Slc26a5 (solute carrier family 26 member 5) - Rat Genome Database

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Gene: Slc26a5 (solute carrier family 26 member 5) Rattus norvegicus
Analyze
Symbol: Slc26a5
Name: solute carrier family 26 member 5
RGD ID: 69334
Description: Enables chloride:bicarbonate antiporter activity and identical protein binding activity. Involved in several processes, including bicarbonate transport; chloride transmembrane transport; and positive regulation of cell size. Located in basolateral plasma membrane and lateral plasma membrane. Biomarker of hypothyroidism. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 61. Orthologous to human SLC26A5 (solute carrier family 26 member 5); INTERACTS WITH acrylamide; ammonium chloride; bisphenol A.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: Pres; prestin; prestin (motor protein); solute carrier family 26 (anion exchanger), member 5; solute carrier family 26, member 5; solute carrier family 26, member 5 (prestin)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8414,102,492 - 14,141,520 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl414,102,492 - 14,141,847 (+)EnsemblGRCr8
mRatBN7.2413,210,260 - 13,249,289 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl413,210,260 - 13,249,289 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx418,355,676 - 18,394,701 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0414,172,343 - 14,209,428 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0412,541,325 - 12,580,338 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.049,795,811 - 9,860,904 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl49,821,541 - 9,860,571 (+)Ensemblrn6Rnor6.0
Rnor_5.049,822,682 - 9,861,708 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.448,657,314 - 8,697,539 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera48,801,513 - 8,840,481 (+)NCBICelera
RGSC_v3.148,657,313 - 8,697,539 (+)NCBI
Cytogenetic Map4q11NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. [Pre-stained slides for differential blood counts (author's transl)] Bostjancic W, etal., Dtsch Med Wochenschr 1977 Aug 19;102(33):1175-7, 1185.
2. Sugar transport by mammalian members of the SLC26 superfamily of anion-bicarbonate exchangers. Chambard JM and Ashmore JF, J Physiol. 2003 Aug 1;550(Pt 3):667-77.
3. Regulation of the voltage-gated potassium channel KCNQ4 in the auditory pathway. Chambard JM and Ashmore JF, Pflugers Arch. 2005 Apr;450(1):34-44. Epub 2005 Jan 20.
4. Cochlear function in Prestin knockout mice. Cheatham MA, etal., J Physiol. 2004 Nov 1;560(Pt 3):821-30. Epub 2004 Aug 19.
5. Prestin gene expression in the rat cochlea following intense noise exposure. Chen GD Hear Res. 2006 Dec;222(1-2):54-61. Epub 2006 Sep 26.
6. Aging outer hair cells (OHCs) in the Fischer 344 rat cochlea: function and morphology. Chen GD, etal., Hear Res. 2009 Feb;248(1-2):39-47. doi: 10.1016/j.heares.2008.11.010. Epub 2008 Dec 10.
7. Conserved dimeric subunit stoichiometry of SLC26 multifunctional anion exchangers. Detro-Dassen S, etal., J Biol Chem. 2008 Feb 15;283(7):4177-88. Epub 2007 Dec 11.
8. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
9. Molecular architecture and the structural basis for anion interaction in prestin and SLC26 transporters. Gorbunov D, etal., Nat Commun. 2014 Apr 8;5:3622. doi: 10.1038/ncomms4622.
10. Expression of prestin mRNA in the organotypic culture of rat cochlea. Gross J, etal., Hear Res. 2005 Jun;204(1-2):183-90.
11. Expression of prestin and Gata-3,-2,-1 mRNA in the rat organ of Corti during the postnatal period and in culture. Gross J, etal., Hear Res. 2010 Mar;261(1-2):9-21. doi: 10.1016/j.heares.2009.12.017. Epub 2009 Dec 16.
12. An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice. Lewis MA, etal., Nat Genet. 2009 May;41(5):614-8. doi: 10.1038/ng.369. Epub 2009 Apr 12.
13. Prestin, a cochlear motor protein, is defective in non-syndromic hearing loss. Liu XZ, etal., Hum Mol Genet. 2003 May 15;12(10):1155-62.
14. Molecular screening of patients with nonsyndromic hearing loss from Nanjing city of China. Lu Y, etal., J Biomed Res. 2011 Sep;25(5):309-18. doi: 10.1016/S1674-8301(11)60042-0.
15. Reciprocal electromechanical properties of rat prestin: the motor molecule from rat outer hair cells. Ludwig J, etal., Proc Natl Acad Sci U S A 2001 Mar 27;98(7):4178-83.
16. The ultrastructural distribution of prestin in outer hair cells: a post-embedding immunogold investigation of low-frequency and high-frequency regions of the rat cochlea. Mahendrasingam S, etal., Eur J Neurosci. 2010 May;31(9):1595-605. doi: 10.1111/j.1460-9568.2010.07182.x.
17. Decrease of prestin expression by increased potassium concentration in organotypic cultures of the organ of Corti of newborn rats. Mazurek B, etal., Neurosci Lett. 2011 Jul 15;499(1):52-6. doi: 10.1016/j.neulet.2011.05.031. Epub 2011 May 20.
18. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
19. The motor protein prestin is a bullet-shaped molecule with inner cavities. Mio K, etal., J Biol Chem. 2008 Jan 11;283(2):1137-45. Epub 2007 Nov 12.
20. Mammalian prestin is a weak Cl⁻/HCO₃⁻ electrogenic antiporter. Mistrík P, etal., J Physiol. 2012 Nov 15;590(22):5597-610. doi: 10.1113/jphysiol.2012.241448. Epub 2012 Aug 13.
21. Deafness and permanently reduced potassium channel gene expression and function in hypothyroid Pit1dw mutants. Mustapha M, etal., J Neurosci. 2009 Jan 28;29(4):1212-23. doi: 10.1523/JNEUROSCI.4957-08.2009.
22. Promyelocytic leukemia zinc finger protein localizes to the cochlear outer hair cells and interacts with prestin, the outer hair cell motor protein. Nagy I, etal., Hear Res. 2005 Jun;204(1-2):216-22.
23. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
24. Intracellular anions as the voltage sensor of prestin, the outer hair cell motor protein. Oliver D, etal., Science. 2001 Jun 22;292(5525):2340-3.
25. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
26. GOA pipeline RGD automated data pipeline
27. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
28. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
29. Anion transport by the cochlear motor protein prestin. Schanzler M and Fahlke C, J Physiol. 2012 Jan 15;590(Pt 2):259-72. doi: 10.1113/jphysiol.2011.209577. Epub 2011 Nov 7.
30. High frequency of the IVS2-2A>G DNA sequence variation in SLC26A5, encoding the cochlear motor protein prestin, precludes its involvement in hereditary hearing loss. Tang HY, etal., BMC Med Genet. 2005 Aug 8;6:30.
31. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
32. Thyroid hormone is a critical determinant for the regulation of the cochlear motor protein prestin. Weber T, etal., Proc Natl Acad Sci U S A 2002 Mar 5;99(5):2901-6.
33. Thyroid hormone receptor alpha1 is a critical regulator for the expression of ion channels during final differentiation of outer hair cells. Winter H, etal., Histochem Cell Biol. 2007 Jul;128(1):65-75. Epub 2007 May 23.
34. Prestin regulation and function in residual outer hair cells after noise-induced hearing loss. Xia A, etal., PLoS One. 2013 Dec 20;8(12):e82602. doi: 10.1371/journal.pone.0082602. eCollection 2013.
35. Long-term administration of salicylate enhances prestin expression in rat cochlea. Yang K, etal., Int J Audiol. 2009 Jan;48(1):18-23. doi: 10.1080/14992020802327998.
Additional References at PubMed
PMID:11125015   PMID:12584604   PMID:14553901   PMID:15649974   PMID:16803873   PMID:17120772   PMID:18226918   PMID:18796539   PMID:20418376   PMID:21344672   PMID:21614551   PMID:23542924  
PMID:24303013   PMID:24603188   PMID:26635354   PMID:27636386   PMID:28097024   PMID:30529910   PMID:33667636  


Genomics

Comparative Map Data
Slc26a5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8414,102,492 - 14,141,520 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl414,102,492 - 14,141,847 (+)EnsemblGRCr8
mRatBN7.2413,210,260 - 13,249,289 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl413,210,260 - 13,249,289 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx418,355,676 - 18,394,701 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0414,172,343 - 14,209,428 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0412,541,325 - 12,580,338 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.049,795,811 - 9,860,904 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl49,821,541 - 9,860,571 (+)Ensemblrn6Rnor6.0
Rnor_5.049,822,682 - 9,861,708 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.448,657,314 - 8,697,539 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera48,801,513 - 8,840,481 (+)NCBICelera
RGSC_v3.148,657,313 - 8,697,539 (+)NCBI
Cytogenetic Map4q11NCBI
SLC26A5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387103,352,730 - 103,446,207 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl7103,352,730 - 103,446,207 (-)Ensemblhg38GRCh38
GRCh377102,993,177 - 103,086,654 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 367102,780,413 - 102,873,834 (-)NCBIBuild 36Build 36hg18NCBI36
Celera797,800,386 - 97,892,942 (-)NCBICelera
Cytogenetic Map7q22.1NCBI
HuRef797,355,533 - 97,447,053 (-)NCBIHuRef
CHM1_17102,926,169 - 103,019,937 (-)NCBICHM1_1
T2T-CHM13v2.07104,667,171 - 104,760,648 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v27102,353,543 - 102,447,443 (-)NCBI
Slc26a5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39522,013,999 - 22,070,602 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl522,015,653 - 22,070,602 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38521,809,001 - 21,865,604 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl521,810,655 - 21,865,604 (-)Ensemblmm10GRCm38
MGSCv37521,316,473 - 21,371,422 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36521,322,479 - 21,377,428 (-)NCBIMGSCv36mm8
Celera518,781,281 - 18,837,517 (-)NCBICelera
Cytogenetic Map5A3NCBI
cM Map59.97NCBI
Slc26a5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554108,358,786 - 8,414,145 (-)Ensembl
ChiLan1.0NW_0049554108,358,780 - 8,414,145 (-)NCBIChiLan1.0ChiLan1.0
SLC26A5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v26140,227,545 - 140,305,630 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17188,497,418 - 188,575,508 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0795,363,028 - 95,437,527 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.17108,088,197 - 108,178,578 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl7108,088,197 - 108,178,578 (-)EnsemblpanPan2panpan1.1
SLC26A5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11816,783,795 - 16,841,946 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1816,788,759 - 16,839,940 (+)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha1816,426,732 - 16,484,887 (+)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.01817,074,350 - 17,132,490 (+)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1817,079,270 - 17,131,472 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11816,839,580 - 16,897,324 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01816,777,413 - 16,835,901 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01817,046,210 - 17,104,115 (+)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Slc26a5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440511858,980,819 - 59,021,086 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493647920,104,595 - 20,144,601 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_00493647920,104,625 - 20,145,392 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLC26A5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9103,378,776 - 103,453,730 (-)EnsemblsusScr11Sscrofa11.1
Sscrofa11.19103,382,558 - 103,420,054 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29113,990,590 - 114,062,746 (-)NCBISscrofa10.2Sscrofa10.2susScr3
SLC26A5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12172,347,276 - 72,418,311 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2172,347,792 - 72,393,765 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604231,608,735 - 31,657,804 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slc26a5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462473925,930,221 - 25,995,828 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_00462473925,925,835 - 25,998,410 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
Slc26a5
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v16151,110,122 - 151,149,587 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Slc26a5
217 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:91
Count of miRNA genes:79
Interacting mature miRNAs:84
Transcripts:ENSRNOT00000015733
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
2302371Stl22Serum triglyceride level QTL 225.15blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)41308014658080146Rat
8552903Pigfal2Plasma insulin-like growth factor 1 level QTL 27.3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)4132668025Rat
724557Plsm1Polydactyly-luxate syndrome (PLS) morphotypes QTL 10.0003forelimb integrity trait (VT:0010562)front foot phalanges count (CMO:0001947)4128392287Rat
9590100Sffal4Serum free fatty acids level QTL 47.360.05blood free fatty acid amount (VT:0001553)plasma free fatty acids level (CMO:0000546)4132668025Rat
8552906Pigfal3Plasma insulin-like growth factor 1 level QTL 3blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)41103870656038706Rat
1357341Gluco5Glucose level QTL 56.4adipocyte free fatty acid secretion trait (VT:0010465)absolute change in adipocyte free fatty acid secretion per unit volume (CMO:0001446)4134142783Rat
1357343Gluco4Glucose level QTL 40.00002adipocyte glucose uptake trait (VT:0004185)adipocyte maximal glucose uptake to basal glucose uptake ratio (CMO:0000874)4134142783Rat
8552782Vie1Viral induced encephalitis QTL 126.4brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
6478766Anxrr47Anxiety related response QTL 470.09637locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)41103870656038706Rat
631642Stl2Serum triglyceride level QTL 23.3blood triglyceride amount (VT:0002644)serum triglyceride level (CMO:0000360)4589457557613242Rat
6478769Anxrr48Anxiety related response QTL 480.02514locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)41103870656038706Rat
631261Tcas3Tongue tumor susceptibility QTL 36.88tongue integrity trait (VT:0010553)number of squamous cell tumors of the tongue with diameter greater than 3 mm (CMO:0001950)41170660492690519Rat
61333Gluco16Glucose level QTL 164.30.00001adipocyte glucose uptake trait (VT:0004185)absolute change in adipocyte glucose uptake (CMO:0000873)4131106810Rat
61408Scl23Serum cholesterol level QTL 230.0005blood HDL phospholipid amount (VT:0010504)serum high density lipoprotein phospholipid level (CMO:0001567)4128392287Rat
631209Bw2Body weight QTL24.2retroperitoneal fat pad mass (VT:0010430)retroperitoneal fat pad weight to body weight ratio (CMO:0000635)4145429897Rat
8552803Bw144Body weight QTL 14416body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
8694374Bw155Body weight QTL 1553.390.001body lean mass (VT:0010483)lean tissue morphological measurement (CMO:0002184)41103870656038706Rat
8552801Bw143Body weight QTL 1437.3body mass (VT:0001259)change in body weight to body weight ratio (CMO:0002216)4135396961Rat
2303168Bp330Blood pressure QTL 3304.250.017arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)45889999148002343Rat
9589046Scfw2Subcutaneous fat weight QTL 25.540.001subcutaneous adipose mass (VT:1000472)abdominal subcutaneous fat pad weight (CMO:0002069)4132668025Rat
6478724Anxrr35Anxiety related response QTL 350.00449defecation behavior trait (VT:0010462)defecation measurement (CMO:0000997)41103870656038706Rat
61351Bp33Blood pressure QTL 330.0018arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4128392287Rat
61415Eae11Experimental allergic encephalomyelitis QTL 112.9nervous system integrity trait (VT:0010566)post-insult time to onset of experimental autoimmune encephalomyelitis (CMO:0001422)4140471598Rat
1641905Colcr1Colorectal carcinoma resistance QTL 14.30.0003intestine integrity trait (VT:0010554)benign colorectal tumor surface area measurement (CMO:0001799)4842855130449094Rat
619616Bp79Blood pressure QTL 790.0292arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)4588999950889999Rat
8552809Vie5Viral induced encephalitis QTL 525.3brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)4135396961Rat
738021Hcar13Hepatocarcinoma resistance QTL 134.3liver integrity trait (VT:0010547)liver nonremodeling tumorous lesion volume to total liver volume ratio (CMO:0001464)4133538816Rat
70192BpQTLcluster5Blood pressure QTL cluster 54.183arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)4163900697Rat
9590304Scort17Serum corticosterone level QTL 174.960.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)41103870656038706Rat
9589097Slep11Serum leptin concentration QTL 115.090.001blood leptin amount (VT:0005667)plasma leptin level (CMO:0000781)4132668025Rat
2316958Gluco58Glucose level QTL 5810blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)412212457182430611Rat
1300141Bp178Blood pressure QTL 178arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)41075870140490708Rat


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
1 2 30 82 25 21 9 8 9 2 66 48 2 78 6 41 12 6 6

Sequence


Ensembl Acc Id: ENSRNOT00000015733   ⟹   ENSRNOP00000015733
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl414,102,492 - 14,141,847 (+)Ensembl
mRatBN7.2 Ensembl413,210,260 - 13,249,289 (+)Ensembl
Rnor_6.0 Ensembl49,821,541 - 9,860,571 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000114029   ⟹   ENSRNOP00000085244
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl414,102,492 - 14,141,847 (+)Ensembl
mRatBN7.2 Ensembl413,210,260 - 13,249,289 (+)Ensembl
RefSeq Acc Id: NM_030840   ⟹   NP_110467
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8414,102,492 - 14,141,520 (+)NCBI
mRatBN7.2413,210,260 - 13,249,289 (+)NCBI
Rnor_6.049,821,541 - 9,860,571 (+)NCBI
Rnor_5.049,822,682 - 9,861,708 (+)NCBI
RGSC_v3.448,657,314 - 8,697,539 (+)RGD
Celera48,801,513 - 8,840,481 (+)RGD
Sequence:
Protein Sequences
Protein RefSeqs NP_110467 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAG30297 (Get FASTA)   NCBI Sequence Viewer  
  CAC21555 (Get FASTA)   NCBI Sequence Viewer  
  CAD21439 (Get FASTA)   NCBI Sequence Viewer  
  EDL99408 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000015733
  ENSRNOP00000015733.2
GenBank Protein Q9EPH0 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_110467   ⟸   NM_030840
- UniProtKB: Q9ERC6 (UniProtKB/Swiss-Prot),   Q9EPH0 (UniProtKB/Swiss-Prot),   A0A8I6A1V5 (UniProtKB/TrEMBL),   A6K5A0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000015733   ⟸   ENSRNOT00000015733
Ensembl Acc Id: ENSRNOP00000085244   ⟸   ENSRNOT00000114029
Protein Domains
STAS

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9EPH0-F1-model_v2 AlphaFold Q9EPH0 1-744 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69334 AgrOrtholog
BioCyc Gene G2FUF-45989 BioCyc
Ensembl Genes ENSRNOG00000011616 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSRNOT00000015733 ENTREZGENE
  ENSRNOT00000015733.3 UniProtKB/Swiss-Prot
Gene3D-CATH 3.30.750.24 UniProtKB/Swiss-Prot
InterPro S04_transporter_CS UniProtKB/Swiss-Prot
  SLC26A/SulP_dom UniProtKB/Swiss-Prot
  SLC26A/SulP_fam UniProtKB/Swiss-Prot
  STAS_dom UniProtKB/Swiss-Prot
  STAS_dom_sf UniProtKB/Swiss-Prot
KEGG Report rno:83819 UniProtKB/Swiss-Prot
NCBI Gene Slc26a5 ENTREZGENE
PANTHER PTHR11814 UniProtKB/Swiss-Prot
Pfam STAS UniProtKB/Swiss-Prot
  Sulfate_transp UniProtKB/Swiss-Prot
PhenoGen Slc26a5 PhenoGen
PROSITE SLC26A UniProtKB/Swiss-Prot
  STAS UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000011616 RatGTEx
Superfamily-SCOP SSF52091 UniProtKB/Swiss-Prot
TIGR TC226893
UniProt A0A8I6A1V5 ENTREZGENE, UniProtKB/TrEMBL
  A6K5A0 ENTREZGENE, UniProtKB/TrEMBL
  Q9EPH0 ENTREZGENE
  Q9ERC6 ENTREZGENE
  S26A5_RAT UniProtKB/Swiss-Prot
UniProt Secondary Q9ERC6 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-03-09 Slc26a5  solute carrier family 26 member 5  Slc26a5  solute carrier family 26 (anion exchanger), member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-08-02 Slc26a5  solute carrier family 26 (anion exchanger), member 5  Slc26a5  solute carrier family 26, member 5 (prestin)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-09-19 Slc26a5  solute carrier family 26, member 5 (prestin)  Slc26a5  solute carrier family 26, member 5  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 Slc26a5  solute carrier family 26, member 5  Pres  prestin (motor protein)  Symbol and Name updated 1299863 APPROVED
2002-06-10 Pres  prestin (motor protein)      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_cellular_localization localizes to the lateral membrane before the onset of hearing but was localized to the entire OHC membrane in hypothyroid rats 70328
gene_domains contains a TRE (thyroid hormone response element) in the second intron upstream of the ATG start site, which binds thyroid hormone receptors 68832
gene_domains contains a TRE (thyroid hormone response element) in the second intron upstream of the ATG start site, which binds thyroid hormone receptors 70328
gene_expression expressed in the apical cell pole of cochlear outer hair cells 68832
gene_expression expressed in the apical cell pole of cochlear outer hair cells 70328
gene_function cochlear motor protein 68832
gene_function cochlear motor protein 70328
gene_regulation transcription is stimulated by thyroid hormone 68832
gene_regulation transcription is stimulated by thyroid hormone 70328