Rasgrf2 (RAS protein-specific guanine nucleotide-releasing factor 2) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Rasgrf2 (RAS protein-specific guanine nucleotide-releasing factor 2) Rattus norvegicus
Analyze
Symbol: Rasgrf2
Name: RAS protein-specific guanine nucleotide-releasing factor 2
RGD ID: 69413
Description: Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction and response to endoplasmic reticulum stress. Predicted to act upstream of or within long-term synaptic potentiation. Predicted to be located in endoplasmic reticulum. Predicted to be active in plasma membrane. Orthologous to human RASGRF2 (Ras protein specific guanine nucleotide releasing factor 2); PARTICIPATES IN mitogen activated protein kinase signaling pathway; INTERACTS WITH ammonium chloride; benzo[a]pyrene; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: guanine nucleotide-releasing factor 2; ras guanine nucleotide exchange factor 2; ras-GRF2; ras-specific guanine nucleotide-releasing factor 2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Candidate Gene For: Bp115
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8224,848,699 - 25,096,773 (-)NCBIGRCr8
mRatBN7.2223,113,613 - 23,361,537 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl223,117,004 - 23,361,240 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx230,154,119 - 30,396,141 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0228,254,458 - 28,496,490 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0223,080,067 - 23,323,713 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0221,460,041 - 21,698,937 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0240,664,646 - 40,904,636 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4222,113,649 - 22,360,970 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1222,034,017 - 22,281,339 (-)NCBI
Celera219,216,953 - 19,453,016 (-)NCBICelera
Cytogenetic Map2q12NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf. Anborgh PH, etal., Mol Cell Biol. 1999 Jul;19(7):4611-22.
2. Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors. Arozarena I, etal., Mol Cell Biol 2004 Feb;24(4):1516-30.
3. The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways. Fan WT, etal., Curr Biol 1998 Jul 30-Aug 13;8(16):935-8.
4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
5. Analysis of candidate genes included in the mammary cancer susceptibility 1 (Mcs1) region. Laes JF, etal., Mamm Genome 2001 Mar;12(3):199-206.
6. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
7. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
8. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
9. GOA pipeline RGD automated data pipeline
10. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. Comprehensive gene review and curation RGD comprehensive gene curation
13. RasGRF2 Rac-GEF activity couples NMDA receptor calcium flux to enhanced synaptic transmission. Schwechter B, etal., Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14462-7. doi: 10.1073/pnas.1304340110. Epub 2013 Aug 12.
14. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
Additional References at PubMed
PMID:15029245   PMID:17931779   PMID:20661302   PMID:27856453   PMID:30053369  


Genomics

Comparative Map Data
Rasgrf2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8224,848,699 - 25,096,773 (-)NCBIGRCr8
mRatBN7.2223,113,613 - 23,361,537 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl223,117,004 - 23,361,240 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx230,154,119 - 30,396,141 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0228,254,458 - 28,496,490 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0223,080,067 - 23,323,713 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0221,460,041 - 21,698,937 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.0240,664,646 - 40,904,636 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4222,113,649 - 22,360,970 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1222,034,017 - 22,281,339 (-)NCBI
Celera219,216,953 - 19,453,016 (-)NCBICelera
Cytogenetic Map2q12NCBI
RASGRF2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38580,960,363 - 81,230,162 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl580,960,363 - 81,230,162 (+)EnsemblGRCh38hg38GRCh38
GRCh37580,256,182 - 80,525,981 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36580,292,314 - 80,557,709 (+)NCBINCBI36Build 36hg18NCBI36
Build 34580,292,313 - 80,557,709NCBI
Celera576,160,831 - 76,426,223 (+)NCBICelera
Cytogenetic Map5q14.1NCBI
HuRef575,465,367 - 75,734,900 (+)NCBIHuRef
CHM1_1579,689,169 - 79,958,778 (+)NCBICHM1_1
T2T-CHM13v2.0581,444,995 - 81,714,744 (+)NCBIT2T-CHM13v2.0
Rasgrf2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391392,028,526 - 92,268,584 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1392,028,519 - 92,268,164 (-)EnsemblGRCm39 Ensembl
GRCm381391,880,407 - 92,131,828 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1391,880,400 - 92,131,656 (-)EnsemblGRCm38mm10GRCm38
MGSCv371392,020,012 - 92,127,647 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv371392,792,695 - 92,901,449 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361392,358,671 - 92,462,280 (-)NCBIMGSCv36mm8
Celera1395,507,627 - 95,744,228 (-)NCBICelera
Cytogenetic Map13C3NCBI
cM Map1347.43NCBI
Rasgrf2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541828,930,616 - 29,065,110 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541828,930,666 - 29,126,495 (-)NCBIChiLan1.0ChiLan1.0
RASGRF2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2434,071,454 - 34,349,753 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1532,225,079 - 32,503,237 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0534,048,832 - 34,326,755 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1534,359,896 - 34,635,488 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl534,359,896 - 34,635,488 (-)Ensemblpanpan1.1panPan2
RASGRF2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1326,047,304 - 26,286,919 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl326,050,260 - 26,286,819 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha327,282,954 - 27,522,340 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0325,961,452 - 26,200,939 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl325,964,823 - 26,201,470 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1325,917,048 - 26,141,554 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0325,882,708 - 26,122,066 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0326,162,682 - 26,402,121 (-)NCBIUU_Cfam_GSD_1.0
Rasgrf2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213182,051,996 - 182,288,402 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936469337,130 - 573,776 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936469337,340 - 573,763 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RASGRF2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl289,528,111 - 89,790,719 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1289,525,948 - 89,794,103 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2291,513,920 - 91,699,524 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RASGRF2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1475,114,512 - 75,378,228 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl475,115,109 - 75,373,851 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604923,980,283 - 24,251,523 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Rasgrf2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247431,604,915 - 1,790,473 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Rasgrf2
2055 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:55
Count of miRNA genes:54
Interacting mature miRNAs:55
Transcripts:ENSRNOT00000019087
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
631682Bp115Blood pressure QTL 1154.30.0001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2137410502Rat
738010Lnnr3Liver neoplastic nodule remodeling QTL 32.94liver integrity trait (VT:0010547)liver remodeling tumorous lesion number (CMO:0001461)2141244106Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)25873687102844969Rat
61368Mcs1Mammary carcinoma susceptibility QTL 14.4mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777223319447Rat
1600379Mcs18Mammary carcinoma susceptibility QTL 182.6mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)2788777242804738Rat
738012Anxrr3Anxiety related response QTL 33.8exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)2902351954023519Rat
10755430Coatc6Coat color QTL 60.02576coat/hair pigmentation trait (VT:0010463)pigmented ventral coat/hair area to total ventral coat/hair area ratio (CMO:0001812)21159110056591100Rat
1578664Bmd9Bone mineral QTL density 95femur mineral mass (VT:0010011)total volumetric bone mineral density (CMO:0001728)21185206249003364Rat
731184Mamtr4Mammary tumor resistance QTL 40.0003mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)21649174061491740Rat
1357990Ael1Aortic elastin QTL 13.10.00091aorta elastin amount (VT:0003905)aortic elastin21907682564076825Rat
731167Glom4Glomerulus QTL 42.40.0082kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)22030467265304672Rat
2300168Bmd47Bone mineral density QTL 476.60.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)22066244865662448Rat

Markers in Region
D2Uwm15  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2223,319,296 - 23,319,447 (+)MAPPERmRatBN7.2
Rnor_6.0221,657,309 - 21,657,459NCBIRnor6.0
Rnor_5.0240,862,862 - 40,863,012UniSTSRnor5.0
RGSC_v3.4222,318,697 - 22,318,848RGDRGSC3.4
RGSC_v3.4222,318,698 - 22,318,848UniSTSRGSC3.4
RGSC_v3.1222,239,066 - 22,239,217RGD
Celera219,411,090 - 19,411,268UniSTS
Cytogenetic Map2q12-q14UniSTS
RH144277  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2223,238,054 - 23,238,199 (+)MAPPERmRatBN7.2
Rnor_6.0221,578,034 - 21,578,178NCBIRnor6.0
Rnor_5.0240,782,837 - 40,782,981UniSTSRnor5.0
RGSC_v3.4222,237,057 - 22,237,201UniSTSRGSC3.4
Celera219,334,802 - 19,334,946UniSTS
RH 3.4 Map15499.68UniSTS
Cytogenetic Map2q12-q14UniSTS
RH141995  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2223,174,166 - 23,174,354 (+)MAPPERmRatBN7.2
Rnor_6.0221,514,115 - 21,514,302NCBIRnor6.0
Rnor_5.0240,719,025 - 40,719,212UniSTSRnor5.0
RGSC_v3.4222,172,288 - 22,172,475UniSTSRGSC3.4
Celera219,271,090 - 19,271,277UniSTS
Cytogenetic Map2q12-q14UniSTS
BG372540  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2223,118,803 - 23,118,941 (+)MAPPERmRatBN7.2
Rnor_6.0221,461,190 - 21,461,327NCBIRnor6.0
Rnor_5.0240,665,795 - 40,665,932UniSTSRnor5.0
RGSC_v3.4222,115,129 - 22,115,266UniSTSRGSC3.4
Celera219,218,126 - 19,218,263UniSTS
RH 3.4 Map21222.7UniSTS
Cytogenetic Map2q12-q14UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSRNOT00000080165   ⟹   ENSRNOP00000069761
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl223,231,220 - 23,361,240 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000096916   ⟹   ENSRNOP00000096121
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl223,117,004 - 23,361,240 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000116049   ⟹   ENSRNOP00000094036
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl223,257,663 - 23,361,240 (-)Ensembl
RefSeq Acc Id: NM_053721   ⟹   NP_446173
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8224,848,699 - 25,096,611 (-)NCBI
mRatBN7.2223,113,613 - 23,361,537 (-)NCBI
Rnor_6.0221,460,041 - 21,698,937 (-)NCBI
Rnor_5.0240,664,646 - 40,904,636 (-)NCBI
RGSC_v3.4222,113,649 - 22,360,970 (-)RGD
Celera219,216,953 - 19,453,016 (-)RGD
Sequence:
RefSeq Acc Id: XM_039101563   ⟹   XP_038957491
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8224,848,699 - 25,096,773 (-)NCBI
mRatBN7.2223,113,613 - 23,361,537 (-)NCBI
RefSeq Acc Id: XM_063281151   ⟹   XP_063137221
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8224,848,699 - 25,003,528 (-)NCBI
Reference Protein Sequences
RefSeq Acc Id: NP_446173   ⟸   NM_053721
- UniProtKB: Q99JE4 (UniProtKB/Swiss-Prot),   A0A8I6AL55 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_038957491   ⟸   XM_039101563
- Peptide Label: isoform X1
- UniProtKB: Q99JE4 (UniProtKB/Swiss-Prot)
RefSeq Acc Id: ENSRNOP00000096121   ⟸   ENSRNOT00000096916
RefSeq Acc Id: ENSRNOP00000094036   ⟸   ENSRNOT00000116049
RefSeq Acc Id: ENSRNOP00000069761   ⟸   ENSRNOT00000080165
RefSeq Acc Id: XP_063137221   ⟸   XM_063281151
- Peptide Label: isoform X2
Protein Domains
DH   IQ   N-terminal Ras-GEF   PH   Ras-GEF

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2JW65-F1-model_v2 AlphaFold A0A0G2JW65 1-849 view protein structure
AF-Q99JE4-F1-model_v2 AlphaFold Q99JE4 1-1190 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69413 AgrOrtholog
BioCyc Gene G2FUF-54873 BioCyc
Ensembl Genes ENSRNOG00000056151 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000080165.2 UniProtKB/TrEMBL
  ENSRNOT00000096916 ENTREZGENE
  ENSRNOT00000096916.1 UniProtKB/TrEMBL
  ENSRNOT00000116049.1 UniProtKB/TrEMBL
Gene3D-CATH 1.10.840.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  1.20.900.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  2.30.29.30 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Son of sevenless (SoS) protein Chain: S domain 1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro DBL_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DH-domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IQ_motif_EF-hand-BS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ras-like_GEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ras-like_Gua-exchang_fac_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ras_G-nucl-exch_fac_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ras_GEF_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF_cat_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF_cat_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:114513 UniProtKB/Swiss-Prot
NCBI Gene 114513 ENTREZGENE
PANTHER FACIOGENITAL DYSPLASIA PROTEIN UniProtKB/TrEMBL
  LD03170P UniProtKB/TrEMBL
  PTHR23113 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTHR23113:SF187 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam PF00169 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGEF_N UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Rasgrf2 PhenoGen
PROSITE DH_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PH_DOMAIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PS50096 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF_CAT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RASGEF_NTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
RatGTEx ENSRNOG00000056151 RatGTEx
SMART RasGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RasGEFN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RhoGEF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00233 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48065 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF48366 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC202173
UniProt A0A0G2JW65_RAT UniProtKB/TrEMBL
  A0A8I6AKS2_RAT UniProtKB/TrEMBL
  A0A8I6AL55 ENTREZGENE, UniProtKB/TrEMBL
  A6I4Q3_RAT UniProtKB/TrEMBL
  A6I4Q4_RAT UniProtKB/TrEMBL
  Q99JE4 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2002-06-10 Rasgrf2  RAS protein-specific guanine nucleotide-releasing factor 2      Symbol and Name status set to approved 70586 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_process controls the RAS oncoprotein GTPase activity 68725