Sult4a1 (sulfotransferase family 4A, member 1)

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Gene: Sult4a1 (sulfotransferase family 4A, member 1) Rattus norvegicus

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Symbol:

Sult4a1

Name:

sulfotransferase family 4A, member 1

RGD ID:

69292

Description:

Predicted to enable identical protein binding activity and sulfotransferase activity. Involved in dendrite arborization. Predicted to be located in cytosol and mitochondrion. Predicted to be active in cytoplasm. Orthologous to human SULT4A1 (sulfotransferase family 4A member 1); INTERACTS WITH (+)-schisandrin B; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.

Type:

protein-coding

RefSeq Status:

PROVISIONAL

Previously known as:

brain sulfotransferase-like protein; nervous system sulfotransferase; NST; rBR-STL; ST4A1; sulfotransferase 4A1; sulfotransferase-related protein; Sulta41; Sultx3

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SULT4A1 (sulfotransferase family 4A member 1)	HGNC	EggNOG, Ensembl, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, PhylomeDB
Mus musculus (house mouse):	Sult4a1 (sulfotransferase family 4A, member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sult4a1 (sulfotransferase family 4A member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SULT4A1 (sulfotransferase family 4A member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SULT4A1 (sulfotransferase family 4A member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sult4a1 (sulfotransferase family 4A member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SULT4A1 (sulfotransferase family 4A member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SULT4A1 (sulfotransferase family 4A member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sult4a1 (sulfotransferase family 4A member 1)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Other homologs ²
Homo sapiens (human):	RUSF1 (RUS family member 1)	HGNC	OMA
Alliance orthologs ³
Homo sapiens (human):	SULT4A1 (sulfotransferase family 4A member 1)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Mus musculus (house mouse):	Sult4a1 (sulfotransferase family 4A, member 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sult4a1 (sulfotransferase family 4A, member 1)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Caenorhabditis elegans (roundworm):	ssu-1	Alliance	DIOPT (InParanoid\|OrthoFinder\|SonicParanoid)
Drosophila melanogaster (fruit fly):	St2	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder\|OrthoInspector\|PhylomeDB)
Drosophila melanogaster (fruit fly):	St4	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|OrthoFinder)
Xenopus tropicalis (tropical clawed frog):	sult4a1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	117,096,064 - 117,120,714 (-)	NCBI		GRCr8
mRatBN7.2	7	115,216,066 - 115,240,156 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	115,216,066 - 115,240,085 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	116,963,947 - 116,987,966 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	119,189,653 - 119,213,672 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	119,159,119 - 119,183,138 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	124,958,546 - 124,982,602 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	124,958,546 - 124,982,566 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	124,946,961 - 124,971,011 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	7	111,522,078 - 111,546,043 (-)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

intellectual disability (ISO)

Phelan-McDermid syndrome (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (EXP)

1,2-dichloroethane (ISO)

1,2-dimethylhydrazine (ISO)

1-naphthyl isothiocyanate (EXP)

2,3,7,8-tetrachlorodibenzodioxine (EXP)

2-naphthol (ISO)

2-naphthylamine (ISO)

3,3',5-triiodo-L-thyronine (ISO)

3,4-methylenedioxymethamphetamine (ISO)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (ISO)

4-nitrophenol (ISO)

6-propyl-2-thiouracil (EXP)

8-Br-cAMP (ISO)

aflatoxin B1 (ISO)

aldehydo-D-glucose (ISO)

arsane (ISO)

arsenic atom (ISO)

benzo[a]pyrene (ISO)

bisphenol A (EXP,ISO)

cefaloridine (EXP)

CGP 52608 (ISO)

chlorpyrifos (ISO)

choline (ISO)

copper atom (EXP)

copper(0) (EXP)

D-glucose (ISO)

estrone (ISO)

ethanol (ISO)

ethylbenzene (ISO)

fenofibrate (EXP)

fipronil (EXP)

folic acid (ISO)

fructose (ISO)

gentamycin (EXP)

glucose (ISO)

kojic acid (EXP)

L-methionine (ISO)

lead(0) (ISO)

metformin (EXP)

methotrexate (ISO)

N-nitrosodiethylamine (EXP)

paracetamol (EXP)

perfluorooctane-1-sulfonic acid (EXP)

resveratrol (ISO)

sunitinib (ISO)

Tesaglitazar (EXP)

tetrachloromethane (EXP)

thyroxine (ISO)

toluene (ISO)

trichloroethene (EXP)

trichostatin A (ISO)

triclosan (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

dendrite arborization (IMP)

steroid metabolic process (IEA)

sulfation (IBA)

sulfur compound metabolic process (ISO)

Cellular Component

cytoplasm (IBA,IEA)

cytosol (ISO)

mitochondrion (ISO)

Molecular Function

identical protein binding (ISO)

protein binding (ISO)

sulfotransferase activity (IBA,IEA,ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	SULT4A1 Modulates Synaptic Development and Function by Promoting the Formation of PSD-95/NMDAR Complex.	Culotta L, etal., J Neurosci. 2020 Sep 9;40(37):7013-7026. doi: 10.1523/JNEUROSCI.2194-19.2020. Epub 2020 Aug 12.
2.	Molecular cloning and expression of novel sulphotransferase-like cDNAs from human and rat brain.	Falany CN, etal., Biochem J 2000 Mar 15;346 Pt 3:857-64.
3.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4.	Rat ISS GO annotations from GOA human gene data--August 2006	GOA data from the GO Consortium
5.	Rat ISS GO annotations from MGI mouse gene data--August 2006	MGD data from the GO Consortium
6.	Electronic Transfer of LocusLink and RefSeq Data	NCBI rat LocusLink and RefSeq merged data July 26, 2002
7.	GOA pipeline	RGD automated data pipeline
8.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
9.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
10.	Tentative Sequence Identification Numbers	Tentative Sequence Data IDs. TIGR Gene Index, Rat Data

Additional References at PubMed

PMID:12039030	PMID:19439498

Genomics

Comparative Map Data

Sult4a1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	7	117,096,064 - 117,120,714 (-)	NCBI		GRCr8
mRatBN7.2	7	115,216,066 - 115,240,156 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	7	115,216,066 - 115,240,085 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	7	116,963,947 - 116,987,966 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	7	119,189,653 - 119,213,672 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	7	119,159,119 - 119,183,138 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	7	124,958,546 - 124,982,602 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	7	124,958,546 - 124,982,566 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	7	124,946,961 - 124,971,011 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	7	111,522,078 - 111,546,043 (-)	NCBI		Celera
Cytogenetic Map	7	q34	NCBI

SULT4A1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	22	43,824,509 - 43,862,513 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	22	43,824,509 - 43,862,513 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	22	44,220,389 - 44,258,393 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	22	42,551,720 - 42,589,711 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	22	42,545,289 - 42,583,257	NCBI
Celera	22	28,131,680 - 28,168,899 (-)	NCBI		Celera
Cytogenetic Map	22	q13.31	NCBI
HuRef	22	27,174,799 - 27,191,668 (-)	NCBI		HuRef
CHM1_1	22	44,179,106 - 44,216,628 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	22	44,307,367 - 44,345,097 (-)	NCBI		T2T-CHM13v2.0

Sult4a1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	83,960,298 - 83,989,955 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	83,960,298 - 83,989,955 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	84,076,097 - 84,105,754 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	84,076,097 - 84,105,754 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	83,906,527 - 83,936,184 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	83,903,863 - 83,933,520 (-)	NCBI		MGSCv36	mm8
Celera	15	86,206,275 - 86,235,878 (-)	NCBI		Celera
Cytogenetic Map	15	E2	NCBI
cM Map	15	39.73	NCBI

Sult4a1
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955413	28,797,645 - 28,821,088 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955413	28,800,537 - 28,821,082 (-)	NCBI	ChiLan1.0	ChiLan1.0

SULT4A1
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	23	53,651,729 - 53,690,705 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	22	56,345,149 - 56,383,037 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	22	24,712,960 - 24,751,078 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	22	42,905,463 - 42,922,260 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	22	42,906,959 - 42,927,236 (-)	Ensembl	panpan1.1		panPan2

SULT4A1
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	10	21,781,562 - 21,815,059 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	10	21,781,487 - 21,814,006 (+)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	10	21,722,268 - 21,755,762 (+)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	10	22,530,422 - 22,563,935 (+)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	10	22,530,347 - 22,562,882 (+)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	10	22,249,779 - 22,283,267 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	10	22,569,893 - 22,603,392 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	10	22,743,989 - 22,777,510 (+)	NCBI		UU_Cfam_GSD_1.0

Sult4a1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	5,420,418 - 5,442,706 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936718	1,533,786 - 1,559,749 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936718	1,537,459 - 1,559,743 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SULT4A1
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	5,131,252 - 5,156,894 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	5,131,272 - 5,156,898 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	2,524,715 - 2,549,854 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SULT4A1
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	19	26,339,693 - 26,379,260 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	19	26,339,582 - 26,379,249 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666045	99,026,953 - 99,063,862 (+)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sult4a1
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624752	5,272,276 - 5,294,615 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624752	5,272,212 - 5,301,350 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Sult4a1
151 total Variants

miRNA Target Status

Predicted Target Of

	Summary Value
Count of predictions:	209
Count of miRNA genes:	143
Interacting mature miRNAs:	175
Transcripts:	ENSRNOT00000075099
Prediction methods:	Miranda, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1300179	Kidm5	Kidney mass QTL 5	3.51		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	43747012	135012528	Rat
1300112	Bp183	Blood pressure QTL 183	3.51		arterial blood pressure trait (VT:2000000)	blood pressure time series experimental set point of the baroreceptor response (CMO:0002593)	7	111182207	135012528	Rat
1331728	Bp214	Blood pressure QTL 214	2.825		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	80221299	124373579	Rat
1331731	Bp216	Blood pressure QTL 216	2.851		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	102297359	133492884	Rat
2298475	Eau6	Experimental allergic uveoretinitis QTL 6		0.0029	uvea integrity trait (VT:0010551)	experimental autoimmune uveitis score (CMO:0001504)	7	84257275	129257275	Rat
71114	Niddm14	Non-insulin dependent diabetes mellitus QTL 14	4.5		blood glucose amount (VT:0000188)	plasma glucose level (CMO:0000042)	7	84257275	129257275	Rat
1357336	Gluco6	Glucose level QTL 6	3.4		blood glucose amount (VT:0000188)	serum glucose level (CMO:0000543)	7	94811326	116294265	Rat
70159	Bp61	Blood pressure QTL 61		0.0001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	103146217	116738842	Rat
631687	Hcas1	Hepatocarcinoma susceptibility QTL 1	3.9	0.001	liver integrity trait (VT:0010547)	liver tumorous lesion volume to total liver volume ratio (CMO:0001082)	7	91412594	129807172	Rat
1357339	Stl14	Serum triglyceride level QTL 14	3.45	0.0001	blood triglyceride amount (VT:0002644)	serum triglyceride level (CMO:0000360)	7	112729683	133492707	Rat
634331	Pia17	Pristane induced arthritis QTL 17	4.7		joint integrity trait (VT:0010548)	arthritic paw count (CMO:0001460)	7	73829340	130221005	Rat
1358914	Bp266	Blood pressure QTL 266			arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat
631504	Cm27	Cardiac mass QTL 27	3.45		heart left ventricle mass (VT:0007031)	heart left ventricle wet weight (CMO:0000071)	7	44421311	118198041	Rat
634322	Bw12	Body weight QTL 12	0		body mass (VT:0001259)	body weight (CMO:0000012)	7	83153392	128153392	Rat
70173	Niddm19	Non-insulin dependent diabetes mellitus QTL 19	4.33	0.00005	blood glucose amount (VT:0000188)	blood glucose level area under curve (AUC) (CMO:0000350)	7	64002457	135012528	Rat
1549899	Stresp8	Stress response QTL 8	4.37	0.0008	stress-related behavior trait (VT:0010451)	defensive burying duration (CMO:0001961)	7	90482196	135012528	Rat
2317052	Aia17	Adjuvant induced arthritis QTL 17	2.13		joint integrity trait (VT:0010548)	left rear ankle joint diameter (CMO:0002149)	7	81737938	126737938	Rat
731176	Glom5	Glomerulus QTL 5	2.5	0.0035	kidney glomerulus morphology trait (VT:0005325)	count of superficial glomeruli not directly contacting the kidney surface (CMO:0001002)	7	96670164	135012528	Rat
631663	Bw6	Body weight QTL 6	3.4		body mass (VT:0001259)	body weight (CMO:0000012)	7	111075573	134976056	Rat
2306821	Bp335	Blood pressure QTL 335		0.001	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	106571501	135012528	Rat
7411607	Foco15	Food consumption QTL 15		0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
1558655	Swd4	Spike wave discharge measurement QTL 4	3.68	0.0002	brain electrophysiology trait (VT:0010557)	brain spike-and-wave discharge severity grade (CMO:0001988)	7	86983365	131983365	Rat
1331768	Kidm10	Kidney mass QTL 10	4.62096		kidney mass (VT:0002707)	left kidney wet weight (CMO:0000083)	7	80221299	125221299	Rat
731174	Uae23	Urinary albumin excretion QTL 23	2.4	0.0042	urine albumin amount (VT:0002871)	urine albumin excretion rate (CMO:0000757)	7	104603555	135012528	Rat
2313102	Bmd79	Bone mineral density QTL 79	2.3	0.0001	tibia mineral mass (VT:1000283)	total volumetric bone mineral density (CMO:0001728)	7	94811085	116738842	Rat
61357	Bp38	Blood pressure QTL 38	1.6	0.052	arterial blood pressure trait (VT:2000000)	systolic blood pressure (CMO:0000004)	7	41333674	119109060	Rat
1331748	Bp215	Blood pressure QTL 215	4.043		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	112308254	133492884	Rat
7411654	Foco25	Food consumption QTL 25	9.3	0.001	eating behavior trait (VT:0001431)	feed conversion ratio (CMO:0001312)	7	75918751	120918751	Rat
2299163	Iddm34	Insulin dependent diabetes mellitus QTL 34	2.71		blood glucose amount (VT:0000188)	age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)	7	91281130	135012528	Rat
631540	Bw9	Body weight QTL 9	4.5		body mass (VT:0001259)	body weight (CMO:0000012)	7	69736226	117455174	Rat
1358891	Bp265	Blood pressure QTL 265	2.21		arterial blood pressure trait (VT:2000000)	mean arterial blood pressure (CMO:0000009)	7	83591953	134666232	Rat

Markers in Region

RH135358

Rat Assembly	Chr	Position (strand)	Source	JBrowse
mRatBN7.2	7	115,216,225 - 115,216,442 (+)	MAPPER	mRatBN7.2
Rnor_6.0	7	124,958,706 - 124,958,922	NCBI	Rnor6.0
Rnor_5.0	7	124,947,121 - 124,947,337	UniSTS	Rnor5.0
Celera	7	111,522,238 - 111,522,454	UniSTS
RH 3.4 Map	7	912.8	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Download All Expressed Objects for this Gene

alimentary part of gastrointestinal system	appendage	circulatory system	ectoderm	endocrine system	endoderm	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	mesenchyme	mesoderm	nervous system	renal system	reproductive system	respiratory system
9	7	41	113	76	75	45	15	45	6	178	72	93	45	60	30

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_031641	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017595067	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AF176343	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF188699	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH473950	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	DQ897974	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	JAXUCZ010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSRNOT00000075099 ⟹ ENSRNOP00000066760

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	115,216,066 - 115,240,085 (-)	Ensembl
Rnor_6.0 Ensembl	7	124,958,546 - 124,982,566 (-)	Ensembl

Ensembl Acc Id:

ENSRNOT00000115395 ⟹ ENSRNOP00000094830

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2 Ensembl	7	115,217,466 - 115,240,085 (-)	Ensembl

RefSeq Acc Id:

NM_031641 ⟹ NP_113829

RefSeq Status:

PROVISIONAL

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	117,096,064 - 117,120,083 (-)	NCBI
mRatBN7.2	7	115,216,066 - 115,240,085 (-)	NCBI
Rnor_6.0	7	124,958,546 - 124,982,561 (-)	NCBI
Rnor_5.0	7	124,946,961 - 124,971,011 (-)	NCBI
Celera	7	111,522,078 - 111,546,043 (-)	RGD

Sequence:

show sequence

GGCACGAGCCCTGGAGCTGCGGGCCGGGCCGGGCGGCAGCATGGCGGAGAGCGAAGCGGAGACC
CCGGGCACCCCGGGCGAGTTCGAGAGCAAGTACTTCGAGTTCCATGGCGTGCGGCTGCCTCCCT
TCTGCCGCGGGAAGATGGAGGACATCGCCGACTTCCCAGTGCGGCCCAGCGATGTGTGGATCGT
CACCTACCCCAAGTCAGGTACGAGCTTGCTGCAAGAGGTGGTCTACTTGGTGAGCCAGGGGGCT
GACCCTGATGAGATTGGCCTCATGAACATTGACGAGCAGCTGCCAGTACTGGAGTACCCACAGC
CCGGGCTGGACATCATCAAGGAACTGACGTCTCCCCGCCTCATCAAGAGCCACCTTCCCTACCG
CTTCCTGCCCTCTGACCTCCACAACGGGGACTCCAAGGTCATCTACATGGCTCGCAACCCAAAG
GACCTGGTGGTATCTTACTATCAGTTCCACCGCTCGCTGCGGACCATGAGTTACCGAGGAACCT
TCCAGGAGTTCTGTCGGAGGTTCATGAACGACAAATTGGGCTATGGCTCCTGGTTTGAGCACGT
TCAGGAATTCTGGGAACATCGAATGGACGCAAATGTGCTTTTCCTCAAGTATGAAGATATGCAC
CGGGACCTGGTGACCATGGTGGAGCAGCTGGCCAGATTCCTGGGTGTGTCCTGTGATAAGGCCC
AGCTGGAGTCCTTGATCGAGCACTGCCACCAGCTGGTGGACCAGTGCTGCAATGCTGAGGCCCT
GCCTGTGGGCCGGGGAAGAGTCGGGCTGTGGAAGGACATCTTCACTGTCTCCATGAACGAGAAG
TTTGATCTAGTGTATAAACAGAAGATGGGGAAGTGTGACCTCACGTTTGACTTTTATTTATAAT
ACCAGAATCCGCAAACTTGCATGCTCACGGTCCCCAGACGCTCTACTAGCTAAAAGTCCTGTTT
GCGTTCATTTATTCCTTGCTGGACACTCCGGAAGTTGCTTGGAAACAGCAGGGGGCGAGCCTGG
TGGAGAGAGCCGAGGAGTGAGATGATGCTGTCTACAGCAGCCGCCTGGCCGTAGCGTTTGAGTC
TCCACGTGCTGGCCATACCACACGCACGGGCAGGCAAATGTCTGCCCCTGTACCCCATGTTATT
CACTGTATTTTATAGCGCTTTTCACTGAAAATCGAAATAAATATGTCAACCAAATGCAAGTCCA
TTTCCAAGGGGGAGCAGGAGCGAGCTGTGCCGGGATGCTAGGAAGCTCTCAGGGGTCACTGTAA
TTTTTATAGTCTTCTCTCTAGGCACAGCCATCCCACCTTGTCCCGAGATCAAAGGACAGGTTGG
GGGGAGCTGGAGAGGTGGGTGTAGCCTGTGGAGTTCAGTTTTCTGGAACCATCCTGACACCAAG
CCAGGTCCTGTCCCAGGTCTCTGAGCCCAGTACAGAATGTTCTGGAAGGGAAGCTGGCCTGAGG
CTGCGGATGGCATCTGAAGGCATCAGTGGTGTGTGAAGCGTACCCACAGACACCAGACTGCACC
AAGAACTAGTATATCTCATAGCCTTCACTTGCTCCCCAAGGCCGTGACTGGCACACTCCCAATG
GCAAGAGACATGACATACCATGGTTCTGAAGTCCCTAGTCATCGTCACGTCTGTGCCACCTGTG
CCAAGGCTCTCGCTCGGGAGACCCAGTCTGCAGGTTGACTGTCCTCCATGCAGATAGGATTGGC
AAGCCCACCTGTCTGAGGGGGCACTTAGCCCTCAAGGATGTCTGAGGGAGCAATGGCCCCATGT
ACTGTCCACCCTGACACCTACCGGCTCTGTCTTCCAGCTCCAATTTGGCTCAAGTGATGACCAG
ATGATGGGTGGACCAGGAGATTGCTGCTTGTGGGGACCAACTTATTCTGTTCCTTACCAGGATG
GGAAGAGTCTTAACGTGGTGGGGGGAGGCTCTGGCTGTGGAAGGTGCCTGCTGTGCGCCATCTC
TGAAGCAGGTTTGGTTGTAGCAGCGTTACCTCTGTCTAGAGGAAAGCTTGTGTGGGTCTGGTGC
ATGGTTCTCTGAGGTGGGCATGGCAGTGCCTTTCCTGTGTGTCTGGGGAGGAAGGCTGCTTTCT
GTGAAATTTTCTTTCTATTTTTCTATTTTTAGTACTGTACGGATGTTCTGGAACCACACACGGT
ACTCTGTGCTTGCTTGCATCTTTAATAAAAGACACCTCCCCTGTCAAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_017595067 ⟹ XP_017450556

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
GRCr8	7	117,097,484 - 117,120,714 (-)	NCBI
mRatBN7.2	7	115,217,369 - 115,240,156 (-)	NCBI
Rnor_6.0	7	124,961,066 - 124,982,602 (-)	NCBI

Sequence:

show sequence

CGTCATGCCCGCGGAGCCCCGCGCCGGCGCCGTGACGTCACGCCCTGGAGCTGCGGGCCGGGCC
GGGCGGCAGCATGGCGGAGAGCGAAGCGGAGACCCCGGGCACCCCGGGCGAGTTCGAGAGCAAG
TACTTCGAGTTCCATGGCGTGCGGCTGCCTCCCTTCTGCCGCGGGAAGATGGAGGACATCGCCG
ACTTCCCAGTGCGGCCCAGCGATGTGTGGATTGTCACCTACCCCAAGTCAGGTACGAGCTTGCT
GCAAGAGGTGGTCTACTTGGTGAGCCAGGGGGCTGACCCTGATGAGATTGGCCTCATGAACATT
GACGAGCAGCTGCCAGTACTGGAGTACCCACAGCCCGGGCTGGACATCATCAAGGAACTGACGT
CTCCCCGCCTCATCAAGAGCCACCTTCCCTACCGCTTCCTGCCCTCTGACCTCCACAACGGGGA
CTCCAAGGTCATCTACATGGCTCGCAACCCAAAGGACCTGGTGGTATCTTACTATCAGTTCCAC
CGCTCGCTGCGGACCATGAGTTACCGAGGAACCTTCCAGGAGTTCTGTCGGAGGTTCATGAACG
ACAAATTGGGCTATGGCTCCTGGTTTGAGCACGTTCAGGAATTCTGGGAACATCGAATGGACGC
AAATGTGCTTTTCCTCAAGTATGAAGATATGCACCGGGACCTGGTGACCATGGTGGAGCAGCTG
GCCAGATTCCTGGGTGTGTCCTGTGATAAGGCCCAGCTGGAGTCCTTGATCGAGCACTGCCACC
AGCTGGTGGACCAGTGCTGCAATGCTGAGGCCCTGCCTGTGGGCCGGGCACATTGCCTCTTTAC
TCAGAAGATCGCCTTGAGGTGGCGAGGATGCAGGGGCTCGGGGAGCCGGCTGCATTGCTTAAAT
TTGGTTCATGTCACAGCATAAATTGTCTTGATTCCAAATCCTAAACCAGGTGGGTGACTCCTCT
GACAAGC

hide sequence

Protein Sequences


Protein RefSeqs	NP_113829	(Get FASTA)	NCBI Sequence Viewer
	XP_017450556	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAF61198	(Get FASTA)	NCBI Sequence Viewer
	AAK64596	(Get FASTA)	NCBI Sequence Viewer
	ABI79446	(Get FASTA)	NCBI Sequence Viewer
	EDM15611	(Get FASTA)	NCBI Sequence Viewer
	EDM15612	(Get FASTA)	NCBI Sequence Viewer
	EDM15613	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSRNOP00000066760.1
	ENSRNOP00000094830.1
	ENSRNOP00055042487
	ENSRNOP00060041890
	ENSRNOP00065043148
GenBank Protein	P63047	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:

NP_113829 ⟸ NM_031641

- UniProtKB:

P63047 (UniProtKB/Swiss-Prot), A6HTA9 (UniProtKB/TrEMBL), A6HTB0 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MAESEAETPGTPGEFESKYFEFHGVRLPPFCRGKMEDIADFPVRPSDVWIVTYPKSGTSLLQEV
VYLVSQGADPDEIGLMNIDEQLPVLEYPQPGLDIIKELTSPRLIKSHLPYRFLPSDLHNGDSKV
IYMARNPKDLVVSYYQFHRSLRTMSYRGTFQEFCRRFMNDKLGYGSWFEHVQEFWEHRMDANVL
FLKYEDMHRDLVTMVEQLARFLGVSCDKAQLESLIEHCHQLVDQCCNAEALPVGRGRVGLWKDI
FTVSMNEKFDLVYKQKMGKCDLTFDFYL

hide sequence

RefSeq Acc Id:	XP_017450556 ⟸ XM_017595067
- Peptide Label:	isoform X1
- UniProtKB:	A0A8I6AMX8 (UniProtKB/TrEMBL), A6HTB1 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAESEAETPGTPGEFESKYFEFHGVRLPPFCRGKMEDIADFPVRPSDVWIVTYPKSGTSLLQEV VYLVSQGADPDEIGLMNIDEQLPVLEYPQPGLDIIKELTSPRLIKSHLPYRFLPSDLHNGDSKV IYMARNPKDLVVSYYQFHRSLRTMSYRGTFQEFCRRFMNDKLGYGSWFEHVQEFWEHRMDANVL FLKYEDMHRDLVTMVEQLARFLGVSCDKAQLESLIEHCHQLVDQCCNAEALPVGRAHCLFTQKI ALRWRGCRGSGSRLHCLNLVHVTA hide sequence

Ensembl Acc Id:

ENSRNOP00000066760 ⟸ ENSRNOT00000075099

Ensembl Acc Id:

ENSRNOP00000094830 ⟸ ENSRNOT00000115395

Protein Domains

Sulfotransferase

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-P63047-F1-model_v2	AlphaFold	P63047	1-284	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Promoters

RGD ID:

13695553

Promoter ID:

EPDNEW_R6078

Type:

multiple initiation site

Name:

Sult4a1_1

Description:

sulfotransferase family 4A, member 1

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Experiment Methods:

Single-end sequencing.

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0	7	124,982,556 - 124,982,616	EPDNEW

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:69292	AgrOrtholog
BioCyc Gene	G2FUF-32584	BioCyc
Ensembl Genes	ENSRNOG00000046975	Ensembl, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	ENSRNOG00055029751	UniProtKB/Swiss-Prot
	ENSRNOG00060028924	UniProtKB/Swiss-Prot
	ENSRNOG00065030451	UniProtKB/Swiss-Prot
Ensembl Transcript	ENSRNOT00000075099.3	UniProtKB/Swiss-Prot
	ENSRNOT00000115395.1	UniProtKB/TrEMBL
	ENSRNOT00055051543	UniProtKB/Swiss-Prot
	ENSRNOT00060050278	UniProtKB/Swiss-Prot
	ENSRNOT00065052501	UniProtKB/Swiss-Prot
Gene3D-CATH	3.40.50.300	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro	P-loop_NTPase	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	Sulfotransferase_dom	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report	rno:58953	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene	Sult4a1	ENTREZGENE
PANTHER	SULFOTRANSFERASE 4A1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
	SULFOTRANSFERASE SULT	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam	Sulfotransfer_1	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen	Sult4a1	PhenoGen
RatGTEx	ENSRNOG00000046975	RatGTEx
	ENSRNOG00055029751	RatGTEx
	ENSRNOG00060028924	RatGTEx
	ENSRNOG00065030451	RatGTEx
Superfamily-SCOP	SSF52540	UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR	TC219757
UniProt	A0A8I6AMX8	ENTREZGENE, UniProtKB/TrEMBL
	A6HTA9	ENTREZGENE, UniProtKB/TrEMBL
	A6HTB0	ENTREZGENE, UniProtKB/TrEMBL
	A6HTB1	ENTREZGENE, UniProtKB/TrEMBL
	P63047	ENTREZGENE
	Q06FK3_RAT	UniProtKB/TrEMBL
	ST4A1_RAT	UniProtKB/Swiss-Prot
UniProt Secondary	O88872	UniProtKB/Swiss-Prot
	Q91XS5	UniProtKB/Swiss-Prot
	Q9CWY7	UniProtKB/Swiss-Prot
	Q9DC97	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2003-04-09	Sult4a1	sulfotransferase family 4A, member 1		sulfotransferase family 4A, member 1	Symbol and Name updated	629477	APPROVED
2003-03-12	Sult4a1	sulfotransferase family 4A, member 1	Sultx3-pending	sulfotransferase-related protein	Data merged from RGD:620409	628472	PROVISIONAL
2002-08-07	Sultx3-pending	sulfotransferase-related protein			Symbol and Name status set to provisional	70820	PROVISIONAL
2002-06-10	Sult4a1	sulfotransferase family 4A, member 1			Name updated	70584	APPROVED

RGD Curation Notes

Note Type	Note	Reference
gene_expression	mRNA expressed specifically in brain, with highest levels in the cortex	70068
gene_homology	protein aa sequence shares 98% identity with human SULT4A1	70068
gene_protein	predicted protein contains 284 aa residues and masses 33 kDa	70068

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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