Slc22a6 (solute carrier family 22 member 6) - Rat Genome Database

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Gene: Slc22a6 (solute carrier family 22 member 6) Rattus norvegicus
Analyze
Symbol: Slc22a6
Name: solute carrier family 22 member 6
RGD ID: 69338
Description: Enables several functions, including chloride ion binding activity; prostaglandin transmembrane transporter activity; and secondary active transmembrane transporter activity. Involved in metanephric proximal tubule development; prostaglandin transport; and sodium-independent organic anion transport. Acts upstream of or within organic anion transport. Located in caveola. Part of protein-containing complex. Orthologous to human SLC22A6 (solute carrier family 22 member 6); PARTICIPATES IN multispecific organic anion transporter mediated transport pathway; amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; INTERACTS WITH (-)-citrinin; 1-naphthyl isothiocyanate; 2,2,2-tetramine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: MGC124962; Oat1; Orctl1; organic anion transporter 1; organic cationic transporter-like 1; Paht; renal organic anion transporter 1; Roat1; rROAT1; solute carrier family 22 (organic anion transporter) member 6; solute carrier family 22 (organic anion transporter), member 6; solute carrier family 22, member 6
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Is Marker For: Strains:   SD-Slc22a6em1Sage  
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81214,951,493 - 214,960,317 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1214,951,867 - 214,960,311 (+)EnsemblGRCr8
mRatBN7.21205,522,579 - 205,531,179 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1205,522,729 - 205,531,173 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1213,928,527 - 213,936,740 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01220,966,506 - 220,974,728 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01213,659,221 - 213,667,443 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01224,824,809 - 224,833,284 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1224,824,799 - 224,833,259 (+)Ensemblrn6Rnor6.0
Rnor_5.01231,761,600 - 231,772,550 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41211,294,178 - 211,302,398 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1203,036,078 - 203,044,298 (+)NCBICelera
RGSC_v3.11211,452,399 - 211,460,822 (+)NCBI
Cytogenetic Map1q43NCBI
JBrowse:




Disease Annotations     Click to see Annotation Detail View
calcinosis  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-citrinin  (EXP)
1,1-dichloroethene  (ISO)
1,2,4-trichloro-5-(2,5-dichlorophenyl)benzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,2,2-tetramine  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
2,3,7,8-Tetrachlorodibenzofuran  (EXP)
2,4,4'-trichlorobiphenyl  (ISO)
2,4-D  (EXP,ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diisothiocyano-trans-stilbene-2,2'-disulfonic acid  (ISO)
4,4'-sulfonyldiphenol  (ISO)
5-azaorotic acid  (EXP,ISO)
5-formyltetrahydrofolic acid  (EXP,ISO)
6-carboxyfluorescein  (ISO)
6-propyl-2-thiouracil  (EXP,ISO)
7,9-dihydro-1H-purine-2,6,8(3H)-trione  (EXP,ISO)
9-[2-(phosphonomethoxy)ethyl]guanine  (ISO)
acetylsalicylic acid  (ISO)
adefovir  (EXP,ISO)
adipic acid  (ISO)
aflatoxin B1  (ISO)
allopurinol  (EXP,ISO)
amitriptyline  (ISO)
ammonium chloride  (EXP)
angelicin  (ISO)
aristolochic acid A  (ISO)
aristolochic acids  (EXP,ISO)
aurantio-obtusin  (ISO)
bacitracin  (EXP)
baicalein  (ISO)
bendroflumethiazide  (ISO)
benzbromarone  (ISO)
benzo[a]pyrene  (ISO)
benzylpenicillin  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bromosulfophthalein  (ISO)
cadmium dichloride  (EXP,ISO)
cefaclor  (ISO)
cefaloridine  (EXP,ISO)
cefdinir  (ISO)
cefoselis sulfate  (ISO)
cefotiam  (ISO)
ceftibuten  (ISO)
ceftizoxime  (ISO)
chlorpyrifos-methyl  (ISO)
chrysophanol  (ISO)
cidofovir anhydrous  (ISO)
ciguatoxin CTX1B  (ISO)
cimetidine  (ISO)
cisplatin  (EXP,ISO)
clothianidin  (ISO)
cyazofamid  (ISO)
D-gluconic acid  (ISO)
diazepam  (ISO)
diclofenac  (ISO)
diethyl hydrogen phosphate  (EXP)
diiodine  (ISO)
disodium cromoglycate  (EXP)
doxycycline  (ISO)
emodin  (ISO)
estrone 3-sulfate  (ISO)
eugenol  (EXP)
fenitrothion  (ISO)
fluorescein (lactone form)  (ISO)
folic acid  (EXP,ISO)
fructose  (EXP)
furan  (EXP)
furosemide  (EXP,ISO)
genistein  (EXP,ISO)
gentamycin  (EXP)
glutaric acid  (ISO)
glutathione  (ISO)
glycidol  (EXP)
GW 4064  (ISO)
herbicide  (EXP)
hydrochlorothiazide  (EXP)
hypoxanthine  (ISO)
ibuprofen  (ISO)
icariin  (ISO)
imperatorin  (ISO)
indometacin  (ISO)
isoimperatorin  (ISO)
ketoprofen  (ISO)
linoleic acid  (ISO)
luteolin  (ISO)
malathion  (ISO)
mefenamic acid  (ISO)
Mercuric oxide  (ISO)
mercury atom  (EXP,ISO)
mercury dichloride  (EXP,ISO)
mercury(0)  (EXP,ISO)
methotrexate  (EXP,ISO)
methoxsalen  (ISO)
methylmercury chloride  (EXP)
mianserin  (ISO)
minocycline  (ISO)
N-acetyl-L-cysteine  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naproxen  (ISO)
Nonylphenol  (EXP)
Obtusifolin  (ISO)
ochratoxin A  (EXP,ISO)
octanoic acid  (EXP)
oroxylin A  (ISO)
oxytetracycline  (ISO)
p-aminohippuric acid  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP)
PCB138  (ISO)
perfluoroheptanoic acid  (EXP,ISO)
perfluorohexanoic acid  (EXP)
perfluorononanoic acid  (EXP)
perfluorooctanoic acid  (EXP,ISO)
phenacetin  (ISO)
PhIP  (ISO)
pirinixic acid  (EXP)
piroxicam  (EXP,ISO)
Potassium 2,6-dihydroxytriazinecarboxylate  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
probenecid  (EXP,ISO)
prostaglandin E2  (EXP)
purines  (EXP)
pyrazine-2-carboxylic acid  (ISO)
quercetin  (EXP,ISO)
quercetin 3-sulfate  (ISO)
ranitidine  (ISO)
resveratrol  (EXP,ISO)
Rhein  (ISO)
riddelliine  (EXP)
rutin  (EXP)
salicylates  (ISO)
salicylic acid  (ISO)
sodium arsenite  (EXP,ISO)
sodium dichromate  (EXP)
sodium hydrogencarbonate  (EXP)
streptozocin  (EXP,ISO)
succinic acid  (ISO)
sulindac  (ISO)
taurocholic acid  (ISO)
tenofovir disoproxil fumarate  (ISO)
testosterone  (ISO)
tetracycline  (ISO)
thiram  (ISO)
trans-piceid  (ISO)
traumatic acid  (EXP,ISO)
triazolam  (ISO)
umbelliferone  (ISO)
valsartan  (EXP)
vancomycin  (EXP,ISO)
wedelolactone  (ISO)
wogonin  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Molecular evidence of organic ion transporters in the rat adrenal cortex with adrenocorticotropin-regulated zonal expression. Beery E, etal., Endocrinology 2003 Oct;144(10):4519-26. Epub 2003 Jun 26.
2. Characterization of uremic toxin transport by organic anion transporters in the kidney. Deguchi T, etal., Kidney Int. 2004 Jan;65(1):162-74. doi: 10.1111/j.1523-1755.2004.00354.x.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rapid isolation of tissue-specific genes from rat kidney. Hu E, etal., Exp Nephrol 2001 Mar-Apr;9(2):156-64.
6. Cell free expression and functional reconstitution of eukaryotic drug transporters. Keller T, etal., Biochemistry. 2008 Apr 15;47(15):4552-64. doi: 10.1021/bi800060w. Epub 2008 Mar 25.
7. Differential gene expression of organic anion transporters in male and female rats. Kobayashi Y, etal., Biochem Biophys Res Commun 2002 Jan 11;290(1):482-7.
8. Co-localization and interaction of organic anion transporter 1 with caveolin-2 in rat kidney. Kwak JO, etal., Exp Mol Med. 2005 Jun 30;37(3):204-12.
9. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
10. Renogenic characterization and in vitro differentiation of rat amniotic fluid stem cells into renal proximal tubular- and juxtaglomerular-like cells. Minocha E, etal., In Vitro Cell Dev Biol Anim. 2019 Feb;55(2):138-147. doi: 10.1007/s11626-018-00315-2. Epub 2019 Jan 15.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
13. GOA pipeline RGD automated data pipeline
14. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
15. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
16. Expression cloning and characterization of a novel multispecific organic anion transporter. Sekine T, etal., J Biol Chem 1997 Jul 25;272(30):18526-9.
17. Effect of methotrexate treatment on expression levels of multidrug resistance protein 2, breast cancer resistance protein and organic anion transporters Oat1, Oat2 and Oat3 in rats. Shibayama Y, etal., Cancer Sci. 2006 Nov;97(11):1260-6. Epub 2006 Aug 22.
18. Expression cloning and characterization of ROAT1. The basolateral organic anion transporter in rat kidney. Sweet DH, etal., J Biol Chem 1997 Nov 28;272(48):30088-95.
19. Transport of xanthurenic acid by rat/human organic anion transporters OAT1 and OAT3. Uwai Y and Honjo E, Biosci Biotechnol Biochem. 2013;77(7):1517-21. doi: 10.1271/bbb.130178. Epub 2013 Jul 7.
20. Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney. Youngblood GL and Sweet DH, Am J Physiol Renal Physiol 2004 Aug;287(2):F236-44. Epub 2004 Apr 06.
Additional References at PubMed
PMID:9887087   PMID:9950961   PMID:10049739   PMID:10751225   PMID:12477932   PMID:12877347   PMID:14749323   PMID:15037815   PMID:15122767   PMID:16024787   PMID:16316345   PMID:16844357  
PMID:17244891   PMID:17245393   PMID:18946499   PMID:18953184   PMID:19028678   PMID:19056867   PMID:19403644   PMID:21652719   PMID:22015764   PMID:22169006   PMID:22759781   PMID:22808265  
PMID:22992436   PMID:23280877   PMID:23376485   PMID:24531880   PMID:25266751   PMID:25391897   PMID:26065488   PMID:26846716   PMID:27053689   PMID:27226107   PMID:27282888   PMID:28534121  
PMID:29436232   PMID:32271169   PMID:32451678   PMID:33790363  


Genomics

Comparative Map Data
Slc22a6
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81214,951,493 - 214,960,317 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1214,951,867 - 214,960,311 (+)EnsemblGRCr8
mRatBN7.21205,522,579 - 205,531,179 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1205,522,729 - 205,531,173 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1213,928,527 - 213,936,740 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01220,966,506 - 220,974,728 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01213,659,221 - 213,667,443 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01224,824,809 - 224,833,284 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1224,824,799 - 224,833,259 (+)Ensemblrn6Rnor6.0
Rnor_5.01231,761,600 - 231,772,550 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41211,294,178 - 211,302,398 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1203,036,078 - 203,044,298 (+)NCBICelera
RGSC_v3.11211,452,399 - 211,460,822 (+)NCBI
Cytogenetic Map1q43NCBI
SLC22A6
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381162,976,597 - 62,984,967 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1162,936,385 - 62,984,967 (-)Ensemblhg38GRCh38
GRCh371162,744,069 - 62,752,439 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361162,500,645 - 62,509,045 (-)NCBIBuild 36Build 36hg18NCBI36
Build 341162,500,645 - 62,509,045NCBI
Celera1160,068,114 - 60,076,514 (-)NCBICelera
Cytogenetic Map11q12.3NCBI
HuRef1159,073,118 - 59,081,543 (-)NCBIHuRef
CHM1_11162,626,827 - 62,635,253 (-)NCBICHM1_1
T2T-CHM13v2.01162,965,855 - 62,974,245 (-)NCBIT2T-CHM13v2.0
Slc22a6
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39198,595,360 - 8,605,663 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl198,595,403 - 8,605,663 (+)EnsemblGRCm39 EnsemblGRCm39
GRCm38198,617,996 - 8,628,299 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl198,618,039 - 8,628,299 (+)Ensemblmm10GRCm38
MGSCv37198,692,486 - 8,702,789 (+)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36198,685,086 - 8,693,568 (+)NCBIMGSCv36mm8
Celera198,376,155 - 8,386,458 (+)NCBICelera
Cytogenetic Map19ANCBI
cM Map195.44NCBI
Slc22a6
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955599301,981 - 311,447 (+)Ensembl
ChiLan1.0NW_004955599302,026 - 307,503 (+)NCBIChiLan1.0ChiLan1.0
SLC22A6
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2964,198,167 - 64,206,697 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11165,243,334 - 65,251,869 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01158,328,476 - 58,336,887 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11161,680,016 - 61,688,223 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1161,680,016 - 61,688,223 (-)EnsemblpanPan2panpan1.1
SLC22A6
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11853,736,669 - 53,745,001 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1853,736,959 - 53,744,396 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1852,342,543 - 52,350,303 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01854,782,055 - 54,789,820 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1854,782,215 - 54,790,398 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11853,884,029 - 53,891,784 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01853,458,362 - 53,466,122 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01854,245,739 - 54,253,490 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc22a6
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494710,235,014 - 10,242,500 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936581349,057 - 356,059 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_004936581348,719 - 356,246 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC22A6
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl28,802,349 - 8,817,337 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.128,809,547 - 8,817,124 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.228,152,459 - 8,160,066 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLC22A6
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1110,918,081 - 10,926,790 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl110,918,770 - 10,925,983 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_023666038108,270,857 - 108,278,591 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc22a6
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249261,363,431 - 1,368,534 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046249261,363,322 - 1,368,768 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc22a6
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v129,305,144 - 9,313,284 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc22a6
35 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:89
Count of miRNA genes:72
Interacting mature miRNAs:76
Transcripts:ENSRNOT00000024757
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1357335Bw39Body weight QTL 393.3body mass (VT:0001259)body weight (CMO:0000012)1207243873252243873Rat
2293674Bss39Bone structure and strength QTL 397.10.0001femur strength trait (VT:0010010)femur total energy absorbed before break (CMO:0001677)1210980612255980612Rat
1354652Kidm20Kidney mass QTL 204.3kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1186658830266453731Rat
1354653Despr9Despair related QTL 90.00019locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1177339686222339686Rat
2293673Bss27Bone structure and strength QTL 2718.630.0001femur morphology trait (VT:0000559)femur midshaft cortical cross-sectional area (CMO:0001663)1181059071226059071Rat
2293677Bss41Bone structure and strength QTL 419.380.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra cross-sectional area (CMO:0001689)1181059071226059071Rat
1549830Bss1Bone structure and strength QTL 14.8femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1182039247227039247Rat
70163Bw20Body weight QTL 205.1body mass (VT:0001259)body weight (CMO:0000012)1183564652228564652Rat
1600395Niddm69Non-insulin dependent diabetes mellitus QTL 694.140.0002blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1205233991267096252Rat
1600396Niddm68Non-insulin dependent diabetes mellitus QTL 684.970.0003blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
1354624Cm35Cardiac mass QTL355.7heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1186658830266453731Rat
1600397Edcs4Endometrial carcinoma susceptibility QTL 42.2uterus morphology trait (VT:0001120)percentage of study population developing endometrioid carcinoma during a period of time (CMO:0001759)1176288899270518180Rat
631838Niddm36Non-insulin dependent diabetes mellitus QTL 360.01insulin secretion trait (VT:0003564)calculated pancreatic islet insulin release measurement (CMO:0001217)1193964073238964073Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
2293689Bss47Bone structure and strength QTL 477.250.0001lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)1181059071226059071Rat
2293694Bss38Bone structure and strength QTL 387.050.0001femur strength trait (VT:0010010)femur stiffness (CMO:0001674)1210980612255980612Rat
1600388Niddm67Non-insulin dependent diabetes mellitus QTL 675.840.000004blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1205233991267096252Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
2293693Bss22Bone structure and strength QTL 2233.520.0001femur morphology trait (VT:0000559)femur cross-sectional area (CMO:0001661)1181059071226059071Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
2300161Bmd43Bone mineral density QTL 438.40.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
1300145Rf7Renal function QTL 72.96urine creatinine amount (VT:0010540)urine creatinine level (CMO:0000125)1194575422239575422Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
8655655Arrd2Age-related retinal degeneration QTL 27.79retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1193400541238400541Rat
1358898Bp255Blood pressure QTL 2553.6arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1200449456256003563Rat
631214Bw61Body weight QTL613.40.0001intramuscular adipose amount (VT:0010044)intramuscular fat area (CMO:0001162)1182535316227535316Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
731175Uae20Urinary albumin excretion QTL 203.50.0018urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1207163993269633915Rat
2300175Bmd40Bone mineral density QTL 4015.40.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)1210980612255980612Rat
2300174Bmd42Bone mineral density QTL 428.40.0001lumbar vertebra mineral mass (VT:0010511)bone mineral density (CMO:0001226)1181059071226059071Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
2293654Bss30Bone structure and strength QTL 3032.650.0001femur strength trait (VT:0010010)femur midshaft polar moment of inertia (CMO:0001669)1181059071226059071Rat
2293655Bss36Bone structure and strength QTL 3610.660.0001femur strength trait (VT:0010010)femur ultimate force (CMO:0001675)1210980612255980612Rat
1298084Thym4Thymus enlargement QTL 410.68thymus mass (VT:0004954)thymus weight to body weight ratio (CMO:0000612)1207243873252243873Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
2300187Bmd41Bone mineral density QTL 418.90.0001femur mineral mass (VT:0010011)volumetric bone mineral density (CMO:0001553)1181059071226059071Rat
2314011Gluco56Glucose level QTL 56blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1209203273254203273Rat
8552891Epfw5Epididymal fat weight QTL 54.4epididymal fat pad mass (VT:0010421)epididymal fat pad weight to body weight ratio (CMO:0000658)1202543537247543537Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
634313Niddm43Non-insulin dependent diabetes mellitus QTL 43blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1208479811269633915Rat
1358292Cm37Cardiac mass QTL 376.28e-07heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)1205674651250674651Rat
61376Bp42Blood pressure QTL 4223.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1207243873252243873Rat
634312Bp143Blood pressure QTL 14330.0002arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1203300512229359342Rat
1358294Bw37Body weight QTL 3750.000011body mass (VT:0001259)body weight (CMO:0000012)1180739993225739993Rat
724559Pancm1Pancreatic morphology QTL 17.1islet of Langerhans morphology trait (VT:0005215)pancreatic islet damage composite score (CMO:0001156)1191190115223964326Rat
2312420Pur17Proteinuria QTL 177.10.0001urine protein amount (VT:0005160)urine total protein excretion rate (CMO:0000756)1172718770228180370Rat
10059600Bp378Blood pressure QTL 3783.080.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1358916Kidm22Kidney mass QTL 223.32kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1212738576257738576Rat
2312564Glom18Glomerulus QTL 182.40.003kidney glomerulus morphology trait (VT:0005325)index of glomerular damage (CMO:0001135)1194786607262083703Rat
2292218Kidm35Kidney mass QTL 35kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1208798288253798288Rat
634321Hc1Hypercalciuria QTL 12.91urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1188241285250779312Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
1300168Bp170Blood pressure QTL 1702.76arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1192995199237995199Rat
61403Niddm4Non-insulin dependent diabetes mellitus QTL 4blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1201464383246464383Rat
2292222Bp307Blood pressure QTL 3073.060.0014arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
2292220Bp306Blood pressure QTL 3063.470.00087arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1186298393231298393Rat
1641926Teswt2Testicular weight QTL 22.82testis mass (VT:1000644)both testes wet weight (CMO:0000175)1203675682248675682Rat
631658Cm7Cardiac mass QTL 75.320.0001aorta mass (VT:0002845)aorta weight (CMO:0000076)1205674651250674651Rat
1600380Niddm70Non-insulin dependent diabetes mellitus QTL 703.10.0008blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)1185979875230979875Rat
1582206Kidm33Kidney mass QTL 336.9kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)1197807365233480676Rat
2293700Bmd27Bone mineral density QTL 276.60.0001femur mineral mass (VT:0010011)trabecular volumetric bone mineral density (CMO:0001729)1210980612255980612Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
2293701Bmd34Bone mineral density QTL 348.30.0001femur strength trait (VT:0010010)femoral neck ultimate force (CMO:0001703)1210980612255980612Rat
634338Hcar4Hepatocarcinoma resistance QTL 44.6liver integrity trait (VT:0010547)liver tumorous lesion number to liver area ratio (CMO:0001210)1202851915223964440Rat
8655855Arrd3Age-related retinal degeneration QTL 33.07lens clarity trait (VT:0001304)cataract incidence/prevalence measurement (CMO:0001585)1193400541238400541Rat
1600374Mcs17Mammary carcinoma susceptibility QTL 173mammary gland integrity trait (VT:0010552)mammary tumor number (CMO:0000343)1207099883252099883Rat
6903303Scl34Serum cholesterol QTL 342.50.0033blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)1173363824227535316Rat
1600363Hc6Hypercalciuria QTL 62.7urine calcium amount (VT:0002985)urine calcium excretion rate (CMO:0000763)1210980612255980612Rat
2293083Iddm25Insulin dependent diabetes mellitus QTL 254.18blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1191260175236260175Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
738032Hcas5Hepatocarcinoma susceptibility QTL 53.12liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1185857683270518180Rat
2325727Pia41Pristane induced arthritis QTL 41joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)1188241285233241285Rat
7394701Uae46Urinary albumin excretion QTL 463.60.0056urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1210980612255980612Rat


Related Rat Strains
The following Strains have been annotated to Slc22a6
SD-Slc22a6em1Sage    


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
11 8 34 129 69 65 41 29 41 4 258 81 3 109 117 63 24 2 2

Sequence


Ensembl Acc Id: ENSRNOT00000024757   ⟹   ENSRNOP00000024756
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1214,951,867 - 214,960,311 (+)Ensembl
mRatBN7.2 Ensembl1205,522,729 - 205,531,173 (+)Ensembl
Rnor_6.0 Ensembl1224,824,799 - 224,833,259 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000147894   ⟹   ENSRNOP00000110076
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1214,951,867 - 214,960,311 (+)Ensembl
RefSeq Acc Id: NM_017224   ⟹   NP_058920
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81214,952,097 - 214,960,317 (+)NCBI
mRatBN7.21205,522,959 - 205,531,179 (+)NCBI
Rnor_6.01224,825,064 - 224,833,284 (+)NCBI
Rnor_5.01231,761,600 - 231,772,550 (+)NCBI
RGSC_v3.41211,294,178 - 211,302,398 (+)RGD
Celera1203,036,078 - 203,044,298 (+)RGD
Sequence:
RefSeq Acc Id: XM_006230978   ⟹   XP_006231040
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81214,951,493 - 214,960,312 (+)NCBI
mRatBN7.21205,522,579 - 205,531,174 (+)NCBI
Rnor_6.01224,824,809 - 224,833,284 (+)NCBI
Rnor_5.01231,761,600 - 231,772,550 (+)NCBI
Sequence:
RefSeq Acc Id: NP_058920   ⟸   NM_017224
- UniProtKB: O35956 (UniProtKB/Swiss-Prot),   A6HZR6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_006231040   ⟸   XM_006230978
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSRNOP00000024756   ⟸   ENSRNOT00000024757
Ensembl Acc Id: ENSRNOP00000110076   ⟸   ENSRNOT00000147894
Protein Domains
Major facilitator superfamily (MFS) profile

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O35956-F1-model_v2 AlphaFold O35956 1-551 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690728
Promoter ID:EPDNEW_R1253
Type:multiple initiation site
Name:Slc22a6_1
Description:solute carrier family 22 member 6
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01224,824,839 - 224,824,899EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69338 AgrOrtholog
BioCyc Gene G2FUF-56524 BioCyc
Ensembl Genes ENSRNOG00000018215 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000024757 ENTREZGENE
  ENSRNOT00000024757.5 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7109188 IMAGE-MGC_LOAD
InterPro MFS_dom UniProtKB/Swiss-Prot
  MFS_sugar_transport-like UniProtKB/Swiss-Prot
  MFS_trans_sf UniProtKB/Swiss-Prot
  Orgcat_transp/SVOP UniProtKB/Swiss-Prot
KEGG Report rno:29509 UniProtKB/Swiss-Prot
MGC_CLONE MGC:124962 IMAGE-MGC_LOAD
NCBI Gene Slc22a6 ENTREZGENE
PANTHER SOLUTE CARRIER FAMILY 22 MEMBER UniProtKB/Swiss-Prot
Pfam Sugar_tr UniProtKB/Swiss-Prot
PharmGKB SLC22A6 RGD
PhenoGen Slc22a6 PhenoGen
PROSITE MFS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000018215 RatGTEx
Superfamily-SCOP SSF103473 UniProtKB/Swiss-Prot
UniProt A0ABK0LV31_RAT UniProtKB/TrEMBL
  A6HZR6 ENTREZGENE, UniProtKB/TrEMBL
  O35956 ENTREZGENE, UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-02-24 Slc22a6  solute carrier family 22 member 6  Slc22a6  solute carrier family 22 (organic anion transporter), member 6  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Slc22a6  solute carrier family 22 (organic anion transporter), member 6    solute carrier family 22, member 6  Name updated 1299863 APPROVED
2002-06-10 Slc22a6  solute carrier family 22, member 6      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization basalateral membrane of proximal tube in kidney 68821
gene_cellular_localization basalateral membrane of proximal tube in kidney 68822
gene_domains contains 12 putative membrane-spannning domains 68821
gene_expression no sex differences in expression in brain, liver and kidney 70250
gene_expression expressed predominantly in a segment of the proximal tubule in kidney 68822
gene_expression expresse in the outer zona fasciculata of the adreneal cortex 1299206
gene_function organic anion/dicarboxylate exchanger 68822
gene_function transports cyclic nucleotides, prostaglandin, uric acid, and a variety of drugs including antibiotics and diuretics 68681
gene_process mediates sodium-independent para-aminohippurate (PAH) uptake 70250
gene_process may have a possible role in cortisol release 1299206
gene_product organic anion transporter family 68822
gene_protein 551 aa 68822