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Gene: Rrad (RRAD, Ras related glycolysis inhibitor and calcium channel regulator) Rattus norvegicus

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Symbol:

Rrad

Name:

RRAD, Ras related glycolysis inhibitor and calcium channel regulator

RGD ID:

69357

Description:

Predicted to enable GTP binding activity and calcium channel regulator activity. Involved in negative regulation of cell growth. Predicted to be located in T-tubule. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human RRAD (RRAD, Ras related glycolysis inhibitor and calcium channel regulator); INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran.

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

GTP-binding protein RAD; RAD1; ras associated with diabetes; Ras-related associated with diabetes

RGD Orthologs

Alliance Orthologs

More Info

more info ...

Latest Assembly:

GRCr8 - GRCr8 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	360,581 - 363,874 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	19	360,973 - 363,871 (+)	Ensembl				GRCr8
mRatBN7.2	19	354,184 - 357,424 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	354,198 - 357,417 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	19	342,318 - 345,516 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	1,109,123 - 1,112,321 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	384,316 - 387,514 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	561,696 - 564,929 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	561,727 - 564,930 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	19	555,959 - 559,189 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	272,791 - 275,957 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	19	350,432 - 353,630 (+)	NCBI		Celera
RGSC_v3.1	19	272,790 - 275,957 (+)	NCBI
Cytogenetic Map	19	p14	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Breast Neoplasms (ISO)

Cardiac Arrhythmias (ISO)

Cardiomegaly (ISO)

congestive heart failure (ISO)

Insulin Resistance (ISO)

lung non-small cell carcinoma (ISO)

type 2 diabetes mellitus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(-)-demecolcine (ISO)

1,2-dimethylhydrazine (ISO)

17alpha-ethynylestradiol (EXP)

17beta-estradiol (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,3,7,8-Tetrachlorodibenzofuran (EXP)

2,4-dibromophenyl 2,4,5-tribromophenyl ether (ISO)

2-hydroxypropanoic acid (ISO)

2-palmitoylglycerol (ISO)

3,3',4,4',5-pentachlorobiphenyl (ISO)

3,7-dihydropurine-6-thione (EXP)

3-chloropropane-1,2-diol (ISO)

4,4'-sulfonyldiphenol (EXP,ISO)

5-aza-2'-deoxycytidine (ISO)

6-propyl-2-thiouracil (EXP)

acrylamide (EXP,ISO)

actinomycin D (ISO)

aflatoxin B1 (ISO)

all-trans-retinoic acid (ISO)

alpha-Zearalanol (EXP)

ammonium chloride (EXP)

amphetamine (EXP)

amphotericin B (ISO)

antimycin A (ISO)

antirheumatic drug (ISO)

aristolochic acid A (ISO)

arotinoid acid (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (EXP,ISO)

benzo[a]pyrene diol epoxide I (ISO)

bis(2-chloroethyl) sulfide (ISO)

bis(2-ethylhexyl) phthalate (ISO)

bisphenol A (EXP)

bisphenol F (EXP,ISO)

buta-1,3-diene (ISO)

butanal (ISO)

Butylbenzyl phthalate (EXP)

cadmium atom (ISO)

cadmium dichloride (ISO)

calcitriol (ISO)

camptothecin (ISO)

cantharidin (ISO)

carbon nanotube (ISO)

CHIR 99021 (ISO)

chloroprene (EXP,ISO)

choline (ISO)

chromium(6+) (ISO)

cisplatin (EXP,ISO)

clothianidin (ISO)

cobalt atom (ISO)

copper atom (EXP,ISO)

copper(0) (EXP,ISO)

copper(II) chloride (ISO)

copper(II) sulfate (ISO)

cortisol (ISO)

cyclosporin A (EXP,ISO)

DDE (ISO)

diallyl trisulfide (ISO)

dibenz[a,h]anthracene (EXP)

dibenzo[a,l]pyrene (EXP)

dibutyl phthalate (EXP)

disulfiram (ISO)

diuron (ISO)

doxorubicin (ISO)

entinostat (ISO)

ethanol (ISO)

fenvalerate (EXP)

fluoranthene (EXP)

flusilazole (EXP)

folic acid (ISO)

formaldehyde (ISO)

fulvestrant (ISO)

furan (EXP)

genistein (ISO)

haloperidol (EXP)

Heliotrine (ISO)

hydrogen chloride (ISO)

hydroquinone (ISO)

inulin (ISO)

isoprenaline (ISO)

L-ascorbic acid (ISO)

L-ascorbic acid 2-phosphate (ISO)

L-methionine (ISO)

Lasiocarpine (ISO)

lead diacetate (ISO)

Licochalcone B (ISO)

lipopolysaccharide (ISO)

lithium chloride (ISO)

malathion (ISO)

melphalan (ISO)

mercaptopurine (EXP)

Mesaconitine (EXP)

methapyrilene (ISO)

methoxychlor (EXP)

methyl methanesulfonate (ISO)

methylisothiazolinone (ISO)

mono(2-ethylhexyl) phthalate (ISO)

N-Nitrosopyrrolidine (ISO)

nitrofen (EXP)

Nutlin-3 (ISO)

O-methyleugenol (ISO)

okadaic acid (ISO)

oxaliplatin (EXP)

paracetamol (EXP,ISO)

paraquat (ISO)

perfluorooctane-1-sulfonic acid (ISO)

perfluorooctanoic acid (EXP,ISO)

phenobarbital (ISO)

phenylarsine oxide (ISO)

phenylephrine (EXP)

pirinixic acid (ISO)

propanal (ISO)

purine-6-thiol (EXP)

quercetin (ISO)

rac-lactic acid (ISO)

raloxifene (ISO)

S-(1,2-dichlorovinyl)-L-cysteine (ISO)

SB 431542 (ISO)

senecionine (ISO)

Senkirkine (ISO)

silicon dioxide (ISO)

silver atom (ISO)

silver(0) (ISO)

sirolimus (ISO)

sodium arsenate (ISO)

sodium arsenite (ISO)

sodium dichromate (EXP)

streptozocin (EXP)

sulforaphane (ISO)

tamoxifen (ISO)

temozolomide (ISO)

tert-butyl hydroperoxide (ISO)

testosterone enanthate (ISO)

tetrachloromethane (ISO)

thimerosal (ISO)

thiram (ISO)

tipifarnib (EXP)

titanium dioxide (ISO)

topotecan (EXP)

triclosan (ISO)

Tungsten carbide (ISO)

urethane (ISO)

vanadyl sulfate (EXP)

vitamin K (EXP)

XAV939 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of cell growth (IMP)

Cellular Component

plasma membrane (IBA,IEA,ISO)

T-tubule (ISO)

Molecular Function

calcium channel regulator activity (IBA)

calmodulin binding (IEA)

GTP binding (IBA,IEA)

GTPase activity (IEA)

nucleotide binding (IEA)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Molecular cloning of the human rad gene: gene structure and complete nucleotide sequence.	Caldwell JS, etal., Biochim Biophys Acta 1996 Aug 23;1316(3):145-8.
2.	Rad GTPase deficiency leads to cardiac hypertrophy.	Chang L, etal., Circulation. 2007 Dec 18;116(25):2976-83. Epub 2007 Dec 3.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Overexpression of Rad in muscle worsens diet-induced insulin resistance and glucose intolerance and lowers plasma triglyceride level.	Ilany J, etal., Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4481-6. Epub 2006 Mar 14.
6.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
7.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
8.	GOA pipeline	RGD automated data pipeline
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Comprehensive gene review and curation	RGD comprehensive gene curation
11.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
12.	A novel Rad gene polymorphism combined with obesity increases risk for type 2 diabetes mellitus.	Wang GY, etal., Chin Med J (Engl). 2004 May;117(5):770-1.
13.	Dominant negative suppression of Rad leads to QT prolongation and causes ventricular arrhythmias via modulation of L-type Ca2+ channels in the heart.	Yada H, etal., Circ Res. 2007 Jul 6;101(1):69-77. Epub 2007 May 24.
14.	Analysis of trinucleotide-repeat combination polymorphism at the rad gene in patients with type 2 diabetes mellitus.	Yuan X, etal., Metabolism. 1999 Feb;48(2):173-5.

Additional References at PubMed

PMID:8889548	PMID:19926875	PMID:21382976	PMID:21549102	PMID:21559360	PMID:31830958

Genomics

Comparative Map Data

Rrad
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	19	360,581 - 363,874 (+)	NCBI	GRCr8	GRCr8		GRCr8
GRCr8 Ensembl	19	360,973 - 363,871 (+)	Ensembl				GRCr8
mRatBN7.2	19	354,184 - 357,424 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	19	354,198 - 357,417 (+)	Ensembl				mRatBN7.2
UTH_Rnor_SHR_Utx	19	342,318 - 345,516 (+)	NCBI	UTH_Rnor_SHR_Utx	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	19	1,109,123 - 1,112,321 (+)	NCBI	UTH_Rnor_SHRSP_BbbUtx_1.0	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	19	384,316 - 387,514 (+)	NCBI	UTH_Rnor_WKY_Bbb_1.0	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	19	561,696 - 564,929 (+)	NCBI	Rnor_6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	19	561,727 - 564,930 (+)	Ensembl			rn6	Rnor6.0
Rnor_5.0	19	555,959 - 559,189 (+)	NCBI	Rnor_5.0	Rnor_5.0	rn5
RGSC_v3.4	19	272,791 - 275,957 (+)	NCBI	RGSC_v3.4	RGSC_v3.4	rn4
Celera	19	350,432 - 353,630 (+)	NCBI		Celera
RGSC_v3.1	19	272,790 - 275,957 (+)	NCBI
Cytogenetic Map	19	p14	NCBI

RRAD
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	16	66,921,685 - 66,925,535 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	16	66,921,682 - 66,926,308 (-)	Ensembl			hg38	GRCh38
GRCh37	16	66,955,588 - 66,959,438 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	16	65,513,089 - 65,516,920 (-)	NCBI	Build 36	Build 36	hg18	NCBI36
Build 34	16	65,513,088 - 65,516,920	NCBI
Celera	16	51,463,841 - 51,467,698 (-)	NCBI		Celera
Cytogenetic Map	16	q22.1	NCBI
HuRef	16	52,829,691 - 52,833,549 (-)	NCBI		HuRef
CHM1_1	16	68,362,590 - 68,366,447 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	16	72,715,985 - 72,719,835 (-)	NCBI		T2T-CHM13v2.0

Rrad
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	8	105,354,702 - 105,357,921 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	8	105,354,702 - 105,357,959 (-)	Ensembl		GRCm39 Ensembl		GRCm39
GRCm38	8	104,628,070 - 104,631,350 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	8	104,628,070 - 104,631,327 (-)	Ensembl			mm10	GRCm38
MGSCv37	8	107,151,966 - 107,155,221 (-)	NCBI	MGSCv37	MGSCv37	mm9	NCBIm37
MGSCv36	8	107,517,580 - 107,520,044 (-)	NCBI		MGSCv36	mm8
Celera	8	108,860,666 - 108,863,921 (-)	NCBI		Celera
Cytogenetic Map	8	D3	NCBI
cM Map	8	53.04	NCBI

Rrad
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955433	23,426,643 - 23,438,923 (-)	Ensembl
ChiLan1.0	NW_004955433	23,426,258 - 23,439,094 (-)	NCBI	ChiLan1.0	ChiLan1.0

RRAD
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	18	76,421,435 - 76,425,352 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	16	82,333,967 - 82,337,877 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	16	47,236,886 - 47,240,799 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	16	66,339,106 - 66,342,396 (-)	NCBI	PanPan1.1	PanPan1.1	panPan2

RRAD
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	82,392,608 - 82,395,574 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	5	82,392,557 - 82,395,561 (+)	Ensembl			canFam3	CanFam3.1
Dog10K_Boxer_Tasha	5	82,381,299 - 82,384,264 (+)	NCBI	Dog10K_Boxer_Tasha	Dog10K_Boxer_Tasha
ROS_Cfam_1.0	5	82,829,207 - 82,832,176 (+)	NCBI	ROS_Cfam_1.0	ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	5	82,828,951 - 82,832,163 (+)	Ensembl				ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	5	82,652,397 - 82,655,362 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	5	82,339,219 - 82,342,172 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	5	82,978,172 - 82,981,138 (+)	NCBI	UU_Cfam_GSD_1.0	UU_Cfam_GSD_1.0

Rrad
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024409349	42,412,632 - 42,415,959 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936475	17,173,165 - 17,176,463 (-)	Ensembl		SpeTri2.0 Ensembl
SpeTri2.0	NW_004936475	17,173,170 - 17,176,446 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RRAD
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	6	27,601,695 - 27,605,083 (-)	Ensembl			susScr11	Sscrofa11.1
Sscrofa11.1	6	27,601,692 - 27,605,127 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

RRAD
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	5	52,620,846 - 52,626,799 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	5	52,621,231 - 52,624,436 (-)	Ensembl		ChlSab1.1 Ensembl	chlSab2	Vervet-AGM
Vero_WHO_p1.0	NW_023666047	23,285,743 - 23,293,154 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Rrad
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624746	19,583,541 - 19,587,598 (+)	Ensembl		HetGla_female_1.0 Ensembl	hetGla2	HetGla_female_1.0 Ensembl
HetGla 1.0	NW_004624746	19,584,061 - 19,587,476 (+)	NCBI	HetGla 1.0	HetGla 1.0	hetGla2

Rrad
(Rattus rattus - black rat)

Black Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Black Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Rrattus_CSIRO_v1	17	12,898,623 - 12,901,849 (-)	NCBI		Rrattus_CSIRO_v1

Variants

Variants in Rrad
3 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	263
Count of miRNA genes:	173
Interacting mature miRNAs:	200
Transcripts:	ENSRNOT00000016259
Prediction methods:	Microtar, Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCr8)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1549847	Bss8	Bone structure and strength QTL 8	4		lumbar vertebra strength trait (VT:0010574)	vertebra ultimate force (CMO:0001678)	19	1	31969901	Rat
7411590	Foco7	Food consumption QTL 7	6.8	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	19	1	24694445	Rat
1331737	Uae29	Urinary albumin excretion QTL 29	5.5		urine albumin amount (VT:0002871)	urine albumin level (CMO:0000130)	19	36289	74246245	Rat
10054132	Srcrt9	Stress Responsive Cort QTL 9	2.87	0.0017	blood corticosterone amount (VT:0005345)	plasma corticosterone level (CMO:0001173)	19	1	27361636	Rat

Markers in Region

RH131648

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	19	357,111 - 357,328 (+)	MAPPER	mRatBN7.2
Rnor_6.0	19	564,617 - 564,833	NCBI	Rnor6.0
Rnor_5.0	19	558,877 - 559,093	UniSTS	Rnor5.0
RGSC_v3.4	19	275,647 - 275,863	UniSTS	RGSC3.4
Celera	19	353,318 - 353,534	UniSTS
Cytogenetic Map	19	p14	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	sensory system	visual system
12	12	67	154	84	83	52	60	52	6	313	160	11	133	81	92	31	13	13

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_053338	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006255055	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	CH474006	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK602305	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CK840773	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM054321	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FM055705	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000019	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	U12187	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000016259 ⟹ ENSRNOP00000016259

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8 Ensembl	19	360,973 - 363,871 (+)	Ensembl
mRatBN7.2 Ensembl	19	354,198 - 357,417 (+)	Ensembl
Rnor_6.0 Ensembl	19	561,727 - 564,930 (+)	Ensembl

Ensembl Acc Id:

ENSRNOT00000081547 ⟹ ENSRNOP00000070963

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	19	561,761 - 564,927 (+)	Ensembl

RefSeq Acc Id:

NM_053338 ⟹ NP_445790

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	360,676 - 363,874 (+)	NCBI
mRatBN7.2	19	354,226 - 357,424 (+)	NCBI
Rnor_6.0	19	561,731 - 564,929 (+)	NCBI
Rnor_5.0	19	555,959 - 559,189 (+)	NCBI
RGSC_v3.4	19	272,791 - 275,957 (+)	RGD
Celera	19	350,432 - 353,630 (+)	NCBI

Sequence:

show sequence

TGAGGGGCTGAGAAGGCCATCAAGGAGAAAAAGGTTGCAGACGTGACAGAGACAAGGCTCCGAG
TCTGAACAGGGGTCTGCGAGTGGGTCTATCTGATTCCCCAGTGGTCTGTGCCGCAGCGCTGATC
AAGTGCTGATAGCATCTGTGCAAGAGTCGACGGCGTCCGACACGATGACCCTGAATGGAGGCAG
CGGAGCGGGCGGCAGCCGTAGCGCGGGCCGGGAGCGCGACCGTCGTCGAGGCAGCACCCCATGG
GGCCCGGCACCCCCACTGCACCGCAGGAGCATGCCGGTGGACGAGCGAGACCTTCAGGCGGCGC
TAACCCCGGGCTCCCTGGCAGCGACTGCAGCTGGAACTCGGACACAGGGGCAGAGGCTGGACTG
GCCTGAAGGCTCCTCCGATTCGCTCAGTTCTGGAGACAGCGGCTCAGAGGATGGCGTTTACAAG
GTGCTGCTGCTGGGGGCACCTGGTGTGGGCAAGAGCGCTCTGGCGCGCATCTTTGGTGGTATAG
AAGACGGACCTGAAGCAGAAGCAGCAGGGCACACATATGACCGTTCTATCACTGTGGATGGAGA
AGAAGCATCACTAATGGTCTATGACATTTGGGAACAGGATGGAGGCTGCTGGCTGCCTGGCCAC
TGCATGGCCATGGGGGATGCATATGTCATTGTGTACTCAATAACGGACAAGGGCAGCTTTGAGA
AAGCCTCAGAACTCCGGGTCCAGCTGCGGCGGGCACGGCAGACAGACAATGTGCCCATCATCCT
AGTGGGCAACAAGAGCGATCTGGTGCGCTCTCGTGAGGTCTCTGTGGATGAGGGCCGGGCCTGC
GCAGTGGTCTTCGACTGCAAGTTCATCGAGACCTCCGCAGCACTGCATCACAACGTCCAGGCAC
TGTTCGAGGGTGTTGTGCGTCAGATACGCCTGCGCAGGGACAGCAAAGAGGATAATGCTCGTCG
ACAAGCTGGCACTCGACGACGGGAGAGCCTTGGCAAGAAGGCCAAACGCTTTCTGGGCCGCATA
GTAGCTCGCAACAGCCGCAAGATGGCCTTTCGTGCCAAGTCCAAGTCCTGCCATGACCTCTCTG
TTCTCTAAGGCCAACGGCCCCCTTGTTTGTGGGTCAGTAGATGGATGGAAGGGCTGGCCCAGCC
AACTGCTCTAAATGTCTCAGAGTTGGCCCACCCTCCGTATTTCTCAGAACTGTCAACTATGCAC
AGCCTGTCTCACGGTCATGGACAGATAGTGCTGACCAGGGAGGCAACTCCAAACGGCCATCGAG
GCCTGGGCCTATGGAGATGCATGTGCAGGCCCACGTGCATACCGAGCAGCCTGAACCCTGCTCT
TGGACAGGACTCTGCCTTTCTCCATGTGGGTGTCTGCCCTGGAGGGAGGCTGTTCTATATGCTT
GCTGTTTGTTTACATGCAGATTTTTGTAATAAAGACTATTTCCTGACAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006255055 ⟹ XP_006255117

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	19	360,581 - 363,874 (+)	NCBI
mRatBN7.2	19	354,184 - 357,419 (+)	NCBI
Rnor_6.0	19	561,696 - 564,929 (+)	NCBI
Rnor_5.0	19	555,959 - 559,189 (+)	NCBI

Sequence:

show sequence

AATAGGAGGCCCTAGAACCGCGATCCAGCGCCAGCTGAGGGGCTGAGAAGGCCATCAAGGAGAA
AAAGGTTGCAGACGTGACAGAGACAAGGCTCCGAGTCTGAACAGGGGTCTGCGAGTGGGTCTAT
CTGATTCCCCAGTGGTCTGTGCCGCAGCGCTGATCAAGTGCTGATAGCATCTGTGCAAGAGTCG
GGTCCTGCCTGTTCCCGCGATAGAGCTGCTATCCCAATTCTTGGTTCCTCAGACGGCGTCCGAC
ACGATGACCCTGAATGGAGGCAGCGGAGCGGGCGGCAGCCGTAGCGCGGGCCGGGAGCGCGACC
GTCGTCGAGGCAGCACCCCATGGGGCCCGGCACCCCCACTGCACCGCAGGAGCATGCCGGTGGA
CGAGCGAGACCTTCAGGCGGCGCTAACCCCGGGCTCCCTGGCAGCGACTGCAGCTGGAACTCGG
ACACAGGGGCAGAGGCTGGACTGGCCTGAAGGCTCCTCCGATTCGCTCAGTTCTGGAGACAGCG
GCTCAGAGGATGGCGTTTACAAGGTGCTGCTGCTGGGGGCACCTGGTGTGGGCAAGAGCGCTCT
GGCGCGCATCTTTGGTGGTATAGAAGACGGACCTGAAGCAGAAGCAGCAGGGCACACATATGAC
CGTTCTATCACTGTGGATGGAGAAGAAGCATCACTAATGGTCTATGACATTTGGGAACAGGATG
GAGGCTGCTGGCTGCCTGGCCACTGCATGGCCATGGGGGATGCATATGTCATTGTGTACTCAAT
AACGGACAAGGGCAGCTTTGAGAAAGCCTCAGAACTCCGGGTCCAGCTGCGGCGGGCACGGCAG
ACAGACAATGTGCCCATCATCCTAGTGGGCAACAAGAGCGATCTGGTGCGCTCTCGTGAGGTCT
CTGTGGATGAGGGCCGGGCCTGCGCAGTGGTCTTCGACTGCAAGTTCATCGAGACCTCCGCAGC
ACTGCATCACAACGTCCAGGCACTGTTCGAGGGTGTTGTGCGTCAGATACGCCTGCGCAGGGAC
AGCAAAGAGGATAATGCTCGTCGACAAGCTGGCACTCGACGACGGGAGAGCCTTGGCAAGAAGG
CCAAACGCTTTCTGGGCCGCATAGTAGCTCGCAACAGCCGCAAGATGGCCTTTCGTGCCAAGTC
CAAGTCCTGCCATGACCTCTCTGTTCTCTAAGGCCAACGGCCCCCTTGTTTGTGGGTCAGTAGA
TGGATGGAAGGGCTGGCCCAGCCAACTGCTCTAAATGTCTCAGAGTTGGCCCACCCTCCGTATT
TCTCAGAACTGTCAACTATGCACAGCCTGTCTCACGGTCATGGACAGATAGTGCTGACCAGGGA
GGCAACTCCAAACGGCCATCGAGGCCTGGGCCTATGGAGATGCATGTGCAGGCCCACGTGCATA
CCGAGCAGCCTGAACCCTGCTCTTGGACAGGACTCTGCCTTTCTCCATGTGGGTGTCTGCCCTG
GAGGGAGGCTGTTCTATATGCTTGCTGTTTGTTTACATGCAGATTTTTGTAATAAAGACTATTT
CCTGACAAA

hide sequence

Protein Sequences


Protein RefSeqs	NP_445790	(Get FASTA)	NCBI Sequence Viewer
	XP_006255117	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAA56719	(Get FASTA)	NCBI Sequence Viewer
	EDL87222	(Get FASTA)	NCBI Sequence Viewer
	EDL87223	(Get FASTA)	NCBI Sequence Viewer
	EDL87224	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000016259
GenBank Protein	P55043	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_445790 ⟸ NM_053338

- UniProtKB:

P55043 (UniProtKB/Swiss-Prot), G3V7K9 (UniProtKB/TrEMBL), A6JXU5 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MTLNGGSGAGGSRSAGRERDRRRGSTPWGPAPPLHRRSMPVDERDLQAALTPGSLAATAAGTRT
QGQRLDWPEGSSDSLSSGDSGSEDGVYKVLLLGAPGVGKSALARIFGGIEDGPEAEAAGHTYDR
SITVDGEEASLMVYDIWEQDGGCWLPGHCMAMGDAYVIVYSITDKGSFEKASELRVQLRRARQT
DNVPIILVGNKSDLVRSREVSVDEGRACAVVFDCKFIETSAALHHNVQALFEGVVRQIRLRRDS
KEDNARRQAGTRRRESLGKKAKRFLGRIVARNSRKMAFRAKSKSCHDLSVL

hide sequence

RefSeq Acc Id:	XP_006255117 ⟸ XM_006255055
- Peptide Label:	isoform X1
- UniProtKB:	P55043 (UniProtKB/Swiss-Prot), G3V7K9 (UniProtKB/TrEMBL), A6JXU5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MTLNGGSGAGGSRSAGRERDRRRGSTPWGPAPPLHRRSMPVDERDLQAALTPGSLAATAAGTRT QGQRLDWPEGSSDSLSSGDSGSEDGVYKVLLLGAPGVGKSALARIFGGIEDGPEAEAAGHTYDR SITVDGEEASLMVYDIWEQDGGCWLPGHCMAMGDAYVIVYSITDKGSFEKASELRVQLRRARQT DNVPIILVGNKSDLVRSREVSVDEGRACAVVFDCKFIETSAALHHNVQALFEGVVRQIRLRRDS KEDNARRQAGTRRRESLGKKAKRFLGRIVARNSRKMAFRAKSKSCHDLSVL hide sequence

Ensembl Acc Id:

ENSRNOP00000016259 ⟸ ENSRNOT00000016259

Ensembl Acc Id:

ENSRNOP00000070963 ⟸ ENSRNOT00000081547

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P55043-F1-model_v2	AlphaFold	P55043	1-306	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13700906

Promoter ID:

EPDNEW_R11430

Type:

single initiation site

Name:

Rrad_1

Description:

RRAD, Ras related glycolysis inhibitor and calcium channel regulator

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	19	561,722 - 561,782	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:69357	AgrOrtholog
BioCyc Gene	G2FUF-6657	BioCyc
Ensembl Genes	ENSRNOG00000011901	Ensembl, ENTREZGENE
Ensembl Transcript	ENSRNOT00000016259	ENTREZGENE
Gene3D-CATH	3.40.50.300	UniProtKB/Swiss-Prot
InterPro	P-loop_NTPase	UniProtKB/Swiss-Prot
	RGK	UniProtKB/Swiss-Prot
	RGK_GTP-binding_reg	UniProtKB/Swiss-Prot
	Small_GTPase	UniProtKB/Swiss-Prot
NCBI Gene	83521	ENTREZGENE
PANTHER	PTHR45775:SF3	UniProtKB/Swiss-Prot
	RAD, GEM/KIR FAMILY MEMBER 2, ISOFORM C	UniProtKB/Swiss-Prot
Pfam	Ras	UniProtKB/Swiss-Prot
PhenoGen	Rrad	PhenoGen
PIRSF	GTP-binding_GEM	UniProtKB/Swiss-Prot
PRINTS	RASTRNSFRMNG	UniProtKB/Swiss-Prot
PROSITE	RAS	UniProtKB/Swiss-Prot
RatGTEx	ENSRNOG00000011901	RatGTEx
SMART	RAB	UniProtKB/Swiss-Prot
	RAS	UniProtKB/Swiss-Prot
	RHO	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot
TIGR	TC218333
UniProt	A6JXU5	ENTREZGENE, UniProtKB/TrEMBL
	A6JXU6_RAT	UniProtKB/TrEMBL
	G3V7K9	ENTREZGENE, UniProtKB/TrEMBL
	P55043	ENTREZGENE, UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-05-20	Rrad	RRAD, Ras related glycolysis inhibitor and calcium channel regulator	Rrad	Ras-related associated with diabetes	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2002-06-10	Rrad	Ras-related associated with diabetes			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - CTD