic Map6B3NCBI
cM Map627.33NCBI
Crhr2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541031,828,506 - 31,875,100 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541031,830,333 - 31,874,384 (-)NCBIChiLan1.0ChiLan1.0
CRHR2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2635,458,742 - 35,511,867 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1783,785,811 - 83,836,595 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0731,265,619 - 31,313,902 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1731,386,026 - 31,434,220 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl731,386,026 - 31,434,220 (-)Ensemblpanpan1.1panPan2
CRHR2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11443,366,849 - 43,414,398 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1443,368,340 - 43,415,142 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1442,799,432 - 42,846,743 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01443,307,910 - 43,355,188 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1443,305,381 - 43,355,288 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11443,423,758 - 43,471,041 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01443,099,719 - 43,147,031 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01443,461,123 - 43,508,563 (-)NCBIUU_Cfam_GSD_1.0
Crhr2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511887,689,367 - 87,736,056 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364786,899,017 - 6,947,790 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364786,901,098 - 6,947,719 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CRHR2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1842,251,749 - 42,295,467 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11842,251,755 - 42,296,457 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21846,648,683 - 46,651,308 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CRHR2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12127,703,637 - 27,738,873 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2127,708,113 - 27,739,116 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604276,965,555 - 77,000,544 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Crhr2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624739114,342 - 161,044 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624739114,383 - 161,010 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Crhr2
201 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:198
Count of miRNA genes:88
Interacting mature miRNAs:96
Transcripts:ENSRNOT00000014925, ENSRNOT00000033672
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358352Srcrt3Stress Responsive Cort QTL 32.29blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)438465774146803430Rat
1549843Bw53Body weight QTL 530.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658103194791Rat
61445Strs3Sensitivity to stroke QTL 33cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)44043338885433388Rat
6893678Bw108Body weight QTL 1082.60.006body mass (VT:0001259)body weight (CMO:0000012)44345797688457976Rat
10755501Bp390Blood pressure QTL 3902.5arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)426775591168368347Rat
1357342Bw40Body weight QTL 400.001body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
631556Bp135Blood pressure QTL 1350.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)478881294117676292Rat
1358363Sradr3Stress Responsive Adrenal Weight QTL 36.19adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)457486946102486946Rat
61330Eau1Experimental allergic uveoretinitis QTL 10.0003uvea integrity trait (VT:0010551)experimental autoimmune uveitis score (CMO:0001504)470362013132642728Rat
70167Bw22Body weight QTL 223.1body mass (VT:0001259)body weight (CMO:0000012)476647384117676292Rat
1549839Bw52Body weight QTL 520.0001body mass (VT:0001259)body weight gain (CMO:0000420)461697658115089733Rat
70177Xhs1X-ray hypersensitivity QTL 125.1intestine integrity trait (VT:0010554)post-insult time to onset of moribundity (CMO:0001896)482798864152731274Rat
724522Bp146Blood pressure QTL 1462.20.0021arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)473630210118630210Rat
8694439Bw168Body weight QTL 1689.570.001retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)44043341485433414Rat
1641919Alc22Alcohol consumption QTL 220.0005drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)481192555126192555Rat
1354660Salc1Saline consumption QTL 111.26drinking behavior trait (VT:0001422)saline drink intake rate (CMO:0001627)444463908148090542Rat
2300179Bmd50Bone mineral density QTL 505.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)460928534105928534Rat
1298082Stresp4Stress response QTL 4blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)450119848146803430Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)462933508114921294Rat
61364Iddm2Insulin dependent diabetes mellitus QTL 2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)478885890102684881Rat
1300139Hrtrt6Heart rate QTL 62.85heart pumping trait (VT:2000009)heart rate (CMO:0000002)439524264116179656Rat
70200Alc18Alcohol consumption QTL 189.2drinking behavior trait (VT:0001422)ethanol intake volume to total fluid intake volume ratio (CMO:0001591)456647873149491524Rat
1578657Bss12Bone structure and strength QTL 128.9femur morphology trait (VT:0000559)femoral neck cross-sectional area (CMO:0001697)460220938105220938Rat
1578658Bss13Bone structure and strength QTL 138femur strength trait (VT:0010010)femoral neck polar moment of inertia (CMO:0001670)460220938105220938Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)411320076180699135Rat
6478684Anxrr30Anxiety related response QTL 300.00087defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
2302051Pia28Pristane induced arthritis QTL 285.30.001blood autoantibody amount (VT:0003725)serum immunoglobulin G-type rheumatoid factor level relative to an arbitrary reference serum (CMO:0002112)473630210118630210Rat
2306794Ean2Experimental allergic neuritis QTL 26.4nervous system integrity trait (VT:0010566)IFNG-secreting splenocyte count (CMO:0002122)48342841995853334Rat
738009Sach4Saccharine consumption QTL 44.90.000016consumption behavior trait (VT:0002069)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)459948935154902892Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41081417091360527Rat
2312567Glom19Glomerulus QTL 191.90.006kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)445456990146803430Rat
738015Pia9Pristane induced arthritis QTL 94.50.048joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)480694870125694870Rat
6478772Anxrr49Anxiety related response QTL 490.15488defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
631646Stl4Serum triglyceride level QTL 46.50.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)473169846132642728Rat
2312569Pur19Proteinuria QTL 193.40.001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)46588210796130297Rat
8655961Kidm43Kidney mass QTL 4318kidney mass (VT:0002707)both kidneys wet weight (CMO:0000085)436303261103194984Rat
1354612Foco1Food consumption QTL 18.87eating behavior trait (VT:0001431)food intake rate (CMO:0000427)444463908148090542Rat
634344Hcar7Hepatocarcinoma resistance QTL 77.8liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)470808386115808386Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45214602146446691Rat
738031Alc14Alcohol consumption QTL 147.60.00003consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1576316Ept5Estrogen-induced pituitary tumorigenesis QTL 53.8pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)483428419177635233Rat
631662Hcar2Hepatocarcinoma resistance QTL 23.10.0003liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)478878504123878504Rat
1576305Emca6Estrogen-induced mammary cancer QTL 65.8mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)444463720155883716Rat
61418Pia5Pristane induced arthritis QTL 54.5joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)462277855128289560Rat
631651Bp124Blood pressure QTL 1243arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)462879517107879517Rat
738016Alc16Alcohol consumption QTL 163.60.00015consumption behavior trait (VT:0002069)ethanol drink intake rate to body weight ratio (CMO:0001616)459948935154902892Rat
1558651Swd3Spike wave discharge measurement QTL 34.620.000024brain electrophysiology trait (VT:0010557)brain spike-and-wave discharge frequency (CMO:0001742)45843213392991462Rat
1641833Alc21Alcohol consumption QTL 218.60.0001drinking behavior trait (VT:0001422)ethanol drink intake rate (CMO:0001407)456698790126192555Rat
2306899Bp338Blood pressure QTL 3380.071arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)481006124120102625Rat
631546Bp86Blood pressure QTL 863.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)45711443291360801Rat
631674Iddm14Insulin dependent diabetes mellitus QTL 14blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)464528739157573521Rat
6478743Anxrr40Anxiety related response QTL 400.83076defecation behavior trait (VT:0010462)defecation rate (CMO:0000998)462753847107753847Rat
7394826Bw126Body weight QTL 1260.002body mass (VT:0001259)body weight gain (CMO:0000420)46293326987483707Rat
12798520Anxrr55Anxiety related response QTL 554.450.01locomotor behavior trait (VT:0001392)number of rearing movements with lid-pushing in an experimental apparatus (CMO:0002715)432583980114627242Rat

Markers in Region
D4Rat170  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2484,236,380 - 84,236,623 (+)MAPPERmRatBN7.2
Rnor_6.0485,299,855 - 85,300,097NCBIRnor6.0
Rnor_5.04149,957,099 - 149,957,341UniSTSRnor5.0
RGSC_v3.4483,852,199 - 83,852,442RGDRGSC3.4
RGSC_v3.4483,852,200 - 83,852,442UniSTSRGSC3.4
RGSC_v3.1484,099,749 - 84,099,992RGD
Celera479,103,518 - 79,103,762UniSTS
SHRSP x BN Map441.93RGD
SHRSP x BN Map441.93UniSTS
Cytogenetic Map4q24UniSTS
BE120072  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2484,230,612 - 84,230,778 (+)MAPPERmRatBN7.2
Rnor_6.0485,294,086 - 85,294,251NCBIRnor6.0
Rnor_5.04149,951,330 - 149,951,495UniSTSRnor5.0
RGSC_v3.4483,846,432 - 83,846,597UniSTSRGSC3.4
Celera479,097,750 - 79,097,915UniSTS
RH 3.4 Map4525.71UniSTS
Cytogenetic Map4q24UniSTS
CRHR2  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2484,225,247 - 84,225,787 (+)MAPPERmRatBN7.2
Rnor_6.0485,288,722 - 85,289,260NCBIRnor6.0
Rnor_5.04149,945,966 - 149,946,504UniSTSRnor5.0
RGSC_v3.4483,841,068 - 83,841,606UniSTSRGSC3.4
Celera479,092,386 - 79,092,924UniSTS
Cytogenetic Map4q24UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 43 41 12 17 12 6 148 89 93 30 54 29

Sequence


Ensembl Acc Id: ENSRNOT00000014925   ⟹   ENSRNOP00000014925
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl484,224,810 - 84,265,904 (-)Ensembl
Rnor_6.0 Ensembl485,286,372 - 85,329,362 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000033672   ⟹   ENSRNOP00000035712
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl484,224,002 - 84,251,198 (-)Ensembl
Rnor_6.0 Ensembl485,287,476 - 85,314,672 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000089492   ⟹   ENSRNOP00000075129
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl484,235,707 - 84,251,198 (-)Ensembl
Rnor_6.0 Ensembl485,299,181 - 85,314,457 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000098668   ⟹   ENSRNOP00000079784
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl484,224,002 - 84,265,904 (-)Ensembl
RefSeq Acc Id: NM_022714   ⟹   NP_073205
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8485,554,268 - 85,581,463 (-)NCBI
mRatBN7.2484,224,002 - 84,251,198 (-)NCBI
Rnor_6.0485,287,476 - 85,314,672 (-)NCBI
Rnor_5.04149,943,615 - 149,986,646 (-)NCBI
RGSC_v3.4483,839,822 - 83,867,017 (-)RGD
Celera479,091,140 - 79,118,337 (-)RGD
Sequence:
RefSeq Acc Id: XM_006236556   ⟹   XP_006236618
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8485,553,163 - 85,596,203 (-)NCBI
mRatBN7.2484,222,897 - 84,265,924 (-)NCBI
Rnor_6.0485,286,371 - 85,329,374 (-)NCBI
Rnor_5.04149,943,615 - 149,986,646 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006236557   ⟹   XP_006236619
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8485,553,163 - 85,596,203 (-)NCBI
mRatBN7.2484,222,897 - 84,265,924 (-)NCBI
Rnor_6.0485,286,371 - 85,329,374 (-)NCBI
Rnor_5.04149,943,615 - 149,986,646 (-)NCBI
Sequence:
RefSeq Acc Id: XM_006236558   ⟹   XP_006236620
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8485,553,163 - 85,582,627 (-)NCBI
mRatBN7.2484,222,897 - 84,252,290 (-)NCBI
Rnor_6.0485,286,371 - 85,315,108 (-)NCBI
Rnor_5.04149,943,615 - 149,986,646 (-)NCBI
Sequence:
RefSeq Acc Id: NP_073205   ⟸   NM_022714
- Peptide Label: precursor
- UniProtKB: P47866 (UniProtKB/Swiss-Prot),   G3V948 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: XP_006236619   ⟸   XM_006236557
- Peptide Label: isoform X2
- UniProtKB: D4A5C4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236618   ⟸   XM_006236556
- Peptide Label: isoform X1
- UniProtKB: D4A5C4 (UniProtKB/TrEMBL),   A0A8I5ZNG6 (UniProtKB/TrEMBL),   A6K0W9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006236620   ⟸   XM_006236558
- Peptide Label: isoform X3
- Sequence:
Ensembl Acc Id: ENSRNOP00000035712   ⟸   ENSRNOT00000033672
Ensembl Acc Id: ENSRNOP00000014925   ⟸   ENSRNOT00000014925
Ensembl Acc Id: ENSRNOP00000075129   ⟸   ENSRNOT00000089492
Ensembl Acc Id: ENSRNOP00000079784   ⟸   ENSRNOT00000098668
Protein Domains
G-protein coupled receptors family 2 profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P47866-F1-model_v2 AlphaFold P47866 1-411 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:70547 AgrOrtholog
BioCyc Gene G2FUF-44742 BioCyc
Ensembl Genes ENSRNOG00000011145 Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ENSRNOG00055010798 UniProtKB/Swiss-Prot
  ENSRNOG00060021958 UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000014925.6 UniProtKB/TrEMBL
  ENSRNOT00000033672.4 UniProtKB/Swiss-Prot
  ENSRNOT00000089492.2 UniProtKB/TrEMBL
  ENSRNOT00000098668.1 UniProtKB/TrEMBL
  ENSRNOT00055018256 UniProtKB/Swiss-Prot
  ENSRNOT00060038158 UniProtKB/Swiss-Prot
Gene3D-CATH 4.10.1240.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Rhodopsin 7-helix transmembrane proteins UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro GPCR_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_CRF2_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_CRF_rcpt UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_extracell_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_extracellular_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCR_2_secretin-like_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:64680 UniProtKB/Swiss-Prot
NCBI Gene 64680 ENTREZGENE
PANTHER CORTICOTROPIN-RELEASING FACTOR RECEPTOR 2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PDF RECEPTOR-LIKE PROTEIN-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam 7tm_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HRM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB CRHR2 RGD
PhenoGen Crhr2 PhenoGen
PRINTS CRFRECEPTOR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CRFRECEPTOR2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  GPCRSECRETIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F2_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F2_4 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000011145 RatGTEx
  ENSRNOG00055010798 RatGTEx
  ENSRNOG00060021958 RatGTEx
SMART HormR UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP Family A G protein-coupled receptor-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF111418 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A0G2K9U2_RAT UniProtKB/TrEMBL
  A0A8I5ZNG6 ENTREZGENE, UniProtKB/TrEMBL
  A6K0W9 ENTREZGENE, UniProtKB/TrEMBL
  CRFR2_RAT UniProtKB/Swiss-Prot
  D4A5C4 ENTREZGENE, UniProtKB/TrEMBL
  G3V948 ENTREZGENE
  P47866 ENTREZGENE
UniProt Secondary G3V948 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2004-09-10 Crhr2  corticotropin releasing hormone receptor 2    corticotrophin releasing hormone receptor 2  Name updated 1299863 APPROVED
2002-06-10 Crhr2  corticotrophin releasing hormone receptor 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression expressed in specific regions of the brain, also in lung and heart 727728
gene_expression expressed in hippocampal regions 70397
gene_function G-protein coupled receptor 70397
gene_function G-protein coupled receptor 631245
gene_process mediates hippocampal neuron protection from stress-induced injury 70397
gene_process mediates hippocampal neuron protection from stress-induced injury 631245