Serpinh1 (serpin family H member 1) - Rat Genome Database

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Gene: Serpinh1 (serpin family H member 1) Rattus norvegicus
Analyze
Symbol: Serpinh1
Name: serpin family H member 1
RGD ID: 69302
Description: Predicted to enable serine-type endopeptidase inhibitor activity and unfolded protein binding activity. Predicted to be involved in collagen fibril organization. Predicted to act upstream of or within chondrocyte development involved in endochondral bone morphogenesis; collagen biosynthetic process; and protein maturation. Predicted to be located in endoplasmic reticulum-Golgi intermediate compartment and membrane raft. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 10 and preterm premature rupture of the membranes. Orthologous to human SERPINH1 (serpin family H member 1); INTERACTS WITH (R)-lipoic acid; (R)-noradrenaline; 1-naphthyl isothiocyanate.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: 47 kDa heat shock protein; Cbp2; collagen binding protein 2; collagen-binding protein; colligin; GP46; HSP47; serine (or cysteine) peptidase inhibitor, clade H, member 1; serine (or cysteine) proteinase inhibitor clade H (heat shock protein 47) member 1; serine (or cysteine) proteinase inhibitor clade H (heat shock protein 47) member 2; serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1; serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 2; serine (or cysteine) proteinase inhibitor, clade H, member 1; serine proteinase inhibitor clade H (heat shock protein 47) member 1; serine proteinase inhibitor, clade H (heat shock protein 47), member 1; serpin H1; serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1); serpin peptidase inhibitor, clade H, member 1; Serpinh2
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81163,055,630 - 163,063,177 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1163,055,630 - 163,062,976 (-)EnsemblGRCr8
mRatBN7.21153,643,500 - 153,650,853 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1153,643,510 - 153,650,801 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1161,639,548 - 161,646,892 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01168,819,703 - 168,827,047 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01161,693,225 - 161,700,569 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01164,301,010 - 164,308,306 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1164,301,010 - 164,308,317 (-)Ensemblrn6Rnor6.0
Rnor_5.01170,503,468 - 170,510,764 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41156,666,914 - 156,674,210 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1151,727,297 - 151,734,593 (-)NCBICelera
RGSC_v3.11156,745,319 - 156,752,617 (-)NCBI
Cytogenetic Map1q32NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(R)-lipoic acid  (EXP)
(R)-noradrenaline  (EXP)
(S)-amphetamine  (ISO)
(S)-nicotine  (ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (EXP,ISO)
17beta-estradiol  (EXP,ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dibromophenyl 2,4,5-tribromophenyl ether  (ISO)
2,6-di-tert-butyl-4-methylphenol  (ISO)
2,6-dimethoxyphenol  (ISO)
2-amino-14,16-dimethyloctadecan-3-ol  (ISO)
2-amino-2-deoxy-D-glucopyranose  (ISO)
2-butoxyethanol  (ISO)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (ISO)
aflatoxin B1  (ISO)
alachlor  (EXP)
aldehydo-D-glucosamine  (ISO)
alendronic acid  (EXP)
all-trans-retinoic acid  (EXP,ISO)
aluminium oxide  (ISO)
amitrole  (EXP)
ammonium chloride  (EXP)
arsane  (ISO)
arsenic atom  (ISO)
arsenite(3-)  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
benazepril  (EXP)
benzo[a]pyrene  (ISO)
beta-D-glucosamine  (ISO)
beta-lapachone  (ISO)
bexarotene  (EXP)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol AF  (ISO)
Bisphenol B  (ISO)
bisphenol F  (ISO)
bleomycin A2  (EXP)
cadmium atom  (EXP,ISO)
cadmium dichloride  (ISO)
cadmium sulfate  (ISO)
calciol  (ISO)
carbon nanotube  (ISO)
carvedilol  (EXP)
celecoxib  (EXP)
chloropicrin  (ISO)
chloroprene  (ISO)
chlorpromazine  (ISO)
chromium(6+)  (ISO)
cisplatin  (ISO)
clofibrate  (ISO)
cobalt dichloride  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
Cuprizon  (EXP)
curcumin  (EXP)
cyanocob(III)alamin  (ISO)
cyclosporin A  (ISO)
cytarabine  (ISO)
DDE  (ISO)
Diallyl sulfide  (EXP)
diarsenic trioxide  (ISO)
Dibutyl phosphate  (ISO)
dibutyl phthalate  (EXP,ISO)
diclofenac  (ISO)
dioxygen  (ISO)
diuron  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
endosulfan  (EXP)
ethanol  (EXP,ISO)
fenamidone  (ISO)
flavonoids  (EXP)
flutamide  (EXP)
furan  (EXP)
furfural  (ISO)
gentamycin  (EXP)
gold atom  (ISO)
gold(0)  (ISO)
hyaluronic acid  (EXP)
hydrogen peroxide  (EXP)
ivermectin  (ISO)
ketoconazole  (ISO)
lead diacetate  (ISO)
levofloxacin  (EXP)
lipoic acid  (EXP)
lipopolysaccharide  (EXP,ISO)
methimazole  (EXP)
methotrexate  (ISO)
methyl methanesulfonate  (ISO)
N,N-diethyl-m-toluamide  (EXP)
N-acetyl-L-cysteine  (ISO)
N-nitrosodimethylamine  (EXP,ISO)
nickel atom  (ISO)
nickel sulfate  (ISO)
nicotine  (ISO)
oxaliplatin  (EXP,ISO)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
pentane-2,3-dione  (EXP)
permethrin  (EXP)
phenobarbital  (EXP)
PhIP  (EXP)
pirinixic acid  (EXP)
potassium dichromate  (ISO)
raloxifene  (EXP)
reactive oxygen species  (ISO)
resveratrol  (ISO)
rotenone  (EXP)
SB 203580  (ISO)
SB 431542  (ISO)
silver atom  (ISO)
silver(0)  (ISO)
sodium arsenate  (ISO)
sodium arsenite  (EXP,ISO)
sodium chloride  (ISO)
sodium fluoride  (EXP)
Soman  (EXP)
sorafenib  (EXP)
streptozocin  (EXP)
sunitinib  (EXP)
tamoxifen  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (ISO)
thimerosal  (ISO)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
topotecan  (EXP)
Tributyltin oxide  (ISO)
trichostatin A  (ISO)
triphenyl phosphate  (ISO)
triptonide  (ISO)
tunicamycin  (ISO)
valproic acid  (ISO)
vinclozolin  (EXP)
wortmannin  (ISO)
zinc atom  (ISO)
zinc(0)  (ISO)
zoledronic acid  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. A collagen-binding protein in the endoplasmic reticulum of myoblasts exhibits relationship with serine protease inhibitors. Clarke EP, etal., J Biol Chem 1991 Sep 15;266(26):17230-5.
2. Therapeutic effect of 1,25(OH)2-VitaminD3 on fibrosis and angiogenesis of peritoneum induced by chlorhexidine. Da J, etal., Biomed Pharmacother. 2020 Sep;129:110431. doi: 10.1016/j.biopha.2020.110431. Epub 2020 Jun 22.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Involvement of heat shock protein 47 in Schistosoma japonicum-induced hepatic fibrosis in mice. Huang JQ, etal., Int J Parasitol. 2014 Jan;44(1):23-35. doi: 10.1016/j.ijpara.2013.08.009. Epub 2013 Dec 1.
6. Xiaochaihu decorction relieves liver fibrosis caused by Schistosoma japonicum infection via the HSP47/TGF-β pathway. Huang Y, etal., Parasit Vectors. 2020 May 14;13(1):254. doi: 10.1186/s13071-020-04121-2.
7. Expression of heat shock protein 47, transforming growth factor-beta 1, and connective tissue growth factor in liver tissue of patients with Schistosoma japonicum-induced hepatic fibrosis. Li L, etal., Parasitology. 2015 Feb;142(2):341-51. doi: 10.1017/S0031182014001115. Epub 2014 Aug 11.
8. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
9. Enhanced expression of heat shock protein 47 in rat model of peritoneal fibrosis. Mishima Y, etal., Perit Dial Int. 2003 Jan-Feb;23(1):14-22.
10. The human genome has only one functional hsp47 gene (CBP2) and a pseudogene (pshsp47). Nagai N, etal., Gene 1999 Feb 18;227(2):241-8.
11. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
12. Antisense oligonucleotides against collagen-binding stress protein HSP47 suppress peritoneal fibrosis in rats. Nishino T, etal., Kidney Int. 2003 Sep;64(3):887-96. doi: 10.1046/j.1523-1755.2003.00169.x.
13. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
14. GOA pipeline RGD automated data pipeline
15. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
16. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
17. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
18. Identification of hypertension-related genes through an integrated genomic-transcriptomic approach. Yagil C, etal., Circ Res. 2005 Apr 1;96(6):617-25. Epub 2005 Feb 24.
19. [Roles of transforming growth factor - β1 and heat shock protein 47 in progression of Schistosoma japonicum-induced hepatic fibrosis]. Yong-Hua Z, etal., Zhongguo Xue Xi Chong Bing Fang Zhi Za Zhi. 2019 Sep 25;31(4):382-387. doi: 10.16250/j.32.1374.2018208.
20. TNP-470, an angiogenesis inhibitor, suppresses the progression of peritoneal fibrosis in mouse experimental model. Yoshio Y, etal., Kidney Int. 2004 Oct;66(4):1677-85. doi: 10.1111/j.1523-1755.2004.00935.x.
Additional References at PubMed
PMID:2158279   PMID:8018053   PMID:10862616   PMID:10995453   PMID:12477932   PMID:15033773   PMID:15308636   PMID:17054723   PMID:21412710   PMID:21606205   PMID:22082260   PMID:22492985  
PMID:22658674   PMID:22718885   PMID:23376485   PMID:24650661   PMID:25204797   PMID:25526199   PMID:30092114   PMID:30361391   PMID:31686426   PMID:35352799   PMID:37724035   PMID:38963323  


Genomics

Comparative Map Data
Serpinh1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81163,055,630 - 163,063,177 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl1163,055,630 - 163,062,976 (-)EnsemblGRCr8
mRatBN7.21153,643,500 - 153,650,853 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1153,643,510 - 153,650,801 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx1161,639,548 - 161,646,892 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01168,819,703 - 168,827,047 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01161,693,225 - 161,700,569 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.01164,301,010 - 164,308,306 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1164,301,010 - 164,308,317 (-)Ensemblrn6Rnor6.0
Rnor_5.01170,503,468 - 170,510,764 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.41156,666,914 - 156,674,210 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera1151,727,297 - 151,734,593 (-)NCBICelera
RGSC_v3.11156,745,319 - 156,752,617 (-)NCBI
Cytogenetic Map1q32NCBI
SERPINH1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381175,562,253 - 75,572,783 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1175,561,564 - 75,572,787 (+)Ensemblhg38GRCh38
GRCh371175,273,298 - 75,283,828 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361174,950,818 - 74,961,494 (+)NCBIBuild 36Build 36hg18NCBI36
Build 341174,950,817 - 74,961,492NCBI
Celera1172,580,950 - 72,591,621 (+)NCBICelera
Cytogenetic Map11q13.5NCBI
HuRef1171,570,181 - 71,580,924 (+)NCBIHuRef
CHM1_11175,156,705 - 75,167,451 (+)NCBICHM1_1
T2T-CHM13v2.01175,491,635 - 75,502,159 (+)NCBIT2T-CHM13v2.0
Serpinh1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39798,994,583 - 99,002,321 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl798,994,583 - 99,002,446 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38799,345,375 - 99,353,239 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl799,345,376 - 99,353,239 (-)Ensemblmm10GRCm38
MGSCv377106,493,885 - 106,501,749 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36799,219,459 - 99,227,179 (-)NCBIMGSCv36mm8
Celera799,670,192 - 99,678,104 (-)NCBICelera
Cytogenetic Map7E1NCBI
cM Map754.07NCBI
Serpinh1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541416,284,845 - 16,292,963 (-)Ensembl
ChiLan1.0NW_00495541416,284,845 - 16,292,828 (-)NCBIChiLan1.0ChiLan1.0
SERPINH1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2976,486,335 - 76,503,355 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11177,528,934 - 77,545,958 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01170,621,893 - 70,632,570 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11173,922,617 - 73,933,379 (+)NCBIPanPan1.1PanPan1.1panPan2
SERPINH1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12123,032,761 - 23,041,649 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2123,032,767 - 23,041,625 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha2122,798,470 - 22,807,285 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.02123,235,602 - 23,244,497 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2123,235,605 - 23,244,400 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12123,034,077 - 23,042,936 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02123,230,397 - 23,239,216 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02123,148,229 - 23,157,093 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
Serpinh1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494762,742,342 - 62,751,791 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364984,341,899 - 4,351,524 (+)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049364984,341,944 - 4,351,432 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SERPINH1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl99,783,042 - 9,794,483 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.199,782,939 - 9,794,485 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2910,966,800 - 10,977,248 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SERPINH1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1166,787,978 - 66,798,930 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl166,788,240 - 66,799,072 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_02366604359,006,758 - 59,017,494 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Serpinh1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248171,561,471 - 1,570,947 (-)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248171,561,471 - 1,570,425 (-)NCBIHetGla 1.0HetGla 1.0hetGla2
Serpinh1
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1297,614,844 - 97,622,125 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in Serpinh1
38 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:132
Count of miRNA genes:97
Interacting mature miRNAs:114
Transcripts:ENSRNOT00000022983
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
61442Strs1Sensitivity to stroke QTL 17.4cerebrum integrity trait (VT:0010549)post-insult time to onset of cerebrovascular lesion (CMO:0002343)1131179947176179947Rat
1578778Pur4Proteinuria QTL 43.30.003urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)1160111531262090437Rat
1354646Kidm18Kidney mass QTL 185.7kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753266453731Rat
1578780Cm52Cardiac mass QTL 523.30.0001heart mass (VT:0007028)heart wet weight (CMO:0000069)1137611478182611478Rat
1578654Bss10Bone structure and strength QTL 104femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)151940904168768703Rat
2302378Insul11Insulin level QTL 113.25blood insulin amount (VT:0001560)serum insulin level (CMO:0000358)1153679879198679879Rat
1598866Bp287Blood pressure QTL 2875.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1578770Stresp23Stress response QTL 23kidney sympathetic nerve activity (VT:0004050)stimulated renal sympathetic nerve activity to basal renal sympathetic nerve activity ratio (CMO:0001786)1132760429191848948Rat
631684Bp117Blood pressure QTL 1178.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1120082258165082258Rat
70160Bw18Body weight QTL 185.7body mass (VT:0001259)body weight (CMO:0000012)1153679879205813246Rat
8694166Bw147Body weight QTL 1476.830.001body mass (VT:0001259)body weight gain (CMO:0000420)1153788989198788989Rat
631199Cm23Cardiac mass QTL 234.60.0004heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1142582336182383862Rat
1354636Lmblg1Limb length QTL 16.4tibia length (VT:0004357)tibia length (CMO:0000450)1160573753210707719Rat
1598850Bp297Blood pressure QTL 2972.1arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1130419227175419227Rat
1549837Hcar15Hepatocarcinoma resistance QTL 150.05liver integrity trait (VT:0010547)liver tumorous lesion number (CMO:0001068)1162548015270518180Rat
152025235Bw194Body weight QTL 1944.86body mass (VT:0001259)1132966869252856240Rat
61341Bp26Blood pressure QTL 26arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1139442053223964440Rat
1598853Memor3Memory QTL 34.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)1152919152268496042Rat
1354634Kidm12Kidney mass QTL 123.9kidney mass (VT:0002707)right kidney wet weight (CMO:0000082)1160573753210707719Rat
152025232Bw192Body weight QTL 1923.93body mass (VT:0001259)1127329268206393015Rat
1578759Uae30Urinary albumin excretion QTL 303.30.003urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)1160111531262090437Rat
61343Bp28Blood pressure QTL 28arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1161077990206077990Rat
724521Uae1Urinary albumin excretion QTL 13.80.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)199645382182701046Rat
1358902Bw47Body weight QTL 471.67body mass (VT:0001259)body weight (CMO:0000012)199645382221502378Rat
61348Bp30Blood pressure QTL 302.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1159894717207261263Rat
8655649Arrd1Age-related retinal degeneration QTL 14.89retinal layer morphology trait (VT:0003727)percentage of study population developing retinopathy during a period of time (CMO:0002453)1109493780193400781Rat
7771612Cm80Cardiac mass QTL 808.4heart left ventricle mass (VT:0007031)heart left ventricle weight (CMO:0000776)1146080545243492863Rat
731168Bp154Blood pressure QTL 1543.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1103779152223964440Rat
631202Gluco13Glucose level QTL 130.0001blood glucose amount (VT:0000188)blood glucose level area under curve (AUC) (CMO:0000350)1141173126169168317Rat
631205Bp196Blood pressure QTL 19640.0001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)198879955208479939Rat
1300158Bp173Blood pressure QTL 1733.48arterial blood pressure trait (VT:2000000)blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)1155359438194575574Rat
631206Niddm40Non-insulin dependent diabetes mellitus QTL 40blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1140833106185833106Rat
737828Hcas3Hepatocarcinoma susceptibility QTL 34.9liver integrity trait (VT:0010547)liver tumorous lesion volume to total liver volume ratio (CMO:0001082)1153679879232414077Rat
1354661Bw33Body weight QTL 335.2body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
1358886Bp260Blood pressure QTL 2603.67arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1160574007235238518Rat
1331751Bp199Blood pressure QTL 1993.60022arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)1116099376191260518Rat
2293140Bp313Blood pressure QTL 313arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1131243790176243790Rat
724531Uae5Urinary albumin excretion QTL 54urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)1160111426262090599Rat
737974Bp161Blood pressure QTL 1610.002arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1129182274174182274Rat
1641895Bp298Blood pressure QTL 298arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1132760429191848948Rat
1354580Scort1Serum corticosterone level QTL 13.4blood corticosterone amount (VT:0005345)blood corticosterone level (CMO:0001172)1154961463266453731Rat
70209Niddm23Non-insulin dependent diabetes mellitus QTL 232.82blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)1162753891207753891Rat
631496Bp97Blood pressure QTL 973.08arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1115183611176289080Rat
634315Niddm45Non-insulin dependent diabetes mellitus QTL 457.16blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)1153680016182383862Rat
634314Niddm44Non-insulin dependent diabetes mellitus QTL 44blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)151941022208479811Rat
61379Bp44Blood pressure QTL 4419.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1153680016183564652Rat
1331793Bp200Blood pressure QTL 2003.71601arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1102780511182384005Rat
6893347Bw98Body weight QTL 980.20.53body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354591Cm36Cardiac mass QTL 364.1heart left ventricle mass (VT:0007031)calculated heart weight (CMO:0000073)1111949780210707719Rat
7421630Bp362Blood pressure QTL 3620.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1128019551173019551Rat
70225Bp58Blood pressure QTL 583.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134184556172281316Rat
10059597Bp377Blood pressure QTL 3773.420.025arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)134565911208798288Rat
631519Pia11Pristane induced arthritis QTL 115.3joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)193903998191260518Rat
6893361Bw104Body weight QTL 1040.590.27body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
724562Rends1Renal damage susceptibility QTL 10.05kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)1139442053223964440Rat
738006Anxrr14Anxiety related response QTL 1440.00035locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1558645Bw55Body weight QTL 553.20.004body mass (VT:0001259)body weight (CMO:0000012)1143092939188092939Rat
1354615Cm32Cardiac mass QTL 325.2heart left ventricle mass (VT:0007031)heart left ventricle wet weight (CMO:0000071)1111949780210707719Rat
634348Bp138Blood pressure QTL 138arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436178317588Rat
1354610Bw34Body weight QTL 344.1body mass (VT:0001259)body weight (CMO:0000012)1160573753266453731Rat
738028Anxrr12Anxiety related response QTL 124.90.00001locomotor behavior trait (VT:0001392)amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)1140048073185048073Rat
1354620Kidm19Kidney mass QTL 194kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)1160573753210707719Rat
8693608Alc24Alcohol consumption QTL 242.30.74drinking behavior trait (VT:0001422)calculated ethanol drink intake rate (CMO:0001615)1159863716177663210Rat
1576310Schws2Schwannoma susceptibility QTL 20.029nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)1153788989198788989Rat
631654Bp107Blood pressure QTL 107arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1135021436180021436Rat
631544Bp84Blood pressure QTL 845.6arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)1132760429191190115Rat
152025212Bw190Body weight QTL 1905.7body mass (VT:0001259)1132966869206393015Rat
631548Bp88Blood pressure QTL 8850.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)1140915717185915717Rat
1358189Cstrr1Cold stress response QTL 10.0001catecholamine amount (VT:0010543)urine norepinephrine level (CMO:0001629)1132760429191848948Rat
1354606Bp246Blood pressure QTL 2463.6arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)1111949780228180370Rat
7411599Foco11Food consumption QTL 1118.50.001eating behavior trait (VT:0001431)feed conversion ratio (CMO:0001312)1153788989198788989Rat
1354602Bw35Body weight QTL 3512.2body mass (VT:0001259)body weight (CMO:0000012)1160573753210707719Rat

Markers in Region
RH128077  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21153,643,656 - 153,643,874 (+)MAPPERmRatBN7.2
Rnor_6.01164,301,159 - 164,301,376NCBIRnor6.0
Rnor_5.01170,503,617 - 170,503,834UniSTSRnor5.0
RGSC_v3.41156,667,063 - 156,667,280UniSTSRGSC3.4
Celera1151,727,446 - 151,727,663UniSTS
RH 3.4 Map11244.7UniSTS
Cytogenetic Map1q32UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 162 91 90 59 46 59 6 310 146 11 141 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000022983   ⟹   ENSRNOP00000022983
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl1164,301,010 - 164,308,317 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000086091   ⟹   ENSRNOP00000070279
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl1163,055,630 - 163,062,976 (-)Ensembl
mRatBN7.2 Ensembl1153,643,510 - 153,650,801 (-)Ensembl
Rnor_6.0 Ensembl1164,301,614 - 164,307,084 (-)Ensembl
RefSeq Acc Id: NM_017173   ⟹   NP_058869
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81163,055,630 - 163,062,976 (-)NCBI
mRatBN7.21153,643,500 - 153,650,846 (-)NCBI
Rnor_6.01164,301,010 - 164,308,306 (-)NCBI
Rnor_5.01170,503,468 - 170,510,764 (-)NCBI
RGSC_v3.41156,666,914 - 156,674,210 (-)RGD
Celera1151,727,297 - 151,734,593 (-)RGD
Sequence:
RefSeq Acc Id: XM_039107102   ⟹   XP_038963030
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81163,055,630 - 163,063,177 (-)NCBI
mRatBN7.21153,643,500 - 153,650,853 (-)NCBI
RefSeq Acc Id: XM_063285943   ⟹   XP_063142013
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81163,055,630 - 163,062,263 (-)NCBI
RefSeq Acc Id: NP_058869   ⟸   NM_017173
- Peptide Label: precursor
- UniProtKB: P29457 (UniProtKB/Swiss-Prot),   Q5RJR9 (UniProtKB/TrEMBL),   A6I6G9 (UniProtKB/TrEMBL),   A0A0G2JXI0 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000022983   ⟸   ENSRNOT00000022983
Ensembl Acc Id: ENSRNOP00000070279   ⟸   ENSRNOT00000086091
RefSeq Acc Id: XP_038963030   ⟸   XM_039107102
- Peptide Label: isoform X1
- UniProtKB: P29457 (UniProtKB/Swiss-Prot),   Q5RJR9 (UniProtKB/TrEMBL),   A6I6G9 (UniProtKB/TrEMBL),   A0A0G2JXI0 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_063142013   ⟸   XM_063285943
- Peptide Label: isoform X1
- UniProtKB: P29457 (UniProtKB/Swiss-Prot),   A0A0G2JXI0 (UniProtKB/TrEMBL),   A6I6G9 (UniProtKB/TrEMBL),   Q5RJR9 (UniProtKB/TrEMBL)
Protein Domains
SERPIN

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P29457-F1-model_v2 AlphaFold P29457 1-417 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13690228
Promoter ID:EPDNEW_R751
Type:multiple initiation site
Name:Serpinh1_1
Description:serpin family H member 1
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01164,308,307 - 164,308,367EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69302 AgrOrtholog
BioCyc Gene G2FUF-58392 BioCyc
Ensembl Genes ENSRNOG00000016831 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000086091 ENTREZGENE
Gene3D-CATH 2.30.39.10 UniProtKB/Swiss-Prot
  3.30.497.10 UniProtKB/Swiss-Prot
IMAGE_CLONE IMAGE:7303866 IMAGE-MGC_LOAD
InterPro Serpin_CS UniProtKB/Swiss-Prot
  Serpin_dom UniProtKB/Swiss-Prot
  Serpin_fam UniProtKB/Swiss-Prot
  Serpin_H1_domain UniProtKB/Swiss-Prot
  Serpin_sf UniProtKB/Swiss-Prot
  Serpin_sf_1 UniProtKB/Swiss-Prot
  Serpin_sf_2 UniProtKB/Swiss-Prot
KEGG Report rno:29345 UniProtKB/Swiss-Prot
MGC_CLONE MGC:105471 IMAGE-MGC_LOAD
NCBI Gene 29345 ENTREZGENE
PANTHER PTHR11461 UniProtKB/Swiss-Prot
  PTHR11461:SF27 UniProtKB/Swiss-Prot
Pfam Serpin UniProtKB/Swiss-Prot
PhenoGen Serpinh1 PhenoGen
PROSITE ER_TARGET UniProtKB/Swiss-Prot
  SERPIN UniProtKB/Swiss-Prot
RatGTEx ENSRNOG00000016831 RatGTEx
SMART SERPIN UniProtKB/Swiss-Prot
Superfamily-SCOP SSF56574 UniProtKB/Swiss-Prot
TIGR TC228672
UniProt A0A0G2JXI0 ENTREZGENE, UniProtKB/TrEMBL
  A6I6G7_RAT UniProtKB/TrEMBL
  A6I6G9 ENTREZGENE, UniProtKB/TrEMBL
  P29457 ENTREZGENE
  Q5RJR9 ENTREZGENE
  SERPH_RAT UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-04-13 Serpinh1  serpin family H member 1  Serpinh1  serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-10-16 Serpinh1  serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)  Serpinh1  serpin peptidase inhibitor, clade H, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2012-03-05 Serpinh1  serpin peptidase inhibitor, clade H, member 1  Serpinh1  serine (or cysteine) peptidase inhibitor, clade H, member 1  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-02-18 Serpinh1  serine (or cysteine) peptidase inhibitor, clade H, member 1  Serpinh1  serine (or cysteine) proteinase inhibitor, clade H, member 1   Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2002-06-10 Serpinh1  serine (or cysteine) proteinase inhibitor, clade H, member 1       Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_disease identified as a possible hypertension gene 1559295