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Gene: Rasa3 (RAS p21 protein activator 3) Rattus norvegicus

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Symbol:

Rasa3

Name:

RAS p21 protein activator 3

RGD ID:

69365

Description:

Predicted to enable GTPase activator activity and calcium channel regulator activity. Acts upstream of or within cellular response to heat. Predicted to be located in cytoplasmic side of plasma membrane. Orthologous to human RASA3 (RAS p21 protein activator 3); INTERACTS WITH 17beta-estradiol; 17beta-estradiol 3-benzoate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

GAP1(IP4BP); Ins P4-binding protein; R-ras gap; R-Ras GTP activating protein; R-ras GTPase activating protein; ras GTPase-activating protein 3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	RASA3 (RAS p21 protein activator 3)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OrthoDB, Panther
Mus musculus (house mouse):	Rasa3 (RAS p21 protein activator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Rasa3 (RAS p21 protein activator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	RASA3 (RAS p21 protein activator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	RASA3 (RAS p21 protein activator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Rasa3 (RAS p21 protein activator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	RASA3 (RAS p21 protein activator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	RASA3 (RAS p21 protein activator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Rasa3 (RAS p21 protein activator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus rattus (black rat):	Rasa3 (RAS p21 protein activator 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Mus musculus (house mouse):	Rasa3 (RAS p21 protein activator 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	RASA3 (RAS p21 protein activator 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	rasa3 (RAS p21 protein activator 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Drosophila melanogaster (fruit fly):	RasGAP1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gap-1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|SonicParanoid)
Caenorhabditis elegans (roundworm):	gap-1	Alliance	DIOPT (Ensembl Compara\|InParanoid\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rasa3	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	rasa3	Alliance	DIOPT (Ensembl Compara\|OMA\|OrthoFinder\|PANTHER\|PhylomeDB)

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	82,557,556 - 82,671,527 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	16	82,557,428 - 82,672,984 (+)	Ensembl				GRCr8
mRatBN7.2	16	75,855,360 - 75,969,349 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	75,855,265 - 75,970,804 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	16	81,135,990 - 81,249,957 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	84,588,959 - 84,702,928 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	79,837,128 - 79,951,690 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	81,320,090 - 81,434,239 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	81,318,633 - 81,434,363 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	16	80,808,492 - 80,922,641 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	16	80,710,463 - 80,824,220 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	16	73,663,562 - 73,777,478 (+)	NCBI		Celera
RGSC_v3.1	16	80,815,596 - 80,825,940 (+)	NCBI
Cytogenetic Map	16	q12.5	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

aplastic anemia (ISS)

Dwarfism (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(S)-nicotine (ISO)

1,1-dichloroethene (ISO)

1,2-dimethylhydrazine (ISO)

1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (ISO)

17beta-estradiol (EXP,ISO)

17beta-estradiol 3-benzoate (EXP)

17beta-hydroxy-5alpha-androstan-3-one (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4,6-trinitrobenzenesulfonic acid (EXP)

2-palmitoylglycerol (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-isobutyl-1-methyl-7H-xanthine (ISO)

4,4'-sulfonyldiphenol (ISO)

4-hydroxyphenyl retinamide (ISO)

5-azacytidine (ISO)

acetamide (EXP)

aflatoxin B1 (ISO)

Aflatoxin B2 alpha (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

aristolochic acid A (ISO)

arsane (ISO)

arsenic atom (ISO)

atrazine (EXP)

benzo[a]pyrene (ISO)

benzo[a]pyrene diol epoxide I (ISO)

benzo[e]pyrene (ISO)

bisphenol A (EXP,ISO)

Butylbenzyl phthalate (ISO)

C60 fullerene (EXP)

cadmium atom (ISO)

cadmium dichloride (EXP)

caffeine (ISO)

carbon nanotube (ISO)

cisplatin (ISO)

crocidolite asbestos (ISO)

cyclosporin A (ISO)

dexamethasone (ISO)

dibutyl phthalate (EXP)

dorsomorphin (ISO)

endosulfan (EXP)

ethanol (ISO)

ethyl methanesulfonate (ISO)

folic acid (ISO)

formaldehyde (ISO)

FR900359 (ISO)

fulvestrant (ISO)

genistein (ISO)

gentamycin (EXP)

glyphosate (ISO)

GSK-J4 (ISO)

hydrogen peroxide (ISO)

ivermectin (ISO)

methapyrilene (ISO)

methyl methanesulfonate (ISO)

methylmercury chloride (ISO)

Muraglitazar (EXP)

N-ethyl-N-nitrosourea (ISO)

nicotine (ISO)

nitrates (ISO)

ozone (ISO)

paracetamol (EXP,ISO)

pirinixic acid (ISO)

S-nitrosoglutathione (ISO)

SB 431542 (ISO)

serpentine asbestos (ISO)

sodium arsenite (ISO)

Soman (EXP)

sunitinib (ISO)

temozolomide (ISO)

Tesaglitazar (EXP)

testosterone (EXP)

tetrachloromethane (EXP,ISO)

titanium dioxide (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triphenyl phosphate (ISO)

tris(2-butoxyethyl) phosphate (ISO)

tungsten (ISO)

valproic acid (ISO)

vinclozolin (EXP)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

cellular response to heat (IDA)

intracellular signal transduction (IEA)

negative regulation of Ras protein signal transduction (IEA)

platelet activation (ISO)

regulation of intracellular signal transduction (IBA)

response to stress (IEA)

Cellular Component

cytoplasmic side of plasma membrane (ISO)

Molecular Function

calcium channel regulator activity (ISO)

GTPase activator activity (IBA,IEA)

metal ion binding (IEA)

zinc ion binding (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	GapIII, a new brain-enriched member of the GTPase-activating protein family.	Baba H, etal., J Neurosci Res. 1995 Aug 15;41(6):846-58.
2.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
3.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
4.	GOA pipeline	RGD automated data pipeline
5.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
6.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
7.	Information Derived from GenBank Report	RGD, Sept. 2003
8.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:10828023	PMID:18952607

Genomics

Comparative Map Data

Rasa3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	16	82,557,556 - 82,671,527 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	16	82,557,428 - 82,672,984 (+)	Ensembl				GRCr8
mRatBN7.2	16	75,855,360 - 75,969,349 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	16	75,855,265 - 75,970,804 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	16	81,135,990 - 81,249,957 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	16	84,588,959 - 84,702,928 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	16	79,837,128 - 79,951,690 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	16	81,320,090 - 81,434,239 (-)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	16	81,318,633 - 81,434,363 (-)	Ensembl			rn6	Rnor6.0
Rnor_5.0	16	80,808,492 - 80,922,641 (-)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	16	80,710,463 - 80,824,220 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	16	73,663,562 - 73,777,478 (+)	NCBI		Celera
RGSC_v3.1	16	80,815,596 - 80,825,940 (+)	NCBI
Cytogenetic Map	16	q12.5	NCBI

RASA3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	13	113,977,783 - 114,132,623 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	13	113,977,783 - 114,132,775 (-)	Ensembl			hg38	GRCh38
GRCh37	13	114,747,194 - 114,898,098 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	13	113,765,296 - 113,916,197 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	13	113,765,296 - 113,916,197	NCBI
Celera	13	95,423,074 - 95,573,004 (-)	NCBI		Celera
Cytogenetic Map	13	q34	NCBI
HuRef	13	95,016,746 - 95,162,033 (-)	NCBI		HuRef
CHM1_1	13	114,715,940 - 114,865,735 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	13	113,188,423 - 113,340,668 (-)	NCBI		T2T-CHM13v2.0

Rasa3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	13,617,218 - 13,727,590 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	13,616,948 - 13,727,603 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	8	13,567,218 - 13,677,587 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	13,566,948 - 13,677,603 (-)	Ensembl			mm10	GRCm38
MGSCv37	8	13,567,218 - 13,677,587 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	8	13,567,195 - 13,677,549 (-)	NCBI		MGSCv36	mm8
Celera	8	13,734,036 - 13,844,447 (-)	NCBI		Celera
Cytogenetic Map	8	A1.1	NCBI
cM Map	8	6.29	NCBI

Rasa3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955404	141,060 - 225,572 (+)	Ensembl
ChiLan1.0	NW_004955404	140,906 - 225,278 (+)	NCBI	ChiLan1.0	ChiLan1.0

RASA3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	14	115,451,429 - 115,622,482 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	13	114,144,769 - 114,304,323 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	13	95,036,382 - 95,195,480 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	13	114,123,816 - 114,271,066 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	13	114,123,816 - 114,271,066 (-)	Ensembl			panPan2	panpan1.1

RASA3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	22	61,093,762 - 61,202,209 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	22	61,095,044 - 61,202,152 (-)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	22	60,805,357 - 60,913,843 (-)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	22	61,780,849 - 61,889,450 (-)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	22	61,780,855 - 61,889,451 (-)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	22	61,218,315 - 61,326,769 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	22	61,225,625 - 61,334,098 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	22	61,252,037 - 61,360,858 (-)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Rasa3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	195,992,373 - 196,074,750 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004937030	40,116 - 122,490 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004937030	40,123 - 122,478 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RASA3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	11	78,951,019 - 79,027,900 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	11	78,951,017 - 79,027,991 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	11	86,685,993 - 86,763,496 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RASA3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	3	91,848,158 - 91,974,675 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	3	91,848,160 - 91,974,555 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666046	49,138,040 - 49,271,270 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rasa3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624793	257,661 - 334,981 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624793	209,616 - 336,304 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Rasa3
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	13	70,022,626 - 70,139,053 (+)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Rasa3
846 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	97
Count of miRNA genes:	83
Interacting mature miRNAs:	88
Transcripts:	ENSRNOT00000067508
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
2300163	Bmd64	Bone mineral density QTL 64	5.3	0.0001	lumbar vertebra mineral mass (VT:0010511)	volumetric bone mineral density (CMO:0001553)	16	44455123	89455123	Rat
7411648	Foco22	Food consumption QTL 22	15	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	16	59428714	91442908	Rat
1578768	Stresp22	Stress response QTL 22	2.8		thymus mass (VT:0004954)	thymus wet weight (CMO:0000855)	16	41992064	86992064	Rat
2293690	Bss45	Bone structure and strength QTL 45	5.13	0.0001	lumbar vertebra morphology trait (VT:0010494)	lumbar vertebra cortical cross-sectional area (CMO:0001690)	16	44455123	89455123	Rat
8694364	Abfw7	Abdominal fat weight QTL 7	12.22	0.001	visceral adipose mass (VT:0010063)	abdominal fat pad weight to body weight ratio (CMO:0000095)	16	59428714	91442908	Rat
8694429	Bw164	Body weight QTL 164	5	0.001	body lean mass (VT:0010483)	lean tissue morphological measurement (CMO:0002184)	16	59428714	91442908	Rat
7205510	Activ5	Activity QTL 5	3.78	0.00028	locomotor behavior trait (VT:0001392)	number of entries into a discrete space in an experimental apparatus (CMO:0000960)	16	49099196	91442908	Rat

Markers in Region

D16Got83

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	75,855,791 - 75,856,008 (-)	MAPPER	mRatBN7.2
Rnor_6.0	16	81,433,593 - 81,433,807	NCBI	Rnor6.0
Rnor_5.0	16	80,921,995 - 80,922,209	UniSTS	Rnor5.0
RGSC_v3.4	16	80,710,894 - 80,711,109	RGD	RGSC3.4
RGSC_v3.4	16	80,710,895 - 80,711,109	UniSTS	RGSC3.4
Celera	16	73,663,994 - 73,664,208	UniSTS
RGSC_v3.1	16	80,711,160 - 80,711,374	RGD
RH 3.4 Map	16	761.6	UniSTS
RH 3.4 Map	16	761.6	RGD
RH 2.0 Map	16	846.8	RGD
Cytogenetic Map	16	q12.5	UniSTS

D16Got98

Rat Assembly	Chr	Position (strand)	Source	JBrowse
GRCr8	16	82,562,640 - 82,562,852 (+)	Marker Load Pipeline
mRatBN7.2	16	75,860,446 - 75,860,660 (-)	MAPPER	mRatBN7.2
Rnor_6.0	16	81,428,943 - 81,429,154	NCBI	Rnor6.0
Rnor_5.0	16	80,917,345 - 80,917,556	UniSTS	Rnor5.0
RGSC_v3.4	16	80,715,548 - 80,715,759	UniSTS	RGSC3.4
Celera	16	73,668,647 - 73,668,858	UniSTS
Cytogenetic Map	16	q12.5	UniSTS

D16Wox25

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	75,853,898 - 75,854,043 (-)	MAPPER	mRatBN7.2
Rnor_6.0	16	81,435,556 - 81,435,700	NCBI	Rnor6.0
Rnor_5.0	16	80,923,958 - 80,924,102	UniSTS	Rnor5.0
RGSC_v3.4	16	80,709,002 - 80,709,146	UniSTS	RGSC3.4
Celera	16	73,662,101 - 73,662,245	UniSTS
Cytogenetic Map	16	q12.5	UniSTS

BF386157

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	75,882,147 - 75,882,313 (-)	MAPPER	mRatBN7.2
Rnor_6.0	16	81,407,290 - 81,407,455	NCBI	Rnor6.0
Rnor_5.0	16	80,895,692 - 80,895,857	UniSTS	Rnor5.0
RGSC_v3.4	16	80,737,247 - 80,737,412	UniSTS	RGSC3.4
Celera	16	73,690,346 - 73,690,511	UniSTS
RH 3.4 Map	16	744.6	UniSTS
Cytogenetic Map	16	q12.5	UniSTS

RH139547

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	16	75,970,468 - 75,970,672 (-)	MAPPER	mRatBN7.2
Rnor_6.0	16	81,318,767 - 81,318,970	NCBI	Rnor6.0
Rnor_5.0	16	80,807,169 - 80,807,372	UniSTS	Rnor5.0
RGSC_v3.4	16	80,825,340 - 80,825,543	UniSTS	RGSC3.4
Celera	16	73,778,581 - 73,778,784	UniSTS
RH 3.4 Map	16	743.1	UniSTS
Cytogenetic Map	16	q12.5	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
16	12	67	162	91	90	59	92	59	6	356	192	11	141	81	92	31	17	17

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031574	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AB020479	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB021982	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB028626	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AB029088	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473970	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	D86045	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000016	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000067508 ⟹ ENSRNOP00000061587

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	16	81,349,400 - 81,434,038 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000080963 ⟹ ENSRNOP00000069783

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	16	82,557,428 - 82,672,984 (+)	Ensembl
mRatBN7.2 Ensembl	16	75,855,265 - 75,970,804 (+)	Ensembl
Rnor_6.0 Ensembl	16	81,318,633 - 81,434,363 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000092335

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	16	81,330,539 - 81,331,874 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106408 ⟹ ENSRNOP00000083443

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	16	82,557,428 - 82,672,984 (+)	Ensembl
mRatBN7.2 Ensembl	16	75,855,265 - 75,970,804 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000106848 ⟹ ENSRNOP00000086788

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	16	82,569,497 - 82,672,984 (+)	Ensembl
mRatBN7.2 Ensembl	16	75,906,166 - 75,970,804 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000160639 ⟹ ENSRNOP00000102623

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	16	82,557,435 - 82,672,983 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000162825 ⟹ ENSRNOP00000108920

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	16	82,569,414 - 82,672,984 (+)	Ensembl

RefSeq Acc Id:

NM_031574 ⟹ NP_113762

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	16	82,557,556 - 82,671,527 (+)	NCBI
mRatBN7.2	16	75,855,360 - 75,969,349 (+)	NCBI
Rnor_6.0	16	81,320,090 - 81,434,239 (-)	NCBI
Rnor_5.0	16	80,808,492 - 80,922,641 (-)	NCBI
RGSC_v3.4	16	80,710,463 - 80,824,220 (+)	RGD
Celera	16	73,663,562 - 73,777,478 (+)	RGD

Sequence:

show sequence

GTCGACGAGCAGCATGGCGGTGGAGGAAGAGGGACTGCGGGTCTTCCAGAGCGTGAGGATCAAG
ATTGGTGAAGCCAAGAATCTCCCTTCCTACCCGGGGCCAAACAAGATGAGGGACTGCTACTGCA
CTGTGAACCTGGACCAGGAGGAGGTTTTCCGGACCAAAATCGTAGAGAAGTCACTCTGCCCCTT
TTACGGAGAGGACTTTTACTGTGAAATTCCTCGGAGTTTCCGCCACCTGTCCTTTTACATTTTT
GATAGAGACGTTTTCCGAAGGGATTCCATCATAGGCAAGGTGGCCATCCAGAAGGAAGACTTGC
AAAGGTACCACAACAGGGACACATGGTTCCAGCTCCAGCATGTGGATGCTGACTCAGAGGTGCA
GGGCAAGGTCCACCTGGAGCTGAGACTGAGTGAGGTCATTACAGACACTGGTGTTGTCTGTCAC
AAACTCGCTGCACGCATCTTCGAGTGCCAGGGACTCCCCATTGTGAACGGGCAGTGCGACCCTT
ACGCCACCGTGACATTGGCCGGACCCTTCAGGTCTGAAGCGAAGAAAACCAAGGTGAAGAAGAA
AACCAACAACCCCCAGTTCGATGAGGTGTTTTATTTTGAGGTGACCAGACCCTGCAGCTACAGC
AAAAAGTCCCACTTCGACTTCGAGGAGGAGGACGTTGACAAACTTGAAATCCGAGTTGACCTCT
GGAACGCCAGCAACCTGAAGTTTGGGGATGAGTTTCTCGGGGAGTTGAGGATCCCTCTCCATGT
GCTGCGATACGCCAGTTCTTACGAAGCCTGGTACTTCCTCCAGCCCCGAGACAATGGCAGTAAG
AGCGTGAAGCCAGATGACTTAGGGTCGCTGAGGTTAAATGTAGTTTACACAGAAGACCACGTCT
TCTCCTCTGAGTACTACAGCCCACTACGTGACCTGTTACTGAAGTCTGCGGATGTGGAGCCTGT
CTCAGCTTCAGCAGCGCACATCCTCGGGGAGGTGTGCAGAGATAAGCAAGAGGCAGCCATCCCG
CTGGTACGGCTCCTGCTGCACTATGGCAGGGTAGTGCCCTTCATCAGTGCCATCGCTAGCGCAG
AGGTGAAGAGGACCCAGGACCCCAATACCATCTTCCGAGGAAACTCACTGACCTCTAAGTGCAT
AGATGAGACAATGAAGCTGGCGGGCATGCACTATCTCCACGTGACCCTGAAGCCCACCATTGAG
GAGATCTGCCAGAGCCATAAGTCCTGTGAGATCGACCCTGTGAAACTGAAAGATGGCGAAAACC
TTGAGAACAACATGGAGAGCCTGAGGCAGTATGTGGATCGAATATTCAGTGTCATCACTAAGTC
AGGGGTGAGCTGCCCCACCGTCATGTGTGACATCTTCTTCTCCCTGCGGGAGGCAGCTGCCAAG
CGCTTCCAAGATGACTTGGATGTGAGGTATACCGCCGTGAGCAGCTTCATCTTCCTGAGGTTCT
TCGCTCCCGCTATCCTGTCCCCGAACCTTTTCCAGCTGACGCCCCACCATACGGATCCACAGAC
TTCTAGAACCCTGACGCTTATCTCAAAGACCATCCAGACCCTTGGCAGCTTGTCCAAGTCCAAG
TCTGCCAGTTTTAAGGAGTCATACATGGCGACGTTCTATGAATTCTTCAATGAGCAGAAGTATG
CAGATGCCGTAAAGAATTTCCTGGATTTGATCTCATCCTCCGGGAGAAGGGACCCCAAGAGCAT
AGAGCAGCCCATCCTGCTTAAAGAAGGCTTCATGATCAAGCGGGCCCAAGGAAGGAAACGCTTT
GGAATGAAGAATTTCAAGAAGAGGTGGTTTCGCCTCACGAACCACGAGTTCACCTACCAGAAAA
GCAAAGGTGATCAGCCGCTCTGCAACATCCCCATCGAGAACATCTTGGCCGTGGAGAGGTTAGA
GGAGGAGTCCTTCCGAATGAAAAATATGTTCCAGGTCATCCAGCCAGAGCGTGCACTGTACATC
CAGGCCAACAACTGTGTGGAGGCCAAGGACTGGATTGACATCCTCACAAAAGTGAGTCAGTGCA
ACCAGAAGCGGCTCACAGTCTTCCACCCATCGGCCTACCTGAACGGCCACTGGCTTTGCTGCAG
GGCCTCTTCAGACACCGCTATTGGCTGCACTCCCTGCACTGGTGGGCTCCCAGCAAACATCCAG
CTGGACATTGATGGGGACCGTGAAACAGAGCGCATCTACTCTCTCTTTAACCTGTACATGGGCA
AGTTGGAAAAGATGCAGGAGGCCTGCGGCAGCAAGTCCGTATACGATGGCCCTGAGCAGGAGGA
ATACTCAACATTCATCATCGATGACCCCCAGGAGACGTACAGGACGCTGAAGCAGGTCATCGCT
GGGGTGGGGACCCTTGAGCAGGAGCACGCGCAGTACAGGAGGAACAAGTTCAAGAAGACGAGAT
ACGGGAGCCAGGAGCACCCTATTGGAGACAAGAGCTTCCAGAACTACATCAGGCAGCAGTCTGA
GATCTCAACCCATTCCATTTAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_113762	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	BAA78368	(Get FASTA)	NCBI Sequence Viewer
	BAA81903	(Get FASTA)	NCBI Sequence Viewer
	BAA89032	(Get FASTA)	NCBI Sequence Viewer
	BAA89047	(Get FASTA)	NCBI Sequence Viewer
	BAF31891	(Get FASTA)	NCBI Sequence Viewer
	EDM08909	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000069783
GenBank Protein	Q9QYJ2	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_113762 ⟸ NM_031574

- UniProtKB:

Q09YN9 (UniProtKB/Swiss-Prot), Q9QYJ2 (UniProtKB/Swiss-Prot), A0A0G2JW85 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAVEEEGLRVFQSVRIKIGEAKNLPSYPGPNKMRDCYCTVNLDQEEVFRTKIVEKSLCPFYGED
FYCEIPRSFRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQRYHNRDTWFQLQHVDADSEVQGKVH
LELRLSEVITDTGVVCHKLAARIFECQGLPIVNGQCDPYATVTLAGPFRSEAKKTKVKKKTNNP
QFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDEFLGELRIPLHVLRYA
SSYEAWYFLQPRDNGSKSVKPDDLGSLRLNVVYTEDHVFSSEYYSPLRDLLLKSADVEPVSASA
AHILGEVCRDKQEAAIPLVRLLLHYGRVVPFISAIASAEVKRTQDPNTIFRGNSLTSKCIDETM
KLAGMHYLHVTLKPTIEEICQSHKSCEIDPVKLKDGENLENNMESLRQYVDRIFSVITKSGVSC
PTVMCDIFFSLREAAAKRFQDDLDVRYTAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTL
TLISKTIQTLGSLSKSKSASFKESYMATFYEFFNEQKYADAVKNFLDLISSSGRRDPKSIEQPI
LLKEGFMIKRAQGRKRFGMKNFKKRWFRLTNHEFTYQKSKGDQPLCNIPIENILAVERLEEESF
RMKNMFQVIQPERALYIQANNCVEAKDWIDILTKVSQCNQKRLTVFHPSAYLNGHWLCCRASSD
TAIGCTPCTGGLPANIQLDIDGDRETERIYSLFNLYMGKLEKMQEACGSKSVYDGPEQEEYSTF
IIDDPQETYRTLKQVIAGVGTLEQEHAQYRRNKFKKTRYGSQEHPIGDKSFQNYIRQQSEISTH
SI

hide sequence

Ensembl Acc Id:

ENSRNOP00000061587 ⟸ ENSRNOT00000067508

Ensembl Acc Id:

ENSRNOP00000069783 ⟸ ENSRNOT00000080963

Ensembl Acc Id:

ENSRNOP00000086788 ⟸ ENSRNOT00000106848

Ensembl Acc Id:

ENSRNOP00000083443 ⟸ ENSRNOT00000106408

Ensembl Acc Id:

ENSRNOP00000108920 ⟸ ENSRNOT00000162825

Ensembl Acc Id:

ENSRNOP00000102623 ⟸ ENSRNOT00000160639

Protein Domains

C2 PH Ras-GAP

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q9QYJ2-F1-model_v2	AlphaFold	Q9QYJ2	1-834	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700226

Promoter ID:

EPDNEW_R10750

Type:

initiation region

Name:

Rasa3_1

Description:

RAS p21 protein activator 3

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	16	81,434,363 - 81,434,423	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:69365	AgrOrtholog
BioCyc Gene	G2FUF-10727	BioCyc
Ensembl Genes	ENSRNOG00000017671	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000080963	ENTREZGENE
Gene3D-CATH	2.30.29.30	UniProtKB/Swiss-Prot
	2.60.40.150	UniProtKB/Swiss-Prot
	GTPase Activation - p120gap, domain 1	UniProtKB/Swiss-Prot
InterPro	C2_dom	UniProtKB/Swiss-Prot
	C2_domain_sf	UniProtKB/Swiss-Prot
	PH-like_dom_sf	UniProtKB/Swiss-Prot
	PH_domain	UniProtKB/Swiss-Prot
	Ras_GTPase	UniProtKB/Swiss-Prot
	RASA3_PH	UniProtKB/Swiss-Prot
	RasGAP_CS	UniProtKB/Swiss-Prot
	RasGAP_dom	UniProtKB/Swiss-Prot
	Rho_GTPase_activation_prot	UniProtKB/Swiss-Prot
	Znf_Btk_motif	UniProtKB/Swiss-Prot
KEGG Report	rno:29372	UniProtKB/Swiss-Prot
NCBI Gene	29372	ENTREZGENE
PANTHER	PTHR10194	UniProtKB/Swiss-Prot
	RAS GTPASE-ACTIVATING PROTEIN 3	UniProtKB/Swiss-Prot
Pfam	BTK	UniProtKB/Swiss-Prot
	PF00168	UniProtKB/Swiss-Prot
	PF00169	UniProtKB/Swiss-Prot
	RasGAP	UniProtKB/Swiss-Prot
PhenoGen	Rasa3	PhenoGen
PROSITE	PH_DOMAIN	UniProtKB/Swiss-Prot
	PS50004	UniProtKB/Swiss-Prot
	RAS_GTPASE_ACTIV_1	UniProtKB/Swiss-Prot
	RAS_GTPASE_ACTIV_2	UniProtKB/Swiss-Prot
	ZF_BTK	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000017671	RatGTEx
SMART	BTK	UniProtKB/Swiss-Prot
	RasGAP	UniProtKB/Swiss-Prot
	SM00233	UniProtKB/Swiss-Prot
	SM00239	UniProtKB/Swiss-Prot
Superfamily-SCOP	PH domain-like	UniProtKB/Swiss-Prot
	SSF48350	UniProtKB/Swiss-Prot
	SSF49562	UniProtKB/Swiss-Prot
TIGR	TC206671
UniProt	A0A0G2JW85	ENTREZGENE, UniProtKB/TrEMBL
	A0A8I5ZZA1_RAT	UniProtKB/TrEMBL
	A0A8I6ADL3_RAT	UniProtKB/TrEMBL
	A0ABK0LDD0_RAT	UniProtKB/TrEMBL
	A0ABK0LSE9_RAT	UniProtKB/TrEMBL
	A6IWG3_RAT	UniProtKB/TrEMBL
	Q09YN9	ENTREZGENE
	Q9QYJ2	ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary	Q09YN9	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2002-06-10	Rasa3	RAS p21 protein activator 3			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	expressed in the developing brain	634611

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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