St14 (ST14 transmembrane serine protease matriptase) - Rat Genome Database

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Gene: St14 (ST14 transmembrane serine protease matriptase) Rattus norvegicus
Analyze
Symbol: St14
Name: ST14 transmembrane serine protease matriptase
RGD ID: 69288
Description: Enables serine-type peptidase activity. Involved in protein catabolic process. Located in basolateral plasma membrane and extracellular space. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 11. Orthologous to human ST14 (ST14 transmembrane serine protease matriptase); INTERACTS WITH 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 1-naphthyl isothiocyanate; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: matriptase; membrane-type serine protease; MT-SP1; suppression of tumorigenicity 14; suppression of tumorigenicity 14 (colon carcinoma matriptase epithin); suppression of tumorigenicity 14 (colon carcinoma); suppression of tumorigenicity 14 (colon carcinoma, matriptase, epithin)
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Black Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8837,798,994 - 37,839,881 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl837,798,995 - 37,855,652 (-)EnsemblGRCr8
mRatBN7.2829,540,805 - 29,581,704 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl829,540,811 - 29,581,517 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx833,610,130 - 33,650,868 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0831,904,527 - 31,945,265 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0829,772,418 - 29,813,130 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0832,240,113 - 32,280,813 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl832,240,133 - 32,280,869 (-)Ensemblrn6Rnor6.0
Rnor_5.0832,266,158 - 32,305,925 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4830,916,769 - 30,932,214 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera831,002,596 - 31,042,887 (-)NCBICelera
RGSC_v3.1830,925,535 - 30,940,977 (-)NCBI
Cytogenetic Map8q13NCBI
JBrowse:




Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane  (EXP,ISO)
1,2-dimethylhydrazine  (ISO)
1-naphthyl isothiocyanate  (EXP)
17alpha-ethynylestradiol  (ISO)
17beta-estradiol  (ISO)
2,2',4,4'-Tetrabromodiphenyl ether  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3-chloropropane-1,2-diol  (EXP)
4,4'-diaminodiphenylmethane  (EXP)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxyphenyl retinamide  (ISO)
6-propyl-2-thiouracil  (EXP)
acetamide  (EXP)
acrylamide  (EXP)
aflatoxin B1  (ISO)
Aflatoxin B2 alpha  (ISO)
all-trans-retinoic acid  (ISO)
alpha-Zearalanol  (EXP)
amitrole  (EXP)
amphetamine  (EXP)
antirheumatic drug  (ISO)
aristolochic acid A  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (ISO)
bis(2-ethylhexyl) phthalate  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
bleomycin A2  (ISO)
butan-1-ol  (ISO)
cadmium dichloride  (ISO)
calcitriol  (ISO)
CGP 52608  (ISO)
choline  (ISO)
cisplatin  (ISO)
cyclophosphamide  (ISO)
dibutyl phthalate  (EXP)
dorsomorphin  (ISO)
doxorubicin  (ISO)
elemental selenium  (ISO)
ethanol  (ISO)
folic acid  (ISO)
folpet  (ISO)
fonofos  (ISO)
furan  (EXP)
gentamycin  (EXP)
hypochlorous acid  (ISO)
indole-3-methanol  (EXP)
isobutanol  (ISO)
L-methionine  (ISO)
leflunomide  (ISO)
lidocaine  (EXP)
menadione  (ISO)
mercury dibromide  (ISO)
mitomycin C  (ISO)
N-methyl-4-phenylpyridinium  (EXP)
N-nitrosodimethylamine  (EXP)
nickel atom  (ISO)
okadaic acid  (ISO)
ozone  (ISO)
panobinostat  (ISO)
parathion  (ISO)
parathion-methyl  (EXP)
perfluorooctanoic acid  (EXP)
phenylmercury acetate  (ISO)
pirinixic acid  (ISO)
progesterone  (ISO)
propiconazole  (ISO)
SB 431542  (ISO)
selenium atom  (ISO)
silicon dioxide  (ISO)
sodium arsenite  (ISO)
sodium dichromate  (ISO)
sulfadimethoxine  (EXP)
terbufos  (ISO)
Tesaglitazar  (EXP)
thioacetamide  (EXP)
thiram  (ISO)
titanium dioxide  (ISO)
tributylstannane  (ISO)
trichostatin A  (ISO)
triptonide  (ISO)
troglitazone  (EXP)
urethane  (ISO)
valproic acid  (ISO)
vorinostat  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
3. Expression of the serine protease, matriptase, in breast ductal carcinoma of Chinese women: correlation with clinicopathological parameters. Jin JS, etal., Histol Histopathol. 2007 Mar;22(3):305-9.
4. Expression of serine protease matriptase in renal cell carcinoma: correlation of tissue microarray immunohistochemical expression analysis results with clinicopathological parameters. Jin JS, etal., Int J Surg Pathol. 2006 Jan;14(1):65-72.
5. Increasing expression of serine protease matriptase in ovarian tumors: tissue microarray analysis of immunostaining score with clinicopathological parameters. Jin JS, etal., Mod Pathol. 2006 Mar;19(3):447-52.
6. Increased expression of matriptase is associated with histopathologic grades of cervical neoplasia. Lee JW, etal., Hum Pathol. 2005 Jun;36(6):626-33.
7. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
8. Expression of matriptase and clinical outcome of human endometrial cancer. Nakamura K, etal., Anticancer Res. 2009 May;29(5):1685-90.
9. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
10. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
11. GOA pipeline RGD automated data pipeline
12. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
14. A role for membrane-type serine protease (MT-SP1) in intestinal epithelial turnover. Satomi S, etal., Biochem Biophys Res Commun 2001 Oct 5;287(4):995-1002.
15. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
16. Evidence for the occurrence of membrane-type serine protease 1/matriptase on the basolateral sides of enterocytes. Tsuzuki S, etal., Biochem J. 2005 Jun 1;388(Pt 2):679-87.
17. Protein expression of matriptase and its cognate inhibitor HAI-1 in human prostate cancer: a tissue microarray and automated quantitative analysis. Warren M, etal., Appl Immunohistochem Mol Morphol. 2009 Jan;17(1):23-30.
18. The macrophage-stimulating protein pathway promotes metastasis in a mouse model for breast cancer and predicts poor prognosis in humans. Welm AL, etal., Proc Natl Acad Sci U S A. 2007 May 1;104(18):7570-5. Epub 2007 Apr 24.
Additional References at PubMed
PMID:11567025   PMID:12477932   PMID:18843291   PMID:19202271   PMID:19592578   PMID:19800422   PMID:19897900   PMID:19911255   PMID:20657595   PMID:20682770   PMID:23038671   PMID:23376485  


Genomics

Comparative Map Data
St14
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8837,798,994 - 37,839,881 (-)NCBIGRCr8GRCr8GRCr8
GRCr8 Ensembl837,798,995 - 37,855,652 (-)EnsemblGRCr8
mRatBN7.2829,540,805 - 29,581,704 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl829,540,811 - 29,581,517 (-)EnsemblmRatBN7.2
UTH_Rnor_SHR_Utx833,610,130 - 33,650,868 (-)NCBIUTH_Rnor_SHR_UtxUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0831,904,527 - 31,945,265 (-)NCBIUTH_Rnor_SHRSP_BbbUtx_1.0UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0829,772,418 - 29,813,130 (-)NCBIUTH_Rnor_WKY_Bbb_1.0UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0832,240,113 - 32,280,813 (-)NCBIRnor_6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl832,240,133 - 32,280,869 (-)Ensemblrn6Rnor6.0
Rnor_5.0832,266,158 - 32,305,925 (-)NCBIRnor_5.0Rnor_5.0rn5
RGSC_v3.4830,916,769 - 30,932,214 (-)NCBIRGSC_v3.4RGSC_v3.4rn4
Celera831,002,596 - 31,042,887 (-)NCBICelera
RGSC_v3.1830,925,535 - 30,940,977 (-)NCBI
Cytogenetic Map8q13NCBI
ST14
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811130,159,782 - 130,210,362 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11130,159,746 - 130,210,367 (+)Ensemblhg38GRCh38
GRCh3711130,029,677 - 130,080,257 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611129,534,892 - 129,585,467 (+)NCBIBuild 36Build 36hg18NCBI36
Build 3411129,534,932 - 129,585,466NCBI
Celera11127,197,379 - 127,248,136 (+)NCBICelera
Cytogenetic Map11q24.3NCBI
HuRef11125,980,949 - 126,032,941 (+)NCBIHuRef
CHM1_111129,915,529 - 129,966,064 (+)NCBICHM1_1
T2T-CHM13v2.011130,195,451 - 130,246,169 (+)NCBIT2T-CHM13v2.0
St14
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39930,999,886 - 31,043,138 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl931,000,698 - 31,043,149 (-)EnsemblGRCm39 EnsemblGRCm39
GRCm38931,088,590 - 31,131,811 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl931,089,402 - 31,131,853 (-)Ensemblmm10GRCm38
MGSCv37930,896,175 - 30,939,384 (-)NCBIMGSCv37MGSCv37mm9NCBIm37
MGSCv36930,838,155 - 30,881,364 (-)NCBIMGSCv36mm8
Celera928,347,788 - 28,391,153 (-)NCBICelera
Cytogenetic Map9A4NCBI
cM Map916.61NCBI
St14
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541231,090,504 - 31,129,050 (+)Ensembl
ChiLan1.0NW_00495541231,091,313 - 31,129,050 (+)NCBIChiLan1.0ChiLan1.0
ST14
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29130,837,315 - 130,888,123 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111131,948,013 - 131,998,803 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011125,001,771 - 125,021,371 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111128,890,780 - 128,913,559 (+)NCBIPanPan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11128,888,124 - 128,913,559 (+)EnsemblpanPan2panpan1.1
ST14
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.154,652,493 - 4,666,728 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl54,651,863 - 4,691,069 (-)EnsemblcanFam3CanFam3.1
Dog10K_Boxer_Tasha54,713,365 - 4,749,564 (-)NCBIDog10K_Boxer_TashaDog10K_Boxer_Tasha
ROS_Cfam_1.054,612,444 - 4,648,611 (-)NCBIROS_Cfam_1.0ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl54,611,806 - 4,650,812 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.154,678,704 - 4,709,995 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.054,655,178 - 4,691,362 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.054,682,587 - 4,719,117 (-)NCBIUU_Cfam_GSD_1.0UU_Cfam_GSD_1.0
St14
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947112,267,586 - 112,312,562 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365722,137,332 - 2,182,742 (-)EnsemblSpeTri2.0 Ensembl
SpeTri2.0NW_0049365722,137,820 - 2,182,674 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ST14
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl956,888,246 - 56,929,767 (+)EnsemblsusScr11Sscrofa11.1
Sscrofa11.1956,888,246 - 56,929,771 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2963,158,988 - 63,198,157 (-)NCBISscrofa10.2Sscrofa10.2susScr3
ST14
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11121,238,666 - 121,290,528 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1121,238,643 - 121,290,007 (+)EnsemblChlSab1.1 EnsemblchlSab2Vervet-AGM
Vero_WHO_p1.0NW_0236660434,817,343 - 4,869,648 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
St14
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248124,583,946 - 4,620,547 (+)EnsemblHetGla_female_1.0 EnsemblhetGla2HetGla_female_1.0 Ensembl
HetGla 1.0NW_0046248124,584,043 - 4,620,410 (+)NCBIHetGla 1.0HetGla 1.0hetGla2
St14
(Rattus rattus - black rat)
Black Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rrattus_CSIRO_v1826,824,839 - 26,864,091 (-)NCBIRrattus_CSIRO_v1

Variants

.
Variants in St14
364 total Variants
miRNA Target Status (No longer updated)

Predicted Target Of
Summary Value
Count of predictions:269
Count of miRNA genes:191
Interacting mature miRNAs:209
Transcripts:ENSRNOT00000009139
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCr8)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357398Slep3Serum leptin concentration QTL 33.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
1358896Bp262Blood pressure QTL 2622.89arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)835464071107982864Rat
2317030Wbc5White blood cell count QTL 53.210.005leukocyte quantity (VT:0000217)white blood cell count (CMO:0000027)81699464261994642Rat
2302278Gluco36Glucose level QTL 364.2blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)83776085958991895Rat
12880044Am9Aortic mass QTL 90.007aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)81038254055382540Rat
724514Uae15Urinary albumin excretion QTL 152.9urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)83776085961459705Rat
631648Stl5Serum triglyceride level QTL 540.0003blood triglyceride amount (VT:0002644)plasma triglyceride level (CMO:0000548)83546407171842899Rat
2301416Bp315Blood pressure QTL 3150.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)81595227960952279Rat
631842Inf1Infertility severity QTL 14.10.001seminal gland mass (VT:0010524)seminal vesicle wet weight (CMO:0001603)83154366176543661Rat
2317032Ginf2Gastrointestinal inflammation QTL 23.210.005liver integrity trait (VT:0010547)liver granuloma severity score (CMO:0002157)81296416557964165Rat
2317036Livw3Liver weight QTL 32.430.01liver mass (VT:0003402)liver weight to body weight ratio (CMO:0000633)81296416557964165Rat
1358907Cm40Cardiac mass QTL 401.89heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)835464071107982864Rat
1598824Memor4Memory QTL 42.5exploratory behavior trait (VT:0010471)total horizontal distance resulting from voluntary locomotion in an experimental apparatus (CMO:0001443)81799386262252873Rat
12880023Bw184Body weight QTL 1840.001body mass (VT:0001259)body weight (CMO:0000012)81038254055382540Rat
2317051Aia18Adjuvant induced arthritis QTL 182.42joint integrity trait (VT:0010548)left rear ankle joint diameter (CMO:0002149)81699464261994642Rat
1358892Kidm26Kidney mass QTL 263.69kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)835464071107982864Rat
12880028Cm103Cardiac mass QTL 1030.02heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)81038254055382540Rat
1359021Bp271Blood pressure QTL 2711.8arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)83412590255607752Rat
2317048Ginf1Gastrointestinal inflammation QTL 13.520.005cecum mucosa thickness (VT:0010234)enterocolitis severity score (CMO:0002138)81296416557964165Rat
2302367Slep5Serum leptin concentration QTL 53.43blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)81799410550763951Rat
12880025Cm102Cardiac mass QTL 1020.044heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)81038254055382540Rat

Markers in Region
D8Arb5  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8837,831,153 - 37,831,348 (+)Marker Load Pipeline
mRatBN7.2829,572,976 - 29,573,171 (+)MAPPERmRatBN7.2
Rnor_6.0832,272,273 - 32,272,467NCBIRnor6.0
Rnor_5.0832,297,385 - 32,297,579UniSTSRnor5.0
Celera831,034,337 - 31,034,541UniSTS
RH 3.4 Map8215.0UniSTS
RH 3.4 Map8215.0RGD
RH 2.0 Map8177.7RGD
SHRSP x BN Map821.12RGD
FHH x ACI Map822.03RGD
Cytogenetic Map8q13UniSTS
AW530531  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2829,548,930 - 29,549,138 (+)MAPPERmRatBN7.2
Rnor_6.0832,248,231 - 32,248,438NCBIRnor6.0
Rnor_5.0832,274,276 - 32,274,483UniSTSRnor5.0
RGSC_v3.4830,924,887 - 30,925,094UniSTSRGSC3.4
Celera831,010,711 - 31,010,918UniSTS
RH 3.4 Map8250.3UniSTS
Cytogenetic Map8q13UniSTS
RH138338  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2829,571,334 - 29,571,533 (+)MAPPERmRatBN7.2
Rnor_6.0832,270,631 - 32,270,829NCBIRnor6.0
Rnor_5.0832,295,743 - 32,295,941UniSTSRnor5.0
Celera831,032,695 - 31,032,893UniSTS
RH 3.4 Map8254.7UniSTS
Cytogenetic Map8q13UniSTS
RH141540  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.2829,540,893 - 29,541,087 (+)MAPPERmRatBN7.2
Rnor_6.0832,240,197 - 32,240,390NCBIRnor6.0
Rnor_5.0832,266,242 - 32,266,435UniSTSRnor5.0
RGSC_v3.4830,916,853 - 30,917,046UniSTSRGSC3.4
Celera831,002,680 - 31,002,873UniSTS
Cytogenetic Map8q13UniSTS
St14  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr8837,802,346 - 37,803,051 (+)Marker Load Pipeline
mRatBN7.2829,544,163 - 29,544,868 (+)MAPPERmRatBN7.2
Rnor_6.0832,243,466 - 32,244,170NCBIRnor6.0
Rnor_5.0832,269,511 - 32,270,215UniSTSRnor5.0
Celera831,005,949 - 31,006,653UniSTS
Cytogenetic Map8q13UniSTS


Expression

RNA-SEQ Expression

alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
musculoskeletal system
nervous system
renal system
reproductive system
respiratory system
sensory system
visual system
16 12 67 161 91 90 59 91 59 6 355 191 11 137 81 92 31 17 17

Sequence


Ensembl Acc Id: ENSRNOT00000009139   ⟹   ENSRNOP00000009139
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl837,798,995 - 37,839,694 (-)Ensembl
mRatBN7.2 Ensembl829,540,811 - 29,581,517 (-)Ensembl
Rnor_6.0 Ensembl832,240,133 - 32,280,869 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000102601   ⟹   ENSRNOP00000097264
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl837,798,995 - 37,855,652 (-)Ensembl
mRatBN7.2 Ensembl829,540,811 - 29,581,517 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000115406   ⟹   ENSRNOP00000090999
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8 Ensembl837,798,995 - 37,839,694 (-)Ensembl
mRatBN7.2 Ensembl829,540,811 - 29,581,517 (-)Ensembl
RefSeq Acc Id: NM_053635   ⟹   NP_446087
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8837,798,994 - 37,839,694 (-)NCBI
mRatBN7.2829,540,810 - 29,581,517 (-)NCBI
Rnor_6.0832,240,113 - 32,280,813 (-)NCBI
Rnor_5.0832,266,158 - 32,305,925 (-)NCBI
RGSC_v3.4830,916,769 - 30,932,214 (-)RGD
Celera831,002,596 - 31,042,887 (-)RGD
Sequence:
RefSeq Acc Id: XM_039080660   ⟹   XP_038936588
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr8837,798,994 - 37,839,881 (-)NCBI
mRatBN7.2829,540,805 - 29,581,704 (-)NCBI
RefSeq Acc Id: NP_446087   ⟸   NM_053635
- UniProtKB: Q9JJI7 (UniProtKB/TrEMBL),   F1LRR7 (UniProtKB/TrEMBL),   A0A9K3Y7V3 (UniProtKB/TrEMBL),   A0A8I6ARC9 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000009139   ⟸   ENSRNOT00000009139
RefSeq Acc Id: XP_038936588   ⟸   XM_039080660
- Peptide Label: isoform X1
- UniProtKB: F1LRR7 (UniProtKB/TrEMBL),   Q9JJI7 (UniProtKB/TrEMBL),   A0A9K3Y7V3 (UniProtKB/TrEMBL),   A0A8I6ARC9 (UniProtKB/TrEMBL)
Ensembl Acc Id: ENSRNOP00000090999   ⟸   ENSRNOT00000115406
Ensembl Acc Id: ENSRNOP00000097264   ⟸   ENSRNOT00000102601
Protein Domains
CUB   Peptidase S1   SEA

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q9JJI7-F1-model_v2 AlphaFold Q9JJI7 1-855 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

Promoters
RGD ID:13695824
Promoter ID:EPDNEW_R6349
Type:initiation region
Name:St14_1
Description:suppression of tumorigenicity 14
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0832,280,848 - 32,280,908EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene RGD:69288 AgrOrtholog
BioCyc Gene G2FUF-31263 BioCyc
Ensembl Genes ENSRNOG00000005903 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000009139 ENTREZGENE
  ENSRNOT00000009139.8 UniProtKB/TrEMBL
  ENSRNOT00000102601.2 UniProtKB/TrEMBL
  ENSRNOT00000115406.2 UniProtKB/TrEMBL
Gene3D-CATH 2.40.10.10 UniProtKB/TrEMBL
  2.60.120.290 UniProtKB/TrEMBL
  3.30.70.960 UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/TrEMBL
IMAGE_CLONE IMAGE:7445508 IMAGE-MGC_LOAD
InterPro CUB UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/TrEMBL
  Pept_cys/ser_Trypsin-like UniProtKB/TrEMBL
  Pept_S1A_C1r/C1S/mannan-bd UniProtKB/TrEMBL
  Peptidase_S1/S6_AS UniProtKB/TrEMBL
  Peptidase_S1_PA_chymotrypsin UniProtKB/TrEMBL
  Peptidase_S1_S6 UniProtKB/TrEMBL
  Peptidase_S1A_matripase UniProtKB/TrEMBL
  SEA UniProtKB/TrEMBL
  SEA_dom_sf UniProtKB/TrEMBL
  sperma_CUB_dom UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
KEGG Report rno:114093 UniProtKB/TrEMBL
MGC_CLONE MGC:114245 IMAGE-MGC_LOAD
NCBI Gene 114093 ENTREZGENE
PANTHER ACROSIN-RELATED UniProtKB/TrEMBL
  SUPPRESSOR OF TUMORIGENICITY 14 PROTEIN HOMOLOG-RELATED UniProtKB/TrEMBL
Pfam CUB UniProtKB/TrEMBL
  Ldl_recept_a UniProtKB/TrEMBL
  SEA UniProtKB/TrEMBL
  Trypsin UniProtKB/TrEMBL
PhenoGen St14 PhenoGen
PIRSF C1r_C1s_MASP UniProtKB/TrEMBL
  ST14 UniProtKB/TrEMBL
PRINTS LDLRECEPTOR UniProtKB/TrEMBL
PROSITE CUB UniProtKB/TrEMBL
  LDLRA_1 UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/TrEMBL
  SEA UniProtKB/TrEMBL
  TRYPSIN_DOM UniProtKB/TrEMBL
  TRYPSIN_HIS UniProtKB/TrEMBL
  TRYPSIN_SER UniProtKB/TrEMBL
RatGTEx ENSRNOG00000005903 RatGTEx
SMART CUB UniProtKB/TrEMBL
  LDLa UniProtKB/TrEMBL
  Tryp_SPc UniProtKB/TrEMBL
Superfamily-SCOP CUB UniProtKB/TrEMBL
  LDL_rcpt_classA_cys-rich UniProtKB/TrEMBL
  Pept_Ser_Cys UniProtKB/TrEMBL
  SSF82671 UniProtKB/TrEMBL
TIGR TC207836
UniProt A0A8I6AEJ8_RAT UniProtKB/TrEMBL
  A0A8I6ARC9 ENTREZGENE, UniProtKB/TrEMBL
  A0A9K3Y7V3 ENTREZGENE, UniProtKB/TrEMBL
  A6JYG0_RAT UniProtKB/TrEMBL
  F1LRR7 ENTREZGENE
  Q9JJI7 ENTREZGENE, UniProtKB/TrEMBL
UniProt Secondary F1LRR7 UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-06-22 St14  ST14 transmembrane serine protease matriptase  St14  suppression of tumorigenicity 14  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-11-25 St14  suppression of tumorigenicity 14  St14  suppression of tumorigenicity 14 (colon carcinoma)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2006-03-30 St14  suppression of tumorigenicity 14 (colon carcinoma)    suppression of tumorigenicity 14  Name updated 1299863 APPROVED
2002-06-10 St14  suppression of tumorigenicity 14      Name updated 70584 APPROVED

RGD Curation Notes
Note Type Note Reference
gene_expression mRNA expressed in the loosely attached cells of the basement membrane of the epithelial layer of the small intestinal upper villi and the colon 634217
gene_process helps in the digestion of fibronectin and laminin 634217