Glrx3 (glutaredoxin 3) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Behavioral & Substance Use Disorder Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: Glrx3 (glutaredoxin 3) Rattus norvegicus
Analyze
Symbol: Glrx3
Name: glutaredoxin 3
RGD ID: 69414
Description: Enables protein kinase C binding activity. Predicted to be involved in several processes, including [2Fe-2S] cluster assembly; cell redox homeostasis; and negative regulation of cardiac muscle hypertrophy. Located in dendrite. Orthologous to human GLRX3 (glutaredoxin 3); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4-dibromophenyl 2,4,5-tribromophenyl ether.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: glutaredoxin-3; MGC105380; PICOT; PKC-interacting cousin of thioredoxin; PKC-theta-interacting protein; PKCq-interacting protein; thioredoxin-like 2; thioredoxin-like protein 2; Txnl2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81201,671,410 - 201,701,722 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1201,671,481 - 201,701,717 (+)EnsemblGRCr8
mRatBN7.21192,241,707 - 192,272,012 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1192,241,701 - 192,272,010 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1200,608,856 - 200,638,933 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01207,760,578 - 207,790,565 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01200,434,029 - 200,464,012 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01209,768,696 - 209,799,912 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1209,768,696 - 209,799,903 (+)Ensemblrn6Rnor6.0
Rnor_5.01216,692,884 - 216,724,100 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41197,176,020 - 197,206,249 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1189,946,939 - 189,976,456 (+)NCBICelera
RGSC_v3.11197,326,013 - 197,356,245 (+)NCBI
Cytogenetic Map1q41NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
Cardiomegaly  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4,6-tribromophenol  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (EXP)
2,4-dinitrotoluene  (EXP)
2,6-dimethoxyphenol  (ISO)
2,6-dinitrotoluene  (EXP)
2-acetamidofluorene  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-chloropropane-1,2-diol  (EXP)
6-propyl-2-thiouracil  (EXP)
aflatoxin B1  (EXP,ISO)
all-trans-retinoic acid  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
benzatropine  (ISO)
benzo[a]pyrene  (ISO)
beta-naphthoflavone  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
Brodifacoum  (EXP)
cadmium atom  (ISO)
cadmium dichloride  (ISO)
calcium atom  (EXP)
calcium(0)  (EXP)
carbon nanotube  (ISO)
CGP 52608  (ISO)
chloropicrin  (ISO)
chromium(6+)  (ISO)
clobetasol  (ISO)
clofibric acid  (EXP)
clozapine  (ISO)
cocaine  (EXP)
copper(II) sulfate  (ISO)
cyclosporin A  (ISO)
decabromodiphenyl ether  (ISO)
diarsenic trioxide  (ISO)
diazinon  (ISO)
ethanol  (ISO)
finasteride  (EXP)
flavonoids  (EXP)
flutamide  (EXP)
frenolicin B  (ISO)
furfural  (ISO)
gentamycin  (EXP)
glutathione  (ISO)
glycidyl methacrylate  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP,ISO)
inulin  (ISO)
irinotecan  (ISO)
ivermectin  (ISO)
lead(0)  (ISO)
methimazole  (EXP)
microcystin-LR  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
N-nitrosodiethylamine  (EXP)
nefazodone  (EXP)
nickel atom  (ISO)
nitrates  (ISO)
ochratoxin A  (ISO)
okadaic acid  (ISO)
ozone  (EXP)
paracetamol  (ISO)
paraquat  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
phenylephrine  (EXP)
quartz  (ISO)
reactive oxygen species  (ISO)
rotenone  (ISO)
SB 431542  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (EXP)
sodium chloride  (ISO)
sodium dichromate  (EXP)
sulfadimethoxine  (EXP)
tamoxifen  (EXP,ISO)
temozolomide  (ISO)
tert-butyl hydroperoxide  (ISO)
thapsigargin  (ISO)
theophylline  (ISO)
thioacetamide  (EXP)
triptonide  (ISO)
trovafloxacin  (EXP)
tunicamycin  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cell cortex  (IEA)
cytosol  (IBA,IEA)
dendrite  (IDA)
iron-sulfur cluster assembly complex  (IEA,ISO)
nucleus  (IBA)
Z disc  (IEA,ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Thioredoxin and glutaredoxin system proteins-immunolocalization in the rat central nervous system. Aon-Bertolino ML, etal., Biochim Biophys Acta. 2011 Jan;1810(1):93-110. Epub 2010 Jul 8.
2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
3. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
4. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
5. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
6. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
7. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
8. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
9. Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain. Witte S, etal., J Biol Chem 2000 Jan 21;275(3):1902-9.
Additional References at PubMed
PMID:12477932   PMID:15489334   PMID:18258855   PMID:22658674   PMID:23376485   PMID:25416956   PMID:26302480   PMID:27519415  


Genomics

Comparative Map Data
Glrx3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81201,671,410 - 201,701,722 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1201,671,481 - 201,701,717 (+)EnsemblGRCr8
mRatBN7.21192,241,707 - 192,272,012 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1192,241,701 - 192,272,010 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1200,608,856 - 200,638,933 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01207,760,578 - 207,790,565 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01200,434,029 - 200,464,012 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01209,768,696 - 209,799,912 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1209,768,696 - 209,799,903 (+)Ensemblrn6Rnor6.0
Rnor_5.01216,692,884 - 216,724,100 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41197,176,020 - 197,206,249 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1189,946,939 - 189,976,456 (+)NCBICelera
RGSC_v3.11197,326,013 - 197,356,245 (+)NCBI
Cytogenetic Map1q41NCBI
GLRX3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3810130,136,391 - 130,180,377 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl10130,136,385 - 130,184,521 (+)Ensemblhg38GRCh38
GRCh3710131,934,655 - 131,978,641 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610131,824,653 - 131,867,860 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3410131,824,671 - 131,872,774NCBI
Celera10125,607,908 - 125,651,111 (+)NCBICelera
Cytogenetic Map10q26.3NCBI
HuRef10125,514,535 - 125,558,544 (+)NCBIHuRef
CHM1_110132,217,042 - 132,261,052 (+)NCBICHM1_1
T2T-CHM13v2.010131,065,390 - 131,109,374 (+)NCBIT2T-CHM13v2.0
Glrx3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397137,039,302 - 137,071,360 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7137,039,343 - 137,070,323 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm387137,437,573 - 137,469,631 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7137,437,614 - 137,468,594 (+)Ensemblmm10GRCm38
MGSCv377144,629,331 - 144,660,277 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv367137,275,991 - 137,306,937 (+)NCBIMGSCv36mm8
Celera7137,253,536 - 137,284,736 (+)NCBICelera
Cytogenetic Map7F4NCBI
cM Map782.32NCBI
Glrx3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554777,715,257 - 7,752,818 (+)Ensembl
ChiLan1.0NW_0049554777,715,257 - 7,748,913 (+)NCBIChiLan1.0ChiLan1.0
GLRX3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v28142,025,459 - 142,134,030 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan110142,030,815 - 142,135,466 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v010126,730,314 - 126,775,918 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.110130,973,022 - 131,019,741 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10130,973,022 - 131,019,742 (+)EnsemblpanPan2panpan1.1
GLRX3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12838,724,895 - 38,755,323 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2838,724,941 - 38,755,316 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2838,781,705 - 38,812,290 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02839,360,801 - 39,391,612 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2839,360,806 - 39,391,610 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12838,847,851 - 38,878,212 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02838,836,160 - 38,866,776 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02839,090,506 - 39,121,238 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Glrx3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_0244072138,328,180 - 8,354,031 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648617,207,309 - 17,233,171 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493648617,201,838 - 17,233,171 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GLRX3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14139,072,575 - 139,111,249 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.114139,072,554 - 139,108,063 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214151,189,259 - 151,224,776 (+)NCBISscrofa10.2Sscrofa10.2susScr3
GLRX3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.19122,737,101 - 122,780,001 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl9122,737,379 - 122,781,391 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604884,120,319 - 84,163,350 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Glrx3
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473716,905,964 - 16,938,048 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473716,906,135 - 16,938,089 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Glrx3
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1264,481,121 - 64,513,093 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Glrx3
97 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:19
Count of miRNA genes:15
Interacting mature miRNAs:19
Transcripts:ENSRNOT00000022406
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
4889428Stresp24Stress response QTL 240.05heart pumping trait (VT:2000009)absolute change in electrocardiographic low frequency R-R spectral component to high frequency R-R spectral component ratio (CMO:0002162)1165278545210278545Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
61347Bp197Blood pressure QTL 1974.2arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)1168063662213063662Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
2303622Vencon6Ventilatory control QTL 60.001respiration trait (VT:0001943)respiration rate (CMO:0000289)1163992710208992710Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1359018Hrtrt20Heart rate QTL 203.08heart pumping trait (VT:2000009)heart rate (CMO:0000002)1194786607207590403Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
61378Bp43Blood pressure QTL 4322.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1191177449205813246Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
619614Bp78Blood pressure QTL 780.001arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1178547286206690557Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
1354618Kidm15Kidney mass QTL 155kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)1165707719210707719Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat
631670Iddm10Insulin dependent diabetes mellitus QTL 101.9blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1183564652205813246Rat

Markers in Region
BE117517  
Rat AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map1q41UniSTS
BE113509  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81201,691,007 - 201,691,179 (+)Marker Load Pipeline
mRatBN7.21192,261,295 - 192,261,467 (+)MAPPERmRatBN7.2
Rnor_6.01209,789,194 - 209,789,365NCBIRnor6.0
Rnor_5.01216,713,382 - 216,713,553UniSTSRnor5.0
RGSC_v3.41197,195,535 - 197,195,706UniSTSRGSC3.4
Celera1189,965,796 - 189,965,967UniSTS
RH 3.4 Map11420.6UniSTS
Cytogenetic Map1q41UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 69 176 91 90 59 116 59 6 390 220 13 155 87 96 31 24 24

Sequence


Ensembl Acc Id: ENSRNOT00000022406   ⟹   ENSRNOP00000022406
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1201,671,481 - 201,701,717 (+)Ensembl
mRatBN7.2 Ensembl1192,241,701 - 192,272,010 (+)Ensembl
Rnor_6.0 Ensembl1209,768,696 - 209,799,903 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000083316   ⟹   ENSRNOP00000073509
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1201,671,702 - 201,701,716 (+)Ensembl
mRatBN7.2 Ensembl1192,241,765 - 192,272,010 (+)Ensembl
Rnor_6.0 Ensembl1209,769,282 - 209,799,903 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000107315   ⟹   ENSRNOP00000079546
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1201,671,702 - 201,699,005 (+)Ensembl
mRatBN7.2 Ensembl1192,241,701 - 192,269,832 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000109827   ⟹   ENSRNOP00000091412
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1201,679,745 - 201,699,544 (+)Ensembl
mRatBN7.2 Ensembl1192,250,032 - 192,269,832 (+)Ensembl
RefSeq Acc Id: NM_032614   ⟹   NP_116003
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81201,671,494 - 201,701,722 (+)NCBI
mRatBN7.21192,241,781 - 192,272,010 (+)NCBI
Rnor_6.01209,768,696 - 209,799,908 (+)NCBI
Rnor_5.01216,692,884 - 216,724,100 (+)NCBI
RGSC_v3.41197,176,020 - 197,206,249 (+)RGD
Celera1189,946,939 - 189,976,456 (+)RGD
Sequence:
RefSeq Acc Id: XM_039088750   ⟹   XP_038944678
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81201,671,985 - 201,701,722 (+)NCBI
mRatBN7.21192,242,356 - 192,272,012 (+)NCBI
RefSeq Acc Id: XM_039088751   ⟹   XP_038944679
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81201,671,410 - 201,701,722 (+)NCBI
mRatBN7.21192,241,707 - 192,272,004 (+)NCBI
RefSeq Acc Id: XM_063272117   ⟹   XP_063128187
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81201,687,294 - 201,701,722 (+)NCBI
RefSeq Acc Id: NP_116003   ⟸   NM_032614
- UniProtKB: Q5RK11 (UniProtKB/Swiss-Prot),   Q9JLZ1 (UniProtKB/Swiss-Prot),   A6HX85 (UniProtKB/TrEMBL),   A0A8I6AG27 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022406   ⟸   ENSRNOT00000022406
Ensembl Acc Id: ENSRNOP00000073509   ⟸   ENSRNOT00000083316
RefSeq Acc Id: XP_038944679   ⟸   XM_039088751
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038944678   ⟸   XM_039088750
- Peptide Label: isoform X1
- UniProtKB: A0A0G2K5P8 (UniProtKB/TrEMBL),   A0A8I5ZN19 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000079546   ⟸   ENSRNOT00000107315
Ensembl Acc Id: ENSRNOP00000091412   ⟸   ENSRNOT00000109827
RefSeq Acc Id: XP_063128187   ⟸   XM_063272117
- Peptide Label: isoform X3
- UniProtKB: A6HX87 (UniProtKB/TrEMBL),   A6HX86 (UniProtKB/TrEMBL)
Protein Domains
Glutaredoxin   Thioredoxin

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JLZ1-F1-model_v2 AlphaFold Q9JLZ1 1-337 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690498
Promoter ID:EPDNEW_R1023
Type:initiation region
Name:Glrx3_1
Description:glutaredoxin 3
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01209,768,688 - 209,768,748EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69414 AgrOrtholog
BioCyc Gene G2FUF-57120 BioCyc
Ensembl Genes ENSRNOG00000016227 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000022406 ENTREZGENE
  ENSRNOT00000022406.7 UniProtKB/Swiss-Prot
  ENSRNOT00000083316 ENTREZGENE
Gene3D-CATH Glutaredoxin UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7301390 IMAGE-MGC_LOAD
InterPro Glutaredoxin UniProtKB/Swiss-Prot
  GRX_PICOT-like UniProtKB/Swiss-Prot
  Monothiol_GRX-rel UniProtKB/Swiss-Prot
  Thioredoxin-like_sf UniProtKB/Swiss-Prot
  Thioredoxin_domain UniProtKB/Swiss-Prot
KEGG Report rno:58815 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105380 IMAGE-MGC_LOAD
NCBI Gene 58815 ENTREZGENE
PANTHER GLUTAREDOXIN-3 UniProtKB/Swiss-Prot
  PTHR10293 UniProtKB/Swiss-Prot
Pfam Glutaredoxin UniProtKB/Swiss-Prot
  Thioredoxin UniProtKB/Swiss-Prot
PhenoGen Glrx3 PhenoGen
PROSITE GLUTAREDOXIN_2 UniProtKB/Swiss-Prot
  THIOREDOXIN_2 UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016227 RatGTEx
Superfamily-SCOP SSF52833 UniProtKB/Swiss-Prot
TIGR TC204832
UniProt A0A0G2K5P8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I5ZN19 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6AG27 ENTREZGENE, UniProtKB/TrEMBL
  A6HX85 ENTREZGENE, UniProtKB/TrEMBL
  A6HX86 ENTREZGENE, UniProtKB/TrEMBL
  A6HX87 ENTREZGENE, UniProtKB/TrEMBL
  GLRX3_RAT UniProtKB/Swiss-Prot
  Q5RK11 ENTREZGENE
  Q9JLZ1 ENTREZGENE
UniProt Secondary Q5RK11 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2008-02-18 Glrx3  glutaredoxin 3  Txnl2  thioredoxin-like 2  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Txnl2  thioredoxin-like 2      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_domains contains an N-terminal thioredoxin homology domain and two tandem repeats of a novel domain 69393