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Gene: Plce1 (phospholipase C, epsilon 1) Rattus norvegicus

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Symbol:

Plce1

Name:

phospholipase C, epsilon 1

RGD ID:

69424

Description:

Enables phosphatidylinositol-4,5-bisphosphate phospholipase C activity and small GTPase binding activity. Involved in G protein-coupled receptor signaling pathway and Ras protein signal transduction. Predicted to be located in cytosol; lamellipodium; and plasma membrane. Human ortholog(s) of this gene implicated in gastric adenocarcinoma; nephrotic syndrome; nephrotic syndrome type 2; and nephrotic syndrome type 3. Orthologous to human PLCE1 (phospholipase C epsilon 1); PARTICIPATES IN calcium/calcium-mediated signaling pathway; inositol phosphate metabolic pathway; phosphatidylinositol 3-kinase signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dinitrotoluene; 3,3',4,4',5-pentachlorobiphenyl.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1; phosphoinositide phospholipase C-epsilon-1; phosphoinositide-specific phospholipase C epsilon-1; phospholipase C epsilon; phospholipase C epsilon 1; phospholipase C, epsilon; phospholipase C-epsilon-1; PLC-epsilon-1; Plce

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	PLCE1 (phospholipase C epsilon 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther
Mus musculus (house mouse):	Plce1 (phospholipase C, epsilon 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Plce1 (phospholipase C epsilon 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	PLCE1 (phospholipase C epsilon 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	PLCE1 (phospholipase C epsilon 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Plce1 (phospholipase C epsilon 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	PLCE1 (phospholipase C epsilon 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	PLCE1 (phospholipase C epsilon 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Plce1 (phospholipase C epsilon 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Plce1 (phospholipase C, epsilon 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	PLCE1 (phospholipase C epsilon 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	plce1 (phospholipase C, epsilon 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	plce1 (phospholipase C, epsilon 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	plc-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	plce1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Allele / Splice:

Plce1^{Tn(sb-T2/Bart3)2.146Mcwi}

Genetic Models:

F344-Plce1^{Tn(sb-T2/Bart3)2.146Mcwi}

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	245,655,855 - 245,964,966 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	245,657,080 - 245,963,828 (+)	Ensembl				GRCr8
mRatBN7.2	1	236,243,445 - 236,552,571 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	236,244,683 - 236,551,438 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	244,666,928 - 244,974,895 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	251,561,834 - 251,868,600 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	244,400,107 - 244,706,858 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	257,156,023 - 257,465,440 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	257,157,264 - 257,466,064 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	264,652,842 - 264,956,664 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	242,794,858 - 243,103,437 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	233,337,820 - 233,642,815 (+)	NCBI		Celera
RGSC_v3.1	1	242,891,416 - 243,199,995 (+)	NCBI
Cytogenetic Map	1	q53	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenocarcinoma (ISO)

benign familial hematuria (ISO)

dengue hemorrhagic fever (ISO)

Diffuse Mesangial Sclerosis (ISO)

esophagus squamous cell carcinoma (ISO)

focal segmental glomerulosclerosis (ISO)

focal segmental glomerulosclerosis 1 (ISO)

gastric adenocarcinoma (ISO)

genetic disease (ISO)

glomerulonephritis (ISO)

kidney disease (ISO)

nephrotic syndrome (ISO)

nephrotic syndrome type 1 (ISO)

nephrotic syndrome type 2 (ISO)

nephrotic syndrome type 3 (ISO)

polycystic kidney disease (ISO)

proteinuria (ISO)

Stomach Neoplasms (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-epigallocatechin 3-gallate (ISO)

1,1-dichloroethene (ISO)

1,2-dichloroethane (ISO)

17beta-estradiol (ISO)

2,3',4,4',5-Pentachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2,4-dinitrotoluene (EXP)

3,3',4,4',5-pentachlorobiphenyl (EXP)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

6-propyl-2-thiouracil (EXP)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

ammonium chloride (EXP)

antirheumatic drug (ISO)

arsane (ISO)

arsenic atom (ISO)

arsenite(3-) (ISO)

asbestos (ISO)

atrazine (EXP)

Azoxymethane (ISO)

belinostat (ISO)

Benoxacor (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

Butylbenzyl phthalate (EXP)

capecitabine (ISO)

carbon nanotube (ISO)

CGP 52608 (ISO)

choline (ISO)

chromium(6+) (ISO)

cobalt dichloride (EXP)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

dextran sulfate (ISO)

Dibutyl phosphate (ISO)

dioxygen (ISO)

dorsomorphin (ISO)

doxifluridine (ISO)

doxorubicin (ISO)

endosulfan (EXP)

ethanol (EXP,ISO)

fluorescein 5-isothiocyanate (ISO)

flutamide (EXP)

folic acid (ISO)

gentamycin (EXP)

glyphosate (EXP)

inulin (ISO)

L-methionine (ISO)

lead diacetate (ISO)

maneb (ISO)

manganese atom (ISO)

manganese(0) (ISO)

manganese(II) chloride (ISO)

menadione (ISO)

mercury dibromide (ISO)

methapyrilene (EXP)

methoxychlor (EXP)

N-nitrosodiethylamine (ISO)

nickel atom (ISO)

nickel sulfate (ISO)

ozone (ISO)

paclitaxel (ISO)

panobinostat (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

perfluorohexanesulfonic acid (ISO)

perfluorononanoic acid (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (ISO)

phenobarbital (ISO)

phenylmercury acetate (ISO)

pirinixic acid (ISO)

potassium chromate (ISO)

potassium dichromate (ISO)

progesterone (ISO)

pyridaben (ISO)

quercitrin (ISO)

SB 431542 (ISO)

sodium arsenite (ISO)

sulforaphane (ISO)

sunitinib (ISO)

tert-butyl hydroperoxide (ISO)

thioacetamide (EXP)

titanium dioxide (ISO)

tributylstannane (EXP)

trichloroethene (EXP)

trichostatin A (ISO)

triphenyl phosphate (ISO)

triptonide (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

diacylglycerol biosynthetic process (IEA,ISO,ISS)

epidermal growth factor receptor signaling pathway (IEA,ISO,ISS)

G protein-coupled receptor signaling pathway (IBA,IEA,IMP)

glomerulus development (IEA,ISO)

intracellular signal transduction (IEA,ISO,ISS)

lipid catabolic process (IEA)

lipid metabolic process (IEA)

phosphatidylinositol metabolic process (IBA)

phosphatidylinositol-mediated signaling (IBA)

phospholipase C-activating G protein-coupled receptor signaling pathway (IEA,ISO,ISS)

positive regulation of lamellipodium assembly (IEA,ISO,ISS)

Ras protein signal transduction (IBA,IDA,IEA,ISO)

release of sequestered calcium ion into cytosol (IBA)

signal transduction (IEA)

small GTPase-mediated signal transduction (IEA)

Cellular Component

cytosol (IEA,ISO,ISS)

Golgi membrane (IEA)

lamellipodium (IEA,ISO,ISS)

plasma membrane (IEA,ISO,ISS)

Molecular Function

C-type glycerophospholipase activity (IEA,ISO,ISS)

enzyme binding (IEA,ISO,ISS)

guanyl-nucleotide exchange factor activity (IEA)

hydrolase activity (IEA)

metal ion binding (IEA)

phosphatidylinositol-4,5-bisphosphate phospholipase C activity (IBA,IDA,IEA,ISO,ISS)

phosphoric diester hydrolase activity (IEA)

protein binding (ISO)

small GTPase binding (IDA,IEA,ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

calcium/calcium-mediated signaling pathway (IEA)

inositol phosphate metabolic pathway (IEA)

phosphatidylinositol 3-kinase signaling pathway (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Mutational analysis of the PLCE1 gene in steroid resistant nephrotic syndrome.	Boyer O, etal., J Med Genet. 2010 Jul;47(7):445-52. doi: 10.1136/jmg.2009.076166.
2.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3.	Mutations in PLCE1 are a major cause of isolated diffuse mesangial sclerosis (IDMS).	Gbadegesin R, etal., Nephrol Dial Transplant. 2008 Apr;23(4):1291-7. Epub 2007 Dec 8.
4.	Positional cloning uncovers mutations in PLCE1 responsible for a nephrotic syndrome variant that may be reversible.	Hinkes B, etal., Nat Genet. 2006 Dec;38(12):1397-405. Epub 2006 Nov 5.
5.	Phospholipase C(epsilon): a novel Ras effector.	Kelley GG, etal., EMBO J 2001 Feb 15;20(4):743-54.
6.	G-protein-coupled receptor agonists activate endogenous phospholipase Cepsilon and phospholipase Cbeta3 in a temporally distinct manner.	Kelley GG, etal., J Biol Chem. 2006 Feb 3;281(5):2639-48. Epub 2005 Nov 28.
7.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
8.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline
9.	KEGG Annotation Import Pipeline	Pipeline to import KEGG annotations from KEGG into RGD
10.	GOA pipeline	RGD automated data pipeline
11.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
13.	Comprehensive gene review and curation	RGD comprehensive gene curation
14.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
15.	Identification of a novel cytosolic poly-phosphoinositide-specific phospholipase C (PLC-86) as the major G-protein-regulated enzyme.	Thomas GM, etal., EMBO J. 1991 Sep;10(9):2507-12.
16.	PLCε1: a potential target of RNA interference therapy for gastric cancer.	Yan F and Fu Q, Biochem Biophys Res Commun. 2014 Jun 13;448(4):409-13. doi: 10.1016/j.bbrc.2014.04.119. Epub 2014 May 2.

Additional References at PubMed

PMID:11022047	PMID:11022048	PMID:11641393	PMID:11788587	PMID:12721365	PMID:12900402	PMID:15322077	PMID:16895916	PMID:18765661	PMID:21550986	PMID:27612188	PMID:29058690
PMID:29535186	PMID:29885334	PMID:30361391	PMID:31217261	PMID:31433293	PMID:32796910	PMID:33662817

Genomics

Comparative Map Data

Plce1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	245,655,855 - 245,964,966 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	1	245,657,080 - 245,963,828 (+)	Ensembl				GRCr8
mRatBN7.2	1	236,243,445 - 236,552,571 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	236,244,683 - 236,551,438 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	1	244,666,928 - 244,974,895 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	251,561,834 - 251,868,600 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	244,400,107 - 244,706,858 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	257,156,023 - 257,465,440 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	257,157,264 - 257,466,064 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	1	264,652,842 - 264,956,664 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	1	242,794,858 - 243,103,437 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	1	233,337,820 - 233,642,815 (+)	NCBI		Celera
RGSC_v3.1	1	242,891,416 - 243,199,995 (+)	NCBI
Cytogenetic Map	1	q53	NCBI

PLCE1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	10	93,993,931 - 94,332,823 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	10	93,993,894 - 94,332,823 (+)	Ensembl			hg38	GRCh38
GRCh37	10	95,753,688 - 96,092,580 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	10	95,743,736 - 96,078,139 (+)	NCBI	Build 36	Build 36	hg18	NCBI36
Celera	10	89,493,881 - 89,828,255 (+)	NCBI		Celera
Cytogenetic Map	10	q23.33	NCBI
HuRef	10	89,417,740 - 89,714,892 (+)	NCBI		HuRef
CHM1_1	10	96,072,191 - 96,370,190 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	10	94,872,907 - 95,211,918 (+)	NCBI		T2T-CHM13v2.0

Plce1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	19	38,469,438 - 38,773,549 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	19	38,469,557 - 38,773,474 (+)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	19	38,481,034 - 38,785,105 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	19	38,481,109 - 38,785,030 (+)	Ensembl			mm10	GRCm38
MGSCv37	19	38,598,687 - 38,859,595 (+)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	19	38,589,341 - 38,848,444 (+)	NCBI		MGSCv36	mm8
Celera	19	39,314,226 - 39,575,892 (+)	NCBI		Celera
Cytogenetic Map	19	C3	NCBI
cM Map	19	33.16	NCBI

Plce1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955507	555,499 - 825,568 (+)	Ensembl
ChiLan1.0	NW_004955507	555,570 - 825,568 (+)	NCBI	ChiLan1.0	ChiLan1.0

PLCE1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	8	106,023,546 - 106,361,193 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	10	106,028,877 - 106,363,017 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	10	90,731,695 - 91,065,846 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	10	94,336,542 - 94,575,024 (+)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	10	94,278,550 - 94,575,024 (+)	Ensembl			panPan2	panpan1.1

PLCE1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	28	8,209,707 - 8,484,427 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	28	8,210,058 - 8,481,770 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	28	8,387,216 - 8,659,466 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	28	8,429,089 - 8,751,544 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	28	8,428,039 - 8,748,665 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	28	8,190,819 - 8,462,238 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	28	8,220,652 - 8,493,537 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	28	8,391,272 - 8,663,966 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Plce1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024407213	39,184,543 - 39,473,227 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936601	816,190 - 1,105,830 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936601	817,151 - 1,105,824 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

PLCE1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	105,458,916 - 105,764,737 (+)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	14	105,422,628 - 105,764,736 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	115,378,315 - 115,615,665 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

PLCE1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	9	87,214,166 - 87,559,010 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	9	87,214,355 - 87,555,733 (+)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666048	47,996,373 - 48,343,637 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Plce1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624737	5,343,570 - 5,695,284 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624737	5,309,157 - 5,699,384 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Variants

Variants in Plce1
1347 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	136
Count of miRNA genes:	100
Interacting mature miRNAs:	121
Transcripts:	ENSRNOT00000067149
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1578778	Pur4	Proteinuria QTL 4	3.3	0.003	urine total protein amount (VT:0000032)	urine total protein excretion rate (CMO:0000756)	1	160111531	262090437	Rat
1354646	Kidm18	Kidney mass QTL 18	5.7		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	160573753	266453731	Rat
1357335	Bw39	Body weight QTL 39	3.3		body mass (VT:0001259)	body weight (CMO:0000012)	1	207243873	252243873	Rat
1354652	Kidm20	Kidney mass QTL 20	4.3		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	186658830	266453731	Rat
2293674	Bss39	Bone structure and strength QTL 39	7.1	0.0001	femur strength trait (VT:0010010)	femur total energy absorbed before break (CMO:0001677)	1	210980612	255980612	Rat
61455	Niddm7	Non-insulin dependent diabetes mellitus QTL 7	5.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	223964326	248681945	Rat
61327	Eae7	Experimental allergic encephalomyelitis QTL 7	5.6		body mass (VT:0001259)	change in body weight (CMO:0002045)	1	226175591	270518180	Rat
1578775	Iddm21	Insulin dependent diabetes mellitus QTL 21	4.13		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	245782829	270518180	Rat
1600395	Niddm69	Non-insulin dependent diabetes mellitus QTL 69	4.14	0.0002	blood insulin amount (VT:0001560)	plasma insulin level (CMO:0000342)	1	205233991	267096252	Rat
1578763	Kidm29	Kidney mass QTL 29	3.3	0.0001	kidney mass (VT:0002707)	both kidneys wet weight (CMO:0000085)	1	218829748	263829748	Rat
1354624	Cm35	Cardiac mass QTL35	5.7		heart left ventricle mass (VT:0007031)	calculated heart weight (CMO:0000073)	1	186658830	266453731	Rat
1600396	Niddm68	Non-insulin dependent diabetes mellitus QTL 68	4.97	0.0003	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	205233991	267096252	Rat
1600397	Edcs4	Endometrial carcinoma susceptibility QTL 4	2.2		uterus morphology trait (VT:0001120)	percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)	1	176288899	270518180	Rat
1549837	Hcar15	Hepatocarcinoma resistance QTL 15		0.05	liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	162548015	270518180	Rat
152025235	Bw194	Body weight QTL 194	4.86		body mass (VT:0001259)		1	132966869	252856240	Rat
1600388	Niddm67	Non-insulin dependent diabetes mellitus QTL 67	5.84	0.000004	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	205233991	267096252	Rat
2293694	Bss38	Bone structure and strength QTL 38	7.05	0.0001	femur strength trait (VT:0010010)	femur stiffness (CMO:0001674)	1	210980612	255980612	Rat
1598853	Memor3	Memory QTL 3	4.5		exploratory behavior trait (VT:0010471)	total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)	1	152919152	268496042	Rat
1578759	Uae30	Urinary albumin excretion QTL 30	3.3	0.003	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	160111531	262090437	Rat
1300108	Rf8	Renal function QTL 8	3.75		renal blood flow trait (VT:2000006)	absolute change in renal vascular resistance (CMO:0001900)	1	237995023	269633915	Rat
734767	Niddm57	Non-insulin dependent diabetes mellitus QTL 57			body mass (VT:0001259)	body weight (CMO:0000012)	1	233480549	270108840	Rat
1358898	Bp255	Blood pressure QTL 255	3.6		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	1	200449456	256003563	Rat
631215	Stl8	Serum triglyceride level QTL 8	9.27	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	1	234540191	270518180	Rat
631843	Bw116	Body weight QTL 116	4.1	0.016	abdominal adipose amount (VT:1000220)	abdominal fat pad weight (CMO:0000088)	1	233480549	270108840	Rat
731175	Uae20	Urinary albumin excretion QTL 20	3.5	0.0018	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	207163993	269633915	Rat
2300175	Bmd40	Bone mineral density QTL 40	15.4	0.0001	femur mineral mass (VT:0010011)	bone mineral density (CMO:0001226)	1	210980612	255980612	Rat
1354661	Bw33	Body weight QTL 33	5.2		body mass (VT:0001259)	body weight (CMO:0000012)	1	160573753	266453731	Rat
724538	Kidm1	Kidney mass QTL 1	3.2		kidney mass (VT:0002707)	calculated kidney weight (CMO:0000160)	1	223134011	262090599	Rat
2293655	Bss36	Bone structure and strength QTL 36	10.66	0.0001	femur strength trait (VT:0010010)	femur ultimate force (CMO:0001675)	1	210980612	255980612	Rat
1298084	Thym4	Thymus enlargement QTL 4	10.68		thymus mass (VT:0004954)	thymus weight to body weight ratio (CMO:0000612)	1	207243873	252243873	Rat
724531	Uae5	Urinary albumin excretion QTL 5	4		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	1	160111426	262090599	Rat
2314011	Gluco56	Glucose level QTL 56			blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	209203273	254203273	Rat
8552891	Epfw5	Epididymal fat weight QTL 5	4.4		epididymal fat pad mass (VT:0010421)	epididymal fat pad weight to body weight ratio (CMO:0000658)	1	202543537	247543537	Rat
734769	Niddm58	Non-insulin dependent diabetes mellitus QTL 58			body mass (VT:0001259)	body weight (CMO:0000012)	1	225108840	270108840	Rat
724533	Rf51	Renal function QTL 51	5.3	0.0002	kidney plasma flow trait (VT:0005524)	renal plasma flow (CMO:0001914)	1	228180370	266453608	Rat
1354580	Scort1	Serum corticosterone level QTL 1	3.4		blood corticosterone amount (VT:0005345)	blood corticosterone level (CMO:0001172)	1	154961463	266453731	Rat
1358292	Cm37	Cardiac mass QTL 37	6.2	8e-07	heart mass (VT:0007028)	heart weight to body weight ratio (CMO:0000074)	1	205674651	250674651	Rat
61376	Bp42	Blood pressure QTL 42	23.4		arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	1	207243873	252243873	Rat
634313	Niddm43	Non-insulin dependent diabetes mellitus QTL 43			blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	208479811	269633915	Rat
70211	Niddm24	Non-insulin dependent diabetes mellitus QTL 24	3.79		blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	1	224633915	269633915	Rat
724552	Glom2	Glomerulus QTL 2	3.3	0.0001	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)	1	232312773	270518180	Rat
2316896	Gluco57	Glucose level QTL 57	7.2		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	238398865	255849249	Rat
1358916	Kidm22	Kidney mass QTL 22	3.32		kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	212738576	257738576	Rat
2312564	Glom18	Glomerulus QTL 18	2.4	0.003	kidney glomerulus morphology trait (VT:0005325)	index of glomerular damage (CMO:0001135)	1	194786607	262083703	Rat
634321	Hc1	Hypercalciuria QTL 1	2.91		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	188241285	250779312	Rat
2292218	Kidm35	Kidney mass QTL 35			kidney mass (VT:0002707)	both kidneys wet weight to body weight ratio (CMO:0000340)	1	208798288	253798288	Rat
61400	Niddm1	Non-insulin dependent diabetes mellitus QTL 1	11		blood glucose amount (VT:0000188)	blood glucose level (CMO:0000046)	1	228180243	255849249	Rat
61403	Niddm4	Non-insulin dependent diabetes mellitus QTL 4			blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	201464383	246464383	Rat
1641926	Teswt2	Testicular weight QTL 2	2.82		testis mass (VT:1000644)	both testes wet weight (CMO:0000175)	1	203675682	248675682	Rat
631658	Cm7	Cardiac mass QTL 7	5.32	0.0001	aorta mass (VT:0002845)	aorta weight (CMO:0000076)	1	205674651	250674651	Rat
1354610	Bw34	Body weight QTL 34	4.1		body mass (VT:0001259)	body weight (CMO:0000012)	1	160573753	266453731	Rat
2293700	Bmd27	Bone mineral density QTL 27	6.6	0.0001	femur mineral mass (VT:0010011)	trabecular volumetric bone mineral density (CMO:0001729)	1	210980612	255980612	Rat
2293701	Bmd34	Bone mineral density QTL 34	8.3	0.0001	femur strength trait (VT:0010010)	femoral neck ultimate force (CMO:0001703)	1	210980612	255980612	Rat
7387289	Uae45	Urinary albumin excretion QTL 45	2.86	0.0021	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	233204160	270518180	Rat
1600374	Mcs17	Mammary carcinoma susceptibility QTL 17	3		mammary gland integrity trait (VT:0010552)	mammary tumor number (CMO:0000343)	1	207099883	252099883	Rat
1581544	Rf52	Renal function QTL 52		0.05	urine total protein amount (VT:0000032)	urine protein excretion rate to body weight ratio (CMO:0001099)	1	241569529	269633915	Rat
1600363	Hc6	Hypercalciuria QTL 6	2.7		urine calcium amount (VT:0002985)	urine calcium excretion rate (CMO:0000763)	1	210980612	255980612	Rat
631536	Lnnr2	Liver neoplastic nodule remodeling QTL 2	2.9	0.0005	liver integrity trait (VT:0010547)	liver remodeling tumorous lesion number to liver total tumorous lesion number ratio (CMO:0001705)	1	243953669	270518180	Rat
738032	Hcas5	Hepatocarcinoma susceptibility QTL 5	3.12		liver integrity trait (VT:0010547)	liver tumorous lesion number (CMO:0001068)	1	185857683	270518180	Rat
2302040	Pia35	Pristane induced arthritis QTL 35	3.8	0.001	blood immunoglobulin amount (VT:0002460)	serum immunoglobulin G1 level (CMO:0002115)	1	226175591	270518180	Rat
631669	Iddm9	Insulin dependent diabetes mellitus QTL 9	2.8	0.039	blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	1	233349180	270518180	Rat
7394701	Uae46	Urinary albumin excretion QTL 46	3.6	0.0056	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	1	210980612	255980612	Rat
1598821	Rf55	Renal function QTL 55	6.3		renal blood flow trait (VT:2000006)	ratio of change in renal blood flow to change in renal perfusion pressure (CMO:0001239)	1	228174566	270518180	Rat

Markers in Region

RH138895

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	1	236,551,249 - 236,551,415 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	257,463,999 - 257,464,164	NCBI	Rnor6.0
Rnor_5.0	1	264,956,475 - 264,956,640	UniSTS	Rnor5.0
RGSC_v3.4	1	243,103,248 - 243,103,413	UniSTS	RGSC3.4
Celera	1	233,642,626 - 233,642,791	UniSTS
RH 3.4 Map	1	1583.2	UniSTS
Cytogenetic Map	1	q53	UniSTS

SEPHS1_9288

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	17	73,357,127 - 73,357,961 (+)	MAPPER	mRatBN7.2
mRatBN7.2	1	236,308,327 - 236,309,637 (+)	MAPPER	mRatBN7.2
Rnor_6.0	1	257,220,875 - 257,222,184	NCBI	Rnor6.0
Rnor_6.0	17	77,315,255 - 77,316,088	NCBI	Rnor6.0
Rnor_5.0	17	78,981,072 - 78,981,905	UniSTS	Rnor5.0
Rnor_5.0	1	264,715,344 - 264,716,653	UniSTS	Rnor5.0
RGSC_v3.4	1	242,859,460 - 242,860,769	UniSTS	RGSC3.4
RGSC_v3.4	17	84,445,846 - 84,446,679	UniSTS	RGSC3.4
Celera	17	72,797,721 - 72,798,554	UniSTS
Celera	1	233,401,328 - 233,402,603	UniSTS
Cytogenetic Map	17	q12.3	UniSTS
Cytogenetic Map	1	q53	UniSTS

Genetic Models

This gene Plce1 is modified in the following models/strains:

F344-Plce1^{Tn(sb-T2/Bart3)2.146Mcwi}

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	161	91	90	59	25	59	6	289	125	11	140	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053758	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017588656	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017588657	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017588658	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017588659	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017588660	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039108292	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063262806	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_063262818	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC117848	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC122568	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AC132689	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF323615	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473953	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB877202	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HB895836	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HC934611	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	HC953245	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000001	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000067149 ⟹ ENSRNOP00000062667

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	245,657,080 - 245,963,828 (+)	Ensembl
mRatBN7.2 Ensembl	1	236,244,683 - 236,551,438 (+)	Ensembl
Rnor_6.0 Ensembl	1	257,157,264 - 257,464,187 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000079219 ⟹ ENSRNOP00000072165

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	1	245,657,080 - 245,963,828 (+)	Ensembl
mRatBN7.2 Ensembl	1	236,244,683 - 236,551,438 (+)	Ensembl
Rnor_6.0 Ensembl	1	257,157,312 - 257,466,064 (+)	Ensembl

RefSeq Acc Id:

NM_053758 ⟹ NP_446210

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	245,657,080 - 245,963,829 (+)	NCBI
mRatBN7.2	1	236,244,683 - 236,551,439 (+)	NCBI
Rnor_6.0	1	257,157,264 - 257,464,188 (+)	NCBI
Rnor_5.0	1	264,652,842 - 264,956,664 (+)	NCBI
RGSC_v3.4	1	242,794,858 - 243,103,437 (+)	RGD
Celera	1	233,337,820 - 233,642,815 (+)	RGD

Sequence:

show sequence

GAGCGCGGAGCGCGGGCTGGCGGCGGGGGCGGCGGGCTAGAGCAGTGGACGGCGGCTGCGCGCC
CCGCTGTGCTCTGCCCGGCTTCTGTTCGCTCCTGGGAATCGGCTGTGCGGCTGACACTCTGTAA
CTGGGACTCTCCACGGCTCTGGGGACGCACGCGCGTGGACCAGGTCCCCAGGGACGCGGCACTC
TGGTCCCGCCGCACGTCTGGCTGGAGATCTAAGGGAACAGAAAACACTCAAACTGGATTTTTAA
ATCATTGCACATTAACGATACAACCCCAAGTTGCAGAATGTGACCTTGAACAAAATCCTTCTAA
AAAATTAGCTTCAGGCAACAGAGAAAAGAAAAGTGAACTGTTGTTTTGAAATACTGGTGTAAAA
CAAACTGTCCTTGTAGGAAATTACAACTGGAAAATTTTGTTTGGCTCTTAATATATCTGAATGA
AAGGAACTGTCACCTTACTTCTCACGACTGGAATTATCTGAGATTATCTGTTGTCTGGACATGA
TCGCCAGGGAAGGGAACACAGAAGAGTAGCAACTCAAGGACGCTGGTCAAGATGACGTCCGAAG
AAATGGCCGCTTCCTTCCTCATCCCGGTGCCTCAAAGGAAAGTGGCTTCTGCCCAGTCAGTGGC
AGAGGAGCGGGGTGAAAAGGTCTCAGAAGCCGGCATTCCTAAGACACGAGCTGGCAGACAGGGT
GGGCTCACCCCTCGTACCATCTCACAGCGGAACGAACCTGAGGAAGAGTCTCCTAGAACTGATT
TTTCCCAGGTCTTCTCAATAGCGAGGGGGGAACTAGACAGCGACGAGAATCACAATGAAAGGTG
CTGGGAGGAAAATGTGCCAGGTTCCACGAAAAACCACGCGGTTAACTGCAACAGCTTATTGCAA
AGCCACCAGCATGCGCTTCCCCCGAGCCAGCTCTGTGAAGTCTGTGACTCTGTCACAGAAGAAC
ACCTGTGTTTGCAGCCTGGGATTCCTTCTCCACTGGAAAGGAAGGTGTTTCCTGGGATCGAACT
GGAGATGGAGGACTCTCCCATGGACGTGAGCCCTTTGGGAAACCAGCCTGGGATCATGGAGTCC
AGCGGACCTCACTCTGACCGCAACATGGCGGTATTTCATTTCCATTATGCAGGTGACAGGACAA
TGCCAGGTGCTTTCCATACCCTGTCAGAAAAATTCATTTTGGATGACTGTGCAAACTGTGTTAC
TCTTCCTGGGGGGCAGCAAAACAAAAATTACATGGCGTATACTTGCAAACTGGTGGAGTTGACA
AGAACCTGTGGTAGTAAGAATGGGCAGCTGAAGTGTGACCACTGCACCTCGCTGCGGGATGAAT
ACCTGTGCTTTGAAAGCTCCTGCCGGAAGGCTGAGGCTCTCTCCTCAGGTGGTGGCTTTTGCGA
GGACGGATTTACTCATGGTCCCTCTGCCAAGACTTTTCTGAACCCTTTGGAGGAATTCTCTGAT
AATTGTGAAGACGTGGACGATATTTTTAAAGGCAAAAAGGAGCGGTCCACTTTGTTAGTCCGAA
GGTTTTGTAAAAATGACAGGGAAGTTAAGAAGTCTGTGTATACTGGGACAAGGGCCATTGTGAG
AACCCTGCCTTCTGGCCACATTGGGCTGGCTGCTTGGAGTTACGTCGATCAGAAGAAAGCTGGT
CTCATGTGGCCTTGTGGGAATGGAATGAGACCTCTGTCCACAGTGGACGTAAGGCAAAGTGGGA
GACAGCGTCTGTCTGAAGCCCAGTGGTGTCTGATCTACAGTGCCGTGAGAAGAGAAGAGACAGA
AGATACGGTTGGCTCTCTTCTGCATTGCTCCACACAGCTCCCAACCCCTGACACAGCCCATGGA
AGGATCGGAGATGGTCCCTGCCTAAAGCAATGTGTGCGAGACAGCGAGTGTGAGTACCGTGCCA
CCCTCCAAAGGACGTCCATAGCTCAGTACATCACCGGTTCTCTCCTAGAGGCAACCACATCTTT
AGGAGCAAGAAGCAGCCTTCTCAGTTCCTTTGGAGGATCCACTGGGCGAATAATGCTGAAAGAA
CGCCAACCGGGCACTTCTATGGCCAATTCCAGTCCTGTTCCTTCAAGTTCAGCTGGAATCAGCA
AGGAGCTGATTGATCTCCAGCCCCTCATTCAGTTCCCGGAGGAAGTAGCCAGCATCTTAACAGA
ACAGGAACAGAACATTTACCGCAGGGTCCTGCCCATGGACTACCTCTGTTTCTTAACCCGGGAC
TTGAGTTCCCCCGAGTGTCAGAGATCACTGCCCCGTCTCAAAGCATGCATCTCAGAATCAATCC
TCATGTCTCAAAGTGGAGAGCACAATGCCCTTGAAGACCTCGTGATGAGATTTAACGAGGTGAG
CTCCTGGGTAACATGGCTGATCCTCACGGCAGGCTCCATGGAGGAGAAGCGGGAAGTCTTTTCT
TATTTGGTGCATGTGGCCAAATGCTGCTGGAACATGGGCAACTACAATGCTGTCATGGAGTTCC
TGGCTGGCCTCAGGTCAAGGAAAGTTCTGAAGATGTGGCAGTTCATGGACCAGTCTGACATCGA
GACCATGAGGAGCCTGAAAGACGCCATGGCTCAGCATGAGTCTTCCGTGGAGTACAAGAAGGTA
GTGACCCGAGCCTTGCACATCCCCGGCTGCAAAGTGGTTCCCTTCTGTGGGGTGTTCCTGAAGG
AGCTCTGTGAGGTGCTTGATGGTGCCTCTGGCCTCCTGAAGCTCTGCCCACGATACAGCTCCCA
AGAAGAAGCCCTGGAGTTTGTAGCGGATTACAGTGGACAAGATAACTTCTTACAGCGAGTGGGG
CAGAATGGCTTGAAGAATCCAGAGAAGGAGCTCACGGTCAACAGCATCTTTCAGATCATCCGGA
GCTGCAGCCGAAGCTTGGAGACGGAGGACGAGGAGAGCGCCAGCGAAGGGAGCGGCTCTAGGAA
AAACTCCCTCAAGGACAAAACCCGGTGGCAGTTTATAATTGGAGATTTGCTGGATTCAGACAAT
GACATCTTTGAGAAGTCCAAAGAGTGCGACCCTCATGGATCAGAGGAGTCACAGAAAGCCTTTG
ACCATGGGACAGAGCTCATCCCATGGTATGTGCTGTCCATCCAAGCGGATGTGCACCAGTTCCT
CCTGCAGGGGGCCACAGTCATCCACTATGACCAGGACACACATCTCTCCGCCCGCTGCTTTCTC
CAGTTGCAGCCTGACAATAGTACCTTGACCTGGATGAAACCTCCCACTGCCTCCCCAGCTGGTG
CCAGACTCAAGCTCGGTGTGCTTAGTAACGTGGCCGAACCTGGCAAGTTCCCATCACTGGGCAA
CGCTGGGGTGAGCGGCCTGGTAGAGGGAATCCTGGATCTGTTTTCAGTGAAGGCTGTGTACATG
GGACACCCTGGCATTGATATACACACTGTGTGTGTCCAGAACAAACTTAGTAGCATGCTTCTGT
CAGAGACTGGGGTGACGCTGCTCTATGGGCTTCAGACCACCGACAATAGATTACTGCACTTCGT
GGCACCAAAGCACACAGCTAAAATGCTTTTCAGTGGATTGCTGGAACTCACTACAGCTGTGAGA
AAGATACGGAAGTTCCCTGACCAAAGACAACAGTGGCTTCGGAAACAGTATGTCAGCTTCTATC
AGGAGGATGGTCGGTATGAAGGCCCAACCTTGGCACATGCTGTGGAGTTGTTTGGTGGTAGGAG
ATGGAGCACTAGAAACCCCAGCCCTGGGATGTCAGCAAAGAATGCCGAGAAGCCCAACATGCAG
AGAAACAACACCCTAGGCATAAGCACCACCAAGAAAAAGAAGAAAATGCTCATGAGGGGGGAGA
GTGGAGAGGTGACGGACGATGAGATGGCCACCCGCAAGGCCAAAATGTACAGAGAGTGTCGCAG
CCGGAGCGGCTCTGATCCTCAAGAGGCTAATGAACAGGAAGACTCAGAGGCCAATGTCATCACT
AACCCTCCCAACCCCCTCCATTCCAGAAGAGCCTACTCATTGACCACGGCTGGGTCCCCCAACT
TGGCTACCGGGATGTCATCTCCTATCAGTGCCTGGAGTAGCAGCAGCTGGCATGGGCGGATCAA
AGGAGGAATGAAAGGCTTCCAGAGCTTCATGGTCTCAGACAGTAACATGAGTTTCATTGAATTC
GTCGAGCTGTTCAAATCATTCAGCATAAGGAGCCGCAAGGACTTGAAGGACATCTTTGACATCT
ACTCTGTACCCTGTAATCGGTCTGCTTCTGAGTCAACCCCACTGTACACCAACCTGACAATCGA
AGAAAATACCAATGACCTTCAGCCTGACCTAGATTTGCTGACTAGAAACGTCTCCGACTTGGGG
CTGTTCATGAAGAGTAAGCAGCAGCTTTCTGACAACCAGAGGCAGATATCTGACGCCATTGCTG
CTGCAAGCATTGTGACTAATGGCACTGGGATTGAAAGCACGTCCCTGGGCATATTTGGGGTCGG
CATACTCCAGCTCAACGACTTCCTGGTGAATTGCCAAGGAGAACACTGCACATATGATGAAATC
CTCAGCATCATCCAGAAGTTCGAGCCCAACATCAGCATGTGTCATCAAGGTCTATTGTCCTTCG
AAGGGTTTGCAAGGTTTCTGATGGATAAAGACAATTTCGCCTCAAAAAATGACGAGTCGCGGGA
GAACAAGAAAGACCTGCAGCTACCCCTCTCCTACTATTACATCGAATCTTCGCACAACACCTAC
CTCACCGGCCATCAGCTCAAGGGGGAGTCCTCTGTGGAGCTCTACAGCCAGGTCCTCTTGCAAG
GATGCAGAAGCATAGAGCTGGACTGCTGGGATGGAGATGATGGGATGCCCATTATTTATCATGG
ACATACGCTGACAACCAAGATCCCCTTCAAGGAAGTGGTGGAAGCCATCGATCGCAGTGCCTTC
ATCACCTCCGACCTGCCAATCATCATATCCATTGAGAACCATTGCTCATTGCCTCAGCAACGGA
AAATGGCAGAAATTTTCAAGAGTGTGTTTGGAGAAAAGCTGGTGGCTAAGTTCTTGTTCGAGAC
CGATTTCTCAGATGACCCAATGCTTCCCTCACCTGACCAACTTAGAAGGAAAGTGCTTCTTAAA
AACAAGAAGCTAAAGGCCCATCAGACACCTGTCGACATCCTCAAACAAAAGGCTCATCAGTTAG
CATCCATGCAAACACAGGCTTTCACTGGTGGGAATGCCAACCCGCCACCTGCCAGTAATGAGGA
AGAGGAAGACGAGGAGGACGAATATGATTATGATTACGAGTCCCTGTCTGATGACAACATTCTG
GAAGACAGACCTGAGAACAAATCATGTGCCGACAAGCTTCAGTTTGAGTACAATGAAGAAGTCC
CCAAGAGGATAAAGAAAGCAGACAACTCCTCCGGCAATAAGGGAAAGGTCTATGACATGGAACT
GGGAGAGGAGTTTTACCTTCCTCAGAACAAAAAAGAAAGCAGGCAGATTGCACCGGAGCTCTCT
GACCTCGTCATCTATTGCCAGGCGGTAAAATTTCCAGGCCTGTCAACTCTAAATTCATCTGGCT
CTGGCAGAGGGAAAGAAAGGAAAAGCAGGAAGTCCATTTTTGGCAACAATCCCGGCAGAATGAG
CCCAGGGGAGACAGCGTCATTTAACAGAACATCTGGAAAAAGTTCTTGTGAAGGAATTCGACAA
ATCTGGGAGGAACCTCCACTCAGCCCAAACACATCCCTCAGCGCCATCATTAGAACTCCTAAAT
GCTATCATATCTCGTCACTGAATGAAAATGCCGCCAAACGTCTGTGTCGCAGGTATTCTCAGAA
ACTGATCCAGCACACTGCTTGCCAGCTGCTGAGGACCTACCCGGCAGCGACCAGAATCGACTCA
TCCAATCCCAACCCCCTCATGTTCTGGCTCCATGGGATACAGCTTGTAGCTCTAAACTACCAGA
CGGATGACCTTCCTTTACATTTAAACGCTGCCATGTTTGAGGCGAATGGTGGGTGTGGCTATGT
TTTGAAGCCCCCTGTCCTGTGGGATAAAAGCTGTCCCATGTATCAGAAGTTTTCACCACTGGAA
AGAGACCTGGACGCCATGGATCCTGCTACCTATTCTTTAACCATCATCTCTGGCCAGAATGTGT
GTCCTAGTAACAGCACCGGAAGTCCGTGCATTGAAGTTGACGTCTTGGGCATGCCCCTGGACAG
CTGCCATTTCCGCACAAAACCCATCCACCGAAACACTCTGAACCCCATGTGGAATGAGCAGTTT
CTCTTCCGGGTTCACTTTGAAGATCTTGTATTTCTTCGTTTTGCAGTTGTGGAGAACAACAGTT
CGGCGATAACGGCTCAGAGAATCATTCCACTCAAAGCTTTAAAGAGAGGATATCGGCATCTTCA
GCTGCGGAACCTCCACAACGAGATCTTGGAAATCTCTAGCTTATTCATAAACAGCAGGAGGATG
GAAGATAATCCCTCTGGCAGTACCCGGCCAGCCTCTTTGATGTTCAATACTGAAGAGAGGAAAT
GTTCTCAGACTCACAAAGTCACAGTGCATGGTGTCCCAGGTCCAGAGCCCTTTGCTGTTTTCAC
AATAAACGAAGGCACCAAGGCAAAGCAGCTTCTCCAACAGATTTTGGCAGTTGACCAGGACACC
AAACTTACAGCCGCAGACTATTTTCTGATGGAAGAGAAGCATTTTATATCTAAGGAAAAGAATG
AATGCAGGAAACAACCATTCCAGAGAGCTGTGGGCCCAGAGGAAGATATTGTGCAGATTTTAAA
CAGCTGGTTCCCAGAAGAAGGCTACGTAGGCAGGATTGTCTTAAAGCCCCAACAAGAAACCCTA
GAAGAGAAAAACATTGTCCACGATGACAGAGAGGTGATCTTGAGCTCAGAAGAGGAGAGTTTCT
TTGTCCAAGTGCACGATGTCTCTCCAGAGCAGCCTCGAACTGTCATCAAAGCCCCACGTGTCAG
CACTGCACAGGATGTGATTCAGCAGACCTTGTGCAAAGCCAAATATTCCTACAGCATCCTGAAC
AACCCCAATCCGTGTGACTATGTGCTTTTGGAAGAGGTAATGAAAGATGCACCCAATAAGAAGT
CTTCTACCCCGAAGTCCTCACAGAGGATCCTCTTGGACCAAGAATGTGTGTTTCAAGCCCAAAG
CAAGTGGAAGGGTGCAGGGAAATTCATCCTTAAGCTAAAGGAGCAGGTGCAGGCATCCAGAGAA
GATAAAAGGAGGGGCATCTCCTTTGCAAGTGAACTCAAGAAACTCACGAAGTCCACTAAGCAAA
CCCGAGGACTCACCTCGCCTCCTCAGCTTGTGGCCTCAGAAAGTGTGCAAAGCAAGGAGGAGAA
ACCCATGGGTGCCTTGGCCTCTGGTGACACAGCGGGCTACCAGTCGTGAGCCAGTGCAGCACAT
TTGATCCAGGGATATGAAGGGGAAGGCCCTTGATGAGAAGCTATCAAGAATGGACATGGTGGAA
AGAAGTATACTTTACCTCCATCACATTCAAACTGGAAATTGATGATTTCCGAACTCCAGAACCT
CCTCACACCCGATGAGAGGTTCATGCAGAGGACAAGCAAAACGGCACAGAACTGCCAACCAACT
TCCTGAGGAATGAAGCAGGGACACCCAGGGCATTGCCCGGGGCATTATGGGTGGAAAAGCCACC
CCTCAAGCTGAAGGCAACAAGGAACACCTGTAAAGGGCCAGGCGGTAAACATTTTAGGGTCGGG
GCCACGTGGCTTCTGTCGAATTCAGTTAGCTCAGCTACTGGATGGCAAATGAAGCTGTCGACAA
CAGGTACAAGAATGAACATCTGACTGAACAATAAAACTTTATTTATGGACACTTAAATCGGAAC
CTCATATAATTTTCACATGTCACACATGTTTAAGTGTTTCAACCACTTAAAATTGTAAAATCTT
TCCTAGTTTAAGGGTCAGACAAAAACAACATGAGGCTGGCTCGAGGACCAGCTTGCTGACCCAG
CTTGGGAGAACTGGGAGCCAAAGGCACAGAGGTTAGAAAACCTCGAAAATTGGCCGTGGGTTTA
ATGAGAAGTGGAAGTCTGGGGACATTGGAAATGTAAATATGTCCTGTTAGATTTGTTAGCAATT
ATTCAAATTAGTTCCTATATTGTGTACCCAGGTGCACTCTTTGGGCTGCCTTTCCTCAAATAGA
AATGTTTTTCCGAAAGCTACGACCCATGCGTCCACAGACTGTCCCATTTTCAGTTCTCACAAAG
TGAATTTAGAATGATGTACAATTTAGTGTCTATCGAGTTGTGATGTCCTCATAAGAAAACCTAA
AAGCAAAAAGTAGACTGAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_039108292 ⟹ XP_038964220

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	245,655,855 - 245,964,966 (+)	NCBI
mRatBN7.2	1	236,243,445 - 236,552,571 (+)	NCBI

RefSeq Acc Id:

XM_063262806 ⟹ XP_063118876

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	245,750,586 - 245,964,966 (+)	NCBI

RefSeq Acc Id:

XM_063262818 ⟹ XP_063118888

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	1	245,757,760 - 245,964,966 (+)	NCBI

Protein Sequences


Protein RefSeqs	NP_446210	(Get FASTA)	NCBI Sequence Viewer
	XP_038964220	(Get FASTA)	NCBI Sequence Viewer
	XP_063118876	(Get FASTA)	NCBI Sequence Viewer
	XP_063118888	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAK06775	(Get FASTA)	NCBI Sequence Viewer
	CBF62950	(Get FASTA)	NCBI Sequence Viewer
	CBF74699	(Get FASTA)	NCBI Sequence Viewer
	CBU87826	(Get FASTA)	NCBI Sequence Viewer
	CBU96773	(Get FASTA)	NCBI Sequence Viewer
	EDM13221	(Get FASTA)	NCBI Sequence Viewer
	EDM13222	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000062667
GenBank Protein	Q99P84	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_446210 ⟸ NM_053758

- UniProtKB:

Q99P84 (UniProtKB/Swiss-Prot), A6I190 (UniProtKB/TrEMBL), G3V9X9 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MTSEEMAASFLIPVPQRKVASAQSVAEERGEKVSEAGIPKTRAGRQGGLTPRTISQRNEPEEES
PRTDFSQVFSIARGELDSDENHNERCWEENVPGSTKNHAVNCNSLLQSHQHALPPSQLCEVCDS
VTEEHLCLQPGIPSPLERKVFPGIELEMEDSPMDVSPLGNQPGIMESSGPHSDRNMAVFHFHYA
GDRTMPGAFHTLSEKFILDDCANCVTLPGGQQNKNYMAYTCKLVELTRTCGSKNGQLKCDHCTS
LRDEYLCFESSCRKAEALSSGGGFCEDGFTHGPSAKTFLNPLEEFSDNCEDVDDIFKGKKERST
LLVRRFCKNDREVKKSVYTGTRAIVRTLPSGHIGLAAWSYVDQKKAGLMWPCGNGMRPLSTVDV
RQSGRQRLSEAQWCLIYSAVRREETEDTVGSLLHCSTQLPTPDTAHGRIGDGPCLKQCVRDSEC
EYRATLQRTSIAQYITGSLLEATTSLGARSSLLSSFGGSTGRIMLKERQPGTSMANSSPVPSSS
AGISKELIDLQPLIQFPEEVASILTEQEQNIYRRVLPMDYLCFLTRDLSSPECQRSLPRLKACI
SESILMSQSGEHNALEDLVMRFNEVSSWVTWLILTAGSMEEKREVFSYLVHVAKCCWNMGNYNA
VMEFLAGLRSRKVLKMWQFMDQSDIETMRSLKDAMAQHESSVEYKKVVTRALHIPGCKVVPFCG
VFLKELCEVLDGASGLLKLCPRYSSQEEALEFVADYSGQDNFLQRVGQNGLKNPEKELTVNSIF
QIIRSCSRSLETEDEESASEGSGSRKNSLKDKTRWQFIIGDLLDSDNDIFEKSKECDPHGSEES
QKAFDHGTELIPWYVLSIQADVHQFLLQGATVIHYDQDTHLSARCFLQLQPDNSTLTWMKPPTA
SPAGARLKLGVLSNVAEPGKFPSLGNAGVSGLVEGILDLFSVKAVYMGHPGIDIHTVCVQNKLS
SMLLSETGVTLLYGLQTTDNRLLHFVAPKHTAKMLFSGLLELTTAVRKIRKFPDQRQQWLRKQY
VSFYQEDGRYEGPTLAHAVELFGGRRWSTRNPSPGMSAKNAEKPNMQRNNTLGISTTKKKKKML
MRGESGEVTDDEMATRKAKMYRECRSRSGSDPQEANEQEDSEANVITNPPNPLHSRRAYSLTTA
GSPNLATGMSSPISAWSSSSWHGRIKGGMKGFQSFMVSDSNMSFIEFVELFKSFSIRSRKDLKD
IFDIYSVPCNRSASESTPLYTNLTIEENTNDLQPDLDLLTRNVSDLGLFMKSKQQLSDNQRQIS
DAIAAASIVTNGTGIESTSLGIFGVGILQLNDFLVNCQGEHCTYDEILSIIQKFEPNISMCHQG
LLSFEGFARFLMDKDNFASKNDESRENKKDLQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQ
VLLQGCRSIELDCWDGDDGMPIIYHGHTLTTKIPFKEVVEAIDRSAFITSDLPIIISIENHCSL
PQQRKMAEIFKSVFGEKLVAKFLFETDFSDDPMLPSPDQLRRKVLLKNKKLKAHQTPVDILKQK
AHQLASMQTQAFTGGNANPPPASNEEEEDEEDEYDYDYESLSDDNILEDRPENKSCADKLQFEY
NEEVPKRIKKADNSSGNKGKVYDMELGEEFYLPQNKKESRQIAPELSDLVIYCQAVKFPGLSTL
NSSGSGRGKERKSRKSIFGNNPGRMSPGETASFNRTSGKSSCEGIRQIWEEPPLSPNTSLSAII
RTPKCYHISSLNENAAKRLCRRYSQKLIQHTACQLLRTYPAATRIDSSNPNPLMFWLHGIQLVA
LNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKSCPMYQKFSPLERDLDAMDPATYSLTIIS
GQNVCPSNSTGSPCIEVDVLGMPLDSCHFRTKPIHRNTLNPMWNEQFLFRVHFEDLVFLRFAVV
ENNSSAITAQRIIPLKALKRGYRHLQLRNLHNEILEISSLFINSRRMEDNPSGSTRPASLMFNT
EERKCSQTHKVTVHGVPGPEPFAVFTINEGTKAKQLLQQILAVDQDTKLTAADYFLMEEKHFIS
KEKNECRKQPFQRAVGPEEDIVQILNSWFPEEGYVGRIVLKPQQETLEEKNIVHDDREVILSSE
EESFFVQVHDVSPEQPRTVIKAPRVSTAQDVIQQTLCKAKYSYSILNNPNPCDYVLLEEVMKDA
PNKKSSTPKSSQRILLDQECVFQAQSKWKGAGKFILKLKEQVQASREDKRRGISFASELKKLTK
STKQTRGLTSPPQLVASESVQSKEEKPMGALASGDTAGYQS

hide sequence

Ensembl Acc Id:

ENSRNOP00000072165 ⟸ ENSRNOT00000079219

Ensembl Acc Id:

ENSRNOP00000062667 ⟸ ENSRNOT00000067149

RefSeq Acc Id:	XP_038964220 ⟸ XM_039108292
- Peptide Label:	isoform X1
- UniProtKB:	Q99P84 (UniProtKB/Swiss-Prot), G3V9X9 (UniProtKB/TrEMBL), A6I190 (UniProtKB/TrEMBL)

RefSeq Acc Id:	XP_063118876 ⟸ XM_063262806
- Peptide Label:	isoform X2
- UniProtKB:	Q99P84 (UniProtKB/Swiss-Prot)

RefSeq Acc Id:	XP_063118888 ⟸ XM_063262818
- Peptide Label:	isoform X3

Protein Domains

C2 PI-PLC X-box PI-PLC Y-box Ras-associating Ras-GEF

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q99P84-F1-model_v2	AlphaFold	Q99P84	1-2281	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13690886

Promoter ID:

EPDNEW_R1410

Type:

initiation region

Name:

Plce1_1

Description:

phospholipase C, epsilon 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	1	257,157,237 - 257,157,297	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:69424	AgrOrtholog
BioCyc Gene	G2FUF-55776	BioCyc
Ensembl Genes	ENSRNOG00000014276	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000067149	ENTREZGENE
Gene3D-CATH	1.10.840.10	UniProtKB/Swiss-Prot
	2.60.40.150	UniProtKB/Swiss-Prot
	3.20.20.190	UniProtKB/Swiss-Prot
	EF-hand	UniProtKB/Swiss-Prot
	Phosphatidylinositol 3-kinase Catalytic Subunit, Chain A, domain 1	UniProtKB/Swiss-Prot
InterPro	C2_dom	UniProtKB/Swiss-Prot
	C2_domain_sf	UniProtKB/Swiss-Prot
	EF-hand-dom_pair	UniProtKB/Swiss-Prot
	PI-PLC_fam	UniProtKB/Swiss-Prot
	PLC-epsilon1	UniProtKB/Swiss-Prot
	PLC-epsilon1_cat	UniProtKB/Swiss-Prot
	PLC-like_Pdiesterase_TIM-brl	UniProtKB/Swiss-Prot
	PLC_epsilon1_EF	UniProtKB/Swiss-Prot
	PLipase_C_PInositol-sp_X_dom	UniProtKB/Swiss-Prot
	PLipase_C_Pinositol-sp_Y	UniProtKB/Swiss-Prot
	RA_dom	UniProtKB/Swiss-Prot
	Ras_GEF_dom_sf	UniProtKB/Swiss-Prot
	RASGEF_cat_dom	UniProtKB/Swiss-Prot
	RASGEF_cat_dom_sf	UniProtKB/Swiss-Prot
	Ubiquitin-like_domsf	UniProtKB/Swiss-Prot
KEGG Report	rno:114633	UniProtKB/Swiss-Prot
NCBI Gene	114633	ENTREZGENE
PANTHER	PTHR10336	UniProtKB/Swiss-Prot
	PTHR10336:SF6	UniProtKB/Swiss-Prot
Pfam	PF00168	UniProtKB/Swiss-Prot
	PF00788	UniProtKB/Swiss-Prot
	PI-PLC-X	UniProtKB/Swiss-Prot
	PI-PLC-Y	UniProtKB/Swiss-Prot
	RasGEF	UniProtKB/Swiss-Prot
PhenoGen	Plce1	PhenoGen
PRINTS	PHPHLIPASEC	UniProtKB/Swiss-Prot
PROSITE	PIPLC_X_DOMAIN	UniProtKB/Swiss-Prot
	PIPLC_Y_DOMAIN	UniProtKB/Swiss-Prot
	PS50004	UniProtKB/Swiss-Prot
	PS50200	UniProtKB/Swiss-Prot
	RASGEF_CAT	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000014276	RatGTEx
SMART	PLCXc	UniProtKB/Swiss-Prot
	PLCYc	UniProtKB/Swiss-Prot
	RasGEF	UniProtKB/Swiss-Prot
	SM00239	UniProtKB/Swiss-Prot
	SM00314	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF47473	UniProtKB/Swiss-Prot
	SSF48366	UniProtKB/Swiss-Prot
	SSF49562	UniProtKB/Swiss-Prot
	SSF51695	UniProtKB/Swiss-Prot
	SSF54236	UniProtKB/Swiss-Prot
TIGR	TC233983
UniProt	A0A0G2K2A6_RAT	UniProtKB/TrEMBL
	A6I190	ENTREZGENE, UniProtKB/TrEMBL
	A6I191_RAT	UniProtKB/TrEMBL
	G3V9X9	ENTREZGENE, UniProtKB/TrEMBL
	PLCE1_RAT	UniProtKB/Swiss-Prot, ENTREZGENE

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2003-04-09	Plce1	phospholipase C, epsilon 1	Plce	phospholipase C, epsilon	Symbol and Name updated	629477	APPROVED
2002-06-10	Plce	phospholipase C, epsilon			Symbol and Name status set to approved	70586	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_function	hydrolyzes membrane phospholipids to generate inositol trisphosphate (IP3)	68714
gene_process	involved in intracellar Ca2+ and diacylglycerol regulation	68714
gene_protein	predicted 2281 amino acid, 255 kDa protein	68714

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - OMIM

Imported Annotations - KEGG (archival)

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Imported Disease Annotations - ClinVar

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Imported Annotations - KEGG (archival)