Fabp4 (fatty acid binding protein 4) - Rat Genome Database

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Gene: Fabp4 (fatty acid binding protein 4) Rattus norvegicus
Analyze
Symbol: Fabp4
Name: fatty acid binding protein 4
RGD ID: 69309
Description: Predicted to enable hormone receptor binding activity; long-chain fatty acid binding activity; and long-chain fatty acid transmembrane transporter activity. Involved in several processes, including fatty acid metabolic process; response to glucocorticoid; and response to gravity. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Biomarker of impotence and muscular atrophy. Orthologous to human FABP4 (fatty acid binding protein 4); PARTICIPATES IN eicosanoid signaling pathway via peroxisome proliferator-activated receptor gamma; INTERACTS WITH 1,2-dimethylhydrazine; 1,3,4-thiadiazole; 1,3,5-trinitro-1,3,5-triazinane.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: A-FABP; adipocyte lipid-binding protein; adipocyte-type fatty acid-binding protein; AFABP; Albp; aP2; fatty acid binding protein 4 adipocyte; fatty acid binding protein 4, adipocyte; fatty acid-binding protein 4; fatty acid-binding protein, adipocyte
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Alliance Orthologs
More Info more info ...
Candidate Gene For: Bw131
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8293,488,251 - 93,492,961 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl293,488,271 - 93,492,972 (+)EnsemblGRCr8
mRatBN7.2291,580,879 - 91,585,567 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl291,580,885 - 91,585,578 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx298,071,495 - 98,075,852 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0296,192,481 - 96,196,839 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0291,249,333 - 91,253,689 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0293,792,666 - 93,797,267 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl293,792,601 - 93,797,305 (+)Ensemblrn6Rnor6.0
Rnor_5.02113,547,703 - 113,552,304 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4293,536,133 - 93,540,734 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera287,183,534 - 87,187,814 (+)NCBICelera
RGSC_v3.1293,481,094 - 93,485,696 (+)NCBI
Cytogenetic Map2q23NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(1->4)-beta-D-glucan  (ISO)
1,2-dichloroethane  (ISO)
1,2-dimethylhydrazine  (EXP,ISO)
1,3,4-thiadiazole  (EXP)
1,3,5-trinitro-1,3,5-triazinane  (EXP)
1,4-bis(2-ethylhexyl) sulfosuccinate  (ISO)
1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-2-benzofuran-5-carbonitrile  (ISO)
1-naphthyl isothiocyanate  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (ISO)
17alpha-hydroxyprogesterone  (ISO)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,2'-Dihydroxy-4-methoxybenzophenone  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2-amino-2-deoxy-D-glucopyranose  (EXP,ISO)
2-amino-2-deoxy-D-glucopyranose 6-phosphate  (ISO)
2-butoxyethanol  (ISO)
2-hydroxypropanoic acid  (ISO)
2-palmitoylglycerol  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3,3',5-triiodo-L-thyronine  (EXP,ISO)
3,3'-Dimethylbisphenol A  (ISO)
3,5,6-trichloro-2-pyridinol  (ISO)
3,5,6-trichloropyridine-2-one  (ISO)
3-chloropropane-1,2-diol  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methylcholanthrene  (ISO)
3-phenylprop-2-enal  (ISO)
4'-Methoxychalcone  (ISO)
4,4'-diaminodiphenylmethane  (EXP,ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-formyltetrahydrofolic acid  (EXP)
6alpha-methylprednisolone  (EXP)
8-(4-chlorophenylthio)-cGMP  (ISO)
[6]-Shogaol  (ISO)
acetamide  (EXP)
Acetyl tributyl citrate  (ISO)
aflatoxin B1  (EXP,ISO)
AL 8810  (ISO)
aldehydo-D-glucosamine  (EXP,ISO)
aldehydo-D-glucosamine 6-phosphate  (ISO)
aldehydo-D-glucose  (EXP,ISO)
Alisol B  (ISO)
all-trans-retinoic acid  (ISO)
Aloe emodin  (ISO)
amiodarone  (ISO)
ammonium chloride  (EXP)
amphetamine  (EXP)
aniline  (ISO)
anthracen-2-amine  (EXP)
antimony(0)  (ISO)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
avobenzone  (ISO)
baicalein  (ISO)
barium sulfate  (EXP)
benzbromarone  (ISO)
benzene  (ISO)
benzo[a]pyrene  (ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
benzofurans  (ISO)
Benzyl parahydroxybenzoate  (ISO)
berberine  (ISO)
beta-carotene  (ISO)
beta-D-glucosamine  (EXP,ISO)
beta-D-glucosamine 6-sulfate  (ISO)
beta-naphthoflavone  (EXP)
bexarotene  (ISO)
bezafibrate  (EXP,ISO)
bicalutamide  (ISO)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bismuth atom  (ISO)
bismuthane  (ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
boric acid  (ISO)
Butylbenzyl phthalate  (ISO)
Butylparaben  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP,ISO)
calcitriol  (ISO)
cannabidiolic acid  (ISO)
cannabigerol  (ISO)
cannabigerolic acid  (ISO)
capsaicin  (EXP,ISO)
carbon nanotube  (EXP,ISO)
celastrol  (ISO)
ceric oxide  (EXP)
chenodeoxycholic acid  (ISO)
chitosan  (EXP)
chlordecone  (ISO)
chlormequat chloride  (EXP)
chloroacetaldehyde  (ISO)
chlorohydrocarbon  (EXP)
chlorpyrifos  (ISO)
choline  (ISO)
ciglitazone  (ISO)
ciguatoxin CTX1B  (ISO)
ciprofibrate  (ISO)
cisplatin  (EXP)
citalopram  (ISO)
Citreoviridin  (EXP,ISO)
CL316243  (EXP)
clofibrate  (ISO)
clofibric acid  (EXP)
cobalt dichloride  (ISO)
copper(II) sulfate  (ISO)
cordycepin  (ISO)
corticosterone  (ISO)
cortisol  (ISO)
cortisone  (ISO)
cucurbitacin B  (ISO)
cucurbitacin I  (ISO)
cyclosporin A  (ISO)
cypermethrin  (ISO)
cyproterone acetate  (ISO)
D-glucose  (EXP,ISO)
daidzein  (ISO)
DDE  (ISO)
DDT  (ISO)
deoxycholic acid  (ISO)
deoxynivalenol  (ISO)
desferrioxamine B  (ISO)
dexamethasone  (EXP,ISO)
dexamethasone phosphate  (ISO)
dextran sulfate  (ISO)
dibutyl phthalate  (ISO)
dibutylstannane  (ISO)
dichlorine  (EXP)
diclofenac  (ISO)
diethyl sulfate  (ISO)
diethylstilbestrol  (EXP,ISO)
dihydroresveratrol  (ISO)
diisononyl phthalate  (ISO)
diosgenin  (ISO)
dioxygen  (ISO)
disodium selenite  (EXP,ISO)
divanadium pentaoxide  (ISO)
doxorubicin  (EXP,ISO)
epoxiconazole  (ISO)
equilin  (ISO)
erianin  (ISO)
ethanol  (EXP,ISO)
ethyl 3,4-dihydroxybenzoate  (ISO)
ethylparaben  (ISO)
farnesol  (ISO)
fenofibrate  (ISO)
fentin chloride  (ISO)
fentin hydroxide  (ISO)
fipronil  (ISO)
fluprostenol  (ISO)
folic acid  (ISO)
fructose  (EXP)
fulvestrant  (ISO)
furan  (EXP)
gadobutrol  (ISO)
gadodiamide hydrate  (ISO)
gadolinium trichloride  (ISO)
genistein  (ISO)
geraniol  (ISO)
ginsenoside Re  (ISO)
glafenine  (EXP)
glucose  (EXP,ISO)
glycerol 2-phosphate  (ISO)
glycochenodeoxycholic acid  (ISO)
glycocholic acid  (ISO)
glycodeoxycholic acid  (ISO)
glycyrrhizinic acid  (ISO)
graphite  (EXP)
guggulsterone  (ISO)
GW 3965  (ISO)
GW 6471  (ISO)
GW 7647  (ISO)
harmine  (ISO)
hesperetin  (ISO)
hydrazines  (ISO)
hydrogen cyanide  (ISO)
hydroquinone  (ISO)
hydroxytyrosol  (ISO)
ibuprofen  (ISO)
imidacloprid  (ISO)
Indeno[1,2,3-cd]pyrene  (ISO)
indole-3-methanol  (EXP)
indometacin  (EXP,ISO)
insulin  (ISO)
inulin  (ISO)
iopamidol  (ISO)
isoliquiritigenin  (ISO)
isonicotinamide  (ISO)
isotretinoin  (EXP)
ivermectin  (ISO)
ketoconazole  (EXP)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lead diacetate  (EXP,ISO)
lead(0)  (EXP,ISO)
Licarin A  (ISO)
linoleic acid  (ISO)
lipopolysaccharide  (ISO)
loliolide  (ISO)
LY294002  (ISO)
melatonin  (ISO)
Melengestrol acetate  (ISO)
Mesaconitine  (EXP)
methotrexate  (EXP)
methylisothiazolinone  (ISO)
methylmercury chloride  (EXP)
mifepristone  (ISO)
mono(2-ethylhexyl) phthalate  (ISO)
monobenzyl phthalate  (ISO)
Monobutylphthalate  (ISO)
Muraglitazar  (EXP)
N-acetyl-L-cysteine  (ISO)
N-nitrosodiethylamine  (EXP,ISO)
naringin  (ISO)
nicotinic acid  (ISO)
nitrofen  (EXP)
norethisterone  (ISO)
norgestrel  (ISO)
ochratoxin A  (ISO)
Octicizer  (ISO)
octocrylene  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
osthole  (ISO)
oxaliplatin  (EXP)
oxybenzone  (ISO)
ozone  (EXP,ISO)
paracetamol  (ISO)
paraquat  (EXP)
PCB138  (ISO)
perfluorobutanesulfonic acid  (ISO)
perfluorohexanesulfonic acid  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (EXP,ISO)
perfluorooctanoic acid  (EXP,ISO)
permethrin  (ISO)
phenacetin  (EXP)
Phenelzine  (ISO)
phenobarbital  (ISO)
Phenylamil  (ISO)
phenylephrine  (EXP)
phenylhydrazine  (EXP)
phorbol 13-acetate 12-myristate  (ISO)
pioglitazone  (ISO)
pirinixic acid  (ISO)
platycodin D  (ISO)
poly(I:C)  (ISO)
potassium cyanide  (ISO)
potassium dichromate  (ISO)
prallethrin  (ISO)
prednisone  (ISO)
prochloraz  (ISO)
progesterone  (EXP,ISO)
propylparaben  (ISO)
prostaglandin D2  (ISO)
prostaglandin F2alpha  (ISO)
pyocyanine  (ISO)
quartz  (EXP)
quinoxyfen  (ISO)
rac-lactic acid  (ISO)
raloxifene  (ISO)
resveratrol  (ISO)
Ro 41-5253  (ISO)
rofecoxib  (ISO)
rosmarinic acid  (ISO)
rotenone  (ISO)
sertraline  (ISO)
sildenafil citrate  (ISO)
silibinin  (ISO)
silicon dioxide  (EXP,ISO)
sodium arsenate  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (EXP)
sodium dodecyl sulfate  (ISO)
sodium fluoride  (ISO)
spironolactone  (ISO)
splitomicin  (ISO)
streptozocin  (ISO)
succimer  (ISO)
sulfasalazine  (ISO)
sulforaphane  (ISO)
sulindac sulfide  (ISO)
tamoxifen  (ISO)
tauroursodeoxycholic acid  (ISO)
Tesaglitazar  (EXP)
tetrachloromethane  (EXP,ISO)
tetracycline  (ISO)
Theaflavin 3,3'-digallate  (ISO)
thiamine(1+) chloride  (EXP,ISO)
thioacetamide  (EXP)
Thiocarbohydrazide  (ISO)
titanium dioxide  (ISO)
tolylfluanid  (ISO)
topotecan  (EXP)
triadimefon  (ISO)
triamcinolone  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triclosan  (ISO)
triflumizole  (ISO)
triphenyl phosphate  (ISO)
triphenylstannane  (ISO)
Triptolide  (EXP)
triptonide  (ISO)
troglitazone  (EXP,ISO)
tungsten  (ISO)
tunicamycin  (ISO)
ursodeoxycholic acid  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vitamin D  (ISO)
Y-27632  (ISO)
zidovudine  (ISO)
zinc atom  (EXP,ISO)
zinc(0)  (EXP,ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (IEA,ISO)
cytosol  (IBA)
lipid droplet  (ISO,TAS)
nucleus  (IBA,IEA,ISO,ISS)

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Proliferation and differentiation of osteoblasts and adipocytes in rat bone marrow stromal cell cultures: effects of dexamethasone and calcitriol. Atmani H, etal., J Cell Biochem. 2003 May 15;89(2):364-72.
2. Fatty acid uptake in diabetic rat adipocytes. Fraser H, etal., Mol Cell Biochem. 1997 Feb;167(1-2):51-60.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein. Hotamisligil GS, etal., Science 1996 Nov 22;274(5291):1377-9.
6. Microarray analysis of gene expression profile in the corpus cavernosum of hypercholesterolemic rats after chronic treatment with PDE5 inhibitor. Jung HG, etal., Life Sci. 2007 Jan 23;80(7):699-708. Epub 2006 Nov 29.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Mechanism by which a novel non-thiazolidinedione peroxisome proliferator-activated receptor gamma agonist, FK614, ameliorates insulin resistance in Zucker fatty rats. Minoura H, etal., Diabetes Obes Metab. 2007 May;9(3):369-78.
9. Serum leptin concentration is linked to chromosomes 2 and 6 in the OLETF rat, an animal model of type 2 diabetes with mild obesity. Ogino T, etal., Mamm Genome 2003 Dec;14(12):839-44.
10. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
11. Transfection of L6 myoblasts with adipocyte fatty acid-binding protein cDNA does not affect fatty acid uptake but disturbs lipid metabolism and fusion. Prinsen CF and Veerkamp JH, Biochem J 1998 Jan 15;329 ( Pt 2):265-73.
12. GOA pipeline RGD automated data pipeline
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. Alterations in serum adipocyte fatty acid binding protein and retinol binding protein-4 in normal pregnancy and preeclampsia. Shangguan X, etal., Clin Chim Acta. 2009 Sep;407(1-2):58-61. doi: 10.1016/j.cca.2009.06.031. Epub 2009 Jun 29.
15. Interaction of rat hormone-sensitive lipase with adipocyte lipid-binding protein. Shen WJ, etal., Proc Natl Acad Sci U S A 1999 May 11;96(10):5528-32.
16. Adipocyte fatty acid binding protein in a Caucasian population: a new marker of metabolic syndrome? Stejskal D and Karpisek M, Eur J Clin Invest. 2006 Sep;36(9):621-5.
17. Fatty acid binding protein 4 and 5 play a crucial role in thermogenesis under the conditions of fasting and cold stress. Syamsunarno MR, etal., PLoS One. 2014 Mar 6;9(6):e90825. doi: 10.1371/journal.pone.0090825. eCollection 2014.
18. Alteration of gene expression profiles in skeletal muscle of rats exposed to microgravity during a spaceflight. Taylor WE, etal., J Gravit Physiol. 2002 Dec;9(2):61-70.
19. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
20. Role of KCa3.1 Channels in Macrophage Polarization and Its Relevance in Atherosclerotic Plaque Instability. Xu R, etal., Arterioscler Thromb Vasc Biol. 2017 Feb;37(2):226-236. doi: 10.1161/ATVBAHA.116.308461. Epub 2016 Dec 29.
Additional References at PubMed
PMID:1618860   PMID:9880671   PMID:11382783   PMID:12077340   PMID:12477932   PMID:15673614   PMID:15684432   PMID:17516629   PMID:17761196   PMID:18492766   PMID:19144635   PMID:19408657  
PMID:19608978   PMID:22262466   PMID:22808905   PMID:23012479   PMID:23533145   PMID:27697222   PMID:28405802   PMID:29849871   PMID:30904493   PMID:35297679   PMID:35357467  


Genomics

Comparative Map Data
Fabp4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8293,488,251 - 93,492,961 (+)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl293,488,271 - 93,492,972 (+)EnsemblGRCr8
mRatBN7.2291,580,879 - 91,585,567 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl291,580,885 - 91,585,578 (+)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx298,071,495 - 98,075,852 (+)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0296,192,481 - 96,196,839 (+)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0291,249,333 - 91,253,689 (+)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0293,792,666 - 93,797,267 (+)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl293,792,601 - 93,797,305 (+)Ensemblrn6Rnor6.0
Rnor_5.02113,547,703 - 113,552,304 (+)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4293,536,133 - 93,540,734 (+)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera287,183,534 - 87,187,814 (+)NCBICelera
RGSC_v3.1293,481,094 - 93,485,696 (+)NCBI
Cytogenetic Map2q23NCBI
FABP4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38881,478,419 - 81,483,233 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl881,477,651 - 81,483,239 (-)Ensemblhg38GRCh38
GRCh37882,390,654 - 82,395,468 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36882,553,481 - 82,558,004 (-)NCBIBuild 36Build 36hg18NCBI36
Build 34882,553,480 - 82,558,004NCBI
Celera878,395,692 - 78,400,433 (-)NCBICelera
Cytogenetic Map8q21.13NCBI
HuRef877,880,663 - 77,885,404 (-)NCBIHuRef
CHM1_1882,442,333 - 82,447,074 (-)NCBICHM1_1
T2T-CHM13v2.0881,910,018 - 81,914,832 (-)NCBIT2T-CHM13v2.0
Fabp4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39310,269,406 - 10,273,653 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl310,269,148 - 10,273,636 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38310,204,342 - 10,208,616 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl310,204,088 - 10,208,576 (-)Ensemblmm10GRCm38
MGSCv37310,204,342 - 10,208,576 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36310,186,879 - 10,191,086 (-)NCBIMGSCv36mm8
Celera310,234,558 - 10,238,773 (-)NCBICelera
Cytogenetic Map3A1NCBI
cM Map32.56NCBI
Fabp4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955444141,840 - 148,467 (+)Ensembl
ChiLan1.0NW_004955444141,955 - 146,279 (+)NCBIChiLan1.0ChiLan1.0
FABP4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2797,216,084 - 97,221,109 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1872,843,910 - 72,848,935 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0878,001,476 - 78,006,006 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1879,624,899 - 79,629,442 (-)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl879,624,899 - 79,630,168 (-)EnsemblpanPan2panpan1.1
FABP4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12928,651,550 - 28,656,255 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2928,652,146 - 28,656,228 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2928,930,953 - 28,935,672 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02928,782,981 - 28,787,700 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2928,782,960 - 28,787,677 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12928,853,143 - 28,857,859 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02928,866,783 - 28,871,503 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02929,223,638 - 29,228,357 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Fabp4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530350,532,455 - 50,536,868 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366562,722,713 - 2,729,046 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049366562,722,970 - 2,727,383 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FABP4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl455,096,404 - 55,101,896 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1455,096,400 - 55,101,209 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
FABP4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1876,895,516 - 76,900,153 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl876,894,512 - 76,900,212 (-)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366603964,295,119 - 64,299,651 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0

Variants

.
Variants in Fabp4
51 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:217
Count of miRNA genes:147
Interacting mature miRNAs:162
Transcripts:ENSRNOT00000014701
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1578777Stresp15Stress response QTL 1520.05blood aldosterone amount (VT:0005346)plasma aldosterone level (CMO:0000551)261556902106556902Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
1598865Bp296Blood pressure QTL 2962.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)282947902127947902Rat
1578772Stresp14Stress response QTL 1450.001blood renin amount (VT:0003349)plasma renin activity level (CMO:0000116)284056790132859658Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845370229470703Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)283465462229820014Rat
10755499Bp389Blood pressure QTL 3892.61arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)220695736231474293Rat
1581576Pur7Proteinuria QTL 70.0001urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)280396178220931218Rat
152025242Bw191Body weight QTL 1913.62body mass (VT:0001259)240306867124537199Rat
631198Cm22Cardiac mass QTL 224.30.0008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)278269809208420281Rat
61465Bp13Blood pressure QTL 133.3blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)278269809104744824Rat
1302794Stl27Serum triglyceride level QTL 274.40.0001blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)227148328145807373Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)280396178220931218Rat
70174BpQTLCluster2Blood pressure QTL cluster 24.24arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)241801363104744824Rat
2317058Aia13Adjuvant induced arthritis QTL 132.9joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)278269809123269809Rat
1358901Cm38Cardiac mass QTL 382heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)24265106205135428Rat
1358899Kidm23Kidney mass QTL 233.88kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1300155Bp174Blood pressure QTL 1744.09arterial blood pressure trait (VT:2000000)absolute change in mean arterial blood pressure (CMO:0000533)244537979112567334Rat
1358908Bw49Body weight QTL 493.36body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
5684990Bmd82Bone mineral density QTL 822.8tibia mineral mass (VT:1000283)bone mineral content (CMO:0001554)261051541105724065Rat
1358910Kidm27Kidney mass QTL 275.77kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
1358911Kidm28Kidney mass QTL 285.42kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
61355Bp36Blood pressure QTL 362.9blood pressure trait (VT:0000183)systolic blood pressure (CMO:0000004)27605533104774005Rat
1358904Cm39Cardiac mass QTL 392.26heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328159440891Rat
1359034Bp274Blood pressure QTL 274arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)25126685996266859Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)267845182205135428Rat
1358887Bw50Body weight QTL 502.39body mass (VT:0001259)body weight (CMO:0000012)227148557159440760Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)283400752223709938Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)244537979205135428Rat
2290453Scl55Serum cholesterol level QTL 552.83blood cholesterol amount (VT:0000180)plasma total cholesterol level (CMO:0000585)228652666139067443Rat
1358894Kidm24Kidney mass QTL 244.03kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)227148328159440891Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)280396034220931416Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)278269809205135428Rat
631500Bp99Blood pressure QTL 992.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)261051883104684275Rat
61392Bp6Blood pressure QTL 67arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)282214549127214549Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
5684996Bmd85Bone mineral density QTL 854.70.024tibia mineral mass (VT:1000283)bone mineral density (CMO:0001226)261051541105724065Rat
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)227148328206613235Rat
2293835Kiddil5Kidney dilation QTL 53.8kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979159440891Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)283465462225110681Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)247856345205135428Rat
1558648Smcn1Smooth muscle cell number QTL 10.039blood vessel smooth muscle cell quantity (VT:0010525)aorta smooth muscle cell count per unit vessel length (CMO:0001646)260861391105861391Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)244537979184731399Rat
2306903Bp336Blood pressure QTL 3360.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)238426449111295694Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)276328396209350714Rat
152025206Hrtrt23Heart rate QTL 235.98heart pumping trait (VT:2000009)230219200171802126Rat
152025204Hrtrt22Heart rate QTL 225.6heart pumping trait (VT:2000009)230219200171802126Rat
61438Cia7Collagen induced arthritis QTL 74.60.0001joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)261051541143746880Rat

Markers in Region
RH128873  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2291,584,169 - 91,585,447 (+)MAPPERmRatBN7.2
Rnor_6.0293,795,912 - 93,797,189NCBIRnor6.0
Rnor_5.02113,550,949 - 113,552,226UniSTSRnor5.0
RGSC_v3.4293,539,379 - 93,540,656UniSTSRGSC3.4
Celera287,186,780 - 87,187,735UniSTS
RH 3.4 Map2569.0UniSTS
Cytogenetic Map2q23UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 64 149 91 90 59 64 59 6 322 161 11 128 78 91 31 7 7

Sequence


Ensembl Acc Id: ENSRNOT00000014701   ⟹   ENSRNOP00000014701
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl293,488,271 - 93,492,972 (+)Ensembl
mRatBN7.2 Ensembl291,580,885 - 91,585,578 (+)Ensembl
Rnor_6.0 Ensembl293,792,601 - 93,797,305 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000077311   ⟹   ENSRNOP00000073333
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl293,792,664 - 93,797,267 (+)Ensembl
Ensembl Acc Id: ENSRNOT00000102431   ⟹   ENSRNOP00000077522
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl293,488,292 - 93,492,956 (+)Ensembl
mRatBN7.2 Ensembl291,580,898 - 91,585,562 (+)Ensembl
RefSeq Acc Id: NM_053365   ⟹   NP_445817
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8293,488,273 - 93,492,961 (+)NCBI
mRatBN7.2291,580,879 - 91,585,567 (+)NCBI
Rnor_6.0293,792,666 - 93,797,267 (+)NCBI
Rnor_5.02113,547,703 - 113,552,304 (+)NCBI
RGSC_v3.4293,536,133 - 93,540,734 (+)RGD
Celera287,183,534 - 87,187,814 (+)RGD
Sequence:
RefSeq Acc Id: XM_063282611   ⟹   XP_063138681
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8293,488,251 - 93,492,961 (+)NCBI
Protein Sequences
Protein RefSeqs NP_445817 (Get FASTA)   NCBI Sequence Viewer  
  XP_063138681 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAB18344 (Get FASTA)   NCBI Sequence Viewer  
  AAD37371 (Get FASTA)   NCBI Sequence Viewer  
  AAH84721 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000014701
  ENSRNOP00000077522
GenBank Protein P70623 (Get FASTA)   NCBI Sequence Viewer  
RefSeq Acc Id: NP_445817   ⟸   NM_053365
- UniProtKB: P70623 (UniProtKB/Swiss-Prot),   Q5XFV4 (UniProtKB/TrEMBL),   F7FMV4 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000014701   ⟸   ENSRNOT00000014701
Ensembl Acc Id: ENSRNOP00000073333   ⟸   ENSRNOT00000077311
Ensembl Acc Id: ENSRNOP00000077522   ⟸   ENSRNOT00000102431
RefSeq Acc Id: XP_063138681   ⟸   XM_063282611
- Peptide Label: isoform X1
- UniProtKB: P70623 (UniProtKB/Swiss-Prot),   A0A8I5Y7N0 (UniProtKB/TrEMBL)
Protein Domains
Cytosolic fatty-acid binding proteins

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P70623-F1-model_v2 AlphaFold P70623 1-132 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13691236
Promoter ID:EPDNEW_R1760
Type:single initiation site
Name:Fabp4_1
Description:fatty acid binding protein 4
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0293,792,619 - 93,792,679EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69309 AgrOrtholog
BioCyc Gene G2FUF-53753 BioCyc
Ensembl Genes ENSRNOG00000010805 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000014701 ENTREZGENE
  ENSRNOT00000102431 ENTREZGENE
Gene3D-CATH 2.40.128.20 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7310595 IMAGE-MGC_LOAD
InterPro Calycin UniProtKB/Swiss-Prot
  Fatty_acid-bd UniProtKB/Swiss-Prot
  ILBP UniProtKB/Swiss-Prot
  Lipocln_cytosolic_FA-bd_dom UniProtKB/Swiss-Prot
MGC_CLONE MGC:105374 IMAGE-MGC_LOAD
NCBI Gene 79451 ENTREZGENE
PANTHER PTHR11955 UniProtKB/Swiss-Prot
Pfam Lipocalin UniProtKB/Swiss-Prot
PhenoGen Fabp4 PhenoGen
PRINTS FATTYACIDBP UniProtKB/Swiss-Prot
PROSITE FABP UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000010805 RatGTEx
Superfamily-SCOP SSF50814 UniProtKB/Swiss-Prot
TIGR TC228687
UniProt A0A8I5Y7N0 ENTREZGENE, UniProtKB/TrEMBL
  F7FMV4 ENTREZGENE, UniProtKB/TrEMBL
  FABP4_RAT UniProtKB/Swiss-Prot, ENTREZGENE
  Q5XFV4 ENTREZGENE, UniProtKB/TrEMBL
  Q9R290_RAT UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-01-27 Fabp4  fatty acid binding protein 4  Fabp4  fatty acid binding protein 4, adipocyte  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2004-09-10 Fabp4  fatty acid binding protein 4, adipocyte    fatty acid binding protein 4  Name updated 1299863 APPROVED
2002-06-10 Fabp4  fatty acid binding protein 4      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_physical_interaction binds and forms a complex with hormone-sensitive lipase (HSL) 68775